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Hartz Companion Animal - Shampoo Therapy in Dogs and Cats
Hartz Companion Animal - Shampoo Therapy in Dogs and Cats
Hartz Companion Animal - Shampoo Therapy in Dogs and Cats
Hartz Companion Animal - Shampoo Therapy in Dogs and Cats
Hartz Companion Animal - Shampoo Therapy in Dogs and Cats
Hartz Companion Animal - Shampoo Therapy in Dogs and Cats
Hartz Companion Animal - Shampoo Therapy in Dogs and Cats
Hartz Companion Animal - Shampoo Therapy in Dogs and Cats
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Hartz Companion Animal - Shampoo Therapy in Dogs and Cats

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With the availability of effective …

With the availability of effective
topical flea products, shampoo therapy
had fallen by the wayside in veterinary
dermatology. However, recent evidence
has shown that percutaneous absorption
of allergens plays a significant role in
propagating, and possibly even
potentiating, allergies in our pets.
There are several guidelines to convey
to clients regarding the use of veterinary
shampoos. First, the use of cool water
and contact times of 5 to 15 minutes
allow for hydration of the skin and a
sufficient period for penetration and
action of the active shampoo ingredients.
Bathing frequency is also important and
depends on the presence of skin disease
as well as the shampoo to be used.

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  • 1. A NEWSLETTER OF PRACTICAL MEDICINE FOR VETERINARY PROFESSIONALS SEPTEMBER 2004 VOLUME 2, NUMBER 3 Shampoo Therapy in Dogs and Cats Anthony A. Yu, DVM, DACVD Ontario Veterinary College University of Guelph Ontario, Canada With the availability of effective is also dictated by seasonal influences. reaction to the shampoo by the patienttopical flea products, shampoo therapy Environmental variations in heat and and the bather also should be considered.had fallen by the wayside in veterinary humidity influence dryness, scaliness, One of the most common signs ofdermatology. However, recent evidence greasiness, and the tendency to develop dermatologic problems in small animalshas shown that percutaneous absorption secondary bacterial or yeast infections. is excess scaling. The process ofof allergens plays a significant role in Shampooing technique is also keratinization is initiated within thepropagating, and possibly even important. I often recommend starting basal keratinocytes of the epidermis.potentiating, allergies in our pets. with the worst affected area—usually Through many transformations, these There are several guidelines to convey the belly, neck, or feet. The mechanical cells eventually migrate to the surfaceto clients regarding the use of veterinary process itself is beneficial because it helps and die, progressing through the basal,shampoos. First, the use of cool water to remove crusts, scales, dirt, organisms,and contact times of 5 to 15 minutes and residual medication.allow for hydration of the skin and a IN THIS ISSUE:sufficient period for penetration and SHAMPOO SELECTION Shampoo Therapy inaction of the active shampoo ingredients. Human-grade shampoo, balanced at Dogs and Cats............................ 1Bathing frequency is also important and pH 5.5 for the human scalp (compareddepends on the presence of skin disease with the neutral skin pH of 7.0 to 7.5 in Ethylene Glycol Poisoning:as well as the shampoo to be used. A most dogs and cats), can cause irritation Effective Treatment Beginsclient may have to shampoo two to three and damage to the epidermal skin barrier with Prevention ......................... 4times weekly until adequate control of as well as unwanted changes in the Ask the Vet ................................ 7scaling, grease, and odor is achieved, at superficial microbial flora. Thus, the Sumitomo Corporation Acquireswhich time they may decrease to a mildest veterinary-labeled product that The Hartz Mountainmaintenance frequency of once weekly or will address the patient’s condition should Corporation ............................... 8monthly. Maintenance shampoo therapy be selected. The possibility of an allergic
