Drug Development Research inPreclinical Imaging Centre (PRIME)        Prof. dr. Otto C. Boerman
RTM: Radboud Translational Medicine                   from molecule to manDiscovery       Screening   preclinical testing ...
RTM: Radboud Translational Medicine                   from molecule to manDiscovery       Screening   preclinical testing ...
PRIME: Preclinical Imaging Centre                                                 microSPECT                            Ra...
From human imaging to small animal imaging
From human imaging to small animal imaging Mouse                 Human Uptake of 123I-IBF  by D2 receptors Neurology      ...
Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Centre, The Netherlands
PRIMEPreclinical Imaging Centre                        microSPECT    PET imaging in PRIME                             Radb...
Annihilation               Radboud University Nijmegen Medical Centre, The Netherlands
FDG-PET: imaging cancerNormal FDG-PET    Metastasized Melanoma
FDG-PET: functional imaging        Monitor response to treatment                                                          ...
FDG-PET: functional imaging        Monitor response to treatment                                                          ...
FDG-PET: functional imaging        Monitor response to treatment                                                          ...
microPET/CT scanner                 Radboud University Nijmegen Medical Centre, The Netherlands
Monitor the therapeutic effect            of a new anti-cancer drug- 1 day                                  Radboud Univer...
Monitor the therapeutic effect            of a new anti-cancer drug- 1 day          1 day                                 ...
Monitor the therapeutic effect            of a new anti-cancer drug- 1 day          1 day        3 days                   ...
Monitor the therapeutic effect            of a new anti-cancer drug- 1 day          1 day        3 days                   ...
PRIMEPreclinical Imaging Centre                        microSPECT   SPECT imaging in PRIME                             Rad...
Small animal SPECT imaging                  Radboud University Nijmegen Medical Centre, The Netherlands
Radboud University Nijmegen Medical Centre, The Netherlands                                                        25
microSPECT imaging               Radboud University Nijmegen Medical Centre, The Netherlands
Imaging transplated islets of LangerhansDiabetes type 1: autoimmune destruction of insulin producing beta cellsIslet trans...
Imaging transplated islets of Langerhans                          Radboud University Nijmegen Medical Centre, The Netherla...
Imaging transplated islets of Langerhans2D                 3WIn-111-Exendin                           6W                  ...
PRIME      Preclinical Imaging Centre                               microSPECTIntravital fluorescence imaging in PRIME    ...
Multi-photon fluorescence microscopy                         Radboud University Nijmegen Medical Centre, The Netherlands
Multi-photon fluorescence microscopyMonitoring of tumor development using the dorsal skinfold chamber model               ...
Multi-photon fluorescence microscopy                                                  Tumor cells                         ...
Multi-photon fluorescence microscopy                                               Tumor cells                            ...
Immunofluorescence Guided Surgery                       Radboud University Nijmegen Medical Center, The Netherlands
Immunofluorescence Guided Surgery                       Radboud University Nijmegen Medical Center, The Netherlands
Multi-modality ImagingFluorescence imaging                          MRI                                     PET           ...
Drug development ResearchHoffmann La RocheNovartisSanofiFuji BiotechnologyFuture ChemistryImmunomedics Inc.SynaffixWilexMi...
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Otto Boerman

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  • At the moment more than 180 million people worldwide suffer from diabetes and an increase of the incidence of diabetes is expected.
  • MIP maximum intensity projection VRT volume rendering technique
  • Otto Boerman

