Human herpes virus_6.spin4


Published on

Published in: Health & Medicine, Technology
  • Be the first to comment

  • Be the first to like this

No Downloads
Total Views
On Slideshare
From Embeds
Number of Embeds
Embeds 0
No embeds

No notes for slide

Human herpes virus_6.spin4

  1. 1. Fatigue causing Human Herpes Virus 6(HHV-6): A Viral Co-infection of ChronicLyme Disease
  2. 2. And Its Link to Chronic Fatigue Syndrome, Fibromyalgia, Fatigue, and CancerHHV-6, a human herpes virus, was first reported in 1986 and is now considered among the mostprevalent of human herpes viruses. It comes in two variants HHV-6A and -6B, and though similar, thereareclear differences in their epidemiology and pathogenicity.HHV-6B is acquired in early childhood (often in daycare centers) and is responsible for infecting up to90% of most populations during infancy. HHV-6A behaves quite differently as it is generally not seenuntil adulthood. Both versions of the virus can be found in saliva and are presumably spread this way aswell.Immunocompromised patients including those who have received new organs, bone marrow, or HIVpositive have the greatest risk for severe HHV-6 complications and chronic Lyme disease patients.How Does HHV-6 Work?HHV-6 attacks diverse types of cells including CD 4 lymphocytes, natural killers, oligodedrocytes, CD 8s,and microglials. The difficulty with treating HHV-6 is the fact that it is not only immune suppressive, butit also can activate other viruses in the body. When HHV-6 is dormant, it can be found in the salivaryglands, kidneys, or brain.CFS, Fibromyalgia, and AutoimmuneDisease Symptoms Linked to HHV-6HHV-6 has been linked to idiopathic illness Chronic Fatigue Syndrome (CFS). It was observed in onestudy that 30 percent of CFS patients tested positive for HHV-6 and after a series of follow-up tests, itwas discovered that an additional 20-40 percent were also positive after initially showing no trace of thevirus. The obvious association between HHV-6 and CFS reaffirms a much broader link between infectionand chronic disease.One study suggests that a "smoldering" central nervous system (CNS) infection may play a role inconditions that plague millions of Americans. A doctor at Jikei University Medical School in Tokyoidentified a novel human herpes virus-6 (HHV-6) protein, “present in Chronic Fatigue Syndrome (CFS)that is a likely contributor to the psychological symptoms that are so often associated with the disorder.It was also found that 71 percent of Chronic Fatigue Symptom patients had antibody SITH-1. What is soremarkable about this discovery is that 53 percent of depression and 76 percent of bipolar disordersufferers have the SITH-1 antibody.HHV-6 is one of the infections found invirtually all Chronic Lyme Disease patients – a chief contributor tofatigue and other neurological symptoms. Antibiotics do not affect this or other herpetic viruses.
  3. 3. HHV-6 as a Potential Causative toChronic Lyme Disease, Parkinson’s, andAlzheimer’sNeurodegenerative diseases such as Alzheimers, Parkinson’s, and Multiple Sclerosis (MS) increasinglyappear to be catalyzed, at least in some cases, by viral infections. Tied to many neurologic problemsincluding encephalitis and mesial temporal lobe epilepsy is neurotropic virus HHV-6.Nevertheless, HHV-6’s route into the central nervous system remains inconclusive. However, amongvarious brain regions examined, the highest frequency of HHV-6 DNA can be routinely identified in theolfactory bulb/tract region. While further tests must be conducted, the olfactory pathway does seemlikely as at least one pathway for HHV-6 to move into the CNS.HHV-6 Infection: Its Role in One Child’sAcute Lymphoblastic LeukemiaEvidence continues to mount that suggests viral infections could play a major causative role in somechildhood leukemia. In one recent case, a child’s acute lymphoblastic leukemia came only two monthsafter an HHV-6 infection was detected.HHV-6 Attacks p53 giving rise to cancersProtein p53 is a critical component of cell cycle regulation. Naturally, it also serves as the body’spremiere tumor suppressor – a major player in helping the body prevent cancer growth.How does p53 work?When DNA damage is detected by p53, the protein snaps into action. It’s typically low levels rise quicklyto initiate effective measure to protect the body by binding to sites in the genome and halting celldivision completely, until the damage can be repaired. Should the damage have progressed too far forrepair, p53 then triggers apoptosis, queuing cell self-destruction, thus ending the problem in theimmediate.
  4. 4. HHV-6 Viral Co-infection of ChronicLyme Disease: Immunity and CancerImplicationsHHV-6 infection has been shown to be a regular perpetrator in altering regulatory influences in cellproliferation. The more research that is done, the more support is gained for the contention that viralinfections exert significant stress in such regard.Envita’s Fully Engages Chronic LymeDisease Complex and Its DangerousHHV-6 Co-infectionEnvita clinical experience in testing chronic Lyme disease patients shows many have activated forms ofco-infection viruses such as HHV-6. That means that many Lyme sufferers are likely carriers of thisinfection as well as others. Biofilm communities and immunodeficiencies could make HHV-6 and othervirus actively replicate.Envita advanced diagnostic tools are capable of testing for a variety of infections like HHV-6, andexamine whether it is a causative factor for other maladies, such as Chronic Fatigue Syndrome. Weutilize the most effective therapies from around the world to modulate and boost immune function inpatients suffering with HHV-6 or those who are immunocompromised and at risk of contracting it.References: • Abel-Haq, N.M. and Asmar BI. Human herpesvirus 6 (HHV-6) infection. Indian J. Pediatr. 2004 Jan; 71(1): 89-96 • Secchiero, Paola, et al. HHV-6 Infection in Immunocompromised Patients. Infections in Medicine.2005; 22(3). • Wisconsin Viral Research Group, Ltd. • Institute of Human Virology, University of Maryland, Baltimore, Baltimore, MD, (citations for the above) • this source to site
  5. 5. • Seror E, DeVillartay P, Leverger G, Lenoir G. SourceService de pédiatriegénérale, hôpital Necker- Enfants-Malades, AP-HP, 149, rue de Sèvres, 75743 Paris cedex 15, France• Dr. David Bell in 2008 on research by Dr. L. Flammand to citation Source Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.• Journal of the American Society of Hematology citations for above