Compiled by
Mrs J Wright, Durban Girls’ High School,2006
Slide 1

The Problem – an Ulcer!

Definition : ulcer n. an open sore on an external
or internal surface
Ulcers – found in the stomach lining, and though to be caused
by stressful living.
Slide 2
Slide 3 Using an endoscope to view an ulcer and a tissue sample then
taken to be analysed

View of an ulcer in the
stomach
Slide 4

rk
wo
eam
T

Dr Robin Warren - pathologist

The curious observation made by
Dr Robin Warren in the samples
given ...
Slide 5

In the laboratory.
Team work to produce
a culture of H. pylori!
Slide 6
Dr Barry Marshall – 1981, Australia
Slide 7
Culture of Helicobacter pylori

A sample was taken
and viewed under the
Electron Microscope

After months of trial...
Slide 8

The villian!

A

Helicobacter pylori

B

C
Slide 9

Scanning E.M of H.pylori on
the stomach walls.

Removal of H. pylori
and healing of the
ulcer?
Slide 10

How the ulcer is formed
H. pylori causes excess production
of HCl by cells of the stomach
lining. The stomach is...
Slide 11

Test kits for
Helicobactera
pylori
Slide 12
Drinking the urea solution:
Blowing out into a test tube.
Slide 13
H. pylori breath test – gas chromatograph reads results.
Slide 14
How the test works.

Ammonia identified in exhaled air.
This is due to H. pylori conversion of
Urea into ammonia.
Slide 15
Results that provide further proof of the
connection between H pylori and ulcers.

H pylori removed within 2 week...
Slide16
Communicating their findings

Book: The Ease &
Difficulty of a New
Discovery.
Author: Robin Warren
Slide17

Acceptance at
last!
Slide 18
Slide 19
Nobel prize announced - 2005

From initial discovery in
1981 until acknowledgment
by the scientific community
in ...
Slide 20

Further findings…
H. pylori in the blood

Spread by
poverty
and down through
the families!
Simple prevention!

N...
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Bacteria helicobacter pylori - ulcers

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Bacteria helicobacter pylori - ulcers

  1. 1. Compiled by Mrs J Wright, Durban Girls’ High School,2006
  2. 2. Slide 1 The Problem – an Ulcer! Definition : ulcer n. an open sore on an external or internal surface
  3. 3. Ulcers – found in the stomach lining, and though to be caused by stressful living. Slide 2
  4. 4. Slide 3 Using an endoscope to view an ulcer and a tissue sample then taken to be analysed View of an ulcer in the stomach
  5. 5. Slide 4 rk wo eam T Dr Robin Warren - pathologist The curious observation made by Dr Robin Warren in the samples given to him to analyse. These observations were investigated by Dr Marshall.
  6. 6. Slide 5 In the laboratory. Team work to produce a culture of H. pylori!
  7. 7. Slide 6 Dr Barry Marshall – 1981, Australia
  8. 8. Slide 7 Culture of Helicobacter pylori A sample was taken and viewed under the Electron Microscope After months of trials and failures, an unplanned long weekend in the incubator produced a result!
  9. 9. Slide 8 The villian! A Helicobacter pylori B C
  10. 10. Slide 9 Scanning E.M of H.pylori on the stomach walls. Removal of H. pylori and healing of the ulcer?
  11. 11. Slide 10 How the ulcer is formed H. pylori causes excess production of HCl by cells of the stomach lining. The stomach is trying to kill the bacterium. The excess acid removes the mucus layer and the stomach cells are then attacked, resulting in an ulcer. Acid inhibitors such as Tagamet now usually prescribed for relief but they have to be taken continually.
  12. 12. Slide 11 Test kits for Helicobactera pylori
  13. 13. Slide 12 Drinking the urea solution: Blowing out into a test tube.
  14. 14. Slide 13 H. pylori breath test – gas chromatograph reads results.
  15. 15. Slide 14 How the test works. Ammonia identified in exhaled air. This is due to H. pylori conversion of Urea into ammonia.
  16. 16. Slide 15 Results that provide further proof of the connection between H pylori and ulcers. H pylori removed within 2 weeks after taking antibiotics!
  17. 17. Slide16 Communicating their findings Book: The Ease & Difficulty of a New Discovery. Author: Robin Warren
  18. 18. Slide17 Acceptance at last!
  19. 19. Slide 18
  20. 20. Slide 19 Nobel prize announced - 2005 From initial discovery in 1981 until acknowledgment by the scientific community in 2005!
  21. 21. Slide 20 Further findings… H. pylori in the blood Spread by poverty and down through the families! Simple prevention! Now thought to be responsible for stomach cancer and heart disease. Remove H pylori and reduce the risk!

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