2. Patient Blood Management:
The Ongoing Message and Mission
“The rational use of blood involves the elimination of all
unnecessary transfusion, it prevents transfusion from becoming a
thoughtless habit…”
Chapelin H N Engl J Med 1969; 281: 364
3. Traditional Thinking (Until the Mid 1990s)
BENEFITS OF TRANSFUSION
RISKS OF
TRANSFUSIONS
Improved Oxygen Delivery
Prevention or Correction
of Bleeding
Known risk of infection
transmission (AIDS,
Hepatitis)
Accelerated Rehabilitation
(Better, Quicker)
3
4. Benefit vs. Risk in 2016
BENEFITS OF
TRANSFUSION
RISKS OF TRANSFUSIONS
Improved Oxygen
Delivery
Systemic Inflammatory Response Syndrome
(SIRS)
Prevention or Correction
of Bleeding
Known risk of infection transmission
Transfusion Associated Lung Injury (TRALI)
Transfusion Associated Circulatory Overload
(TACO)
SEPSIS Risk
Infectious Disease Risk (AIDS, Hepatitis)
Transfusion Related Immunomodulation
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9. Transfusion Literature
Journal of Vascular Surg. Vol 51, No. 3, Mar 2010. P 616-621.
“To conclude, our study in a large number of patients undergoing lower
extremity revascularization indicates that allogeneic intraoperative transfusion
is associated with higher postoperative morbidity and mortality. This finding is
true after adjusting for propensity for transfusion, thus, the reason that
transfused patients do poorly is not because they have a lower preoperative
hematocrit. When do the risks of anemia outweigh the hazards of transfusion?
In the absence of acute bleeding, hemoglobin levels consistent with the TRICC
trial (7.0-9.0 g/dL) are well tolerated. There is little evidence that RBC
transfusion in the non-bleeding patient with a hemoglobin concentration greater
than 7.0 g/dL leads to improved outcome”
9
10. Transfusion Literature
Journal of Vascular Surg. Vol 51, No. 3, Mar 2010. P 616-621.
“To conclude, our study in a large number of patients undergoing lower
extremity revascularization indicates that allogeneic intraoperative transfusion
is associated with higher postoperative morbidity and mortality. This finding is
true after adjusting for propensity for transfusion, thus, the reason that
transfused patients do poorly is not because they have a lower preoperative
hematocrit. When do the risks of anemia outweigh the hazards of transfusion?
In the absence of acute bleeding, hemoglobin levels consistent with the TRICC
trial (7.0-9.0 g/dL) are well tolerated. There is little evidence that RBC
transfusion in the non-bleeding patient with a hemoglobin concentration greater
than 7.0 g/dL leads to improved outcome”
10