WELCOME

Joe Keil www.whenjustsaynodoesntwork.com

920-323-2354
na
wi
we that
do gs
ow dru
H
f or
on
st
r
wa have lo 0+
e
t4
w
as
e p e a rs ?
th
y

ION!
T
VEN
PRE
UNITED STATES HAS ? of the
WORLD POPULATION
CONSUMES ? % of the Worlds
ILLEGAL DRUGS
day

STAT
S

 NYC consumes 10 tons of illegal drugs each
 121 Million Scripts for Hydrocodone in 2012
 20% of people wh...
 20% of people in US using pills for no reason
 More people are using Pills than Cocaine,
Heroin, Hallucinogens and Inha...
n:
t io
es
Qu
v ia
ri
T
do e s
t
Wha

ean?
RX m
In 20
01 C
han g
e in
Vi tal
Sig n
s

 Respi
ratio
ns
 Heart
rate
 Blood
pres
sure
 Body

 Big C

temp
eratu
re

ha n...
6 Ty
pe s o
f Dru
gs

 OTC
 RX Pr
escr
 RX Co iption
ntrol
led
 Contr

rolle
d Ille
Drug
gal S
s
treet
Desi
gner
Drug
...
Typ e
s of

Dr ug
Use

 Expe

a sub rimentat
by p stance b ion: Tryin
eer p
y ch o
g
ressu
ice o
re
r

 Abus

get h e: u...
EYE EXAM and Drug Influence
III-1
M-U-R-D-E-R-S, I-N-C, I

VI-3A
The Eleven Systems of Human
Physiology: Murders, Inc. I
M is for Muscular System
U is for Urinary System
R is for Respirat...
 The body has three different

Muscular System

kinds of muscles

 The heart, or cardiac muscle
 Smooth muscles, which ...
Urinary System

• This system consists of two

•

kidneys, the bladder, ureters
connecting the kidneys to the
bladder, and...
Respiratory System

 The major parts of the Respiratory System are

the lungs and the diaphragm
 The diaphragm is a smoo...
Digestive System

 Major components of this system are the

tongue, teeth, esophagus, stomach, intestines,
liver and panc...
Endocrine System

• The Endocrine System is made up of a number
•
•

of different glands, that secrete hormones
Hormones a...
Reproductive System

 The functions of the

Reproductive System fall into
two roles 1. Self producing
(cytogenic) 2. Horm...
Skeletal System

 Consists of bones, cartilage and ligaments
 The Skeletal System provides support to the
body, permits ...
1981

1982

1985

My Prom Date
Integumentary System

 Consists of skin, hair, finger and toe nails, and
accessory structures

 The chief functions of t...
Outside Temperature 14
Nervous System
 This system consists of the brain, the




brain stem, the spinal cord and the
nerves
Nerves keep the ...
Circulatory System
•
•
•
•
•

For our purposes, the Circulatory
System consists of the heart, the blood
vessels (veins and...
IMMUNE SYSTEM

 The immune system protects against disease

by destroying “foreign” cells and by
inactivating toxins and ...
Homeostasis

• The human body is exposed to constantly
changing external environment.
• Changes are neutralized by the int...
Homeostasis: is the key to drug use: the body is out of
balance

Dynamic balance or steady state involving
levels of salts...
Whe
n you
r sic k

 You ta

ake m
your
body eds to pu
bala
t
back
nce
into
Whe
n you
get h
igh i take drug
t is d
your
on...
The Male Brain compared to the
Female Brain
Seriously
S er io
usly
Add
in g E
T OH
to
Da te
Nigh
t
Motor Nerves

Sensory Nerves

Efferent

Afferent

Voluntary Autonomic
Parasympathetic

Sympathetic
Motor Nerves

Sensory Nerves

Efferent

Afferent

Voluntary Autonomic
Parasympathetic

Sympathetic
Fundamental Notions

 If something interferes with the messages to

the brain sent along the motor nerves, the
brain’s co...
Motor Nerves

• There are two sub-systems of motor nerves:

– The voluntary nerves send messages to the striated
–

muscle...
The Autonomic Sub-System

• The Autonomic Sub-System divides into two
groups:

– First, the Sympathetic nerves command the...
The Autonomic Sub-System

• Second, the Parasympathetic nerves carry

messages that produce relaxed and tranquil
activitie...
Drugs & the Autonomic SubSystems

• Some drugs mimic the neurotransmitters that
•
•

travel in the Sympathetic and Parasym...
A Simplified Concept of a Nerve

 The nerves that carry messages to
and from the brain often are
pictured as “wires” or “...
Simple Concept
of a Nerve

How does this affect
your health?
T he
abso
rbtio
elim
inati
n an d
on o
f dru
gs

 Alcoh

at ? ol is a fix
ed ra
te
Drug
s are
½ liv
Wha
es
t is a
h a lf
...
½ liv
es

 Lets s

a
is 5 h y a drug
o ur s
s ha l
f lif e
T ha t
simp
5 ho
l
ur ha y means
l f of
gone
the d every
r ug ...
ADDITIVE EFFECT
Effect