  • 2. spiny, granular, and cornified layers. Antiparasitic Shampoos A NEWSLETTER OF PRACTICAL MEDICINE FOR VETERINARY PROFESSIONALS Many shampoos are formulated based on Most flea products contain acceptable SEPTEMBER 2004 VOLUME 2, NUMBER 3 this cell-turnover process. Animal skin concentrations of naturally derived varies from one to three epidermal cell pyrethrins or synthetic pyrethroids. Consulting Editors layers in cats and three to five epidermal They kill adult fleas, ticks, and other cell layers in dogs, with a 21-day transit ectoparasites present at the time of Albert Ahn, DVM time. bathing and help to wash off adherent Corporate Vice President Owner acceptance is most often the eggs or larvae. If additional therapeutic Chief Scientific Officer determining factor in the selection of a modalities are required, always consult The Hartz Mountain Corporation shampoo. If odor, color, staining or and follow label directions. bleaching potential, and lathering ability Bruce Truman of a shampoo are not acceptable to the Antiseborrheic Shampoos Divisional Vice President bather, then the shampoo will never make Seborrhea is excess scale formation Animal Health and Nutrition its way onto the pet. Finally, if a costly caused by abnormal cell migration, medicated shampoo is prescribed, it may increased cell division in the stratum The Hartz Mountain Corporation be helpful to first use an inexpensive basale, biochemical anomalies in keratin product so that the medicated shampoo production, and aberrations in intercellular HARTZ® COMPANION ANIMALSM is not wasted on initial attempts to cut lipid production. Antiseborrheic shampoos is produced for The Hartz Mountain through the grease and dirt. eliminate surface scale by causing cell Corporation by Veterinary Learning damage and ballooning, which results in Systems, 780 Township Line Rd., Types of Shampoo softening and shedding of the stratum Yardley, PA 19067. Cleansing and Moisturizing corneum (keratolysis). These products also Shampoos/Sprays decrease cell turnover via inhibitory effects Copyright © 2004 The Hartz Mountain Cleansing and moisturizing shampoos on basal cell growth (keratoplasty). Corporation. All rights reserved. are mildly medicated, hypoallergenic products that clean using soap substitutes Sulfur and Salicylic Shampoos Hartz® and other marks are owned by and anionic/amphoteric surfactant Sulfur and salicylic acid are common The Hartz Mountain Corporation. systems. They mainly serve to rehydrate ingredients in antiseborrheic shampoos. and cleanse the skin and can be used as a Because the efficacy of sulfur depends on Printed in U.S.A. No part of this maintenance shampoo for normal-coated direct interaction with the skin, it is often publication may be reproduced in any dogs and cats. formulated as a colloid to increase the skin form without the express written Moisturizers (e.g., emollients, contact surface area. Keratoplastic activity permission of the publisher. humectants) are commonly used for mild, caused by sulfur is primarily related to the dry, and scaly conditions or even after use formation of cystine, an important For more information on The Hartz of a potential drying agent. Emollients constituent of the stratum corneum. Mountain Corporation, visit are vegetable- and animal-oil products Keratolytic, antifungal, antibacterial, and www.hartz.com. that protect and soften the skin by filling antiparasitic (mites and lice but not fleas) in the spaces between the dry flakes— activities are primarily a result of hydrogen flattening roughened surfaces of the sulfide and pentathionic acid formation between cells, promoting the shedding of stratum corneum. Humectants, which from the combination of sulfur with attached surface cells. include lactic acid, urea, carboxylic acid, cysteine. Sulfur also has been demonstrated Sulfur–salicylic acid combinations glycerin, and propylene glycol, rehydrate to decrease itching and to be extremely are used for primary keratinization the skin without using oils. Instead, they safe, even on newborn animals. abnormalities causing a dry scaling draw moisture to the skin from the pet’s Attributes of salicylic acid include dermatosis and conditions secondary to own body fluids. keratoplastic, keratolytic, antipruritic, bacterial pyoderma, parasitic infections, Emollients and humectants are astringent, and bacteriostatic activities. allergy, autoimmune disorders, available in shampoo or spray form. The keratolytic activity of salicylic acid is environmental influences, and metabolic Of the sprays, emollients are preferably produced by decreasing surface pH, imbalances (e.g., hypothyroidism). applied directly after a bath to provide an which results in increased hydration of Numerous sulfur–salicylic acid oil barrier that keeps moisture on the keratin and swelling of cells in the shampoos are available. Some contain skin. Humectants can be used daily to stratum corneum. Salicylic acid also lanolin to condition a pet’s coat. Sodium alleviate dry, scaly conditions. solubilizes the natural binding material salicylate enhances the shampoo’s2 HARTZ COMPANION ANIMAL ® SM • SEPTEMBER 2004 • VOL. 2, NO. 3
