H7N9 AVIAN INFLUENZAVOL.2新潟大学大学院 医歯学総合研究科 国際保健学分野(~2013.4.26)Division of International Health (Public Health)Graduate Scho...
H7N9 ウイルス遺伝子の特徴• HA遺伝子はアヒル(H7N3)、NAは野鳥の(H7N9)、内部遺伝子はニワトリの(H9N2)• 二度大きな遺伝子組み換えが起こったと考えられる(1) A/Shanghai/1/2013(2) A/Shangha...
• H7セグメント:浙江省の鴨群と韓国の野鳥群から分離• N9セグメント:韓国の野鳥(wild bird)から分離上の2つ以外の残り6つのセグメントはH9N2由来で、中国の上海・浙江・江蘇などの土地にいる鶏群からのものであった。野鳥が移動する過...
HA and PB2 mutations associated with virusadaptation in mammalsH3 a.a. position (H5 no.)110(103)158160(156)224226(222)228(...
HA遺伝子開裂部位=低病原性リシン、アルギニンの連続配列の欠如proteolytic cleavagemotifAbsence of polybasic sequences (K and R) in the recent H7N9 indica...
1_PB2human H1N1pdm09swine fluhuman H3N2avian fluA/Environment/Hangzhou/34/2013 | A / H7N9 | 2013-04-04 | PB2A/chicken/Zhej...
2_PB1avian fluhuman H1N1pdm09swine fluhuman H3N2A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | PB1A/Shanghai/...
3_PAavian fluhuman H1N1pdm09swine fluhuman H3N2A/Shanghai/2/2013 | H7N9 | 2013-01-01 | PAA/Chicken/Shanghai/S1053/2013 | A...
4_HAhuman H1N1pdm09swine fluavian fluhuman H3N2A/Hangzhou/1/2013 | A / H7N9 | 2013-03-24 | HAA/Environment/Hangzhou/34/201...
5_NPavian fluhuman H1N1pdm09swine fluhuman H3N2A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | NPA/Chicken/Sha...
avian flu6_NAhuman H3N2swine fluhumanH1N1pdm09swine fluA/Hangzhou/1/2013 | A / H7N9 | 2013-03-24 | NAA/chicken/Zhejiang/DT...
7_MPavian fluhuman H1N1pdm09swine fluhuman H3N2swine fluA/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | MPA/Anhui/1/2013 | A /...
avian fluhuman H1N1pdm09swine fluhuman H3N28_NSA/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | NSA/chicken/Zhejiang/D...
Influenza H7N9 Reassortant2011 2012 2013H9N2 chickenA/chicken/Zhejiang/611/2011H7N9 wild birdH7N3 duckH9N2 chickenA/chicke...
We gratefully acknowledge the authors,originating and submitting laboratoriesof the sequences from GISAID’s EpiFlu Databas...
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H7N9 in China 2

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H7N9 in China 2

  1. 1. H7N9 AVIAN INFLUENZAVOL.2新潟大学大学院 医歯学総合研究科 国際保健学分野(~2013.4.26)Division of International Health (Public Health)Graduate School of Medical and Dental Sciences,Niigata University
  2. 2. H7N9 ウイルス遺伝子の特徴• HA遺伝子はアヒル(H7N3)、NAは野鳥の(H7N9)、内部遺伝子はニワトリの(H9N2)• 二度大きな遺伝子組み換えが起こったと考えられる(1) A/Shanghai/1/2013(2) A/Shanghai/2/2013 clusters• 低病原性 HA遺伝子の開裂部位に塩基性配列が欠如している• HA遺伝子に哺乳類へ適応する変異: Q226L/I とT160A• PB2 に哺乳類の体温に適応する変異: E627K とD701N新潟大学大学院 医歯学総合研究科 国際保健学分野
  3. 3. • H7セグメント:浙江省の鴨群と韓国の野鳥群から分離• N9セグメント:韓国の野鳥(wild bird)から分離上の2つ以外の残り6つのセグメントはH9N2由来で、中国の上海・浙江・江蘇などの土地にいる鶏群からのものであった。野鳥が移動する過程で、長江デルタ地域の鴨群・鶏群との間でreassortantを起こした可能性が高いと考えられている。上海市を流れる黄浦江(Huangpu river)で起こった、伝染病で死んだ豚の大量投棄(6,000~10,000頭)と今回の鳥インフルエンザとの関連性は、豚の死骸からH7N9ウィルスが検出されなかったことを根拠に否定されている。(豚の伝染病が何であったのかという報道は無い。)また、同時期に四川省で1.000羽のアヒルの死骸が大量投棄されているのも発見されたが、死因が特定されず、今回のH7N9との関連性も確認されていない。新潟大学大学院 医歯学総合研究科 国際保健学分野
  4. 4. HA and PB2 mutations associated with virusadaptation in mammalsH3 a.a. position (H5 no.)110(103)158160(156)224226(222)228(224)318PB2:627PB2:701A/H5N1 wild-type H N T N Q G T E DA/H5N1 mutant Y D A K L S I K NA/Shanghai/1/2013 Q N A N Q G T K DA/Shanghai/2/2013 Q N A N L G T K DA/Chicken/Shanghai/S1053/2013 Q N A N L G T E DA/Environment/Shanghai/S1088/2013Q N A N L G T E DA/Pigeon/Shanghai/S1069/2013 Q N A N L G T E DA/Anhui/1/2013 Q N A N L G T K DA/Hangzhou/1/2013 Q N A N I* G T -- DA/Hangzhou/2/2013 Q N A N L G T K DA/Hangzhou/3/2013 Q N A N L G T K DA/Environment/Hangzhou/34/2013 Q N A N L G T E DA/Zhejiang/DTID-ZJU01/2013 Q N A N L G T E NA/chicken/Zhejiang/DTID-ZJU01/2013Q N A N Q G T E DFouchier et al. Science (2012) 336:1534 [HA:H110Y, T160A, Q226L, G228S and PB2:E627K]Kawaoka et al. Nature (2012) 486:420 [HA: N158D, N224K, Q226L, T318I]Chen et al. Lancet (2013) [HA: T156A, Q226L and PB2:D701N]Gao et al. NEJM (2013) and Kageyama et al. Eurosurveillance (2013) 18:20453 [HA: T156A, Q226L and PB2:E627K]Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b新潟大学大学院 医歯学総合研究科 国際保健学分野
  5. 5. HA遺伝子開裂部位=低病原性リシン、アルギニンの連続配列の欠如proteolytic cleavagemotifAbsence of polybasic sequences (K and R) in the recent H7N9 indicates lowpathogenicity. Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b新潟大学大学院 医歯学総合研究科 国際保健学分野
