Working to Overcome the Global Impact of Neglected Tropical Diseases   Annexe I   Working to overcome   the global impact ...
WHO Library Cataloguing-in-Publication DataFirst WHO report on neglected tropical diseases 2010: working to overcome the g...
Working to Overcome the Global Impact of Neglected Tropical Diseases       Annexe I                               Contents...
First WHO report on neglected tropical diseases                     PART 2                     5. Neglected tropical disea...
Working to Overcome the Global Impact of Neglected Tropical Diseases     Annexe I                              Foreword   ...
First WHO report on neglected tropical diseases                     settings, they do not spread to distant countries and ...
Working to Overcome the Global Impact of Neglected Tropical Diseases       Annexe Ineglected tropical diseases. The Millen...
Working to Overcome the Global Impact of Neglected Tropical Diseases    Annexe I                   Executive summaryN     ...
First WHO report on neglected tropical diseases                          Actions to address the suffering caused by NTDs a...
Working to Overcome the Global Impact of Neglected Tropical Diseases    Annexe I   As control interventions reach more peo...
Part 1   1               Neglected tropical                   diseases:                   a paradigm shift                ...
First WHO report on neglected tropical diseases                    1.1 Common features of neglected tropical diseases     ...
Neglected tropical diseases: a paradigm shift       Part 1      flexibility of treatment that allows the expansion of its ...
First WHO report on neglected tropical diseases                    NTDs rather than to their diseases; (ii) interventions ...
Neglected tropical diseases: a paradigm shift       Part 1Box 1.4.1 Common features of neglected tropical diseases A proxy...
Sixty years of growing concern       Part 1   2               Sixty years of                   growing concern            ...
First WHO report on neglected tropical diseases                    exercise intolerance and fatigue, and the impairment of...
Sixty years of growing concern       Part 1Table 2.2.1 Summary of landmarks in overcoming neglected tropical diseases1948 ...
First WHO report on neglected tropical diseases                        Most important has been the development by WHO of a...
Sixty years of growing concern        Part 1Working Group on monitoring and evaluation, concerned with the needsof nationa...
Human and economic burden        Part 1   3              Human and                  economic burden                       ...
First WHO report on neglected tropical diseases Table 3.1.1 Estimated number of disability-adjusted life years (DALYs) (in...
Human and economic burden        Part 1pain and to other forms of impairment. Small differences in disability weights,when...
First WHO report on neglected tropical diseases Table 3.2.1.1 Economic costs of selected neglected tropical diseasesa (dat...
Human and economic burden        Part 13.2.2 Costs of interventions  Assessing the burden of NTDs in terms of DALYs is a p...
First WHO report on neglected tropical diseases Table 3.2.2.1 Cost-effectiveness of controlling neglected tropical disease...
Human and economic burden        Part 1REFERENCES 1. The global burden of disease: 2004 update. Geneva, World Health Organ...
Ways forward        Part 1  4               Ways forward                                                                  ...
First WHO report on neglected tropical diseases                     to control trachoma combines the large-scale distribut...
Ways forward        Part 1Table 4.1.1.1 WHO-recommended anthelminthic medicines for use in preventive chemotherapya,b,c   ...
First WHO report on neglected tropical diseases                        Progress towards including preventive chemotherapy ...
Ways forward        Part 1              Fig. 4.1.1.1 Global coverage (%)a of preventive chemotherapy                      ...
First WHO report on neglected tropical diseases                     for preventive chemotherapy. Infection may be asymptom...