  • 3. latherability. Triclosan and chlorhexidine of benzoyl peroxide is generally glucan has been concentrated in certainderivatives are sometimes added to considered to be an advantage. However, oatmeal-based shampoos because it isenhance a shampoo’s antimicrobial activity. animals with sensitive skin may develop believed to provide oatmeal with its excessive drying or irritation. This can be antiinflammatory effect.Tar Shampoos relieved by alternating treatments with a Lastly, shampoos containing Tar shampoos are often combined with milder product or using emollients. antiinflammatory agents such assulfur and salicylic acid, which permits Benzoyl peroxides tend not to lather well hydrocortisone, diphenhydramine, anddecreased concentrations while providing and have the potential to bleach fabrics essential fatty acids, have been introducedthe desired keratolytic activity. Treatments and haircoats. to the veterinary market to addressshould be discontinued or followed by a inflammation at the local level. So far,conditioning rinse if drying or irritation Antimicrobial Shampoos they have proven to be useful adjuncts inoccurs. Antimicrobial shampoos help eliminate our attempts to minimize the use of oral Tars induce antimitotic, keratolytic, overgrowth of pathogenic organisms on medications to control itch. Strictantipruritic, degreasing, and antiinflam- the skin surface. As previously mentioned, adherence to the 10- to 15-minutematory effects. The antimitotic effects are benzoyl peroxide shampoos have the contact time rule, especially with thesedue to suppression of epidermal growth greatest residual activity (48 hours). Other products, will help achieve optimaland DNA synthesis of the stratum basale. antimicrobials include chlorhexidine, results.The primary clinical application of tar which is a synthetic biguanide withshampoos is to treat the extremely greasy broad-spectrum activity against bacteria, CONCLUSIONdog. The higher the concentration, the fungi, and yeasts but exhibits no Finally, a plethora of shampoosbetter the effects of the tar, but the patient antiseborrheic effects. It is characterized with advanced time-released microsomesmight be more susceptible to developing a by rapid kill and 36-hour residual activity. has also become available for use incontact allergy, excessive drying, or skin When combined with water, ethyl veterinary medicine. This technologyirritation. Tar shampoos should be avoided lactate forms lactic acid, which provides improves residual activity of thein cats. antimicrobial activity, and ethanol, a aforementioned active shampoo good degreaser without the drying effects ingredients and minimizes any dryingSelenium Sulfide of tar and benzoyl peroxides. A gentle, effects by slowly releasing emollients and Selenium sulfide is antiseborrheic but antiseptic, and keratoplastic shampoo conditioners.has limited usage due to its staining, containing a 10% concentration of ethyl With all these recent advances indrying, and irritating effects on mucous lactate is available for use in dogs and cats shampoo therapy, it may seem a dauntingmembranes and the scrotum. Selenium of any age with bacterially infected task to choose the most appropriatesulfide causes keratoplastic and keratolytic seborrheic dermatitis. product for your pet. However, by simplyactivity by depressing epidermal cell Iodine preparations have good activity understanding the principles of theturnover rate and interfering with against bacteria, viruses, and fungi, various categories of shampoos, you canhydrogen bond formation in the keratin. especially when combined with select and use a medicated shampoo thatSelenium sulfide also is a potent degreaser. pyrrolidone nitrogen. Residual effects, will most benefit your patients.This product is definitely not recommended however, last only 6 to 8 hours. Sidefor use in cats. effects include irritation, staining, and Suggested Readings Chesney CJ: Water: Its form, function and importance in contact hypersensitivity. Iodine shampoos the skin of domestic animals. J Small Anim PractBenzoyl Peroxide are not recommended for use in cats. 34:65–71, 1993. Benzoyl peroxide induces excellent Griffin CE, Kwochka