Your SlideShare is downloading. ×
9 hn,rf,transplant 2003
Upcoming SlideShare
Loading in...5

Thanks for flagging this SlideShare!

Oops! An error has occurred.

Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

9 hn,rf,transplant 2003


Published on

Published in: Health & Medicine
  • Be the first to comment

  • Be the first to like this

No Downloads
Total Views
On Slideshare
From Embeds
Number of Embeds
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

No notes for slide


  • 1. HYDRONEPFROSISDefinitionChronic aseptic dilatation of the pelvi-calyceal system due to partialor complete intermittent obstruction.EtiologyA- UnilateralStoneStrictureExternal compressionB- Bilateral1- Causes in both ureters: ex. Stones, stricture, reflux2- Causes in the bladder / or bladder neck ex. Bladder tumor, BPH3- Causes in the urethra ex. stricture
  • 2. HYDRONEPFROSISPathophysiology:Nature of obstructionA- Functional for example increased collagen depositionat the UPJ leads to reduced distensilbilityB- Organic- Partial or complete- Acute or chronicImpedance to flow of urine higher than normal pressureabove the site of obstruction  Chronic progressivedilation of pelvi-collecting system Vascularcompression ischemic atrophy  loss of kidneyfunction.
  • 3. HYDRONEPFROSISCauses of low intra-pelvic pressure are:1-Protective arterial vasoconstriction2-Backflow reflux of the intrapelvic contents into therenal tubules (pyelotubular)rena , the renal veins(pyelovenous) or the iterstitium of the kidney (-pyelointerstitial) .The first renal function to be affected is urineconcentrating power  increasd urine output.
  • 4. HYDRONEPFROSISClinical pictureSymptoms:Pain colicky or heaviness in the flankSwellingHematuria usually mildSigns:Abdominal swellingS&S of the cause of hydronephrosis eg; bladder mass,BPH,etc
  • 5. HYDRONEPFROSISInvestigations:1-Laboratory:-Urine analysis-Renal function tests2-Radiologic:-Plain X-ray film:Soft tissue shadow of the kidney? Stone-IVP:Loss of waist flattening clubbing ballooningThin parenchyma-UltrasoundDilated system- Thickness of the remaining parenchyma
  • 7. HYDRONEPFROSISTREATMENTA- If the kidney function is good treat the causeB- If the kidney function is bad preliminary diversion (Nephrostomy) treat the causeC- Non-functioning kidney (<10% by isotope) Nephrectomy
  • 9. RENAL FAILUREThe role of urologist:1- To rule out a correctable obstruction2- Urologic surgery FOR chronic renal failure ofobstructive cause
  • 10. ACUTE RENAL FAILUREDefinition: Sudden renal deterioration over aperiod of hours to daysDaily increase of serum creatinine of >0.5mg/dlOliguria : ( Urine output </= 400ml/24 hours )Anuria : ( Total cessation of urine output )
  • 11. ACUTE RENAL FAILUREClassification and CausesI- Prerenal :A. Volume depletion- Heamorrhage/ Burns/ Third space losses e.g peritonitisB. Circulatory- CHF, Sepsis, Shock, Cirrhosis with ascitisC. Local renal ischeamia- Renal artery occlusion/ Renal vein occlusionII- RenalAcute tubular necrosis/ Acute glomerulonephritisIII- Postrenal- Bilateral ureteric obstruction- Unilateral obstruction of a solitary kidney
  • 12. ACUTE RENAL FAILUREDrugs Associated with ARF Aminoglucosides Penicillin Sulpha Cyclosporin Certain anaesthetics Iodinated contrast media Non-Steroidal anti-inflammatory drugs Furosemide and Thiazide Captopril Cimetidine
  • 13. ACUTE RENAL FAILUREDiagnosis of Anuria & acute Retention*Anuria = Empty bladder* Acute Urine Retention = Full bladderDifferentiation by:1. Physical examination2. Abdominal Ultrasound3. Urethral catheterization
  • 14. ACUTE RENAL FAILURETreatmentShould be focused on:1. Reversing the underlying cause2. Preventing further renal injury3. Correcting fluid and electrolyte imbalance4. Providing supportive measuresIf ARF is severe and prolonged, it is best treatedwith peritoneal dialysis or haemodialysis.
  • 15. CHRONIC RENAL FAILUREDefinition: (Slowly progressive decrease in the GFR andtubular function) When the patient requires renal replacementtherapy End stage renal disease.Causes:-DM - Hypertension- Glomerulonephritis - Congenital diseases- Obstructive uropathy -Interstitial nephritis- Chronic pyelonephritis.
  • 16. CHRONIC RENAL FAILUREClinical Picture of CRF1. Constitutional symptoms2. GIT symptoms3. Cardiovascular symptoms4. Hematological symptoms5. Neurological symptoms6. Endocrinal symptoms7. Renal osteodystrophy8. Acquired cystic kidney disease9. Erectile dysfunction
  • 17. CHRONIC RENAL FAILURETreatment of CRFIs the responsibility of the Nephrologist1-Treatment of Anaemia2- Correction of Coagulopathy3- Protein restriction4- Potassium restriction5- Sodium restriction6- Fluid intake7- Treatment of Ascitis8-Treatment of Renal osteodystrophy
  • 18. CHRONIC RENAL FAILUREDialysis “Nephrologist “Definition:(Is any process that changes the concentration of solutesin the plasma by exposure to a second solution across asemi- permeable membrane)Indications:* Urea nitrogen > 100 mg / DL* Creatinine Clearance < 0.1 ml / min/ KgTypes:A. Peritoneal dialysisB. Haemodialysis
  • 19. RENAL TRANSPLANTATIONRequirements:1. Donor- Living related kidney donor- Cadaveric renal donor2. Recipient (ESRD)3. Pretransplantation work up4. Immunologic work up5. Surgical technique6. Postoperative management
  • 20. RENAL TRANSPLANTATIONComplications:1. Graft rejection2. Vascular complications3. Urologic complications4. Complications of drugs (Cyclosporin)Usually, the graft works for about 10 years