What causes disease?
Nutritional & Environmental
Medicine: Putting all the pieces Gastrointestinal abnormalities.
together. Nutrient imbalances/diet.
Blake Graham, B.Sc (Honours), AACNEM Environmental. (e.g. heavy metals)
Clinical Nutritionist Allergies/intolerances.
www.nutritional- Chemical imbalances. (e.g. hormones)
(08) 9381 4112 Disordered sleep.
February 16th 2008 Lifestyle factors.
Multi-factorial model. Web of inter-relationships and vicious cycles.
All disease is
Ripple effect. Spectrums.
Self healing. Disease treatment models.
1. Treat symptoms:
Complex corrective mechanisms.
Nausea = anti-nausea medication
Identify and remove: High cholesterol = cholesterol lowering medication
Dry skin = moisturizer
Causes. Insomnia = sedatives
Impediments to healing. 2. Address underlying causes:
e.g. nausea caused by gastrointestinal infection
Reduce burden of stressors on the body e.g. high cholesterol caused by poor diet
below the threshold which the body can e.g. dry skin caused by fatty acid deficiency
e.g. insomnia caused by anxiety
Disease treatment models.
Disease centred diagnosis. Person centred diagnosis.
Irritable bowel syndrome. Nutrient deficiencies.
Chronic Fatigue Syndrome.
Depression. Intestinal infection.
Inter- Specific links of interest:
genetics and environment. 1. Environmental chemical metabolism.
Environment influences genetic 2. Nutrient imbalances.
expression. 3. Gastrointestinal health.
Genetics influence reaction to 4. Allergies/intolerances.
environment. 5. Chemical imbalances. (e.g. hormones)
6. Immune integrity.
Genetics. Genetic testing.
Eczema/asthma/hay fever/hives Allergies
Crohn's Disease Increased intestinal variation!
ADD/ADHD Abnormal zinc metabolism
Imbalanced gastrointestinal flora ('dysbiosis').
Gastrointestinal infections (bacteria, parasitic, yeast).
Gastrointestinal health. Increased intestinal permeability ('leaky gut').
Stomach acid deficiency (hypochlorhydria).
Pancreatic enzyme insufficiency.
Bile acid deficiency.
Functions of healthy flora:
Produce short chain fatty acids which are needed by the intestinal mucosa
intestinal Harmful bacteria.
Produce biofilm (mucus barrier) to protect intestinal mucosa
Interact with the gut associated lymphoid tissue (GALT) – 70% of Produce toxic chemicals as metabolic by-products which have
immune system, e.g. systemic effects, e.g.
Improves antibody formation Ammonia Hyperammonemia
Reduce allergies (eczema and asthma)
D-lactic acid D-lactic acidosis
Regulate cytokine levels / inflammation modulation
Synthesize nutrients (certain amino acids and vitamins) Decrease production of short chain fatty acids
Improve digestion/absorption Produce antigens which disrupt immune function
Inhibit the overgrowth of harmful bacteria, yeast, viruses and parasites
parasites Reduce levels of healthy flora
Improve intestinal motility and stool formation
Impair nutrient digestion/absorption
Influence genetic expression
Assist the detoxification of various substances and convert some toxins Degradation/consumption of nutrients
into less toxic forms : Damage intestinal wall
Hormones (e.g. estrogen)
Potentially carcinogenic chemicals
Lipids (e.g. cholesterol)
Intestinal flora testing.
Gastrointestinal health: Yeast.
Great exacerbating factor.
Releases harmful chemicals.
Lab tests are notoriously unreliable.
Yeast symptoms/signs. Yeast testing.
Vaginal itching or redness, vaginitis or 'jock itch' – often scratching/itching at genital
White or grayish-white coating on your tongue or inner cheeks, or white patches in
Nasal congestion or stuffiness, swelling of the nasal membranes or sinusitis
Previously noticed a decline in your health following antibiotics or antibiotics
exacerbate your current health problem
Fungus infections of the skin (e.g. athletes foot) or nails
Psoriasis, eczema or hives
Puffiness/bloating/swelling in the hands, face and feet
Eating sugar make you feel worse/worsens certain symptoms
Negative reaction to certain dietary yeasts/molds
Very high fondness for yeasty foods
Chemical sensitivities (e.g. car exhaust, petrol, cigarette smoke, perfumes, etc.)