KW, MacDonald JM: Current veterinary dermatology, in The Science and Art ofkeratolytic activity, and a residual Antipruritic Shampoos Therapy. St Louis, Mosby, 1993.antibacterial spectrum of 48 hours Topical antipruritic therapy is gaining Halliwell REW: Rational use of shampoos in veterinaryalso makes it one of the most active increasing interest as an adjunct to control dermatology. J Small Anim Pract 32:401–407, 1991. Kwochka KW: Rational shampoo therapy in veterinaryantibacterial agents. It is the only product itching. The main source of relief evolves dermatology. Proc 11th Annual Kal Kan Sympavailable that has follicular flushing from oatmeal-based shampoos. It is Treatment Small Anim Dis, 1988.properties, which enhance removal of believed that harmful agents and allergens Lin AN, Reimer RJ, Carter DM: Sulfur revisited. J Am Acad Dermatol 18(3):553–558, 1988.scale, glandular secretions, and bacteria are absorbed through the skin, resulting Miller WH: Antiseborrheic agents in dermatology, infrom hair follicles. It is often used before in itching. Oatmeal is formulated as a Kirk RW (ed): Current Veterinary Therapy IX.treatment for generalized demodicosis colloid to provide a large surface area for Philadelphia, WB Saunders, 1986, pp 596–601. Muller GH, Kirk RW, Scott DW: Small Animalbecause it flushes mites from hair adsorption and subsequent elimination of Dermatology, ed 6. Philadelphia, WB Saunders,follicles. The excellent degreasing activity these mediators. In addition, oat beta 2004. HARTZ® COMPANION ANIMALSM • SEPTEMBER 2004 • VOL. 2, NO. 3 3
  • 4. Ethylene Glycol Poisoning: Effective Treatment Begins with Prevention Steven R. Hansen, DVM, MS, DABT, DABVT ASPCA Animal Poison Control Center Urbana, Illinois Ethylene glycol (1,2-ethanediol) is volumes of ethylene glycol solutions. vomiting, weakness, and dyspnea. In- used in many commercial and household Ethylene glycol is rapidly absorbed, clinic diagnostic tests (EGT KitTM, PRN products, including automobile antifreeze, yielding peak blood concentrations in Pharmacal) are available. brake fluid, disinfectants and cleaners, dogs within 1 to 4 hours. The plasma When in-clinic qualitative tests are paints, sealants, and solvents. Ethylene half-life for unmetabolized ethylene used, false-positive results can occur from glycol concentrations vary from about glycol is 3 to 5 hours. The lethal dose of propylene glycol (and other glycols), 90% in automobile antifreeze to less than undiluted ethylene glycol is 4.4 to 6.6 metaldehyde, glycerol, and formaldehyde 1% in some paints. Most significant ml/kg in dogs and 1.4 ml/kg in cats. ingestion. False-positives do not result poisonings in dogs and cats are from Metabolism occurs primarily in the from ethanol, methanol, or isopropanol exposure to automobile antifreeze liver, with excretion of both unmetabolized ingestion. Definitive quantitative analyses solutions containing ethylene glycol. ethylene glycol and metabolites via the are typically available at diagnostic The ASPCA Animal Poison Control kidneys. Ethylene glycol is initially laboratories. Local human hospitals or Center (APCC) managed 510 animal metabolized by alcohol dehydrogenase. It veterinary diagnostic laboratories can exposures to ethylene glycol between July is at this first rate-limiting metabolic step provide analytic capabilities, including 1995 and December 1997. Dogs and cats that competitive inhibition by the quantification of parent ethylene glycol and represented 98% of exposed species, administration of fomepizole in dogs some metabolite concentrations. Other although dogs are two to three times more (Antizol-VetTM, Orphan Medical) and diagnostic findings include an increased likely to be exposed than cats. The ethanol in cats can be lifesaving. osmolar gap (>20 mOsm/kg), acidosis, an majority of animals were adults, with an Continued processing of ethylene glycol increased anionic gap (>25 mEq/L), equal gender distribution. Most exposures metabolites yields intermediates that hypocalcemia, and calcium oxalate occurred around the home and resulted cause acidosis, renal tubular nephrosis crystalluria,3 but the absence of crystalluria from container spills and engine flushes or (Figures 1 and 2), and death. Clinical does not rule out ethylene glycol toxicosis. leaks. Three percent of cases were assessed effects, including depression and as intentional. Of cases with known ataxia, occur early from unmetabolized Treatment outcomes, 59% did not develop clinical ethylene glycol. During the next 12 to The rapid absorption of ethylene signs and 28% died or were euthanized. 