  6. 6. 1_PB2human H1N1pdm09swine fluhuman H3N2avian fluA/Environment/Hangzhou/34/2013 | A / H7N9 | 2013-04-04 | PB2A/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | PB2A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | PB2A/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | PB2A/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | PB2A/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | PB2 (D701N)A/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | PB2 (E627K)A/Anhui/1/2013 | A / H7N9 | 2013-01-01 | PB2 (E627K)A/Hangzhou/3/2013 | A / H7N9 | 2013-04-02 | PB2 (E627K)A/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | PB2 (E627K)A/Hangzhou/2/2013 | A / H7N9 | 2013-03-25 | PB2 (E627K)A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | PB2A/chicken/Shanghai/C1/2012 | A / H9N2 | PB2 | 2012-01-01A/chicken/Zhejiang/611/2011 | A / H9N2 | PB2 | 2011-06-01A/Netherlands/127/03 | A / H7N7 | PB2 | 2003-01-01A/green-winged teal/Xianghai/430/2011 | A / H5N2 | PB2 | 2011-10-01A/canvasback/Xianghai/428/2011 | A / H5N2 | PB2 | 2011-10-01A/duck/Jiangsu/4/2010 | A / H3N6 | PB2 | 2010-03-01A/baikal teal/Xianghai/426/2011 | A / H5N2 | PB2 | 2011-10-01A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | PB2 | 2011-10-01A/swine/Guangdong/K4/2011 | A / H4N8 | PB2 | 2011-10-21A/duck/Guangdong/W12/2011 | A / H3N2 | PB2 | 2011-12-22A/duck/Hubei/5/2010 | A / H6N6 | PB2 | 2010-05-22A/swine/Hubei/101/2009 | A / H1N1 | PB2 | 2009-08-18A/duck/Zhejiang/10/2011 | A / H7N3 | PB2 | 2011-06-01A/duck/Zhejiang/12/2011 | A / H7N3 | PB2 | 2011-06-01A/duck/Zhejiang/0611-8/2011 | A / H1N3 | PB2 | 2011-06-01A/duck/Jiangsu/10-d4/2011 | A / H11N3 | PB2 | 2011-10-01A/duck/Zhejiang/0224-6/2011 | A / H1N2 | PB2 | 2011-01-01A/duck/Jiangsu/1-15/2011 | A / H4N2 | PB2 | 2011-01-12A/duck/Jiangsu/m234/2012 | A / H5N2 | PB2 | 2012-01-18A/duck/Guangxi/GXd-2/2010 | A / H6N2 | PB2 | 2010-04-02A/baikal teal/Xianghai/421/2011 | A / H9N2 | PB2 | 2011-10-01A/chicken/Vietnam/212/2005 | A / H5N1 | PB2 | 2005-12-09A/duck/Guangxi/GXd-5/2010 | A / H6N1 | PB2 | 2010-05-08A/turkey/Minnesota/1/1988 | A / H7N9 | PB2 | 1988-07-13A/blue-winged teal/Ohio/566/2006 | A / H7N9 | PB2 | 2006-01-01A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | PB2 | 2011-01-08A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | PB2 | 2008-02-07A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | PB2 | 2008-03-05A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | PB2 | 1995-05-21A/Shanghai/60T/2009 | A / H1N1 | PB2 | 2009-05-28A/Shanghai/37T/2009 | A / H1N1 | PB2 | 2009-05-24A/Zhejiang/2/2009 | A / H1N1 | PB2 | 2009-05-31A/Guangdong/02/2009 | A / H1N1 | PB2 | 2009-05-29A/Zhoushan/52/2009 | A / H1N1 | PB2 | 2009-12-19A/Shandong/1/2009 | A / H1N1 | PB2 | 2009-05-10A/Nanjing/2/2009 | A / H1N1 | PB2 | 2009-06-17A/Beijing/01/2009 | A / H1N1 | PB2 | 2009-05-15(2)A/Beijing/01/2009 | A / H1N1 | PB2 | 2009-05-15A/GuangzhouSB/01/2009 | A / H1N1 | PB2 | 2009-05-17A/Jiangsu/S61/2009 | A / H1N1 | PB2 | 2009-11-10A/swine/Hong Kong/2237/2010 | A / H1N2 | PB2 | 2010-08-02A/swine/Hubei/04/2009 | A / H1N2 | PB2 | 2009-03-10A/swine/Guangdong/1/2010 | A / H1N2 | PB2 | 2010-01-30A/swine/Guangdong/1/2010 | A / H1N1 | PB2 | 2010-01-15A/swine/Guangdong/2712/2010 | A / H1N2 | PB2 | 2010-08-26A/swine/Guangdong/2676/2010 | A / H1N2 | PB2 | 2010-08-26A/swine/Guangdong/09/2009 | A / H1N1 | PB2 | 2009-09-02A/swine/Guangdong/05/2009 | A / H1N1 | PB2 | 2009-05-05A/Jilin-Chuanying/1156/2011 | A / H3N2 | PB2 | 2011-03-03A/Hunan-Yanfeng/165/2011 | A / H3N2 | PB2 | 2011-04-14A/Heilongjiang-Nangang/124/2011 | A / H3N2 | PB2 | 2011-03-08A/Shanghai-Luwan/188/2011 | A / H3N2 | PB2 | 2011-02-14A/Shanghai-Fengxian/1170/2011 | A / H3N2 | PB2 | 2011-05-10A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | PB2 | 2011-03-09A/Tianjin-Hedong/195/2011 | A / H3N2 | PB2 | 2011-02-15A/Beijing-Xicheng/1409/2011 | A / H3N2 | PB2 | 2011-02-22A/Hunan-Beihu/1143/2011 | A / H3N2 | PB2 | 2011-03-11A/Chongqing-Wanzhou/182/2011 | A / H3N2 | PB2 | 2011-02-20100887673701009692100100757399100100100100100100100999410099911009210099981009982 10099977970100100889985Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b新潟大学大学院 医歯学総合研究科 国際保健学分野
  7. 7. 2_PB1avian fluhuman H1N1pdm09swine fluhuman H3N2A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | PB1A/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | PB1A/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | PB1A/Anhui/1/2013 | A / H7N9 | 2013-01-01 | PB1A/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | PB1A/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | PB1A/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | PB1A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | PB1A/chicken/Shanghai/C1/2012 | A / H9N2 | PB1 | 2012-01-01A/chicken/Zhejiang/611/2011 | A / H9N2 | PB1 | 2011-06-01A/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | PB1A/duck/Guangdong/W12/2011 | A / H3N2 | PB1 | 2011-12-22A/swine/Guangdong/K4/2011 | A / H4N8 | PB1 | 2011-10-21A/duck/Jiangsu/1-15/2011 | A / H4N2 | PB1 | 2011-01-12A/duck/Guangxi/GXd-5/2010 | A / H6N1 | PB1 | 2010-05-08A/duck/Jiangsu/4/2010 | A / H3N6 | PB1 | 