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    Tang nutrition vit a Tang nutrition vit a Presentation Transcript

    • Using Bio-fortified Crops for Community Intervention Studies Guangwen Tang, Ph.D. Carotenoids and Health Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging Friedman School of Nutrition Science and Policy Tufts University
    • To combat vitamin A deficiency: • vitamin A capsule supplementation • food fortification • dietary approach (the best and major long-term solution) Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Food Sources of Vitamin A animal products plant products preformed pro-vitamin A vitamin A carotenoids
    • Provitamin A Carotenoids Can Convert to Vitamin A ß-carotene in SERUM CH2OH ß-carotene + retinol Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Conversion Factors of Plant b-Carotene to Retinol Using Isotope Reference Method in Adult Subjects Conversion Food matrix Dose Reference Factor (by wt) 10 mg b-C 15 : 1 Tang, et al. carrot 3 mg 2H8 vitamin A (8 to 25 : 1) AJCN 2005 n=7 21 : 1 11 mg b-C Tang, et al. spinach (11 to 47 : 1) 3 mg 2H8vitamin A AJCN 2005 n = 14 Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • RDA: men 900 mg and women 700 mg retinol Children 4 – 8y, 400 mg 2,500 mg 21 to 1 50 g b-carotene 100 mg 50 g 3,000 mg 15 to 1 300 mg retinol b-carotene 200 mg 50 g 85 mg retinol 200 ml or 90 mg retinol 305 mg retinol 30 g 15 g 130 mg retinol
    • Conversion Factors of an Acute Dose of Golden Rice or Maize b-Carotene to Retinol Conversion Subjects Dose Reference Factor (by wt) 1 – 1.5 mg b-C Golden Rice 3.8 : 1 Tang, et al. 0.5 – 1 mg 13C10 5 Adults (2 to 6 : 1) AJCN 2009 vitamin A 1 mg b-C Tang, et al. Golden Rice 0.5 mg 13C10 2.0 : 1 FASEB J. 2010 24 Children vitamin A Yellow Maize 0.6 mg maize b-C US Women 6.5 : 1 Li, et al. 250 g n=5 ( 3.9 to 13.3 : 1) AJCN 2010 porridge 1.2 mg maize b-C Zimbabwean 300 g porridge 3.2 : 1 Muzhingi et al (1.5 to 5.3 : 1) FASEB J. 2010 Men, n = 8 1 mg 13C8vitamin A (reference dose) Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • These results indicate that Golden Rice and high b- carotene yellow maize are more bioavailable to provide vitamin A nutrition. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Based on the Progress in Nutrition: How do we maximize impact and speed up delivery? Win community support !!! Conduct community studies to feed these staples daily to needed children. It will provide direct evidences on improving vitamin A status with the biofortified staples. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Large scale intervention trials to evaluate the efficacy Choose right locations Inform and communicate with local government agency School and parent supports Good intervention study practice Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Hengyang, South of Hunan Province
    • South-west Zhejiang Province
    • A Small Town of Xianju County Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Recruitment meeting: Local Office, Parent, Teacher, and Scientists Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Meeting with Parents Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Presenting the Protocol Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Asking Questions Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Sterilizer Cabinet for Utensils
    • Purchase Foods from Reliable Sources Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Distributing Labeled VA Capsules as a Reference Dose Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Providing Healthy Meals Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
    • Get Ready for Blood Draw
    • Before the End of Study Meeting
    • Gifts for Participation
    • Putting Gifts Together
    • Sign to Receive Gifts for Participation
    • Large scale community efficacy intervention trials will bring the new crops to their daily life, gain first-hand health impact information, and promote the acceptance. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University