N & E 2008 Slides


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N & E 2008 Slides

  1. 1. What causes disease? Nutritional & Environmental Genetics. Medicine: Putting all the pieces Gastrointestinal abnormalities. together. Nutrient imbalances/diet. Blake Graham, B.Sc (Honours), AACNEM Environmental. (e.g. heavy metals) Clinical Nutritionist Allergies/intolerances. www.nutritional-healing.com.au www.nutritional- Chemical imbalances. (e.g. hormones) (08) 9381 4112 Disordered sleep. Psycho-social factors. Psycho- February 16th 2008 Lifestyle factors. Multi-factorial model. Web of inter-relationships and vicious cycles. All disease is multi-factorial! Ripple effect. Spectrums. 1
  2. 2. Self healing. Disease treatment models. 1. Treat symptoms: Complex corrective mechanisms. Nausea = anti-nausea medication anti- Identify and remove: High cholesterol = cholesterol lowering medication Dry skin = moisturizer Causes. Insomnia = sedatives Impediments to healing. 2. Address underlying causes: e.g. nausea caused by gastrointestinal infection Reduce burden of stressors on the body e.g. high cholesterol caused by poor diet below the threshold which the body can e.g. dry skin caused by fatty acid deficiency e.g. insomnia caused by anxiety restore balance. Disease treatment models. Disease centred diagnosis. Person centred diagnosis. Irritable bowel syndrome. Nutrient deficiencies. Chronic Fatigue Syndrome. Migraines. Sleep deprivation. Food intolerances. Genetics. Depression. Intestinal infection. Genetics. Genetics. Inter-relationship between Inter- Specific links of interest: genetics and environment. 1. Environmental chemical metabolism. Environment influences genetic 2. Nutrient imbalances. expression. 3. Gastrointestinal health. Genetics influence reaction to 4. Allergies/intolerances. environment. 5. Chemical imbalances. (e.g. hormones) 6. Immune integrity. 2
  3. 3. Genetics. Genetic testing. Family history: Eczema/asthma/hay fever/hives Allergies Depression/anxiety/OCD Neurotransmitters Huge genetic Crohn's Disease Increased intestinal variation! permeability ADD/ADHD Abnormal zinc metabolism Reference: www.genovations.com/ Gastrointestinal imbalances. Imbalanced gastrointestinal flora ('dysbiosis'). ('dysbiosis'). Gastrointestinal infections (bacteria, parasitic, yeast). Gastrointestinal health. Increased intestinal permeability ('leaky gut'). Maldigestion/malabsorption. Stomach acid deficiency (hypochlorhydria). Pancreatic enzyme insufficiency. Bile acid deficiency. Intestinal flora. Functions of healthy flora: Produce short chain fatty acids which are needed by the intestinal mucosa intestinal Harmful bacteria. for energy Produce biofilm (mucus barrier) to protect intestinal mucosa Interact with the gut associated lymphoid tissue (GALT) – 70% of Produce toxic chemicals as metabolic by-products which have by- immune system, e.g. systemic effects, e.g. Improves antibody formation Ammonia Hyperammonemia Reduce allergies (eczema and asthma) D-lactic acid D-lactic acidosis Regulate cytokine levels / inflammation modulation Synthesize nutrients (certain amino acids and vitamins) Decrease production of short chain fatty acids Improve digestion/absorption Produce antigens which disrupt immune function Inhibit the overgrowth of harmful bacteria, yeast, viruses and parasites parasites Reduce levels of healthy flora Improve intestinal motility and stool formation Impair nutrient digestion/absorption Influence genetic expression Assist the detoxification of various substances and convert some toxins Degradation/consumption of nutrients into less toxic forms : Damage intestinal wall Mercury Hormones (e.g. estrogen) Potentially carcinogenic chemicals Drugs Lipids (e.g. cholesterol) 3
