The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships”
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The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships”

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Environmental sampling,Smart Dust Kris Pister, UCB (1996),Silicon nanostructures mimic the beetle shell

Environmental sampling,Smart Dust Kris Pister, UCB (1996),Silicon nanostructures mimic the beetle shell

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  • Samples collected in the field are transported back to the laboratory for more detailed analysis. The delay reduces the effectiveness of remediation efforts. Santa Margarita Ecological Reserve, Aug 2002
  • 2 chips fabbed in 0.25um CMOS “ Mote on a chip” worked, missing radio RX 900 MHz transceiver worked “ The Smart Dust project is probing microfabrication technology's limitations to determine whether an autonomous sensing, computing, and communication system can be packed into a cubic millimeter mote (a small particle or speck) to form the basis of integrated, massively distributed sensor networks.” - Computer , 34 , 44-51 (2001). Records set for low power CMOS ADC 8 bits, 100kS/s [email_address] Microprocessor 8 bits, 1MIP [email_address] 900 MHz radio 100kbps, “bits in, bits out” 20 m indoors 0.4mA @ 3V
  • 2 chips fabbed in 0.25um CMOS “ Mote on a chip” worked, missing radio RX 900 MHz transceiver worked “ The Smart Dust project is probing microfabrication technology's limitations to determine whether an autonomous sensing, computing, and communication system can be packed into a cubic millimeter mote (a small particle or speck) to form the basis of integrated, massively distributed sensor networks.” - Computer , 34 , 44-51 (2001). Records set for low power CMOS ADC 8 bits, 100kS/s [email_address] Microprocessor 8 bits, 1MIP [email_address] 900 MHz radio 100kbps, “bits in, bits out” 20 m indoors 0.4mA @ 3V
  • Scattering the reflection is given over a wider angle (the color appear constant from every direction) alters the reflection from the multilayer reflector to achieve both a diffuse reflection and a weak reflectance in each direction Diffraction is caused by a surface with a repeating pattern. If the pattern size is of the order of the wavelength of incidence light, then different wavelengths of lights are reflected at different angles. Figure: (A) Calloodes grayanus , which results in a diffuse green reflection. (B) Anoplognathus parvulus , which results in a directional, gold (specular) reflectance. [email_address]
  • Scattering the reflection is given over a wider angle (the color appear constant from every direction) alters the reflection from the multilayer reflector to achieve both a diffuse reflection and a weak reflectance in each direction Diffraction is caused by a surface with a repeating pattern. If the pattern size is of the order of the wavelength of incidence light, then different wavelengths of lights are reflected at different angles. Figure: (A) Calloodes grayanus , which results in a diffuse green reflection. (B) Anoplognathus parvulus , which results in a directional, gold (specular) reflectance. [email_address]
  • Encoded microparticles use a nanoporous Si or SiO 2 material. Methods to load, seal, and trigger release of small molecule, peptide, or protein-based drugs have been developed.
  • Multifunctional particles to diagnose and treat disease Modular – each part adaptable to generic nanoparticle system First step – targeting nanoparticles – something our group began looking at a few years ago…
  • University of Wisconsin/Madison Environmental Health, Safety & Risk Management Asbestos Management Program Image Page Heating/Chilling Plant: Furnace/Boiler #1 Abatement (Phase II) December 1997-January 1998

Transcript

  • 1. The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships” Jack Ealy Workshop La Jolla, CA July 2006 Professor Michael J. Sailor UC San Diego Dept. of Chemistry and Biochemistry msailor@ucsd.edu http://chem-faculty.ucsd.edu/sailor/
  • 2. Death on the Danube The Economist, 2/15/00The Economist, 2/15/00
  • 3. Environmental sampling Field Lab
  • 4. Smart Dust Kris Pister, UCB (1996) Available: •wireless radios •data processing •networking protocols
  • 5. Smart Dust Kris Pister, UCB (1996) Need: •sensors •power sources
  • 6. Silicon vapor sensors QuickTime™ and a DV/DVCPRO - NTSC decompressor are needed to see this picture.
  • 7. Making a silicon nanostructure 20 µm QuickTime™ and aH.263 decompressorare needed to see this picture. Electrochemical machining of nanopores
  • 8. Silicon nanostructures mimic the beetle shell chitinmultilaye n = 1.73n = 1.40 Calloodes grayanus 2 mm Chitin multilayer
  • 9. Silicon nanostructures mimic the beetle shell Silicon multilayer
  • 10. Silicon Microsensors
  • 11. William R. Freeman, M.D. and Lingyun Cheng, M.D. Jacobs Retina Center UCSD
  • 12. Mother-Ships for Nanotherapies color changes when particle releases drug Porous silicon micro-particle in the eye
  • 13. Ruoslahti, Cancer Cell, 2002 UCSD Moores Cancer Center NIH nanoTUMOR center Erkki Ruoslahti, Burnham Inst. Sangeeta Bhatia, MIT Michael Sailor, UCSD Diagnostic Therapeutic Activation Targeting Self-Destruct Sensor Targeted Nanomachines
  • 14. Backup slides
  • 15. As with any new technology, reasonable concerns about potential hazards are appropriate. Hazards of nanotechnology QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. University of Wisconsin, Madison Asbestos Management Program Heating/Chilling Plant: Furnace/Boiler Abatement (December 1997- January 1998) QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. Asbestos fibers (Nikon, inc)
  • 16. Hazards of nanotechnology Shvedova, A. A. et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A 66, 1909-1926 (2003). Derfus, A., Chan, W. & Bhatia, S. N. Probing the Cytotoxicity of Semiconductor Quantum Dots. Nano Lett. (2004). QuickTime™ and a TIFF (Uncompressed) decompressor are needed to see this picture. 5 nm CdSe (A. Paul Alivisatos, UC Berkeley)
  • 17. Making a silicon nanostructure 20 µmQuickTime™ and aH.263 decompressorare needed to see this picture.
  • 18. Encoded particles self-assemble oxidize alkylate QuickTime™ and a MPEG-4 Video decompressor are needed to see this picture.
  • 19. Magnetic manipulation of microparticles Nature Mater. 2004, 3, 896-899. 30 nm magnanopartic [O]