2010-03-01A/duck/Jiangsu/m234/2012 | A / H5N2 | PB1 | 2012-01-18A/baikal teal/Xianghai/421/2011 | A / H9N2 | PB1 | 2011-10-01A/duck/Guangxi/GXd-2/2010 | A / H6N2 | PB1 | 2010-04-02A/duck/Zhejiang/0224-6/2011 | A / H1N2 | PB1 | 2011-01-01A/green-winged teal/Xianghai/430/2011 | A / H5N2 | PB1 | 2011-10-01A/canvasback/Xianghai/428/2011 | A / H5N2 | PB1 | 2011-10-01A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | PB1 | 2011-10-01A/baikal teal/Xianghai/426/2011 | A / H5N2 | PB1 | 2011-10-01A/duck/Zhejiang/12/2011 | A / H7N3 | PB1 | 2011-06-01A/duck/Jiangsu/10-d4/2011 | A / H11N3 | PB1 | 2011-10-01A/duck/Zhejiang/10/2011 | A / H7N3 | PB1 | 2011-06-01A/duck/Zhejiang/0611-8/2011 | A / H1N3 | PB1 | 2011-06-01A/duck/Hubei/5/2010 | A / H6N6 | PB1 | 2010-05-22A/swine/Hubei/101/2009 | A / H1N1 | PB1 | 2009-08-18A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | PB1 | 2008-02-07A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | PB1 | 2008-03-05A/blue-winged teal/Ohio/566/2006 | A / H7N9 | PB1 | 2006-01-01A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | PB1 | 2011-01-08A/turkey/Minnesota/1/1988 | A / H7N9 | PB1 | 1988-07-13A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | PB1 | 1995-05-21A/Jilin-Chuanying/1156/2011 | A / H3N2 | PB1 | 2011-03-03A/Hunan-Yanfeng/165/2011 | A / H3N2 | PB1 | 2011-04-14A/Heilongjiang-Nangang/124/2011 | A / H3N2 | PB1 | 2011-03-08A/Shanghai-Luwan/188/2011 | A / H3N2 | PB1 | 2011-02-14A/Shanghai-Fengxian/1170/2011 | A / H3N2 | PB1 | 2011-05-10A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | PB1 | 2011-03-09A/Tianjin-Hedong/195/2011 | A / H3N2 | PB1 | 2011-02-15A/Beijing-Xicheng/1409/2011 | A / H3N2 | PB1 | 2011-02-22A/Chongqing-Wanzhou/182/2011 | A / H3N2 | PB1 | 2011-02-20A/Hunan-Beihu/1143/2011 | A / H3N2 | PB1 | 2011-03-11A/Shanghai/60T/2009 | A / H1N1 | PB1 | 2009-05-28A/Zhejiang/2/2009 | A / H1N1 | PB1 | 2009-05-31A/Shanghai/37T/2009 | A / H1N1 | PB1 | 2009-05-24A/Guangdong/02/2009 | A / H1N1 | PB1 | 2009-05-29A/GuangzhouSB/01/2009 | A / H1N1 | PB1 | 2009-05-17A/Beijing/01/2009 | A / H1N1 | PB1 | 2009-05-15A/Nanjing/2/2009 | A / H1N1 | PB1 | 2009-06-17A/Beijing/01/2009 | A / H1N1 | PB1 | 2009-05-15(2)A/Jiangsu/S61/2009 | A / H1N1 | PB1 | 2009-11-10A/Zhoushan/52/2009 | A / H1N1 | PB1 | 2009-12-19A/Shandong/1/2009 | A / H1N1 | PB1 | 2009-05-10A/swine/Guangdong/2676/2010 | A / H1N2 | PB1 | 2010-08-26A/swine/Guangdong/2712/2010 | A / H1N2 | PB1 | 2010-08-26A/swine/Guangdong/1/2010 | A / H1N1 | PB1 | 2010-01-15A/swine/Hong Kong/2237/2010 | A / H1N2 | PB1 | 2010-08-02A/swine/Hubei/04/2009 | A / H1N2 | PB1 | 2009-03-10A/swine/Guangdong/1/2010 | A / H1N2 | PB1 | 2010-01-30A/swine/Guangdong/05/2009 | A / H1N1 | PB1 | 2009-05-05A/swine/Guangdong/09/2009 | A / H1N1 | PB1 | 2009-09-0210010098998687821001008677100979782969484100100100100971009697100100100841007710010010010078100991000.02Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b新潟大学大学院 医歯学総合研究科 国際保健学分野
  8. 8. 3_PAavian fluhuman H1N1pdm09swine fluhuman H3N2A/Shanghai/2/2013 | H7N9 | 2013-01-01 | PAA/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | PAA/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | PAA/Anhui/1/2013 | H7N9 | 2013-01-01 | PAA/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | PAA/Shanghai/1/2013 | H7N9 | 2013-01-01| PAA/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | PAA/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | PAA/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | PAA/chicken/Shanghai/C1/2012 | A / H9N2 | PA | 2012-01-01A/chicken/Zhejiang/611/2011 | A / H9N2 | PA | 2011-06-01A/duck/Zhejiang/12/2011 | A / H7N3 | PA | 2011-06-01A/duck/Zhejiang/0611-8/2011 | A / H1N3 | PA | 2011-06-01A/duck/Zhejiang/10/2011 | A / H7N3 | PA | 2011-06-01A/duck/Jiangsu/10-d4/2011 | A / H11N3 | PA | 2011-10-01A/duck/Hubei/5/2010 | A / H6N6 | PA | 2010-05-22A/canvasback/Xianghai/428/2011 | A / H5N2 | PA | 2011-10-01A/green-winged teal/Xianghai/430/2011 | A / H5N2 | PA | 2011-10-01A/duck/Jiangsu/4/2010 | A / H3N6 | PA | 2010-03-01A/duck/Jiangsu/1-15/2011 | A / H4N2 | PA | 2011-01-12A/duck/Jiangsu/m234/2012 | A / H5N2 | PA | 2012-01-18A/duck/Guangxi/GXd-5/2010 | A / H6N1 | PA | 2010-05-08A/baikal teal/Xianghai/421/2011 | A / H9N2 | PA | 2011-10-01A/swine/Guangdong/K4/2011 | A / H4N8 | PA | 2011-10-21A/duck/Guangxi/GXd-2/2010 | A / H6N2 | PA | 2010-04-02A/duck/Zhejiang/0224-6/2011 | A / H1N2 | PA | 2011-01-01A/duck/Guangdong/W12/2011 | A / H3N2 | PA | 2011-12-22A/baikal teal/Xianghai/426/2011 | A / H5N2 | PA | 2011-10-01A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | PA | 2011-10-01A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | PA | 1995-05-21A/turkey/Minnesota/1/1988 | A / H7N9 | PA | 