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  1. 1. Working to Overcome the Global Impact of Neglected Tropical Diseases Annexe I Working to overcome the global impact ofneglected tropical diseasesFirst WHO report on neglected tropical diseases
  2. 2. WHO Library Cataloguing-in-Publication DataFirst WHO report on neglected tropical diseases 2010: working to overcome the global impact of neglected tropical diseases. 1 Tropical medicine - trends. 2 Endemic diseases. 3 Poverty areas. 4. Parasitic diseases. 5 Developing countries. 6. Annual reports. I. World Health OrganizationISBN 978 92 4 1564090 (NLM Classification: WC 680)Working to overcome the global impact of neglected tropical diseases was produced under the overall direction and supervision ofDr Lorenzo Savioli (Director, WHO Department of Control of Neglected Tropical Diseases) and Dr Denis Daumerie (Programme Manager,WHO Department of Control of Neglected Tropical Diseases), with contributions from staff serving in the department.Regional directors and members of their staff provided support and advice.Valuable inputs in the form of contributions, peer reviews and suggestions were received by members of the Strategic and TechnicalAdvisory Group for Neglected Tropical Diseases.The report was edited by Professor David W.T. Crompton, assisted by Mrs Patricia Peters.© World Health Organization 2010All rights reserved. Publications of the World Health Organization can be obtained from WHO Press, World Health Organization, 20Avenue Appia, 1211 Geneva 27, Switzerland (tel.: +41 22 791 3264; fax: +41 22 791 4857; e-mail: bookorders@who.int). Requestsfor permission to reproduce or translate WHO publications – whether for sale or for noncommercial distribution – should be addressedto WHO Press, at the above address (fax: +41 22 791 4806; e-mail: permissions@who.int).The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoeveron the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, orconcerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which theremay not yet be full agreement.The mention of specific companies or of certain manufacturers’ products does not imply that they are endorsed or recommended bythe World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, thenames of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication.However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility forthe interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damagesarising from its use.Design and cover: Denis MeissnerLayout: Denis Meissner, Claudia CorazzolaFigures: Christophe GrangierPrinted by WHO/DUPWHO/HTM/NTD/2010.1
  3. 3. Working to Overcome the Global Impact of Neglected Tropical Diseases Annexe I ContentsForeword by the Director-General iiiExecutive summary viiPART 11. Neglected tropical diseases: a paradigm shift 1 1.1 Common features of neglected tropical diseases 2 1.2 New strategic approaches 2 1.3 Refocusing 4 1.4 Lessons learnt 42. Sixty years of growing concern 7 2.1 World Health Assembly resolutions 8 2.2 Landmarks in prevention and control 8 2.3 Strategic and Technical Advisory Group for Neglected Tropical Diseases 103. Human and economic burden 13 3.1 Epidemiological burden 13 3.2 Economic burden 15 3.2.1 Economic impact 15 3.2.2 Costs of interventions 174. Ways forward 21 4.1 Approaches to overcoming neglected tropical diseases 21 4.1.1 Preventive chemotherapy 22 4.1.2 Intensified case-management 25 4.1.3 Vector control 26 4.1.4 Safe water, sanitation and hygiene 22 4.1.5 Veterinary public health: 28 zoonotic aspects of neglected tropical diseases 4.2 Current policies and strategies 29 4.2.1 The Global plan to combat neglected tropical diseases 2008–2015 31 4.2.2 Neglected tropical diseases and the Millennium Development Goals 32 4.2.3 Neglected tropical diseases and health-system strengthening 34 i
  4. 4. First WHO report on neglected tropical diseases PART 2 5. Neglected tropical diseases in the world today 39 5.1 Dengue 41 5.2 Rabies 47 5.3 Trachoma 55 5.4 Buruli ulcer (Mycobacterium ulcerans infection) 59 5.5 Endemic treponematoses 64 5.6 Leprosy (Hansen disease) 69 5.7 Chagas disease (American trypanosomiasis) 75 5.8 Human African trypanosomiasis (sleeping sickness) 82 5.9 Leishmaniasis 91 5.10 Cysticercosis 97 5.11 Dracunculiasis (guinea-worm disease) 103 5.12 Echinococcosis 107 5.13 Foodborne trematode infections 113 5.14 Lymphatic filariasis 117 5.15 Onchocerciasis (river blindness) 123 5.16 Schistosomiasis (bilharziasis) 129 5.17 Soil-transmitted helminthiases 135 6. Global and regional plans for prevention and control 143 6.1 Health targets 143 6.2 Regional plans 146 7. Conclusions 147 Overcoming neglected tropical diseases: 7 gains, 7 challenges Annexes 153 1. Resolutions of the World Health Assembly on neglected tropical diseases 155 2. Official list of indicators for monitoring progress on the Millennium 159 Development Goals 3. Summary of metadata 163 4. Methods used to prepare maps and charts 169 Available in electronic format WHO’s global and regional plans for prevention and control African Region Region of the Americas Eastern Mediterranean Region South-East Asia Region Western Pacific Regionii