  4. 4. Intestinal flora testing. Gastrointestinal health: Yeast. Opportunistic/secondary. Great exacerbating factor. Releases harmful chemicals. Lab tests are notoriously unreliable. Yeast symptoms/signs. Yeast testing. Genital thrush Vaginal itching or redness, vaginitis or 'jock itch' – often scratching/itching at genital area White or grayish-white coating on your tongue or inner cheeks, or white patches in grayish- in the mouth Nasal congestion or stuffiness, swelling of the nasal membranes or sinusitis Previously noticed a decline in your health following antibiotics or antibiotics antibiotics exacerbate your current health problem Fungus infections of the skin (e.g. athletes foot) or nails Psoriasis, eczema or hives Puffiness/bloating/swelling in the hands, face and feet Sugar cravings Eating sugar make you feel worse/worsens certain symptoms Negative reaction to certain dietary yeasts/molds yeasts/molds Very high fondness for yeasty foods Chemical sensitivities (e.g. car exhaust, petrol, cigarette smoke, perfumes, etc.) smoke, Multiple food sensitivities Lower abdominal bloating Gas, frequent constipation, loose/unformed stools, diarrhea or foul smelling stools Itchy rectal/anal area or red ring immediately around the anus Attention problems Feel ‘spaced out’ &/or ‘brain fogged’ Intestinal parasite symptoms/signs. Gastrointestinal health: Parasites. Current illness began with diarrhea/food poisoning Frequent diarrhea diarrhea/food Loose/unformed stools Abdominal bloating Remarkably common. Abdominal pain/discomfort Excessive flatulence Under-diagnosed due to: Under- Visible mucus or pus in stools Itchy anal/rectal area Lack of consideration. Foul smelling stools Inadequate laboratory Frequent constipation Frequent nausea and/or vomiting techniques. Food allergies/intolerances Teeth grinding (bruxism) while sleeping Skin conditions (bluish cast around lips, hives, psoriasis, eczema, skin ulcers) eczema, Fatigue/weakness Forgetfulness or unclear thinking Giardia intestinalis Nervousness, apathy, depressed, anxious or headaches Dizziness 4
  5. 5. Parasite testing. Maldigestion/malabsorption. Stomach acid deficiency (hypochlorhydria). Pancreatic enzyme insufficiency. Bile acid deficiency. Digestive function testing. Hypochlorhydria symptoms/signs. Undigested food in stool Trouble digesting red meat Food or water ‘sits in stomach’ Poor appetite or feel overly full easily Stomach aching/pain/discomfort or bloating after meals Reflux &/or heartburn High fat foods cause nausea/stomach upset Nausea/reflux after supplements (e.g. fish oil) Feel unwell/fatigued right after meals Lemon juice improves digestion Low iron levels Heidelberg pH Diagnostic System. Gastrointestinal treatments. Probiotics/prebiotics. Probiotics/prebiotics. Anti-microbials. Anti-microbials. Dietary changes. Digestive enzymes. Stomach acid supplement (Betaine HCl). HCl). Bile acids. Reference: www.phcapsule.com/ 5
  6. 6. Nutrient status continuum. Nutrients. Nutrient status continuum. Nutrition: Nutritional status. I. Intake: • Food choices • Soil levels, food storage, food processing II. Digestion/assimilation III. Genetics IV. Synthesis (vitamins K & D) (vitamins V. Other factors (hormone imbalances, toxic (hormone chemicals, infections, other nutrient levels, medications, oxidative stress, emotional stress, activity levels, kidney/liver problems, etc.) etc.) Fatty acid deficiency symptoms/signs. Dry skin (e.g. feet/face/general) Nutrient supplementation uses. Scaly or flaky skin (e.g. legs) Cracking/peeling fingertips & skin (e.g. heels) Lackluster skin Small bumps on back of upper arms 1. Optimizing levels. Patchy dullness &/or color variation of skin Irregular quilted appearance of skin (e.g. legs) 2. Therapeutic value. Thick or cracked calluses Dandruff or cradle cap Dry, lackluster, brittle or unruly hair lackluster, Soft, fraying, splitting or brittle fingernails Dull nails - lack of surface shine Slow growing fingernails Dry eyes Menstrual cramps or premenstrual breast pain/tenderness Excessive ear wax Excessive thirst Allergic (e.g. eczema/asthma/hay fever/hives) Crave fats/fatty foods Stiff or painful joints 6
  7. 7. Magnesium deficiency symptoms/signs. Muscle cramps, spasms or pain (e.g. back ache, neck ache, leg/foot leg/foot cramps) Hair mineral analysis. Muscle tension Muscle twitches, tics or jerks Muscle weakness Muscle tremors Restless legs Fatigue / sighing Breathlessness / chest tightness Heart palpitations / arrhythmias Numbness or tingling of skin or “creepy-crawly” feeling under skin “creepy- Sensitivity to loud noises or sudden bright light Menstrual cramps Headaches / migraines Frequent constipation or anal spasms Difficulty falling asleep and/or restless sleep Irritable, depressed, anxious, nervous or panic attacks Reference: www.doctorsdata.com/ RBC fatty acid analysis. Plasma amino acids. Reference: www.metametrix.com/ Reference: www.doctorsdata.com/ Nutrient imbalance treatments. Nutrient supplementation case study. Nutrient supplementation. Symptoms: Frequent urination Dietary changes. Night time urination Correct absorption problems. Night thirst Blurred vision after heavy exercise Mineral supplementation: “From one day to the next at least 90% of my symptoms vanished. These are symptoms I have lived with and have worsened for more than 10 years. Quite amazing.” 7