24 hours, metabolic acidosis results in glycol coupled with short plasma half-life Ethylene glycol exposures accounted for cardiopulmonary effects, including underscores the necessity for early, 0.5% of case volume for the data collection tachypnea, tachycardia, central nervous aggressive intervention. Since a delay in period.1 Generally, cats, rabbits, and system (CNS) depression, seizures, and treatment is often fatal, presumptive cases humans are considered the most sensitive pulmonary edema. Oliguric renal failure of ethylene glycol poisoning based on species. Dogs, pigs, rodents, and cattle are may begin as early as 12 hours after clinical presentation and available considered of intermediate sensitivity. ingestion in cats but not beyond 72 hours diagnostics with or without known in cats or dogs. Death results from exposure warrant initiation of treatment Mechanism of Action cardiopulmonary or renal effects.2 before definitive laboratory confirmation. Ethylene glycol is commercially Initial treatment in an asymptomatic available for automobile use as a Diagnosis animal within an hour of exposure may concentrated solution that is typically The most common clinical signs include the administration of an emetic mixed 50:50 with water. Dogs and cats reported to the APCC include such as hydrogen peroxide (3%, 1 ml/lb; will unpredictably consume various depression, ataxia, seizures, tremors, maximum dose: 45 ml) via oral syringe or4 HARTZ COMPANION ANIMAL ® SM • SEPTEMBER 2004 • VOL. 2, NO. 3
  • 5. stomach tube after feeding a moist mealsuch as canned food. Activated charcoal(1–3 g/kg) can be administered early,preferably within the hour, to potentiallyreduce gastrointestinal absorption.Administration of activated charcoalproducts may yield false-positive resultsfrom in-clinic ethylene glycol test kitsbecause of propylene glycol cross- Figure 1— Ethylene glycol– Figure 2— Ethylene glycol–reactivity. Overuse of activated charcoal induced renal tubular nephrosis. induced nephrosis showingin small or dehydrated animals must be (Photo courtesy Dr. Sharon Gwaltney, birefringent crystals. (Photo courtesyavoided because of the risk for electrolyte APCC; hematoxylin–eosin, original Dr. Sharon Gwaltney, APCC;abnormalities, including hypernatremia. magnification ×100) hematoxylin–eosin, original Successful management of ethylene magnification ×40; shown underglycol toxicosis depends on competitive used to correct acidosis. Furosemide polarized light)inhibition of alcohol dehydrogenase. (2.2–4.4 mg/kg IV bid) combined withCurrently accepted treatment in dogs dopamine (2–5 µg/kg/min) may increase often can dispose of ethylene glycolincludes the use of fomepizole or ethanol. urine output in oliguric patients. antifreeze properly or inform the petFomepizole is advantageous in dogs because Peritoneal dialysis or hemodialysis, if owner about approved disposal techniques.it is approved for this use, is effective and available, should be considered for anuric Some antifreeze formulations containeasy to administer, and does not contribute patients. Recovery depends on how propylene glycol; these formulations areto CNS depression or acidosis. In dogs, quickly treatment can be started. Initiation significantly less toxic than ethylene glycolfomepizole is administered in four doses at of treatment within the hour—and formulations but are not nontoxic and still12-hour intervals, each given slowly over 15 possibly up to 4 hours—in nonazotemic require the same vigilance regardingto 30 minutes. The first dose is 20 mg/kg, patients may prove successful. Severely storage, use, and disposal.followed by 15 mg/kg at 12 and 24 azotemic or anuric patients, especially A significant amount of recenthours and then 5 mg/kg at 36 hours. In animals whose care is initiated 12 hours legislative debate has focused oncats, fomepizole may be effective at high or longer after exposure, warrant a grave requiring that bittering or other aversivedoses early, but the product is not labeled as prognosis. Ultimately, recovery may be agents be added to antifreeze and othersuch. In cats, ethanol is generally the complete or residual renal insufficiency household products. The APCC does notpreferred treatment. may remain. support this requirement. The promotion Ethanol administration is inexpensive of products containing aversive agents bybut time intensive, produces additional