Health Valley   March 13, 2013Radboud Personalized Healthcare                             Prof.dr. Andrea W.M. Evers &    ...
Major shift toPersonalized Healthcare concepts       One-size-fits-all Healthcare tailored to needs  and characteristics o...
Need for Personalized Healthcare tools              Mechanism ?       Prognosis ?                                         ...
4Working in complex human biological systems    requires a system biology approach
Radboud University Medical CentreExcelling in research,patient care and educationfor personalized healthcare9500 employees...
Our missionTo have a significantimpact on healthcareOur vision Distinctive quality Personalized healthcare Operational ...
Our missionTo have a significant impacton healthcareOur principles Patient as Partner  & Participatory Healthcare Transl...
Following ESF Recommendations1. Generation of datasets to   develop, refine, and apply   new disease taxonomy2. Revised mo...
Investments in preconditions forimplementationInfrastructureCross-disciplinary workingInterdisciplinary structuresBioba...
Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, and methodologicalresearchers    ...
Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, andmethodological researchers    ...
Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, andmethodological researchers    ...
Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, andmethodological researchers    ...
Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, and methodologicalresearchers    ...
Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, and methodologicalresearchers    ...
Radboud Personalized HealthcareDefinition Radboud Personalized Healthcare  • Translational and interdisciplinary research ...
Radboud Personalized Healthcare“We enable personalized and participatory patient care through interdisciplinary research”
Radboud Personalized Healthcare“We enable personalized and participatory patient care through interdisciplinary research”
Radboud Personalized Healthcare“We enable personalized and participatory patient care through interdisciplinary research”
Radboud Personalized Healthcare•Majority of (current and future) RUMC research representsresearch on Personalized Healthca...
Personalized Healthcare @ Radboud UMCVarious best practice examplesMalaria treatmentMacula degenerationRare metabolic dise...
Best-Practice Examples      RadboudPersonalized Healthcare
Malaria controlMolecule                                                                  Molecular evaluation of          ...
Age-related                                  Macula degeneration                                                   Patient...
Prostate cancerPSA screening: 30%                                 Patientreduction in prostatecancer mortality.However, al...
Participatory E-health care          for chronic somatic conditionsE-health screeningfor disease-relatedphysical,psycholog...
Planning 2013Radboud Personalized Healthcare• Proactive stimulation of Personalized Healthcare research  within Radboud UM...
Investments and networks with industrialand university partners
29Personalized Healthcare Stakeholders
Investments and networks with industrialand university partnersInfrastructureCross-disciplinary workingInterdisciplinary...
Radboud Biobankfor biomarkers and other data collection
TopSectorplan Life Science & Health             {www.rijksoverheid.nl}   {http://www.zonmw.nl/nl/roadmaps-lsh/}          R...
Biomarkers and self-diagnosis …
Participatory E-health UMC St Radboud:Digital outpatient clinics and communities          Mijn Radboud             Dossier...
Participatory E-health UMC St Radboud:Digital personalized selfmanagementPersonalized selfmanagement care• Flexible choice...
European networksRadboud Personalized HealthcareEuropean ScienceFoundation (2013)Radboud University Medical Centeras field...
European networksPersonalized Healthcare & Self-managementEuropean CentrePersonalized Healthcareand Self-managementInitiat...
EU-Horizon 2020 topics       and Radboud Personalized Healthcare   Understanding the              Developing effective det...
Radboud Personalized HealthcareSpeakers     I.Norstedt, ERC Coordinator Personalized Medicine
Plenary Session   Health Valley      RadboudPersonalized Healthcare         with  Paul Smits (dean)    Thank you     for y...