Multiple food sensitivities
Lower abdominal bloating
Gas, frequent constipation, loose/unformed stools, diarrhea or foul smelling stools
Itchy rectal/anal area or red ring immediately around the anus
Feel ‘spaced out’ &/or ‘brain fogged’
Intestinal parasite symptoms/signs.
Gastrointestinal health: Parasites. Current illness began with diarrhea/food poisoning
Remarkably common. Abdominal pain/discomfort
Under-diagnosed due to:
Under- Visible mucus or pus in stools
Itchy anal/rectal area
Lack of consideration. Foul smelling stools
Inadequate laboratory Frequent constipation
Frequent nausea and/or vomiting
techniques. Food allergies/intolerances
Teeth grinding (bruxism) while sleeping
Skin conditions (bluish cast around lips, hives, psoriasis, eczema, skin ulcers)
Forgetfulness or unclear thinking
Nervousness, apathy, depressed, anxious or headaches
Parasite testing. Maldigestion/malabsorption.
Stomach acid deficiency (hypochlorhydria).
Pancreatic enzyme insufficiency.
Bile acid deficiency.
Digestive function testing. Hypochlorhydria symptoms/signs.
Undigested food in stool
Trouble digesting red meat
Food or water ‘sits in stomach’
Poor appetite or feel overly full easily
Stomach aching/pain/discomfort or bloating after meals
Reflux &/or heartburn
High fat foods cause nausea/stomach upset
Nausea/reflux after supplements (e.g. fish oil)
Feel unwell/fatigued right after meals
Lemon juice improves digestion
Low iron levels
Heidelberg pH Diagnostic System. Gastrointestinal treatments.
Stomach acid supplement (Betaine HCl).
Nutrient status continuum.
Nutrient status continuum. Nutrition: Nutritional status.
• Food choices
• Soil levels, food storage, food processing
IV. Synthesis (vitamins K & D)
V. Other factors (hormone imbalances, toxic
chemicals, infections, other nutrient levels,
medications, oxidative stress, emotional stress,
activity levels, kidney/liver problems, etc.)
Fatty acid deficiency symptoms/signs.
Dry skin (e.g. feet/face/general)
Nutrient supplementation uses. Scaly or flaky skin (e.g. legs)
Cracking/peeling fingertips & skin (e.g. heels)
Small bumps on back of upper arms
1. Optimizing levels. Patchy dullness &/or color variation of skin
Irregular quilted appearance of skin (e.g. legs)
2. Therapeutic value. Thick or cracked calluses
Dandruff or cradle cap
Dry, lackluster, brittle or unruly hair
Soft, fraying, splitting or brittle fingernails
Dull nails - lack of surface shine
Slow growing fingernails
Menstrual cramps or premenstrual breast pain/tenderness
Excessive ear wax
Allergic (e.g. eczema/asthma/hay fever/hives)
Crave fats/fatty foods
Stiff or painful joints
Magnesium deficiency symptoms/signs.
Muscle cramps, spasms or pain (e.g. back ache, neck ache, leg/foot
cramps) Hair mineral analysis.
Muscle twitches, tics or jerks
Fatigue / sighing
Breathlessness / chest tightness
Heart palpitations / arrhythmias
Numbness or tingling of skin or “creepy-crawly” feeling under skin
Sensitivity to loud noises or sudden bright light
Headaches / migraines
Frequent constipation or anal spasms
Difficulty falling asleep and/or restless sleep
Irritable, depressed, anxious, nervous or panic attacks
RBC fatty acid analysis. Plasma amino acids.
Reference: www.metametrix.com/ Reference: www.doctorsdata.com/
Nutrient imbalance treatments. Nutrient supplementation case study.