1988-07-13A/swine/Guangdong/2676/2010 | A / H1N2 | PA | 2010-08-26A/swine/Guangdong/2712/2010 | A / H1N2 | PA | 2010-08-26A/swine/Guangdong/1/2010 | A / H1N1 | PA | 2010-01-15A/swine/Hong Kong/2237/2010 | A / H1N2 | PA | 2010-08-02A/swine/Guangdong/1/2010 | A / H1N2 | PA | 2010-01-30A/swine/Hubei/04/2009 | A / H1N2 | PA | 2009-03-10A/GuangzhouSB/01/2009 | A / H1N1 | PA | 2009-05-17A/Jiangsu/S61/2009 | A / H1N1 | PA | 2009-11-10A/Zhoushan/52/2009 | A / H1N1 | PA | 2009-12-19A/Nanjing/2/2009 | A / H1N1 | PA | 2009-06-17A/Shanghai/37T/2009 | A / H1N1 | PA | 2009-05-24A/Guangdong/02/2009 | A / H1N1 | PA | 2009-05-29A/Shanghai/60T/2009 | A / H1N1 | PA | 2009-05-28A/Zhejiang/2/2009 | A / H1N1 | PA | 2009-05-31A/Shandong/1/2009 | A / H1N1 | PA | 2009-05-10A/Beijing/01/2009 | A / H1N1 | PA | 2009-05-15A/Beijing/01/2009 | A / H1N1 | PA | 2009-05-15(2)A/blue-winged teal/Ohio/566/2006 | A / H7N9 | PA | 2006-01-01A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | PA | 2011-01-08A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | PA | 2008-02-07A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | PA | 2008-03-05A/swine/Hubei/101/2009 | A / H1N1 | PA | 2009-08-18A/swine/Guangdong/05/2009 | A / H1N1 | PA | 2009-05-05A/swine/Guangdong/09/2009 | A / H1N1 | PA | 2009-09-02A/Heilongjiang-Nangang/124/2011 | A / H3N2 | PA | 2011-03-08A/Hunan-Yanfeng/165/2011 | A / H3N2 | PA | 2011-04-14A/Jilin-Chuanying/1156/2011 | A / H3N2 | PA | 2011-03-03A/Shanghai-Luwan/188/2011 | A / H3N2 | PA | 2011-02-14A/Shanghai-Fengxian/1170/2011 | A / H3N2 | PA | 2011-05-10A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | PA | 2011-03-09A/Beijing-Xicheng/1409/2011 | A / H3N2 | PA | 2011-02-22A/Tianjin-Hedong/195/2011 | A / H3N2 | PA | 2011-02-15A/Chongqing-Wanzhou/182/2011 | A / H3N2 | PA | 2011-02-20A/Hunan-Beihu/1143/2011 | A / H3N2 | PA | 2011-03-1110084831008698100100100100100100100739998100100991001009910082798910095859110099991009910010085791000.02Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b新潟大学大学院 医歯学総合研究科 国際保健学分野
  9. 9. 4_HAhuman H1N1pdm09swine fluavian fluhuman H3N2A/Hangzhou/1/2013 | A / H7N9 | 2013-03-24 | HAA/Environment/Hangzhou/34/2013 | A / H7N9 | 2013-04-04 | HAA/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | HAA/chicken/Jiangsu/K27/2013 | A / H7N9 | 2013-04-01 | HAA/Hangzhou/3/2013 | A / H7N9 | 2013-04-02 | HAA/Shanghai/2/2013 | 2013-01-01 | H7N9 | HAA/Anhui/1/2013 | 2013-01-01 | H7N9 | HAA/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | HAA/chicken/Jiangsu/K89/2013 | A / H7N9 | 2013-04-01 | HAA/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | HAA/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | HAA/Hangzhou/2/2013 | A / H7N9 | 2013-03-25 | HAA/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | HAA/Shanghai/1/2013 | 2013-01-01 | H7N9 | HAA/duck/Zhejiang/10/2011 | A / H7N3 | HA | 2011-06-01A/duck/Zhejiang/12/2011 | A / H7N3 | HA | 2011-06-01A/turkey/Minnesota/1/1988 | A / H7N9 | HA | 1988-07-13A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | HA | 1995-05-21A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | HA | 2011-01-08A/blue-winged teal/Ohio/566/2006 | A / H7N9 | HA | 2006-01-01A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | HA | 2008-02-07A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | HA | 2008-03-05A/duck/Jiangsu/1-15/2011 | A / H4N2 | HA | 2011-01-12A/swine/Guangdong/K4/2011 | A / H4N8 | HA | 2011-10-21A/duck/Guangdong/W12/2011 | A / H3N2 | HA | 2011-12-22A/duck/Jiangsu/4/2010 | A / H3N6 | HA | 2010-03-01A/Beijing-Xicheng/1409/2011 | A / H3N2 | HA | 2011-02-22A/Hunan-Beihu/1143/2011 | A / H3N2 | HA | 2011-03-11A/Chongqing-Wanzhou/182/2011 | A / H3N2 | HA | 2011-02-20A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | HA | 2011-03-09A/Shanghai-Fengxian/1170/2011 | A / H3N2 | HA | 2011-05-10A/Shanghai-Luwan/188/2011 | A / H3N2 | HA | 2011-02-14A/Hunan-Yanfeng/165/2011 | A / H3N2 | HA | 2011-04-14A/Jilin-Chuanying/1156/2011 | A / H3N2 | HA | 2011-03-03A/Heilongjiang-Nangang/124/2011 | A / H3N2 | HA | 2011-03-08A/Tianjin-Hedong/195/2011 | A / H3N2 | HA | 2011-02-15A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | HAA/chicken/Shanghai/C1/2012 | A / H9N2 | HA | 2012-01-01A/chicken/Zhejiang/611/2011 | A / H9N2 | HA | 2011-06-01A/baikal teal/Xianghai/421/2011 | A / H9N2 | HA | 2011-10-01A/duck/Jiangsu/10-d4/2011 | A / H11N3 | HA | 2011-10-01A/baikal teal/Xianghai/426/2011 | A / H5N2 | HA | 2011-10-01A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | HA | 2011-10-01A/green-winged teal/Xianghai/430/2011 | A / H5N2 | HA | 2011-10-01A/canvasback/Xianghai/428/2011 | A / H5N2 | HA | 2011-10-01A/duck/Jiangsu/m234/2012 | A / H5N2 | HA | 2012-01-18A/duck/Hubei/5/2010 | A / H6N6 | HA | 2010-05-22A/duck/Guangxi/GXd-5/2010 | A / H6N1 | HA | 2010-05-08A/duck/Guangxi/GXd-2/2010 | A / H6N2 | HA | 2010-04-02A/duck/Zhejiang/0224-6/2011 | A / H1N2 | HA | 2011-01-01A/duck/Zhejiang/0611-8/2011 | A / H1N3 | HA | 2011-06-01A/swine/Guangdong/1/2010 | A / H1N1 | HA | 2010-01-15A/swine/Hubei/101/2009 | A / H1N1 | HA | 2009-08-18A/swine/Guangdong/05/2009 | A / H1N1 | HA | 2009-05-05A/swine/Guangdong/09/2009 | A / H1N1 | HA | 2009-09-02A/swine/Guangdong/1/2010 | A / H1N2 | HA | 2010-01-30A/swine/Hubei/04/2009 | A / H1N2 | HA | 2009-03-10A/swine/Guangdong/2676/2010 | A / H1N2 | HA | 2010-08-26A/swine/Guangdong/2712/2010 | A / H1N2 | HA | 2010-08-26A/swine/Hong Kong/2237/2010 | A / H1N2 | HA | 2010-08-02A/Beijing/01/2009 | A / H1N1 | HA | 2009-05-15A/GuangzhouSB/01/2009 | A / H1N1 | HA | 2009-05-17A/Nanjing/2/2009 | A / H1N1 | HA | 2009-06-17A/Shandong/1/2009 | A / H1N1 | HA | 2009-05-10A/Jiangsu/S61/2009 | A / H1N1 | HA | 2009-11-10A/Guangdong/02/2009 | A / H1N1 | HA | 2009-05-29A/Zhoushan/52/2009 | A / H1N1 | HA | 2009-12-19A/Shanghai/37T/2009 | A / H1N1 | HA | 2009-05-24A/Shanghai/60T/2009 | A / H1N1 | HA | 2009-05-28A/Zhejiang/2/2009 | A / H1N1 | HA | 2009-05-31998699748099909999999999998688999884989699999999979999999978999699999899998099949999avian fluData source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b新潟大学大学院 医歯学総合研究科 国際保健学分野
  10. 10. 5_NPavian fluhuman H1N1pdm09swine fluhuman H3N2A/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | NPA/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | NPA/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | NPA/Anhui/1/2013 | A / H7N9 | 2013-01-01 | NPA/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | NPA/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | NPA/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | NPA/chicken/Zhejiang/611/2011 | A / H9N2 | NP | 2011-06-01A/chicken/Shanghai/C1/2012 | A / H9N2 | NP | 2012-01-01A/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | NPA/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | NPA/duck/Guangxi/GXd-5/2010 | A / H6N1 | NP | 2010-05-08A/duck/Jiangsu/m234/2012 | A / H5N2 | NP | 2012-01-18A/duck/Jiangsu/1-15/2011 | A / H4N2 | NP | 2011-01-12A/duck/Jiangsu/4/2010 | A / H3N6 | NP | 2010-03-01A/duck/Hubei/5/2010 | A / H6N6 | NP | 2010-05-22A/baikal teal/Xianghai/421/2011 | A / H9N2 | NP | 2011-10-01A/wild duck/Mongolia/1-241/2008 | A / H7N9 | 2008-04-01 | NPA/swine/Guangdong/K4/2011 | A / H4N8 | NP | 2011-10-21A/duck/Zhejiang/0224-6/2011 | A / H1N2 | NP | 2011-01-01A/duck/Zhejiang/10/2011 | A / H7N3 | NP | 2011-06-01A/duck/Guangdong/W12/2011 | A / H3N2 | NP | 2011-12-22A/duck/Zhejiang/12/2011 | A / H7N3 | NP | 2011-06-01A/duck/Jiangsu/10-d4/2011 | A / H11N3 | NP | 2011-10-01A/duck/Zhejiang/0611-8/2011 | A / H1N3 | NP | 2011-06-01A/swine/Hubei/101/2009 | A / H1N1 | NP | 2009-08-18A/duck/Guangxi/GXd-2/2010 | A / H6N2 | NP | 2010-04-02A/baikal teal/Xianghai/426/2011 | A / H5N2 | NP | 2011-10-01A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | NP | 2011-10-01A/canvasback/Xianghai/428/2011 | A / H5N2 | NP | 2011-10-01A/green-winged teal/Xianghai/430/2011 | A / H5N2 | NP | 2011-10-01A/turkey/Minnesota/1/1988 | A / H7N9 | NP | 1988-07-13A/blue-winged teal/Ohio/566/2006 | A / H7N9 | NP | 2006-01-01A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | NP | 2011-01-08A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | NP | 1995-05-21A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | NP | 2008-02-07A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | NP | 2008-03-05A/Shanghai/60T/2009 | A / H1N1 | NP | 2009-05-28A/Shandong/1/2009 | A / H1N1 | NP | 2009-05-10A/Shanghai/37T/2009 | A / H1N1 | NP | 2009-05-24A/Guangdong/02/2009 | A / H1N1 | NP | 2009-05-29A/Zhejiang/2/2009 | A / H1N1 | NP | 2009-05-31A/Zhoushan/52/2009 | A / H1N1 | NP | 2009-12-19A/Beijing/01/2009 | A / H1N1 | NP | 2009-05-15A/Nanjing/2/2009 | A / H1N1 | NP | 2009-06-17A/Beijing/01/2009 | A / H1N1 | NP | 2009-05-15(2)A/GuangzhouSB/01/2009 | A / H1N1 | NP | 2009-05-17A/Jiangsu/S61/2009 | A / H1N1 | NP | 2009-11-10A/swine/Hong Kong/2237/2010 | A / H1N2 | NP | 2010-08-02A/swine/Hubei/04/2009 | A / H1N2 | NP | 2009-03-10A/swine/Guangdong/1/2010 | A / H1N2 | NP | 2010-01-30A/swine/Guangdong/1/2010 | A / H1N1 | NP | 2010-01-15A/swine/Guangdong/2712/2010 | A / H1N2 | NP | 2010-08-26A/swine/Guangdong/2676/2010 | A / H1N2 | NP | 2010-08-26A/swine/Guangdong/09/2009 | A / H1N1 | NP | 2009-09-02A/swine/Guangdong/05/2009 | A / H1N1 | NP | 2009-05-05A/Shanghai-Fengxian/1170/2011 | A / H3N2 | NP | 2011-05-10A/Hunan-Yanfeng/165/2011 | A / H3N2 | NP | 2011-04-14A/Heilongjiang-Nangang/124/2011 | A / H3N2 | NP | 2011-03-08A/Jilin-Chuanying/1156/2011 | A / H3N2 | NP | 2011-03-03A/Shanghai-Luwan/188/2011 | A / H3N2 | NP | 2011-02-14A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | NP | 2011-03-09A/Tianjin-Hedong/195/2011 | A / H3N2 | NP | 2011-02-15A/Hunan-Beihu/1143/2011 | A / H3N2 | NP | 2011-03-11A/Beijing-Xicheng/1409/2011 | A / H3N2 | NP | 2011-02-22A/Chongqing-Wanzhou/182/2011 | A / H3N2 | NP | 2011-02-208189751001001009998861001009210010096931009694701008899100991008077100 1001008572841000.02Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b新潟大学大学院 医歯学総合研究科 国際保健学分野
