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Succinilcolina
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  • 1. Farmacología de la Succinilcolina Dra. Diana M. Finkel Jefa División Anestesiología H.G.A.R.M. - GCBA.
  • 2. Relajante Muscular de acción periférica perteneciente al grupo de los Despolarizantes Es un Agonista de la UNM, NO es un Bloqueante Neuromuscular
  • 3. Es una diacetilcolina CH3 CH3 H3C-NCH2-CH2COCH2 CH2-COCH2-CH2N-CH3 CH3 CH3
  • 4. Administrada por vía intravenosa Dosis: 0,5 a 1 mg/kg Una vez administrada comienza su biotransformación Llega a biofase solamente un 10 % de la dosis Pocos datos de su farmacocinética
  • 5. • Disminución de la producción hepática • Interacción con drogas (insecticidas, estrógenos, ciclofosfamidas, metoclopramida, etc.) • Colinesterasa atípica