  8. 8. Increased toxic chemical exposure. Lead levels of human bones are ~1000 times higher than pre- higher pre- Toxic chemicals. industrial bones. Cadmium 500 times higher. Autism – mercury Study 1. Heavy metal sources: 221 children with ASD vs. 18 controls Food: • Direct contact with heavy Post-DMSA urine levels Post- Soil metal containing or Pesticides contaminated substances Mercury was 3.15 times higher!! Cooking items Paints Water Cigarettes Air Household chemicals Medical: Body products Amalgam fillings Many many others! Vaccines Jeff Bradstreet, M.D. David Geier, B.A. Jerold Kartzinel, M.D. James Adams, Ph.D. Mark Geier, M.D.,Ph.D. A Case-Control Study of Mercury Burden in Children with Autistic Spectrum Disorders. Journal of American Physicians and Surgeons Volume 8 Number 3 Fall 2003 Autism – mercury Study 2. 14 children with Autism vs. 11 controls Mercury was 3 times higher in baby teeth!! teeth!! Adams JB. A Review of the Autism-Mercury Connection. Conference Proceedings of the Annual. Meeting of the Autism Society of America, July 2004. 8
  9. 9. Toxic chemical treatments. Chemical avoidance. Chelation agents. Supportive nutrients/herbs. Far infrared (FIR) saunas. Electromagnetic radiation (EMR). Other environmental influences. 9
  10. 10. EMR testing. Toxic mould. Mould testing. Sick building syndrome symptoms/signs. Ongoing or frequent coughing / dry throat or mouth Irritated, stinging or burning sensation of throat or mouth Throat hoarseness / changed voice (e.g. raspy) Metallic taste in mouth Wheezing, irritated lungs or bronchitis Shortness of breath / chest tightness Irritated, sore or burning eyes Red or watery/tearing eyes Sensitivity to bright light / blurred vision Nasal congestion / running or stuffy nose / sneezing / nose bleeds bleeds Irritated, stinging or burning nose or nasal passage / nasal itching itching Sinusitis / sinus congestion or pressure Stinging, burning or itchy skin / skin sensitivity to light touch touch Skin rash or reddening of skin Dizziness / vertigo Headaches Fatigue / weakness Food reactivity. Many reasons why a person may react negatively to specific foods. foods. Allergy Allergies/intolerances. Intolerance e.g. lactose intolerance or fructose malabsorption e.g. impaired ability to metabolize salicylates, etc. e.g. gut flora/leaky gut mediated e.g. pharmacologic properties of the food - aspartame e.g. toxins in foods No one lab test for diagnosis of all negative reactions. 10
  11. 11. Food intolerance or allergy symptoms/signs. Itchy, tingly, irritated or burning tongue/lips/palate/throat during or after meals during Swollen lips/mouth or recurrent mouth ulcers Frequent hives - generally or around mouth/lips (e.g. rash or ring around mouth ) Increased mucus production in throat / regularly clearing throat Elimination/provocation testing. Excess drooling / excess saliva production / spitting during speech speech Irregular patches on tongue (geographic map-like) or mottled tongue map- Puffiness or ‘bags’ below eyes; or puffy or swollen nose/face Dark circles under eyes (‘allergic shiners’) GRAINS - Whole grain rice Inner corners of eyes itch or whole eyes itch / eye rubbing or scratching scratching Watery, glassy or glazed eyes; or red eyes Itchy nose / nose rubbing or scratching (‘nasal salute’) MEAT - 100% unrefined lamb Nasal or sinus congestion / sinusitis / runny or snuffly nose / sneezing Postnasal drip (nasal mucus draining down the back of the throat) throat) Abnormally red and/or flushed appearance of cheeks or nose (e.g. red tip nose) VEGETABLES - Cabbage, kale, carrots, Red ears / hot or ‘burning’ earlobes Eczema or wool intolerance / psoriasis cauliflower, squash, broccoli & sweet potatoes Itchy arms, ear canals, hands, legs or skin in general Puffy or swollen hands/knuckles/feet Asthma or recurrent wheezy bronchitis / infection or exercise induced wheezing induced FRUIT – Pears Abdominal pain, bloating or vomiting Increased frequency of stools / unformed bowel movements / frequent constipation frequent OILS/SEASONINGS - Olive oil & sea salt Feel best when don’t eat or skip meals Feel worse (energy, mood, concentration, etc.) or look pale/red after some meals Strong particular food cravings and dislikes / fussy eater Recurrent ear infections and/or recurrent glue ear Headaches/migraines Inhalant allergies. Food intolerance case study. Dust. Fibromyalgia. Cats/dogs. Elimination diet 50% drop in symptoms. Pollen. Lactose intolerance. Grass. Neurotransmitter & hormone imbalances. Neurotransmitters: Hormones: Serotonin Adrenal hormones Chemical imbalances. Dopamine Thyroid hormones Noradrenaline Sex hormones GABA Growth hormone Acetylcholine Endorphins 11