  11. 11. avian flu6_NAhuman H3N2swine fluhumanH1N1pdm09swine fluA/Hangzhou/1/2013 | A / H7N9 | 2013-03-24 | NAA/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | NAA/Hangzhou/3/2013 | A / H7N9 | 2013-04-02 | NAA/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | NAA/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | NAA/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | NAA/Environment/Hangzhou/34/2013 | A / H7N9 | 2013-04-04 | NAA/Hangzhou/2/2013 | A / H7N9 | 2013-03-25 | NAA/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | NAA/Anhui/1/2013 | A / H7N9 | 2013-01-01 | NAA/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | NAA/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | NAA/turkey/Minnesota/1/1988 | A / H7N9 | NA | 1988-07-13A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | NA | 1995-05-21A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | NA | 2008-03-05A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | NA | 2008-02-07A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | NA | 2011-01-08A/blue-winged teal/Ohio/566/2006 | A / H7N9 | NA | 2006-01-01A/duck/Jiangsu/4/2010 | A / H3N6 | NA | 2010-03-01A/duck/Hubei/5/2010 | A / H6N6 | NA | 2010-05-22A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | NA | 2011-10-01A/green-winged teal/Xianghai/430/2011 | A / H5N2 | NA | 2011-10-01A/baikal teal/Xianghai/426/2011 | A / H5N2 | NA | 2011-10-01A/canvasback/Xianghai/428/2011 | A / H5N2 | NA | 2011-10-01A/duck/Guangxi/GXd-2/2010 | A / H6N2 | NA | 2010-04-02A/baikal teal/Xianghai/421/2011 | A / H9N2 | NA | 2011-10-01A/duck/Zhejiang/0224-6/2011 | A / H1N2 | NA | 2011-01-01A/duck/Jiangsu/1-15/2011 | A / H4N2 | NA | 2011-01-12A/duck/Jiangsu/m234/2012 | A / H5N2 | NA | 2012-01-18A/duck/Guangdong/W12/2011 | A / H3N2 | NA | 2011-12-22A/chicken/Zhejiang/611/2011 | A / H9N2 | NA | 2011-06-01A/chicken/Shanghai/C1/2012 | A / H9N2 | NA | 2012-01-01A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | NAA/swine/Guangdong/1/2010 | A / H1N2 | NA | 2010-01-30A/swine/Hubei/04/2009 | A / H1N2 | NA | 2009-03-10A/swine/Guangdong/2712/2010 | A / H1N2 | NA | 2010-08-26A/swine/Guangdong/2676/2010 | A / H1N2 | NA | 2010-08-26A/swine/Hong Kong/2237/2010 | A / H1N2 | NA | 2010-08-02A/Shanghai-Fengxian/1170/2011 | A / H3N2 | NA | 2011-05-10A/Jilin-Chuanying/1156/2011 | A / H3N2 | NA | 2011-03-03A/Heilongjiang-Nangang/124/2011 | A / H3N2 | NA | 2011-03-08A/Hunan-Yanfeng/165/2011 | A / H3N2 | NA | 2011-04-14A/Shanghai-Luwan/188/2011 | A / H3N2 | NA | 2011-02-14A/Chongqing-Wanzhou/182/2011 | A / H3N2 | NA | 2011-02-20A/Hunan-Beihu/1143/2011 | A / H3N2 | NA | 2011-03-11A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | NA | 2011-03-09A/Beijing-Xicheng/1409/2011 | A / H3N2 | NA | 2011-02-22A/Tianjin-Hedong/195/2011 | A / H3N2 | NA | 2011-02-15A/duck/Zhejiang/10/2011 | A / H7N3 | NA | 2011-06-01A/duck/Jiangsu/10-d4/2011 | A / H11N3 | NA | 2011-10-01A/duck/Zhejiang/0611-8/2011 | A / H1N3 | NA | 2011-06-01A/duck/Zhejiang/12/2011 | A / H7N3 | NA | 2011-06-01A/swine/Guangdong/K4/2011 | A / H4N8 | NA | 2011-10-21A/swine/Guangdong/05/2009 | A / H1N1 | NA | 2009-05-05A/swine/Guangdong/09/2009 | A / H1N1 | NA | 2009-09-02A/duck/Guangxi/GXd-5/2010 | A / H6N1 | NA | 2010-05-08A/swine/Hubei/101/2009 | A / H1N1 | NA | 2009-08-18A/swine/Guangdong/1/2010 | A / H1N1 | NA | 2010-01-15A/GuangzhouSB/01/2009 | A / H1N1 | NA | 2009-05-17A/Nanjing/2/2009 | A / H1N1 | NA | 2009-06-17A/Beijing/01/2009 | A / H1N1 | NA | 2009-05-15A/Beijing/01/2009 | A / H1N1 | NA | 2009-05-15(2)A/Guangdong/02/2009 | A / H1N1 | NA | 2009-05-29A/Shandong/1/2009 | A / H1N1 | NA | 2009-05-10A/Shanghai/37T/2009 | A / H1N1 | NA | 2009-05-24A/Shanghai/60T/2009 | A / H1N1 | NA | 2009-05-28A/Zhejiang/2/2009 | A / H1N1 | NA | 2009-05-31A/Zhoushan/52/2009 | A / H1N1 | NA | 2009-12-19A/Jiangsu/S61/2009 | A / H1N1 | NA | 2009-11-101009894100958484879795978288908972100959492929595Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b新潟大学大学院 医歯学総合研究科 国際保健学分野
