The Fight Against Infectious Diseases – Magic Bullets Mr McDonald
What we will learn: <ul><li>What progress was made in the fight by 1900. </li></ul><ul><li>The work by Paul Ehrlich </li><...
What progress had already been made by 1900? <ul><li>By 1900, the germs for the most common diseases had been discovered. ...
Paul Ehrlich <ul><li>One factor that helped the fight against infectious diseases was the development of industry, in part...
 
Ehrlich and Magic Bullets <ul><li>Ehrlich became leader of his own team. </li></ul><ul><li>In 1899, the team started to te...
Salvarsan 606 <ul><li>In 1906, the syphilis microbe was found. </li></ul><ul><li>Syphilis is sexually transmitted disease ...
Salvarsan 606 <ul><li>Ehrlich called the drug Salvarsan 606. </li></ul><ul><li>He continued to re-testing, lots of it to a...
 
Gerhard Domagk <ul><li>Worked for a chemical firm in Germany. </li></ul><ul><li>He was fascinated by Ehrlich’s work. </li>...
Prontosil <ul><li>He did not know whether the treatment would work on humans as he had only tested it on animals. </li></u...
Sulphonamide <ul><li>Sulphonamides are drugs based on chemical from coal tar. This discovery was made by a French research...
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The Fight Against Infectious Diseases – Magic Bullets

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The Fight Against Infectious Diseases – Magic Bullets

  1. 1. The Fight Against Infectious Diseases – Magic Bullets Mr McDonald
  2. 2. What we will learn: <ul><li>What progress was made in the fight by 1900. </li></ul><ul><li>The work by Paul Ehrlich </li></ul><ul><li>What a magic bullet is. </li></ul><ul><li>The work by Gerhard Domagk </li></ul>
  3. 3. What progress had already been made by 1900? <ul><li>By 1900, the germs for the most common diseases had been discovered. </li></ul><ul><li>The work by Pasteur and Koch had developed a number of vaccines for the great killers. </li></ul><ul><li>Finally, the work already done had meant Governments had made laws to stop the spread of disease. </li></ul><ul><li>However, there was still work to do. There was a need for a chemical treatment to some diseases. </li></ul>
  4. 4. Paul Ehrlich <ul><li>One factor that helped the fight against infectious diseases was the development of industry, in particular the work to create synthetic dyes to stain microbes under the microscopes. </li></ul><ul><li>Ehrlich had joined Koch’s team in 1889 and began working with Behring on the disease Diptheria. </li></ul><ul><li>He was fascinated by the work anti-bodies which he called MAGIC BULLETS! Seeking out the disease. </li></ul><ul><li>Ehrlich thought a chemical could do just the same! </li></ul>
  5. 6. Ehrlich and Magic Bullets <ul><li>Ehrlich became leader of his own team. </li></ul><ul><li>In 1899, the team started to test chemical dyes. </li></ul><ul><li>Dyes were found to attack Malaria and Sleeping Sickness but it took a long time and a great deal of perseverance. </li></ul>
  6. 7. Salvarsan 606 <ul><li>In 1906, the syphilis microbe was found. </li></ul><ul><li>Syphilis is sexually transmitted disease that killed thousands every year. </li></ul><ul><li>In 1907 Ehrlich tested arsenic compounds – over 600 and said they were useless. All seemed to be a failure! </li></ul><ul><li>However in 1909, a Japanese assistant named Hata was asked to retest the compounds already thought to be useless. </li></ul><ul><li>He found one of the compounds had worked and not failed – CHANCE had played a key factor here! </li></ul>
  7. 8. Salvarsan 606 <ul><li>Ehrlich called the drug Salvarsan 606. </li></ul><ul><li>He continued to re-testing, lots of it to avoid any possible harmful reaction by patients. </li></ul><ul><li>The treatment was first used in 1911 but the treatment was not welcomed by everyone! </li></ul><ul><li>It was painful to inject into a patient. </li></ul><ul><li>Others believed it would mean people would not be bothered about catching sexually transmitted disease. </li></ul><ul><li>It was also an arsenic based product and poison was not something doctors liked to use as a treatment. </li></ul>
  8. 10. Gerhard Domagk <ul><li>Worked for a chemical firm in Germany. </li></ul><ul><li>He was fascinated by Ehrlich’s work. </li></ul><ul><li>He also decided to use dyes to combat disease. </li></ul><ul><li>In 1932 he found a dye that attacked the germ that caused blood poisoning – PRONTOSIL. </li></ul><ul><li>Again a chance element made his discovery take a medicinal aspect. </li></ul>
  9. 11. Prontosil <ul><li>He did not know whether the treatment would work on humans as he had only tested it on animals. </li></ul><ul><li>However his daughter had pricked herself and developed blood poisoning. </li></ul><ul><li>He gave the girl a large dose of the drug and she survived – although she turned a reddish tinge! </li></ul>
  10. 12. Sulphonamide <ul><li>Sulphonamides are drugs based on chemical from coal tar. This discovery was made by a French research team. </li></ul><ul><li>This development was built on in 1938 by a British firm (May and Baker), they found the 693 rd compound worked in fighting pneumonia. However sulphonamides had disadvantages – they could cause kidney and liver damage. The treatments also could not deal with the stronger microbes. </li></ul>

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