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  • Paris, October 21, 2010
  • Andrea Evers

    1. 1. Health Valley March 13, 2013Radboud Personalized Healthcare Prof.dr. Andrea W.M. Evers & Prof.dr. Alain J. van Gool on behalf of the Taskforce Personalized Healthcare Radboud University Medical Centre Nijmegen, The Netherlands
    2. 2. Major shift toPersonalized Healthcare concepts One-size-fits-all Healthcare tailored to needs and characteristics of the individual Reactive medicine Pro-active, pre-emptive, and preventive healthcare European Science Foundation
    3. 3. Need for Personalized Healthcare tools Mechanism ? Prognosis ? Patient classification ? Diagnosis ? Other (latent) diseases ? Treatment Disease Disease state Drug exposure ? Cross-species differences ? Target engagement ? Off-target drug effects ? Modulation of mechanism ? High need for (molecular) tools to improve disease management
    4. 4. 4Working in complex human biological systems requires a system biology approach
    5. 5. Radboud University Medical CentreExcelling in research,patient care and educationfor personalized healthcare9500 employees3500 students950 beds3000 scientific publications150 dissertations each year
    6. 6. Our missionTo have a significantimpact on healthcareOur vision Distinctive quality Personalized healthcare Operational excellence Sustainable networks
    7. 7. Our missionTo have a significant impacton healthcareOur principles Patient as Partner & Participatory Healthcare Translational research Implementation in Care, Research & Education
    8. 8. Following ESF Recommendations1. Generation of datasets to develop, refine, and apply new disease taxonomy2. Revised models and decision- making processes focused on the individual3. Interdisciplinary, participative, and translational research4. Infrastructure and resources (funding and support) European Science Foundation
    9. 9. Investments in preconditions forimplementationInfrastructureCross-disciplinary workingInterdisciplinary structuresBiobanksAccess to core technologiesPromotion of health (literacy)Education & training programs European Science Foundation
    10. 10. Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, and methodologicalresearchers in Personalized Healthcarea patient representativecommunication expertsvalorization expert Laboratory Anthropo- Communicatio Medicine genetics n Oncology Radboud Valorization Personalized Neurology Healthcare Task Force Health care Patient innovation Medical Health Psychology Evidence
    11. 11. Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, andmethodological researchers in Personalized Healthcarea patient representativecommunication expertsvalorization expert Laboratory Anthropo- Communicatio Medicine genetics n Oncology Radboud Valorization Personalized Neurology Healthcare Task Force Health care Patient innovation Medical Health Psychology Evidence
    12. 12. Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, andmethodological researchers in Personalized Healthcarea patient representativecommunication expertsvalorization expert Laboratory Anthropo- Communicatio Medicine genetics n Oncology Radboud Valorization Personalized Neurology Healthcare Task Force Gynae- Patient cology Medical Health Psychology Evidence
    13. 13. Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, andmethodological researchers in Personalized Healthcarea patient representativecommunication expertsvalorization expert Laboratory Anthropo- Communicatio Medicine genetics n Oncology Radboud Valorization Personalized Neurology Healthcare Task Force Health care Patient innovation Medical Health Psychology Evidence
    14. 14. Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, and methodologicalresearchers in Personalized Healthcarea patient representativecommunication expertsvalorization expert Laboratory Anthropo- Communicatio Medicine genetics n Oncology Radboud Valorization Personalized Neurology Healthcare Task Force Health care Patient innovation Medical Health Psychology Evidence
    15. 15. Radboud Personalized HealthcareInterdisciplinary taskforce (2012)fundamental, clinical, and methodologicalresearchers in Personalized Healthcarea patient representativecommunication expertsvalorization expert Laboratory Anthropo- Medicine genetics Communicatio n Oncology Radboud Valorization Personalized Neurology Healthcare Task Force Health care Patient innovation Medical Health Psychology Evidence
    16. 16. Radboud Personalized HealthcareDefinition Radboud Personalized Healthcare • Translational and interdisciplinary research (From molecule to men to population back to men) • Connection to Patient as Partner “It’s far more important (Education and Health care) to know what person the disease has than what disease the person has.” Hippocrates, 400 B.C
    17. 17. Radboud Personalized Healthcare“We enable personalized and participatory patient care through interdisciplinary research”
    18. 18. Radboud Personalized Healthcare“We enable personalized and participatory patient care through interdisciplinary research”
    19. 19. Radboud Personalized Healthcare“We enable personalized and participatory patient care through interdisciplinary research”
    20. 20. Radboud Personalized Healthcare•Majority of (current and future) RUMC research representsresearch on Personalized Healthcare•Personalized Healthcare research is about equallyrepresented in all research institutese.g. Oncology, Rare diseases, Inflammation, Neurology “Personalized Healthcare builds onto the historic roots of the university and the Radboud University Medical Center.” Interview research director
    21. 21. Personalized Healthcare @ Radboud UMCVarious best practice examplesMalaria treatmentMacula degenerationRare metabolic diseasesGenome sequencingParkinson careParticipatory E-health care
    22. 22. Best-Practice Examples RadboudPersonalized Healthcare