  12. 12. 7_MPavian fluhuman H1N1pdm09swine fluhuman H3N2swine fluA/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | MPA/Anhui/1/2013 | A / H7N9 | 2013-01-01 | MPA/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | MPA/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | MPA/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | MPA/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | MPA/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | MPA/Hangzhou/1/2013 | A / H7N9 | 2013-03-24 | MPA/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | MPA/chicken/Shanghai/C1/2012 | A / H9N2 | MP | 2012-01-01A/chicken/Zhejiang/611/2011 | A / H9N2 | MP | 2011-06-01A/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | MPA/duck/Jiangsu/4/2010 | A / H3N6 | MP | 2010-03-01A/duck/Guangxi/GXd-5/2010 | A / H6N1 | MP | 2010-05-08A/duck/Hubei/5/2010 | A / H6N6 | MP | 2010-05-22A/duck/Guangxi/GXd-2/2010 | A / H6N2 | MP | 2010-04-02A/duck/Jiangsu/10-d4/2011 | A / H11N3 | MP | 2011-10-01A/duck/Zhejiang/0611-8/2011 | A / H1N3 | MP | 2011-06-01A/duck/Zhejiang/12/2011 | A / H7N3 | MP | 2011-06-01A/duck/Zhejiang/10/2011 | A / H7N3 | MP | 2011-06-01A/swine/Guangdong/K4/2011 | A / H4N8 | MP | 2011-10-21A/baikal teal/Xianghai/421/2011 | A / H9N2 | MP | 2011-10-01A/green-winged teal/Xianghai/430/2011 | A / H5N2 | MP | 2011-10-01A/canvasback/Xianghai/428/2011 | A / H5N2 | MP | 2011-10-01A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | MP | 2011-10-01A/baikal teal/Xianghai/426/2011 | A / H5N2 | MP | 2011-10-01A/duck/Zhejiang/0224-6/2011 | A / H1N2 | MP | 2011-01-01A/duck/Guangdong/W12/2011 | A / H3N2 | MP | 2011-12-22A/duck/Jiangsu/1-15/2011 | A / H4N2 | MP | 2011-01-12A/duck/Jiangsu/m234/2012 | A / H5N2 | MP | 2012-01-18A/swine/Guangdong/2676/2010 | A / H1N2 | MP | 2010-08-26A/swine/Guangdong/2712/2010 | A / H1N2 | MP | 2010-08-26A/swine/Guangdong/1/2010 | A / H1N1 | MP | 2010-01-15A/swine/Hong Kong/2237/2010 | A / H1N2 | MP | 2010-08-02A/swine/Hubei/101/2009 | A / H1N1 | MP | 2009-08-18A/Zhejiang/2/2009 | A / H1N1 | MP | 2009-05-31A/Beijing/01/2009 | A / H1N1 | MP | 2009-05-15A/Beijing/01/2009 | A / H1N1 | MP | 2009-05-15(2)A/Nanjing/2/2009 | A / H1N1 | MP | 2009-06-17A/GuangzhouSB/01/2009 | A / H1N1 | MP | 2009-05-17A/Shandong/1/2009 | A / H1N1 | MP | 2009-05-10A/Jiangsu/S61/2009 | A / H1N1 | MP | 2009-11-10A/Zhoushan/52/2009 | A / H1N1 | MP | 2009-12-19A/Guangdong/02/2009 | A / H1N1 | MP | 2009-05-29A/Shanghai/37T/2009 | A / H1N1 | MP | 2009-05-24A/Shanghai/60T/2009 | A / H1N1 | MP | 2009-05-28A/blue-winged teal/Ohio/566/2006 | A / H7N9 | MP | 2006-01-01A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | MP | 2011-01-08A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | MP | 1995-05-21A/turkey/Minnesota/1/1988 | A / H7N9 | MP | 1988-07-13A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | MP | 2008-02-07A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | MP | 2008-03-05A/swine/Guangdong/05/2009 | A / H1N1 | MP | 2009-05-05A/swine/Guangdong/09/2009 | A / H1N1 | MP | 2009-09-02A/swine/Guangdong/1/2010 | A / H1N2 | MP | 2010-01-30A/swine/Hubei/04/2009 | A / H1N2 | MP | 2009-03-10A/Hunan-Yanfeng/165/2011 | A / H3N2 | MP | 2011-04-14A/Jilin-Chuanying/1156/2011 | A / H3N2 | MP | 2011-03-03A/Heilongjiang-Nangang/124/2011 | A / H3N2 | MP | 2011-03-08A/Shanghai-Luwan/188/2011 | A / H3N2 | MP | 2011-02-14A/Shanghai-Fengxian/1170/2011 | A / H3N2 | MP | 2011-05-10A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | MP | 2011-03-09A/Tianjin-Hedong/195/2011 | A / H3N2 | MP | 2011-02-15A/Chongqing-Wanzhou/182/2011 | A / H3N2 | MP | 2011-02-20A/Beijing-Xicheng/1409/2011 | A / H3N2 | MP | 2011-02-22A/Hunan-Beihu/1143/2011 | A / H3N2 | MP | 2011-03-1192749791100100100100100998810010010010010088100100100100977789100881000.01Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b新潟大学大学院 医歯学総合研究科 国際保健学分野
  13. 13. avian fluhuman H1N1pdm09swine fluhuman H3N28_NSA/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-03 | NSA/chicken/Zhejiang/DTID-ZJU01/2013 | A / H7N9 | 2013-04-01 | NSA/Shanghai/1/2013 | A / H7N9 | 2013-01-01 | NSA/Pigeon/Shanghai/S1069/2013 | A / H7N9 | 2013-04-02 | NSA/Environment/Shanghai/S1088/2013 | A / H7N9 | 2013-04-03 | NSA/Chicken/Shanghai/S1053/2013 | A / H7N9 | 2013-04-03 | NSA/Shanghai/2/2013 | A / H7N9 | 2013-01-01 | NSA/Anhui/1/2013 | A / H7N9 | 2013-01-01 | NSA/brambling/Beijing/16/2012 | A / H9N2 | 2012-11-07 | NSA/chicken/Zhejiang/611/2011 | A / H9N2 | NS | 2011-06-01A/chicken/Shanghai/C1/2012 | A / H9N2 | NS | 2012-01-01A/duck/Hubei/5/2010 | A / H6N6 | NS | 2010-05-22A/duck/Guangxi/GXd-5/2010 | A / H6N1 | NS | 2010-05-08A/swine/Guangdong/K4/2011 | A / H4N8 | NS | 2011-10-21A/duck/Guangdong/W12/2011 | A / H3N2 | NS | 2011-12-22A/duck/Jiangsu/m234/2012 | A / H5N2 | NS | 2012-01-18A/duck/Jiangsu/1-15/2011 | A / H4N2 | NS | 2011-01-12A/green-winged teal/Xianghai/430/2011 | A / H5N2 | NS | 2011-10-01A/duck/Guangxi/GXd-2/2010 | A / H6N2 | NS | 2010-04-02A/duck/Zhejiang/0224-6/2011 | A / H1N2 | NS | 2011-01-01A/duck/Jiangsu/4/2010 | A / H3N6 | NS | 2010-03-01A/spot-billed duck/Xianghai/427/2011 | A / H5N2 | NS | 2011-10-01A/canvasback/Xianghai/428/2011 | A / H5N2 | NS | 2011-10-01A/baikal teal/Xianghai/426/2011 | A / H5N2 | NS | 2011-10-01A/baikal teal/Xianghai/421/2011 | A / H9N2 | NS | 2011-10-01A/duck/Zhejiang/10/2011 | A / H7N3 | NS | 2011-06-01A/duck/Zhejiang/0611-8/2011 | A / H1N3 | NS | 2011-06-01A/duck/Jiangsu/10-d4/2011 | A / H11N3 | NS | 2011-10-01A/duck/Zhejiang/12/2011 | A / H7N3 | NS | 2011-06-01A/ruddy turnstone/Delaware Bay/220/1995 | A / H7N9 | NS | 1995-05-21A/turkey/Minnesota/1/1988 | A / H7N9 | NS | 1988-07-13A/blue-winged teal/Ohio/566/2006 | A / H7N9 | NS | 2006-01-01A/northern shoverl/Mississippi/11OS145/2011 | A / H7N9 | NS | 2011-01-08A/blue-winged teal/Guatemala/CIP049-01/2008 | A / H7N9 | NS | 2008-02-07A/blue-winged teal/Guatemala/CIP049-02/2008 | A / H7N9 | NS | 2008-03-05A/swine/Hubei/101/2009 | A / H1N1 | NS | 2009-08-18A/Chongqing-Wanzhou/182/2011 | A / H3N2 | NS | 2011-02-20A/Beijing-Xicheng/1409/2011 | A / H3N2 | NS | 2011-02-22A/Hunan-Beihu/1143/2011 | A / H3N2 | NS | 2011-03-11A/Tianjin-Hedong/195/2011 | A / H3N2 | NS | 2011-02-15A/Heilongjiang-Xiangyang/1125/2011 | A / H3N2 | NS | 2011-03-09A/Shanghai-Fengxian/1170/2011 | A / H3N2 | NS | 2011-05-10A/Shanghai-Luwan/188/2011 | A / H3N2 | NS | 2011-02-14A/Jilin-Chuanying/1156/2011 | A / H3N2 | NS | 2011-03-03A/Heilongjiang-Nangang/124/2011 | A / H3N2 | NS | 2011-03-08A/Hunan-Yanfeng/165/2011 | A / H3N2 | NS | 2011-04-14A/swine/Guangdong/05/2009 | A / H1N1 | NS | 2009-05-05A/swine/Guangdong/09/2009 | A / H1N1 | NS | 2009-09-02A/swine/Guangdong/2676/2010 | A / H1N2 | NS | 2010-08-26A/swine/Guangdong/2712/2010 | A / H1N2 | NS | 2010-08-26A/swine/Guangdong/1/2010 | A / H1N1 | NS | 2010-01-15A/swine/Hubei/04/2009 | A / H1N2 | NS | 2009-03-10A/swine/Guangdong/1/2010 | A / H1N2 | NS | 2010-01-30A/swine/Hong Kong/2237/2010 | A / H1N2 | NS | 2010-08-02A/GuangzhouSB/01/2009 | A / H1N1 | NS | 2009-05-17A/Beijing/01/2009 | A / H1N1 | NS | 2009-05-15(2)A/Shandong/1/2009 | A / H1N1 | NS | 2009-05-10A/Nanjing/2/2009 | A / H1N1 | NS | 2009-06-17A/Beijing/01/2009 | A / H1N1 | NS | 2009-05-15A/Shanghai/37T/2009 | A / H1N1 | NS | 2009-05-24A/Shanghai/60T/2009 | A / H1N1 | NS | 2009-05-28A/Guangdong/02/2009 | A / H1N1 | NS | 2009-05-29A/Zhejiang/2/2009 | A / H1N1 | NS | 2009-05-31A/Jiangsu/S61/2009 | A / H1N1 | NS | 2009-11-10A/Zhoushan/52/2009 | A / H1N1 | NS | 2009-12-1970989875100100881001009982100100100991001001001001001009810096809388Data source : GISAID http://platform.gisaid.org/epi3/frontend#5f426b新潟大学大学院 医歯学総合研究科 国際保健学分野
  14. 14. Influenza H7N9 Reassortant2011 2012 2013H9N2 chickenA/chicken/Zhejiang/611/2011H7N9 wild birdH7N3 duckH9N2 chickenA/chicken/Shanghai/C1/2012H7N9 humanA/Shanghai/1/2013H7N9 humanA/Shanghai/2/2013A/Anhui/2/2013A/duck/Zhejiang/12/2011NAHANP内部遺伝子A/Zhejiang/DTID-ZJU01/2013新潟大学大学院 医歯学総合研究科 国際保健学分野
  15. 15. We gratefully acknowledge the authors,originating and submitting laboratoriesof the sequences from GISAID’s EpiFlu Database on these analysis is based.The list is detailed below.All submitters of data may be contacted directly via the GISAID websitewww.gisaid.org or click on the links above (requires registration with GISAID)Isolate IDSegmentsCountryCollection date Isolate name Originating/Submitting Lab. SubmitterEPI_ISL_1387378 segments China 26 February 2013 A/Shanghai/1/2013 WHO Chinese National Influenza Center Yang, LeiEPI_ISL_1387388 segments China 05 March 2013 A/Shanghai/2/2013 WHO Chinese National Influenza Center Yang, LeiEPI_ISL_1387398 segments China 20 March 2013 A/Anhui/1/2013 WHO Chinese National Influenza Center Yang, LeiEPI_ISL_1389778 segments China 24 March 2013 A/Hangzhou/1/2013Hangzhou Center for Disease Control andPreventionLi, JunEPI_ISL_1389858 segments China 02 April 2013 A/Pigeon/Shanghai/S1069/2013 Harbin Veterinary Research Institute Kong, HuihuiEPI_ISL_1389848 segments China 03 April 2013A/Environment/Shanghai/S1088/2013Harbin Veterinary Research Institute Kong, HuihuiEPI_ISL_1389838 segments China 03 April 2013 A/Chicken/Shanghai/S1053/2013 Harbin Veterinary Research Institute Kong, HuihuiEPI_ISL_139364 8 segments China April 2013 A/Zhejiang/DTID-ZJU01/2013State Key Laboratory of Diagnosisand Treatment of Infectious Diseases, ZhejiangUniversityEPI_ISL_139501 8 segments China April 2013 A/chicken/Zhejiang/DTID-ZJU01/2013State Key Laboratory of Diagnosisand Treatment of Infectious Diseases, ZhejiangUniversity新潟大学大学院 医歯学総合研究科 国際保健学分野

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