Nutrient supplementation. Symptoms:
Dietary changes. Night time urination
Correct absorption problems. Night thirst
Blurred vision after heavy exercise
“From one day to the next at least 90% of my
symptoms vanished. These are symptoms I
have lived with and have worsened for more
than 10 years. Quite amazing.”
Increased toxic chemical exposure.
Lead levels of human bones are
~1000 times higher than pre-
Toxic chemicals. industrial bones.
Cadmium 500 times higher.
Autism – mercury Study 1.
Heavy metal sources:
221 children with ASD vs. 18 controls
Food: • Direct contact with heavy Post-DMSA urine levels
Soil metal containing or
Pesticides contaminated substances Mercury was 3.15 times higher!!
Cooking items Paints
Air Household chemicals
Medical: Body products
Amalgam fillings Many many others!
Jeff Bradstreet, M.D. David Geier, B.A. Jerold Kartzinel, M.D. James Adams, Ph.D. Mark Geier, M.D.,Ph.D. A Case-Control Study of Mercury
Burden in Children with Autistic Spectrum Disorders. Journal of American Physicians and Surgeons Volume 8 Number 3 Fall 2003
Autism – mercury Study 2.
14 children with Autism vs. 11 controls
Mercury was 3 times higher in baby teeth!!
Adams JB. A Review of the Autism-Mercury Connection. Conference Proceedings of the Annual. Meeting of the Autism Society of America,
Toxic chemical treatments.
Far infrared (FIR)
Electromagnetic radiation (EMR).
Other environmental influences.
EMR testing. Toxic mould.
Mould testing. Sick building syndrome symptoms/signs.
Ongoing or frequent coughing / dry throat or mouth
Irritated, stinging or burning sensation of throat or mouth
Throat hoarseness / changed voice (e.g. raspy)
Metallic taste in mouth
Wheezing, irritated lungs or bronchitis
Shortness of breath / chest tightness
Irritated, sore or burning eyes
Red or watery/tearing eyes
Sensitivity to bright light / blurred vision
Nasal congestion / running or stuffy nose / sneezing / nose bleeds
Irritated, stinging or burning nose or nasal passage / nasal itching
Sinusitis / sinus congestion or pressure
Stinging, burning or itchy skin / skin sensitivity to light touch
Skin rash or reddening of skin
Dizziness / vertigo
Fatigue / weakness
Many reasons why a person may react negatively to specific foods.
e.g. lactose intolerance or fructose malabsorption
e.g. impaired ability to metabolize salicylates, etc.
e.g. gut flora/leaky gut mediated
e.g. pharmacologic properties of the food - aspartame
e.g. toxins in foods
No one lab test for diagnosis of all negative reactions.
Food intolerance or allergy symptoms/signs.
Itchy, tingly, irritated or burning tongue/lips/palate/throat during or after meals
Swollen lips/mouth or recurrent mouth ulcers
Frequent hives - generally or around mouth/lips (e.g. rash or ring around mouth )
Increased mucus production in throat / regularly clearing throat
Excess drooling / excess saliva production / spitting during speech
Irregular patches on tongue (geographic map-like) or mottled tongue
Puffiness or ‘bags’ below eyes; or puffy or swollen nose/face
Dark circles under eyes (‘allergic shiners’) GRAINS - Whole grain rice
Inner corners of eyes itch or whole eyes itch / eye rubbing or scratching
Watery, glassy or glazed eyes; or red eyes
Itchy nose / nose rubbing or scratching (‘nasal salute’)
MEAT - 100% unrefined lamb
Nasal or sinus congestion / sinusitis / runny or snuffly nose / sneezing
Postnasal drip (nasal mucus draining down the back of the throat)
Abnormally red and/or flushed appearance of cheeks or nose (e.g. red tip nose)
VEGETABLES - Cabbage, kale, carrots,
Red ears / hot or ‘burning’ earlobes
Eczema or wool intolerance / psoriasis
cauliflower, squash, broccoli & sweet potatoes
Itchy arms, ear canals, hands, legs or skin in general
Puffy or swollen hands/knuckles/feet
Asthma or recurrent wheezy bronchitis / infection or exercise induced wheezing
FRUIT – Pears
Abdominal pain, bloating or vomiting
Increased frequency of stools / unformed bowel movements / frequent constipation
frequent OILS/SEASONINGS - Olive oil & sea salt
Feel best when don’t eat or skip meals
Feel worse (energy, mood, concentration, etc.) or look pale/red after some meals
Strong particular food cravings and dislikes / fussy eater
Recurrent ear infections and/or recurrent glue ear
Inhalant allergies. Food intolerance case study.
