Bio Pharmic2

Technology: Hematology Lead Product: Blood BackUp

BioPharmic to Present Blood Substitute Strategy at RENN Capital Investor Conference Aug 11, 2009 9:00am EDT, Washington D.C. ,[object Object],[object Object],[object Object]

BioPharmic Announces Results of All Blood BackUp Animal Studies Washington D.C., BUSINESS WIRE, Sep. 16, 2009 ,[object Object],[object Object],[object Object],[object Object]

GRAND Opening ,[object Object],[object Object]

Lack of Blood in the U.S. ,[object Object],[object Object],[object Object],[object Object]

Lack of Blood in the U.S. ,[object Object]

Problems Encountered This Past Round ,[object Object],[object Object]

Expired Blood? ,[object Object],[object Object],[object Object]

Stability of Blood BackUp ,[object Object],[object Object],[object Object],[object Object]

Stability of Blood BackUp ,[object Object],[object Object],[object Object],[object Object],[object Object]

Scale-Up ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Scale-Up ,[object Object],[object Object],[object Object],[object Object]

Animal Studies Demonstrating Safety and Effectiveness ,[object Object],[object Object],[object Object],[object Object],[object Object]

PRECLINICAL/ANIMAL STUDIES CONT. ,[object Object],[object Object],[object Object]

PRECLINICAL/ANIMAL STUDIES ,[object Object],[object Object],[object Object],[object Object],[object Object]

PRECLINICAL/ANIMAL STUDIES CONT. ,[object Object],[object Object],[object Object],[object Object]

RESULTS ,[object Object],[object Object],[object Object]

RESULTS CONT. ,[object Object]

RESULTS CONT. ,[object Object],[object Object]

IND APPLICATION SUMMARY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

IND APPLICATION SUMMARY CONT. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

APPROVED APPROVED APPROVED FOR PHASE 1 CLINICAL STUDIES

Clinical Trials PHASE I & II METHODS ,[object Object],[object Object],[object Object],[object Object],[object Object]

STUDY DESIGN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

STUDY DESIGN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

STUDY DESIGN ,[object Object],[object Object],[object Object],[object Object],[object Object]

MEASUREMENTS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

STATISTICAL METHODS ,[object Object],[object Object]

RESULTS ,[object Object],[object Object],[object Object],[object Object]

BLOOD BACK-UP INFUSION ,[object Object],[object Object],[object Object],[object Object],[object Object]

HEMOGLOBIN DATA ,[object Object],[object Object],[object Object],Blood Back-up plasma Table 1. Hemoglobin concentration (g/dL) in study patients Blood Back-Up Figure 1. Data for total [Hb] and RBC [Hb] before and after Poly SFH-P infusion.

OXYGEN UTILIZATION ,[object Object],[object Object],Blood Back-up Table 2. O2 loading/unloading

SAFETY ,[object Object],[object Object]

SAFETY Figure 5. Data for creatinine clearance before and after Blood BackUp infusion. Figure 3. Data for heart rate before and after Blood BackUp infusion. Figure 4. Data for mean arterial pressure before and after Blood BackUp infusion. Figure 2. Data for temperature before and after Blood BackUp infusion.

SAFETY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SAFETY Table 3. Organ function for the entire population. Table 4. Organ function after excluding patients with abnormal pre-infusion values.

BLOOD UTILIZATION ,[object Object],[object Object]

CONCLUSION ,[object Object],[object Object],[object Object]

CONCLUSION ,[object Object],[object Object],[object Object],[object Object],[object Object]

Financial ,[object Object],[object Object],[object Object],[object Object],[object Object]

Financial ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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