Prevention manufacturers would lead to a false senseCNS depression, and exacerbates Veterinary professionals are encouraged of security among pet owners that couldmetabolic acidosis. Cats (and dogs if to address poison prevention during unintentionally lead to poisonings. Infomepizole is unavailable) should be routine client visits. Pet owners should animals, poison prevention must focus ongiven 8.6 ml/kg of a 7% (70 mg/ml) read and understand all labels, follow proper storage and disposal and not onethanol solution as a slow bolus over 30 product use and disposal recommendations, the unlikely protective mechanismminutes followed by maintenance store all garage/household products and afforded by taste-aversive agents.administration of 100 to 200 mg/kg/hr pharmaceuticals out of reach of childrenconstant-rate infusion.4 When medical- and pets, and understand that childproof References 1. Kahn SA, Schell MM, Trammel HL, et al: Ethylenegrade ethanol solutions are not available, lids and packaging are easily destroyed glycol exposures managed by the ASPCA Nationalvodka can be used, preferably with an (and contents consumed) by even the Animal Poison Control Center from July 1995 to December 1997. Vet Hum Toxicol 41(6):403–406, 1999.in-line filter.5 To produce a 7% ethanol smallest and most timid of pets. Pet 2. Richardson JA, Gwaltney-Brant SM: Ethylenesolution, a volume of 175 ml should be owners should search the garage and home toxicosis in dogs and cats. NAVC Clin Briefremoved from a 1.0 L bag of D5W or for items that are accessible by the pet, Jan:13–19, 2003.other appropriate solution and replaced including items on counters. Proper 3. Thrall MA, Grauer GF, Connally HE, et al: Small Animal Toxicology: Ethylene Glycol. Philadelphia, WBwith 175 ml of 80 proof vodka. disposal of automobile antifreeze is critical. Saunders, 2001, pp 33–504. Supportive care designed to promote Exposure often occurs from used product 4. Plunkett SJ: Ethylene glycol, in Emergency Proceduresdiuresis, maintain renal function, and drained from cars and farm machinery. for the Small Animal Veterinarian, ed 2. Philadelphia, WB Saunders, 2000, pp 319–326.correct acid–base imbalance remains Local recycling/garbage collection 5. Plumb DC: Veterinary Drug Handbook, ed 3. Iowaimportant. Sodium bicarbonate can be companies or automobile repair facilities State University Press, 1999, pp 257–258. HARTZ® COMPANION ANIMALSM • SEPTEMBER 2004 • VOL. 2, NO. 3 5
  • 6. A Breakthrough in Canine Hair Care! Special Nutrient Beads Encapsulation keeps botanicals fresh until shampooing New Unique, silk proteins long-lasting conditioner Botanical leaves coat fragrance soft and shiny Easy to use "No Drip Cap " ™ NEW LIVING ™ otanicals Shampoo ™Hartz , a leader in pet hair care, has created a new line of luxury shampoos, ®Hartz PET SHOPPE™ LIVING™ Botanicals™. Each is specially formulated with ® Tearless Soothinga unique combination of ingredients that soothe the skin while cleaning and Puppy Oatmealconditioning the coat, leaving it feeling soft and silky. For a complimentary Shampoo Beautifying Shampoo ®sample, please call 800-999-3000 x5970.* Shampoo VISIT OUR WEBSITE www.hartz.com *Supplies are limited. Please call by 11/1/04. Void where prohibited, taxed or restricted. Please allow 2-4 weeks for delivery. Hartz and other trademarks are trademarks of The Hartz Mountain Corporation. ©The Hartz Mountain Corporation, Secaucus, NJ 07094 USA
  • 7. Albert Ahn, DVM, is a veterinarian, Corporate Vice President, and Chief Scientific Officer of The Hartz Mountain Corporation. ASK TH E VETQ In reference to Dr. Littman’s June 2004 article, “Update on Frequently Asked Questions About Canine toxicity (Adrade SF, Sakate M: The comparative efficacy of yohimbine and atipamezole to treat amitraz intoxication in dogs. Vet Hum Toxicol Lyme Disease: Diagnosis and Treatment,” 45(3):124–127, 2003), but this dose and route of can atipamezole be used to treat amitraz administration need more study before I recommend collar intoxication and at what dose? it for clinical use in patients. Also, what dose of yohimbine is used to Meryl P. Littman, VMD, DACVIM treat amitraz toxicoses? School of Veterinary MedicineA University of Pennsylvania Author Response: Philadelphia, Pennsylvania Rarely have dogs eaten the discarded cut-off ends of collars or, more rarely, the collars themselves. “If a dog ingests a . . . collar and exhibits [amitraz] intoxication (primary sign is severe depression), induce vomiting, administer