  5. 5. Working to Overcome the Global Impact of Neglected Tropical Diseases Annexe I Foreword by the Director-General of the World Health Organization Tackling neglected tropical diseases: a pro-poor strategy on a grand scaleT hough medically diverse, neglected tropical diseases form a group because all are strongly associated with poverty, all flourish in impoverished environments and all thrive best in tropical areas, where they tend to co-exist. Most are ancient diseases that have plagued humanity for centuries. Once widely prevalent, many of these diseases gradually disappeared fromlarge parts of the world as societies developed and living conditions and hygieneimproved. Today, though neglected tropical diseases impair the lives of anestimated 1 billion people, they are largely hidden, concentrated in remote ruralareas or urban slums and shantytowns. They are also largely silent, as the peopleaffected or at risk have little political voice. Neglected tropical diseases have traditionally ranked low on national andinternational health agendas. They cause massive but hidden and silent suffering,and frequently kill, but not in numbers comparable to the deaths caused byHIV/AIDS, tuberculosis or malaria. Tied as they are to impoverished tropical iii
  6. 6. First WHO report on neglected tropical diseases settings, they do not spread to distant countries and only rarely affect travellers as, for example, during outbreaks of dengue. Because they are a threat only in impoverished settings they have low visibility in the rest of the world. Though greatly feared in affected populations, they are little known and poorly understood elsewhere. While the scale of the need for prevention and treatment is huge, the poverty of those affected limits their access to interventions and the services needed to deliver them. Diseases linked to poverty likewise offer little incentive to industry to invest in developing new or better products for a market that cannot pay. Today, neglected tropical diseases have their breeding grounds in the places left furthest behind by socioeconomic progress, where substandard housing, lack of access to safe water and sanitation, filthy environments, and abundant insects and other vectors contribute to efficient transmission of infection. Close companions of poverty, these diseases also anchor large populations in poverty. Onchocerciasis and trachoma cause blindness. Leprosy and lymphatic filariasis deform in ways that hinder economic productivity and cancel out chances for a normal social life. Buruli ulcer maims, especially when limbs have to be amputated to save a life. Human African trypanosomiasis (sleeping sickness) severely debilitates before it kills, and mortality approaches 100% in untreated cases. Without post-exposure prophylaxis, rabies causes acute encephalitis and is always fatal. Leishmaniasis, in its various forms, leaves deep and permanent scars or entirely destroys the mucous membranes of the nose, mouth and throat. In its most severe form, it attacks the internal organs and is rapidly fatal if untreated. Chagas disease can cause young adults to develop heart conditions, so that they fill hospital beds instead of the labour force. Severe schistosomiasis disrupts school attendance, contributes to malnutrition and impairs the cognitive development of children. Guinea-worm disease causes excruciating, debilitating pain, sometimes for extended periods and often coinciding with the peak agricultural season. Dengue has emerged as a rapidly spreading vector-borne disease affecting mostly poor, urban populations; it is also the leading cause of hospital admissions in several countries. The consequences are costly for societies and for health care. Such costs include intensive care for dengue haemorrhagic fever and clinical rabies, surgery and prolonged hospital stays for Chagas disease and Buruli ulcer, and rehabilitation for leprosy and lymphatic filariasis. For some diseases, such as sleeping sickness and leishmaniasis, treatments are old, cumbersome to administer and toxic. For others, especially the diseases that cause blindness, the damage is permanent. Clinical development of rabies can be prevented through timely immunization after exposure, but access to life-saving biologicals is expensive and is not affordable in many Asian and African countries. For most of these diseases, stigma and social exclusion compound the misery, especially for women. Fortunately, these problems are now much better documented and much more widely recognized. They are also being addressed. Recent developments on several fronts have radically changed the prospects for controlling these diseases, and new initiatives are enabling the people left behind by socioeconomic progress to catch up. The ambitions for health development have broadened, creating space foriv