  12. 12. Biochemical continuum. Serotonin deficiency signs/symptoms. Depressed Nervous/anxious Worrier Fears/phobias Negative/pessimistic Irritable/impatient/edgy Obsessive compulsive tendency Think about the same things over & over again Self destructive or suicidal thoughts/plans Low self esteem/confidence Rage/anger/explosive behavior/assaultive Sleep problems/light sleeper Crave sugar/carbohydrates/alcohol/marijuana Use these substances to improve mood & relax Feel worse in & dislike dark weather Chronic pain (e.g. headaches, backaches, fibromyalgia) fibromyalgia) Serotonin pathway. Adrenal Rhythm. Reference: Bioconcepts. [www.bioconcepts.com.au/] Reference: www.diagnostechs.com/ Mild adrenal insufficiency signs/symptoms. Saliva Adrenal Stress Profile. Fatigue/lethargy not relieved by sleep Trouble getting up in the morning Crave salt or salty food Low blood pressure Light-headed or dizzy when getting up to stand from laying or sitting Light- Feel unwell during/after emotional stress, e.g. exhausted, shaky or confused Decreased ability to handle stress/pressure Tendency for low blood sugar Intolerance to cold / frequently feel cold Unstable body temperature Light sensitivity Increased frequency/severity of allergies Dark brown spots on face/neck/shoulders Poor exercise tolerance Increased time to recover from infection Thin, can't gain weight or weight loss Insomnia / sleep disturbance Anxious or panic attacks Reference: www.gdx.net/ 12
  13. 13. Adrenal hormone case study. Sleep. “I am feeling so much better than when we first consulted over 6 months ago… for the last month I have been doing about 500 metres of swimming + 2 kms of walking about 5 times a week. This compares to just barely struggling to do the weekly shopping! The feelings of exhaustion are not very common anymore. Depression and anxiety totally under control. Sleeping is much better. Overall, I am beginning to feel like a completely different person.” Sleep. Sleep. Inadequate sleep quantity and quality are extremely common. Functions of sleep: Rejuvenation/Repair Growth Detoxification Memory storage Energy conservation Reference: Dr. Reza Samvat, www.sleep4health.com.au/ Sleep – treatment. Remove causes. Supportive lifestyle, environment and sleep Stress. routine. Dietary changes. Herbal/nutritional supplements. Relaxation techniques. See: www.nutritional-healing.com.au ‘Articles’ for more info. 13
  14. 14. Psycho-social stress. Psycho-social stress – Management. Universal disease exacerbator. exacerbator. Treatment options: Known effects: Eckhart Tolle [www.eckharttolle.com/]. www.eckharttolle.com/ Impairs immune function. Emotional Freedom Techniques (EFT). Increase nutrient requirements (e.g. [www.integrative-clearing.com.au/] www.integrative-clearing.com.au/] magnesium). Breathing/muscle relaxation exercises. Impair digestion. Biochemical. Impair sleep. Exercise. Impair neurotransmitter balance. Impair hormone (e.g. cortisol, DHEA, thyroid hormones, sex hormones) balance. Lifestyle factors. Smoking. Lifestyle. Alcohol. Drug use. Exercise. Rest. Fun. How to put it all together. How to put it all together. 1. Optimize basics: 1. Optimize basics: General diet. General diet. Sleep. Sleep. Stress. Stress. Lifestyle. Lifestyle. Healthy environment. Healthy environment. 2. Identify contributing factors: Gastrointestinal issues. Nutrient imbalances. Environmental. Allergies/intolerances. Neurotransmitters & hormone imbalances. 14
  15. 15. Questionnaire. Nutritional & Environmental Medicine: Putting all the pieces together. Blake Graham, B.Sc (Honours), AACNEM Clinical Nutritionist (08) 9381 4112 February 16th 2008 *Join our FREE email newsletter at www.nutritional-healing.com.au ‘Newsletter’. 15