Chronic Lyme Disease Viral Co-infectionHuman Herpes Virus 6 (HHV-6): FatigueIts Link to Chronic Fatigue Syndrome, Fibromyalgia, Fatigue, andCancerHuman herpesvirus 6 (HHV-6) was first reported in 1986 and has since become one of the mostwidespread members of human herpes viruses. It is composed of two closely related variants that shareover 90% of their DNA homology: HHV-6A and HHV-6B.Although these two variants are closely related, there are still differences in their epidemiology andpathogenicity. HHV-6B is acquired in early childhood, infecting up to 90% of most populations duringinfancy. HHV-6A, on the other hand, is generally not seen until adulthood. The virus is usually found insaliva and is presumably spread this way as well.HHV-6 is of greatest concern to those patients who are immunocompromised, in particular, those whohave undergone organ or bone marrow transplants or who are HIV positive and chronic Lyme disease.People are carriers of this virus from a young age, and is commonly picked up in dare care centers.
How Does HHV-6 Work?The virus attacks certain cells, including CD4 lymphocytes, natural killer cells, oligodendrocytes, CD8cells, and microglial cells. HHV-6 is also animmune suppressive virus that also serves to activate otherviruses. It can be latent in cells for long stretches of time, only to bring about infection later on whenreactivated. HHV-6 can persist in salivary glands, the kidneys, and even the brain until activated.CFS, Fibromyalgia and AutoimmuneDisease Symptoms Linked to HHV-6.HHV-6 infection has been associated with a range of maladies including Chronic Fatigue Syndrome (CFS.)Chronic Fatigue patients typically suffer from immunologic abnormalities and neurologic problems. Inone such study, 30% of CFS patients tested positive in an initial screening for HHV-6. Follow-up culturesin patients who initially tested negative, later proved positive in an additional 20%-40% of cases. Healthycontrol patients have not demonstrated positive cultures as described above. The association betweenHHV-6 and CFS reaffirms the link between infection and chronic disease.One study suggests that a "smoldering" central nervous system (CNS) infection may play a role inconditions that plague millions of Americans. Jikei University Medical School in Tokyo identified a novelhuman herpesvirus-6 (HHV-6) protein, “present in Chronic Fatigue Syndrome (CFS) that is a likelycontributor to the psychological symptoms that are so often associated with the disorder. It was alsofound that 71 percent of Chronic Fatigue Symptom patients had antibody SITH-1. What is so remarkableabout this discovery is that 53 percent of depression and 76 percent of bipolar disorder sufferers havethe SITH-1 antibody.HHV-6 is one of the infections found invirtually all Chronic Lyme Disease patients – a chief contributor tofatigue and other neurological symptoms. Antibiotics do not affect this or other herpetic viruses.HHV-6 as a Potential Causative toChronic Lyme Disease, Parkinson’s, andAlzheimer’s
Viruses have been implicated in the development of neurodegenerative diseases such as Alzheimers,Parkinson’s, and Multiple Sclerosis (MS.) More specifically, neurotropic virus HHV-6 has been clinicallyshown to be directly linked to many neurologic problems including encephalitis, mesial temporal lobeepilepsy, and many others.Despite the copious research, HHV-6’s route into the central nervous system remains inconclusive.However, among various brain regions examined, the highest frequency of HHV-6 DNA was routinelyidentified in the olfactory bulb/tract region. While further tests must be conducted the olfactorypathway does seem likely as at least one pathway for HHV-6 to move into the CNS.HHV-6 Infection: Its Role in One Child’sAcute Lymphoblastic LeukemiaIn one case, a child was found to be infected by HHV-6 and just two months later began an acutelymphoblastic leukemia. This is just another example of the suggestion that viral infections could play amajor causative role in some childhood leukemia.HHV-6 Attacks p53 giving rise to cancersThe protein p53 is vital for multicellular organisms as it serves to regulate the cell cycle. As a result it isan important tumor suppressor that helps the body naturally prevent cancer. The p53 is so criticallyimportant because of the incessant exposure our cells face on a daily basis. From toxic chemicals,viruses, radiation, to an almost endless barrage of others, our cells are continually at risk. And as ourcells go, we go.If cells are damaged in sensitive areas by these marauders, there can be devastating repercussions. It isnot uncommon to see key regulatory elements damaged and normal cell growth blocked – setting thestage for irregular growth and a rapid tumor producing result. The tumor suppressor p53 acts as one ofour best defenses in such circumstance as it snaps into action when it detects DNA damage. Thetypically low levels of the protein rise and initiate protective measures by binding to sites in the genomeand halts cell division until the damage can be repaired. If it has progressed too far, p53 will initiateHHV-6Viral Co-infection of Chronic LymeDisease: Immunity and CancerImplicationsWhile data is difficult to sort out, the more research that is done seems to further support thatadditional regulatory influences in cell proliferation and cell death, including cytokines and growth
factors, are definitively altered after viral infections. HHV-6 is often the culprit for such significant andimpactful changes.Envita’s Fully Engages Chronic LymeDisease Complex and Its DangerousHHV-6Co-infectionEnvita clinical experience in testing chronic Lyme disease patients, Chronic fatigue syndrome andfibromyalgia shows many have activated forms of co-infection viruses such as HHV-6. That means thatmany Lyme sufferers are likely carriers of this infection as well as others. Biofilm communities andimmunodeficiencies could contribute toHHV-6and other virus actively replicate.Envita employs only the most advanced diagnostic tools to test for a variety of infections like HHV-6, andexamine whether it is a causative factor for other maladies, such as Chronic Fatigue Syndrome. Weutilize the most effective therapies from around the world to modulate and boost immune function inpatients suffering with HHV-6 or those who are immunocompromised and at risk of contracting it.References: • Abel-Haq, N.M. and Asmar BI. Human herpesvirus 6 (HHV-6) infection. Indian J. Pediatr. 2004 Jan; 71(1): 89-96 • Secchiero, Paola, et al. HHV-6 Infection in Immunocompromised Patients. Infections in Medicine.2005; 22(3). • Wisconsin Viral Research Group, Ltd. wisconsinlab.com • Institute of Human Virology, University of Maryland, Baltimore, Baltimore, MD, (citations for the above) • http://www.medicalnewstoday.com/releases/112548.php this source to site • Seror E, DeVillartay P, Leverger G, Lenoir G. SourceService de pédiatriegénérale, hôpital Necker- Enfants-Malades, AP-HP, 149, rue de Sèvres, 75743 Paris cedex 15, France • Dr. David Bell in 2008 on research by Dr. L. Flammand to citation Source Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. • Journal of the American Society of Hematology citations for above