non-oily laxative, Q How much taurine is required in cat/ kitten food? activated charcoal, and enema. Provide supportive therapy until collar fragments are voided. If dog cannot be roused, Yohimbine, 0.1 mg/kg by A Taurine is a very important amino acid for cats and kittens. Deficiency of taurine in cats may result in fetal abnormalities, reproductive failure, intravenous injection is antidotal. Repeat as needed.” abnormal development, retinal degeneration, and/or cardiomyopathy. Cats can synthesize I thank Dr. Ken Drobatz (Director of Emergency taurine only on a limited basis. Cats also need Service at the University of Pennsylvania’s Ryan taurine to conjugate bile acids. Veterinary Hospital), who told me that yohimbine (Yobine®, Lloyd Laboratories) is still their first choice According to nutrient profiles of the AAFCO for amitraz intoxication. If yohimbine is unavailable, (Association of American Feed Control Officials), atipamezole (Antisedan®, Pfizer Animal Health) can the minimum requirement for taurine for cat food be used at 0.055 mg/kg IM. is 0.10% in dry foods and 0.20% in canned foods. Supplementation with vitamins containing taurine By literature search, I found that atipamezole was would be required in cases where the levels of given experimentally at 0.2 mg/kg IV for amitraz taurine in the cat’s diet are below this level.Articles found in the Hartz Companion Animal sm newsletter can be copied and distributed to your colleagues, staff, and clients. Additional newsletters may also be obtained by contacting us at feedback@hartz.com or by phone at 800-275-1414. We want to hear from you! • Have questions or comments? Call our Consumer Relations Department at 800-275-1414 and ask to speak to a Hartz staff veterinarian or email us at feedback@hartz.com. • To obtain a Hartz Veterinary Catalog of products, please call 800-999-3000 x5118 or email us at feedback@hartz.com. HARTZ® COMPANION ANIMALSM • SEPTEMBER 2004 • VOL. 2, NO. 3 7
  • 8. Sumitomo Corporation AcquiresThe Hartz Mountain Corporation Sumitomo Corporation of America (SCOA), together with products and technological solutions that will ensure their petsits parent, Sumitomo Corporation (SC), an integrated global lead longer, happier, and healthier lives. Hartz Mountain alsotrading company, purchased JWC Hartz Holdings, Inc., the actively contributes to the pet care community and is dedicatedholding company of The Hartz Mountain Corporation, the to the health and well-being of companion animals.leading U.S. pet supplies company, from J.W. Childs Equity The acquisition will allow Hartz the opportunity toPartners II, L.P. undertake a number of new business initiatives, such as The announcement was made on June 21, 2004, by Atsushi enhanced cross-border sourcing and development of newNishijo, President and CEO of Sumitomo Corporation of markets and distribution channels in Asia and Europe.America, and Robert Devine, President and CEO of The Hartz “Hartz is a brand name with a very strong history and greatMountain Corporation. credibility,” said Atsushi Nishijo, President and CEO of SCOA. “The change in ownership is a very positive development for “This is a significant acquisition for SCOA and SC, and we areour business,” said Robert Devine. “Hartz will continue the very pleased that the Hartz management team will be part of theeffort to reposition the brand and drive growth with new SCOA family.”products and technologies. Sumitomo Corporation of America was established in 1952 We also envision a number of valuable synergies emerging and is the largest wholly owned subsidiary of Sumitomofrom this new relationship, not the least of which is a chance for Corporation. An integrated global trading company withus to expand our reach into markets and channels with a high diversified investments and trading businesses, SCOA worksdegree of sophistication and a history of pet ownership. The closely with its parent as an organizer of multinational projectsnew Hartz Mountain will be stronger and more global.” and a financier. SCOA is an investor in several venture capital For over 78 years, Hartz Mountain has been committed to funds and participates as a strategic Japanese partner withproviding pet lovers across America with the most innovative companies in the biotech and life sciences communities.Veterinary Learning Systems PRESORTED STANDARD780 Township Line Road U.S. POSTAGEYardley, PA 19067 PAID BENSALEM, PA PERMIT #118 400486

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