    23. 23. Malaria controlMolecule Molecular evaluation of hotspot interventions on parasite populationsIdentification ofmalaria proteins thatare recognized bymalaria-exposedpopulations Personalized interventions 1. households next to a swamp: larve control 2. households with few nets: additional nets 3. households with parasite carriers: prophylactic treatment Mapping immune responses to this protein to find malaria hotspots , olds seh T. Bousema et al., Radboud re hou ts a gnition UMC, a : do map A-1 rec o Population Health Valley 2013, Pecha Are r AM u Kucha colo
    24. 24. Age-related Macula degeneration PatientNeovascular AMD can betreated with anti-VEGFinjections, but 10% of patientsdo not respond to theseexpensive and invasivetherapy Treatment Genes Patients with a low genetic load can effectively be treated with anti-VEGF therapy The genetic load of risk alleles in CHF and ARMS2 can help predict the response to anti-VEFG treatment Complement activity Genetic studies (exome sequencing) may reveal new pathogenic pathways in AMD that can be targeted with new therapies Patients with a high genetic load and high complement activation may benefit A. Den Hollander & C. from a combination therapy of anti- Hojing, Radboud UMC VEGF and complement inhibitors
    25. 25. Prostate cancerPSA screening: 30% Patientreduction in prostatecancer mortality.However, also about40% over treatment ofinsignificant tumors Molecule Personalized interventions Molecular profiling leads to non-invasive urine test Only men with significant tumors will be treated (i.e., 40% less operations). Focal surgical treatment will be possible: 1. Cryo surgery Person 2. Laser surgery 3.HIFU and/or 4. Brachy Multi-parametric MRI and MRI-guided biopsies lead to J. Barentsz, J. Schalken et improved localization of al., Radboud UMC significant tumors
    26. 26. Participatory E-health care for chronic somatic conditionsE-health screeningfor disease-relatedphysical,psychological orsocial adjustment About 1/3 of Personalized E-health treatment modulesproblems patients with Physical Psychological Social chronic somatic functioning functioning functioning conditions suffer from adjustments problems Patient not at risk: Standard care Personalized E-health self-management E-health risk profile treatments personalized to Patient at risk: disease- and patient-specific Personalized E-health self- problems and risk and management treatments resilience factors A. Evers, P vd Kerkhof et al., Radboud UMC
    27. 27. Planning 2013Radboud Personalized Healthcare• Proactive stimulation of Personalized Healthcare research within Radboud UMC• Incorporate Personalized Healthcare in core tasks: Health Care, Research, Education• Strengthen technological and methodological infrastructure Radboud Personalized Healthcare• Join forces with external partners (NL,EU) to implement Personalized Healthcare in translational networks
    28. 28. Investments and networks with industrialand university partners
    29. 29. 29Personalized Healthcare Stakeholders
    30. 30. Investments and networks with industrialand university partnersInfrastructureCross-disciplinary workingInterdisciplinary structuresBiobanksAccess to core technologiesPromotion of health (literacy)Education & training programs
    31. 31. Radboud Biobankfor biomarkers and other data collection
    32. 32. TopSectorplan Life Science & Health {www.rijksoverheid.nl} {http://www.zonmw.nl/nl/roadmaps-lsh/} Roadmap Molecular Diagnostics: •Build an efficient biomarker development pipeline in the Netherlands •Bring all stakeholders together in a functional open innovation network based on public-private-partnerships •Have end-users (patients) direct biomarker discovery in beginning •Improve progress of biomarkers from discovery to clinical implementation
    33. 33. Biomarkers and self-diagnosis …
    34. 34. Participatory E-health UMC St Radboud:Digital outpatient clinics and communities Mijn Radboud Dossier Mijn Zorgnet
    35. 35. Participatory E-health UMC St Radboud:Digital personalized selfmanagementPersonalized selfmanagement care• Flexible choice treatment modules, depending from the risk profile of patients Mijn E-coach• Stepped care
    36. 36. European networksRadboud Personalized HealthcareEuropean ScienceFoundation (2013)Radboud University Medical Centeras field lab to implement Forward Look‘Personalised Medicinefor the European Citizen’
    37. 37. European networksPersonalized Healthcare & Self-managementEuropean CentrePersonalized Healthcareand Self-managementInitiative of TNO and CBOwith Radboud University Medical Center (A. Evers)& other industrial, university and care partners
    38. 38. EU-Horizon 2020 topics and Radboud Personalized Healthcare Understanding the Developing effective determinants of health, screening programmes and Improving surveillance and imrpoving health Understanding disease Developing better vaccines improving the assessment preparedness promotion and disease of disease susceptibility prevention Optimising the efficiency Improving diagnosis Personalised and effectiveness of healthcare systems and reducing inequalities Brain & Cancer through evidence based Cognition decision making and dissemination of best practices and innovativeUsing in-silico medicine for technologies Immunity & Rare improving disease management and Infection Diseases prediction Regenerative Quality Promoting integrated care Medicine of Care Treating disease Medicine Improving scientific toolsTransferring knowledge to Individual empowerment and methods to support Active ageing, independent clinical practice and Better use of health data for self-management of policy making and and assisted livingscalable innovation actions health regulatory needs
    39. 39. Radboud Personalized HealthcareSpeakers I.Norstedt, ERC Coordinator Personalized Medicine
    40. 40. Plenary Session Health Valley RadboudPersonalized Healthcare with Paul Smits (dean) Thank you for your attention!

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