Effect

1 + 1 = reinforced 1
NULL EFFECT
No Effect

No Effect

0+0=0
OVERLAPPING EFFECT
No Effect

Effect

0+1=1
ANTAGONISTIC EFFECT
Opposite
Effect

Effect

1 + -1 = ????
Joe Keil
Joe Keil
Joe Keil
Joe Keil
Joe Keil
Joe Keil
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Joe Keil

  1. 1. WELCOME Joe Keil www.whenjustsaynodoesntwork.com 920-323-2354
  2. 2. na wi we that do gs ow dru H f or on st r wa have lo 0+ e t4 w as e p e a rs ? th y ION! T VEN PRE
  3. 3. UNITED STATES HAS ? of the WORLD POPULATION CONSUMES ? % of the Worlds ILLEGAL DRUGS
  4. 4. day STAT S  NYC consumes 10 tons of illegal drugs each  121 Million Scripts for Hydrocodone in 2012  20% of people who take Benadryl become stimulated  Illegal Drug Business is a 400 billion market  Meth: 2011 MS 2096, TN 1687, ID 1437 and KY 1188
  5. 5.  20% of people in US using pills for no reason  More people are using Pills than Cocaine, Heroin, Hallucinogens and Inhalants COMBINED  2010 2.4 million people tried Marijuana for the first time  2010 2.2 million tried pain pills for the first time
  6. 6. n: t io es Qu v ia ri T do e s t Wha ean? RX m
  7. 7. In 20 01 C han g e in Vi tal Sig n s  Respi ratio ns  Heart rate  Blood pres sure  Body  Big C temp eratu re ha n g adde e: PA d IN w as
  8. 8. 6 Ty pe s o f Dru gs  OTC  RX Pr escr  RX Co iption ntrol led  Contr rolle d Ille Drug gal S s treet Desi gner Drug Herb s al  
  9. 9. Typ e s of Dr ug Use  Expe a sub rimentat by p stance b ion: Tryin eer p y ch o g ressu ice o re r  Abus get h e: using a dr u igh g  Addic phys ction: Wh body ical harm en the long and you to your er m r l if e atter no s! to
  10. 10. EYE EXAM and Drug Influence III-1
  11. 11. M-U-R-D-E-R-S, I-N-C, I VI-3A
  12. 12. The Eleven Systems of Human Physiology: Murders, Inc. I M is for Muscular System U is for Urinary System R is for Respiratory System D is for Digestive System E is for Endocrine System R is for Reproductive System S is for Skeletal System I is for Integumentary system N is for Nervous System* C is for Circulatory System* I is for Immune System VI-3B
  13. 13.  The body has three different Muscular System kinds of muscles  The heart, or cardiac muscle  Smooth muscles, which control the body’s involuntary operations  Striated muscles, which carry out our voluntary movements
  14. 14. Urinary System • This system consists of two • kidneys, the bladder, ureters connecting the kidneys to the bladder, and the urethra, which transports the urine out of the body Kidneys filter waste or harmful products, such as drugs and their metabolites, from the blood, and dump these waste products into the bladder. What the Hell is a metabolite?
  15. 15. Respiratory System  The major parts of the Respiratory System are the lungs and the diaphragm  The diaphragm is a smooth muscle that draws the air into the lungs and forces it out  Lungs take oxygen and transfer it to the blood, and remove carbon dioxide and some other waste products from the blood, and expel them into the outside air
  16. 16. Digestive System  Major components of this system are the tongue, teeth, esophagus, stomach, intestines, liver and pancreas  The Digestive System breaks down large particles of food, until they are of a size and chemical composition that can be absorbed in the blood
  17. 17. Endocrine System • The Endocrine System is made up of a number • • of different glands, that secrete hormones Hormones are complex chemicals that travel through the blood stream and that control or regulate certain body processes Some drugs can mimic the effects of hormones, or can react with the hormones in ways that alter the hormones’ effects
  18. 18. Reproductive System  The functions of the Reproductive System fall into two roles 1. Self producing (cytogenic) 2. Hormone producing (endocrinic)  We are primarily concerned with hormone production since the hormones produced by the Reproductive System aid the nervous system in its regulatory role
  19. 19. Skeletal System  Consists of bones, cartilage and ligaments  The Skeletal System provides support to the body, permits movement, and forms blood cells  It is however, affected by drug abuse, we just may not be able to see it
  20. 20. 1981 1982 1985 My Prom Date
  21. 21. Integumentary System  Consists of skin, hair, finger and toe nails, and accessory structures  The chief functions of the Integumentary System include protection of the body, control of body temperature, excretion of wastes (i.e. through the sweat) and sensory perception
  22. 22. Outside Temperature 14
  23. 23. Nervous System  This system consists of the brain, the    brain stem, the spinal cord and the nerves Nerves keep the brain informed of changes in the body’s external and internal environments Nerves also carry messages from the brain to the body’s muscles, tissues and organs The Nervous System controls, coordinates and integrates all physiological process, so the normal body functions can be maintained