    1. 1. Drug Development Research inPreclinical Imaging Centre (PRIME) Prof. dr. Otto C. Boerman
    2. 2. RTM: Radboud Translational Medicine from molecule to manDiscovery Screening preclinical testing Clinical trials Radboud University Nijmegen Medical Centre, The Netherlands
    3. 3. RTM: Radboud Translational Medicine from molecule to manDiscovery Screening preclinical testing Clinical trials Radboud University Nijmegen Medical Centre, The Netherlands
    4. 4. PRIME: Preclinical Imaging Centre microSPECT Radboud University Nijmegen Medical Centre, The Netherlands
    5. 5. From human imaging to small animal imaging
    6. 6. From human imaging to small animal imaging Mouse Human Uptake of 123I-IBF by D2 receptors Neurology Dopamine w/ 99mTc-TRODAT 99m Tc-MIBICardiovascular Stress 99mTc-MIBI [99mTc] Minigastrin Oncology Renal Cell Carcinoma *functional imaging
    7. 7. Radboud University Nijmegen Medical Centre, The Netherlands
    8. 8. Radboud University Nijmegen Medical Centre, The Netherlands
    9. 9. Radboud University Nijmegen Medical Centre, The Netherlands
    10. 10. Radboud University Nijmegen Medical Centre, The Netherlands
    11. 11. Radboud University Nijmegen Medical Centre, The Netherlands
    12. 12. PRIMEPreclinical Imaging Centre microSPECT PET imaging in PRIME Radboud University Nijmegen Medical Centre, The Netherlands
    13. 13. Annihilation Radboud University Nijmegen Medical Centre, The Netherlands
    14. 14. FDG-PET: imaging cancerNormal FDG-PET Metastasized Melanoma
    15. 15. FDG-PET: functional imaging Monitor response to treatment Pre treatment 4 weeks after start of treatment 24 weeks after start of treatmentPre treatment Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
    16. 16. FDG-PET: functional imaging Monitor response to treatment Pre treatment 4 weeks after start of treatment 24 weeks after start of treatmentPre treatment 1 week after start of imatinib treatment Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
    17. 17. FDG-PET: functional imaging Monitor response to treatment Pre treatment 4 weeks after start of treatment 24 weeks after start of treatmentPre treatment 1 week after start of imatinib treatment Dept. Nuclear Medicine, Radboud University Nijmegen Medical Centre
    18. 18. microPET/CT scanner Radboud University Nijmegen Medical Centre, The Netherlands
    19. 19. Monitor the therapeutic effect of a new anti-cancer drug- 1 day Radboud University Nijmegen Medical Center, The Netherlands
    20. 20. Monitor the therapeutic effect of a new anti-cancer drug- 1 day 1 day Radboud University Nijmegen Medical Center, The Netherlands
    21. 21. Monitor the therapeutic effect of a new anti-cancer drug- 1 day 1 day 3 days Radboud University Nijmegen Medical Center, The Netherlands
    22. 22. Monitor the therapeutic effect of a new anti-cancer drug- 1 day 1 day 3 days 7 days Radboud University Nijmegen Medical Center, The Netherlands
    23. 23. PRIMEPreclinical Imaging Centre microSPECT SPECT imaging in PRIME Radboud University Nijmegen Medical Centre, The Netherlands
    24. 24. Small animal SPECT imaging Radboud University Nijmegen Medical Centre, The Netherlands
    25. 25. Radboud University Nijmegen Medical Centre, The Netherlands 25
    26. 26. microSPECT imaging Radboud University Nijmegen Medical Centre, The Netherlands
    27. 27. Imaging transplated islets of LangerhansDiabetes type 1: autoimmune destruction of insulin producing beta cellsIslet transplantation is a promising treatment for patients with type1 diabetesAIM: Non-invasive in vivo determination of beta cell mass after islet transplantation. In-111-DTPA- Exendin islets Radboud University Nijmegen Medical Centre, The Netherlands
    28. 28. Imaging transplated islets of Langerhans Radboud University Nijmegen Medical Centre, The Netherlands
    29. 29. Imaging transplated islets of Langerhans2D 3WIn-111-Exendin 6W 8W 11W Radboud University Nijmegen Medical Centre, The Netherlands
    30. 30. PRIME Preclinical Imaging Centre microSPECTIntravital fluorescence imaging in PRIME Radboud University Nijmegen Medical Centre, The Netherlands
    31. 31. Multi-photon fluorescence microscopy Radboud University Nijmegen Medical Centre, The Netherlands
    32. 32. Multi-photon fluorescence microscopyMonitoring of tumor development using the dorsal skinfold chamber model Radboud University Nijmegen Medical Centre, The Netherlands
    33. 33. Multi-photon fluorescence microscopy Tumor cells Extracellular matrix, collagen, muscle fibers Fat cells, nerves Blood vessels, immune cells Radboud University Nijmegen Medical Centre, The Netherlands
    34. 34. Multi-photon fluorescence microscopy Tumor cells Extracellular matrix, collagen, muscle fibers Fat cells, nerves Blood vessels, immune cells Radboud University Nijmegen Medical Centre, The Netherlands
    35. 35. Immunofluorescence Guided Surgery Radboud University Nijmegen Medical Center, The Netherlands
    36. 36. Immunofluorescence Guided Surgery Radboud University Nijmegen Medical Center, The Netherlands
    37. 37. Multi-modality ImagingFluorescence imaging MRI PET Multiphoton imaging Radboud University Nijmegen Medical Centre, The Netherlands
    38. 38. Drug development ResearchHoffmann La RocheNovartisSanofiFuji BiotechnologyFuture ChemistryImmunomedics Inc.SynaffixWilexMilabs Radboud University Nijmegen Medical Centre, The Netherlands

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