Antitussives , expectorants and mucolytics
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Antitussives , expectorants and mucolytics

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    Antitussives , expectorants and mucolytics Antitussives , expectorants and mucolytics Presentation Transcript

    • Drug therapy for cough Dr. Gyanendra Raj Joshi PharmD , RPh
    • Cough • Productive cough • Unproductive cough
    • Sites of action for treatment • Peripheral sites – Afferent side – Efferent side • Central nervous system – Medullary paths – Cerebral cortex – Subcortical paths
    • Antitussives acting peripherally • Demulcents – Linctus containing syrup, glycerine , liquorice – Cough drops – Water aerosol inhalation – Steam inhalation – Compound benzoin tincture • Local anesthetics – Nebulised lidocaine
    • Antitussives that act centrally (cough centre suppressants) • Opiods – Dethadone , codeine • Non opioids – Dextromethorphan, pholcodine, noscapine • Antihistamines – Chlorpheniramine , diphenhydramine , promethazine
    • Expectorants(Mucokinetics) • Mucolytics : – Carbocysteine, mecysteine – Water inhalation via an aerosol – Bromhexine – Ambroxol – Dornase α • Bronchial secretion enhancers : – Direct acting : – Reflexly acting :
    • Nasal decongestants • • • • α adrenergic receptor agonist Mechanism Examples Adverse effects
    • Cold remedies • • • • Benign self limited syndrome Viral Combination of drugs Drugs – – – – – – – – – Intranasal ipratropium Cromolyn sodium Antihistamines Antitussives Expectorants Decongestants Intranasal glucocorticoids Leukotriene receptor antagonists Zinc
    • – Vitamins and herbal remedies – Antiviral therapy – Antibiotic therapy – NSAIDS – Exercise – Face mask – Gargling – Hydration – Warm fluids