Cats/dogs. Elimination diet 50% drop in symptoms.
Pollen. Lactose intolerance.
Neurotransmitter & hormone imbalances.
Serotonin Adrenal hormones
Chemical imbalances. Dopamine Thyroid hormones
Noradrenaline Sex hormones
GABA Growth hormone
Biochemical continuum. Serotonin deficiency signs/symptoms.
Obsessive compulsive tendency
Think about the same things over & over again
Self destructive or suicidal thoughts/plans
Low self esteem/confidence
Sleep problems/light sleeper
Use these substances to improve mood & relax
Feel worse in & dislike dark weather
Chronic pain (e.g. headaches, backaches, fibromyalgia)
Reference: Bioconcepts. [www.bioconcepts.com.au/] Reference: www.diagnostechs.com/
Mild adrenal insufficiency signs/symptoms. Saliva Adrenal Stress Profile.
Fatigue/lethargy not relieved by sleep
Trouble getting up in the morning
Crave salt or salty food
Low blood pressure
Light-headed or dizzy when getting up to stand from laying or sitting
Feel unwell during/after emotional stress, e.g. exhausted, shaky or confused
Decreased ability to handle stress/pressure
Tendency for low blood sugar
Intolerance to cold / frequently feel cold
Unstable body temperature
Increased frequency/severity of allergies
Dark brown spots on face/neck/shoulders
Poor exercise tolerance
Increased time to recover from infection
Thin, can't gain weight or weight loss
Insomnia / sleep disturbance
Anxious or panic attacks
Adrenal hormone case study.
“I am feeling so much better than when we first consulted
over 6 months ago… for the last month I have been doing
about 500 metres of swimming + 2 kms of walking about 5
times a week. This compares to just barely struggling to do
the weekly shopping! The feelings of exhaustion are not very
common anymore. Depression and anxiety totally under
control. Sleeping is much better. Overall, I am beginning to
feel like a completely different person.”
Inadequate sleep quantity and quality are
extremely common. Functions of sleep:
Reference: Dr. Reza Samvat, www.sleep4health.com.au/
Sleep – treatment.
Supportive lifestyle, environment and sleep Stress.
See: www.nutritional-healing.com.au ‘Articles’ for more info.
Psycho-social stress. Psycho-social stress – Management.
Universal disease exacerbator.
exacerbator. Treatment options:
Known effects: Eckhart Tolle [www.eckharttolle.com/].
Impairs immune function. Emotional Freedom Techniques (EFT).
Increase nutrient requirements (e.g. [www.integrative-clearing.com.au/]
magnesium). Breathing/muscle relaxation exercises.
Impair digestion. Biochemical.
Impair sleep. Exercise.
Impair neurotransmitter balance.
Impair hormone (e.g. cortisol, DHEA, thyroid
hormones, sex hormones) balance.
How to put it all together. How to put it all together.
1. Optimize basics: 1. Optimize basics:
General diet. General diet.
Lifestyle. Healthy environment.
Healthy environment. 2. Identify contributing factors:
Neurotransmitters & hormone imbalances.
Questionnaire. Nutritional & Environmental
Medicine: Putting all the pieces
Blake Graham, B.Sc (Honours), AACNEM
(08) 9381 4112
February 16th 2008
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