  7. 7. Working to Overcome the Global Impact of Neglected Tropical Diseases Annexe Ineglected tropical diseases. The Millennium Declaration and its Goals recognizethe contribution of health to the overarching objective of reducing poverty. Effortsto control neglected tropical diseases constitute a pro-poor strategy on a grandscale. The logic has changed: instead of waiting for these diseases to graduallydisappear as countries develop and living conditions improve, a deliberate effortto make them disappear is now viewed as a route to poverty alleviation that canitself spur socioeconomic development. As this report shows, reaching such an objective is now entirely feasible for themasses of people known to be affected or at risk. Good medicines are availablefor many of these diseases, and research continues to document their safetyand efficacy when administered individually or in combination. Generous drugdonations by pharmaceutical companies have helped relieve some of the financialbarriers and allowed programmes to scale up coverage. A strategy of preventivechemotherapy, which mimics the advantages of childhood immunization, is beingused to protect entire at-risk populations and reduce the reservoir of infection. Thefact that many of these diseases overlap geographically has practical advantages:preventive chemotherapy regimens are being integrated so that several diseases canbe tackled together, thus streamlining operational demands and cutting costs. Anintegrated approach to vector management likewise maximizes the use of resourcesand tools for controlling vector-borne diseases. Governments and foundations have contributed substantial funds. Researchto develop new tools (such as medicines, diagnostics, vaccines and medicaldevices) and improve the delivery of existing ones has increased. The momentumcontinues to grow. As the report shows, nearly 670 million people had been reachedwith preventive chemotherapy by the end of 2008. For some of these diseases,evidence indicates that, when a certain threshold of population coverage isreached, transmission drops significantly; this raises the possibility that severalof these ancient diseases could be eliminated by 2020 if current efforts to scale upinterventions for preventive chemotherapy are increased. While the report highlights a number of remaining challenges, the overallmessage is overwhelmingly positive. It is entirely possible to control neglectedtropical diseases. Aiming at their complete control and even elimination is fullyjustified, and this report sets out the solid evidence needed to achieve control.Above all, it makes the case for doing more, as an international community, torelieve hidden misery, on a grand scale, among people who would otherwise sufferin silence. Dr Margaret Chan Director-General World Health Organization v
  8. 8. Working to Overcome the Global Impact of Neglected Tropical Diseases Annexe I Executive summaryN eglected tropical diseases (NTDs) blight the lives of a billion people worldwide and threaten the health of millions more. These ancient companions of poverty weaken impoverished populations, frustrate theachievement of health in the Millennium Development Goals and impede globalGHYHORSPHQW RXWFRPHV $ PRUH UHOLDEOH HYDOXDWLRQ RI WKHLU VLJQL¿FDQFH WR SXEOLFhealth and economies has convinced governments, donors, the pharmaceuticalindustry and other agencies, including nongovernmental organizations (NGOs), toinvest in preventing and controlling this diverse group of diseases. Global efforts tocontrol “hidden” diseases, such as dracunculiasis (guinea-worm disease), leprosy,VFKLVWRVRPLDVLV OPSKDWLF ¿ODULDVLV DQG DZV KDYH LHOGHG SURJUHVVLYH KHDOWKgains including the imminent eradication of dracunculiasis. Since 1989 (whenmost endemic countries began reporting monthly from each endemic village),the number of new dracunculiasis cases has fallen from 892 055 in 12 endemiccountries to 3190 in 4 countries in 2009, a decrease of more than 99%. The World Health Organization (WHO) recommends five public-healthstrategies for the prevention and control of NTDs: preventive chemotherapy;intensified case-management; vector control; the provision of safe water,sanitation and hygiene; and veterinary public health (that is, applying veterinarysciences to ensure the health and well-being of humans). Although one approachPD SUHGRPLQDWH IRU FRQWURO RI D VSHFL¿F GLVHDVH RU JURXS RI GLVHDVHV HYLGHQFHVXJJHVWV WKDW PRUH HIIHFWLYH FRQWURO UHVXOWV ZKHQ DOO ¿YH DSSURDFKHV DUH FRPELQHGand delivered locally. Activities to prevent and control NTDs are included in the policies and budgetsof many endemic countries. This has led to the development of interventions thatare appropriate to existing health systems, often with the support of implementingSDUWQHUV 2YHUDOO DW OHDVW PLOOLRQ SHRSOH LQ FRXQWULHV EHQH¿WWHG IURPpreventive chemotherapy during 2008, although not all were given the fullSDFNDJH RI PHGLFLQHV /PSKDWLF ¿ODULDVLV RQFKRFHUFLDVLV VFKLVWRVRPLDVLV VRLOtransmitted helminthiases and trachoma are being controlled mostly through thisapproach. These are a group of infections with a high disease burden for whichsafe and simple treatments are available. vii