  24. 24. Circulatory System • • • • • For our purposes, the Circulatory System consists of the heart, the blood vessels (veins and arteries), and the blood Blood carries food, water, oxygen, hormones, antibodies etc. to the tissues and organs Blood also carries heat through the body Blood is the main carrier that brings drugs to the brain The heart pumps and forces the blood to circulate through the body
  25. 25. IMMUNE SYSTEM  The immune system protects against disease by destroying “foreign” cells and by inactivating toxins and other foreign chemicals with its antibodies.
  26. 26. Homeostasis • The human body is exposed to constantly changing external environment. • Changes are neutralized by the internal environment – the blood • Oxygen, foods, water and other substances are • • constantly leaving body fluids to enter cells, while carbon dioxide and other wastes are leaving the cells to enter these fluids Yet the chemical composition of these fluids remains within very narrow limits This phenomenon is called homeostasis
  27. 27. Homeostasis: is the key to drug use: the body is out of balance Dynamic balance or steady state involving levels of salts, water, sugars and other material in the body’s fluids VI-3D
  28. 28. Whe n you r sic k  You ta ake m your body eds to pu bala t back nce into Whe n you get h igh i take drug t is d your one s to b to pu to fe ody out t e l hi of ba gh o r fee lance l goo d. 
  29. 29. The Male Brain compared to the Female Brain
  30. 30. Seriously
  31. 31. S er io usly
  32. 32. Add in g E T OH to Da te Nigh t
  33. 33. Motor Nerves Sensory Nerves Efferent Afferent Voluntary Autonomic Parasympathetic Sympathetic
  34. 34. Motor Nerves Sensory Nerves Efferent Afferent Voluntary Autonomic Parasympathetic Sympathetic
  35. 35. Fundamental Notions  If something interferes with the messages to the brain sent along the motor nerves, the brain’s control over the heart, the lungs, the muscles and other organs will be distorted  If something interferes with the messages the brain receives from the sensory nerves, the brain’s perception of the outside world and of the body’s status will be distorted  THIS IS HOW DRUGS WORK ON THE FUNCTIONING OF THE NERVOUS SYTEM
  36. 36. Motor Nerves • There are two sub-systems of motor nerves: – The voluntary nerves send messages to the striated – muscles that we consciously control The autonomic nerves send messages to the muscles and organs that we do not consciously control, i.e., smooth muscle and cardiac muscle
  37. 37. The Autonomic Sub-System • The Autonomic Sub-System divides into two groups: – First, the Sympathetic nerves command the body to react in response to fear, stress, excitement, etc. • “Fight or Flight” Responses: – Blood pressure elevated – Pupils to dilate – Sweat glands to activate – Hair to stand on end – Heart beat to increase and strengthen – Blood vessels of the skin to constrict – Inhibited digestion
  38. 38. The Autonomic Sub-System • Second, the Parasympathetic nerves carry messages that produce relaxed and tranquil activities – Pupils to constrict – Heartbeat to slow – Peripheral blood vessels to dilate – Blood pressure to decrease – Digestion to be facilitated
  39. 39. Drugs & the Autonomic SubSystems • Some drugs mimic the neurotransmitters that • • travel in the Sympathetic and Parasympathetic nerve systems Drugs that mimic neurotransmitters in the Sympathetic system are called Sympathomimetic drugs. These drugs will artificially create the same effects. Drugs that mimic neurotransmitters in the Parsympathetic system are called Parasympathomimetic drugs. These drugs will artificially create the same effects.
  40. 40. A Simplified Concept of a Nerve  The nerves that carry messages to and from the brain often are pictured as “wires” or “telephone wires” that carry electrical signals  A more accurate, but still simplified concept would envision a nerve as a series of broken wire segments, with the segments separated by short spaces, or gaps
  41. 41. Simple Concept of a Nerve How does this affect your health?
  42. 42. T he abso rbtio elim inati n an d on o f dru gs  Alcoh at ? ol is a fix ed ra te Drug s are ½ liv Wha es t is a h a lf how life a does nd it wo rk?  
  43. 43. ½ liv es  Lets s a is 5 h y a drug o ur s s ha l f lif e T ha t simp 5 ho l ur ha y means l f of gone the d every r ug i T he r s efore hour s the the first 5 drug ma j o rity o is go ne o T he r r hal f the e are f of i t. half lives usually a b o ut 8   
  44. 44. ADDITIVE EFFECT Effect Effect 1 + 1 = reinforced 1
  45. 45. NULL EFFECT No Effect No Effect 0+0=0
  46. 46. OVERLAPPING EFFECT No Effect Effect 0+1=1
  47. 47. ANTAGONISTIC EFFECT Opposite Effect Effect 1 + -1 = ????

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