CDISC - Healthcare, meet the Semantic Web
by hoot72 on Nov 13, 2009
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Presented at CDISC 2009 in Baltimore, it explores what the Semantic Web can bring to Healthcare. Can it be deployed right now? With ease? CDISC sets standards for the exchange of clinical trial data. ...
Presented at CDISC 2009 in Baltimore, it explores what the Semantic Web can bring to Healthcare. Can it be deployed right now? With ease? CDISC sets standards for the exchange of clinical trial data. Once deployed, they remove much of the redundancy and paper processing that characterizes a typical trial today. Its membership includes government regulators like the US FDA, all the major drug companies and their IT vendors.
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NOT HTML ... Querying like DB querying, not page fetching
FORM-CONCEPT-QUERY
run thru on baltimore becomes linkable data about baltimore
web didn’t make hyperlinks or protocols or page layout
SEM WEB: ONE MORE WEB THING ... the power, the scale was link anywhere
SIMPLE ENCOUNTER
Detailed discussion of semi-structured (not going to get into this aspect)
Observable (OBX|4|CE|30949-2^Vaccination adverse event outcome^LN|1|005^required hospitalization^NIP|)
NIP= National Immunization Program within the Center for Disease Control
One standard code is 30949-2.
For the astute: better if code became URI.
From: HCLS == the w3c Health Care and Life Sciences Interest Group
Patient Data is secure - “intranet” LINK OUT
RxNorm not yet an ontology but has web api so can represent it as a SPARQL end point
Simplied to fit. Ingredient = consists of to ingredient to brand name etc.
Dumb AI
from obese to desoxyn ... we need entities
Middleware - format gets out of the way. IT gets out of the reformatting business.
NOT CLASS HIER.
Gen purpose (demographics) and PubMed, Drug Bank, GeneID, Diseasome
Arrows representing linking out to another conceptual scheme
1. STANFORD and BIO-MED guys big ...
2. ONTOLOGY == “TYPE” vs “THING” ... TYPE AND THING
CDASH ODM (machine readable)
CDISC SDTM and other terminology goes through an extensive process of definition, development, and review before it is declared ready for release. Terminology that has completed this process is tagged as "Production," and now includes some 50 SDTM codelists with about 2,200 terms covering demographics, interventions, findings, events, trial design, units, frequency, and ECG terminology. This terminology is maintained and distributed as part of NCI Thesaurus
We will have standard and local ontologies, standard and local queries
there may be several different ways to express the same concept. Human users may be able to recognise that these are essentially the same, but the rules for doing so must be made explicit to be usable by computer. -- Why is Terminology hard?, Alan Rector
CONTENT KING
FDA: “Improve Interoperability: The Target EA establishes enterprise-wide standards that promote platform and vendor independence, enabling greater interoperability across disparate applications, both internal and external”
DOCUMENT model vs GRAPH model
Trial == Snapshot. Extrapolated from individual observations (weight gain etc)
... Here at the Drug Information Association (DIA), you can see a “live” implementation of the interoperability that is possible between Electronic Health Record (EHR) systems and Electronic Data Capture (EDC) systems used for clinical research, which leverages the Integrating the Healthcare Enterprise’s (IHE) Retrieve Form for Data Capture (RFD) integration profile along with CDISC’s ODM and CDASH standards
Contrast to RDIF XFORMs.
The big picture ... Concept and Concrete, Users and Contributors in one web
Trial Recruitment, Drug Safety, Outcomes research
HL7 everywhere means v2. Small V3.
Pick out message type, patient name, contact relationship, body weight observation
SO MANY CODES IN HEALTHCARE
Key is automatic i.e. requirement
Mapping is on the site.
Moving beyond rough logs.
STILL TOO ACADEMIC
The Integration Control Number (ICN) - ASTM e1714-95 standard for a universal health identifier.
Like the efforts in the showcase to interop EMRs
Note Multiple VistAs
HL7 is triggered. Data there and WHEN it is there.
GE TOO - FLU TO CDC
DO SEGWAY
EMR NOT LEFT OUT OF THE PICTURE, not just a “old” aside.
Looking in the code, you could see ...