LOCAL HORMONESecreted by body tissue to act locally 1) histamine 2) serotonin 3) prostaglandins 4) erythropoietin 5) gastrointestinal hormones
HISTAMINE Hormone that chemically similar to the hormone serotonin Produce by mast cells and basophilsFUNCTIONS: Plays a role in localized immune responses and allergic reaction Increase capillary permeability and vasodilatation Stimulates secretion of gastric juice
SEROTONIN Itis a neurotransmitter and primarily found in platelet, brain and intestinal wallFUNCTIONS: Causes intestinal secretion and contraction of smooth muscles Blood clotting
PROSTAGLANDIN produced naturally by the body derived from fatty acids, such as arachidonic acid or linoleic acid and they act as mediatorsFUNCTIONS: Inhibit aggregation Regulating blood pressure Blood clotting Uterine contraction during labour Mediating pain and inflammation
ERYTHROPOIETIN Synthesized in the kidneysFUNCTIONS: to promote the differentiation and development of red blood cells and to initiate the production of hemoglobin, the molecule within red cells that transports oxygen.
GASTRIN Polypeptidehormone secreted by the mucous lining of the stomachFUNCTION: promote gastric juice secretion
SECRETIN it stimulates adenylate cyclase activity and converts ATP to cyclic AMP as it combine with secretin receptor reduces acid secretion from the stomach by inhibiting gastrin release from G cell and helps neutralize the pH of the digestive products entering the duodenum from the stomach
CHOLECYSTOKININ mediates a number of physiological processes, including digestion located in the small intestine causes the increased production of hepatic bile stimulates the contraction of the gall bladder and the relaxation of the Sphincter of Oddi