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PPT PSYCH AMYGDALA
PPT PSYCH AMYGDALA
PPT PSYCH AMYGDALA
PPT PSYCH AMYGDALA
PPT PSYCH AMYGDALA
PPT PSYCH AMYGDALA
PPT PSYCH AMYGDALA
PPT PSYCH AMYGDALA
PPT PSYCH AMYGDALA
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PPT PSYCH AMYGDALA

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  • 1. The Amygdala
    By: Alinka, Harel, Vjosa
  • 2. General Information; Function
  • 3. General Information; Location
  • 4. Study 1
    Aim: Determine the volume in the amygdala in a series of brains post-mortems
    Procedure:
    Amygdala volume was estimated using point-counting in both hemispheres of brains of 10 male and 8 female patients with schizophrenia
    Had a comparison group of 9 male and 9 female post-mortems without neuropsychiatric disorder
    Results: No significant reduction of amygdala found 
    Implications: Significant volume reduction isn’t not consistent feature in schizophrenia 
  • 5. Study 2
    Aim: Examine neural activity in amygdala during episodes of mania. 
    Procedure:
    9 manic participants & 9 healthy comparison subjects underwent fMRI while performing a neuropsychological paradigm known to activate the amygdala
    Experimental Task: participants see faces displaying affection
    Control task: geometric forms
    Goal: Match them to one of two similar images presented at same time
    Results: Manic participants had significantly increased activation in the left amygdala and reduced bilateral activation in the lateral orbit frontal cortex relative to the comparison participants.
    Implications: Increased activation in the amygdala and decreased activation in the orbitofrontal cortex may represent disruption of a specific neuroanatomic circuit involved in mania. These brain regions may be implicated in disorders involving regulation of affect.
  • 6. Study 3
    Aim: Investigate what happens in the brain during and after phobia treatment
    Procedure:
    Examined brain activity of 18 people w/ social phobia as they spoke in front of a group using PET scans
    1/3 of the participants received 9 weeks of cognitive-behavioral therapy
    1/3 received the selective serotonin reuptake inhibitor Citalopram and 1/3 received no treatment.
    Participants were tested again, using the same public speaking task, at 9 weeks and again after one year.
    Results: Activation in the amygdala and related cortical areas at 9 weeks could predict which people's symptoms would improve after one year
  • 7. Dysfunction

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