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Hemostasis
 

Hemostasis

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    Hemostasis Hemostasis Presentation Transcript

    • Hemostasis
    • Blood Components: Platelets• Coagulate, form plug, prevent blood loss• Formed by fragmentation from megakaryoctyes Figure 16-10c: Megakaryocytes and platelets
    • Overview of Hemostasis:Clot Formation & Vessel Repair Figure 16-11: Overview of hemostasis and tissue repair
    • Hemostasis: Vasoconstriction & Plug Formation• Vasoconstriction• Platelet activation – Multiple factors – Positive feedback• Aggregation• Loose plug
    • Hemostasis: Vasoconstriction & Plug Formation Figure 16-12: Platelet plug formation
    • Hemostasis: Coagulation & Clot Stabilization• Prothrombin• Ca++• Fibrinogen• Fibrin• Polymerization Figure 16-13: The coagulation cascade
    • Dissolving the Clot and Anticoagulants• Bleeding stopped• Vessel repair• Plasmin• Fibrinolysis• Clot dissolved
    • Dissolving the Clot and Anticoagulants Figure 16-14: Coagulation and fibrinolysis
    • Coagulation and Disease• Hemophilia• Cardiovascular Diseases – Key problem – clots block undamaged blood vessels – Anticoagulants prevent coagulation • Keep platelets from adhering • Prevent fibrin coagulation – "Clot Busters": Prevent further clotting • Speed fibrinolysis • Limit tissue damage (heart, brain…)
    • Summary• Blood is about 50% plasma, water solvent & solutes: ions, elements, gasses, proteins, wastes & nutrients• White blood cells function in internal defense• Iron in hemoglobin is key to RBC transport of O2• Platelet activation initiates clot formation• Clotting prevents blood loss but is a problem in cardiovascular disease