  9. 9. First WHO report on neglected tropical diseases Actions to address the suffering caused by NTDs and assess how their impact extends into sectors other than health will promote development by breaking the cycle of poverty and disease; foster health security by reducing the vulnerability of human and animal populations to infection; and strengthen health systems by embedding strategic approaches and locally appropriate interventions into national health programmes. The development of regional plans in response to the Global plan to combat neglected tropical diseases 2008–2015 has also led to growing awareness of NTDs and the suffering they cause. The involvement of the pharmaceutical industry in NTDs, and subsequent donations made to support their control, have increased access to high-quality medicines free of charge for hundreds of millions of poor people. The increasing willingness and commitment of local and global communities of partners to work with endemic countries have brought resources, innovation, expertise and advocacy to efforts to overcome NTDs. Intersectoral collaboration, involving education, nutrition and agriculture, has reinforced NTD control. $FKLHYLQJ DQG VXVWDLQLQJ LQWHQVL¿HG FRQWURO RI 17V ZLOO EH D FULWLFDO PLOHVWRQH for WHO in realizing its objective that all people attain the highest possible level RI KHDOWK )RU H[DPSOH WKH QXPEHU RI QRWL¿HG QHZ FDVHV RI WKH FKURQLF IRUP RI human African trypanosomiasis (T. b. gambiense) has fallen by 62%, from 27 862 in 1999 to 10 372 in 2008, and the number of newly reported cases of the acute form (T. b. rhodesiense) has fallen by 58%, from 619 to 259, due largely to LQWHQVL¿HG FDVHGHWHFWLRQ DQG PDQDJHPHQW 7KLV UHSRUW DOVR LGHQWL¿HV FKDOOHQJHV WKDW ZLOO KDYH WR EH IDFHG LI WKH FXUUHQW achievements in NTD prevention and control are to be sustained and extended. Despite global economic constraints, support from Spain, the United Kingdom, the United States, other countries, agencies and NGOs will need to be sustained. These commitments should encourage others to expand their support for developing the services needed to overcome NTDs. Planning for the development and control of NTDs should take into account the effects of porous borders, population growth and migration, urbanization, the movement of livestock and vectors, and the political and geographical consequences of climate change. Several of these factors help to explain the rapidly increasing global spread of dengue. From 2001 to 2009, a total of 6 626 950 cases were reported to WHO from more than 30 countries in WHO’s Region of the Americas, where all four serotypes of the virus circulate. During the same period, there were 180 216 cases of dengue haemorrhagic fever and 2498 deaths reported to WHO. Dengue has resurged in the region because successful vector surveillance and control measures were not sustained after the campaign to eradicate Aedes aegypti, the principal vector, during the 1960s and early 1970s. Explosive outbreaks now occur every 35 years. The South-East Asia Region accounts for most deaths, but the decline in case-fatality rates since 2007 has been attributed mainly to effective training in standardized case-management, based on a network of expertise, and training materials developed by Member countries in the region.viii
  10. 10. Working to Overcome the Global Impact of Neglected Tropical Diseases Annexe I As control interventions reach more people and new technology is embraced,quicker responses will need to be made to information about the epidemiology,transmission and burden of NTDs. Similarly, programme managers will needto react quickly to information about the coverage, compliance, acceptance andimpact of interventions. Expertise in individual NTDs is lacking in some countries and continues todecline in others. The decline in expertise is severe in the areas of vector control,case-management, pesticide management and veterinary aspects of public health.The ways to prevent and control rabies – a zoonotic disease that kills about 55 000people annually in Africa and Asia and necessitates post-exposure prophylaxisof more than 14 million patients worldwide following contact with suspect rabidanimals – are not known or well understood in many countries where the diseaseexists. As expansion of prevention and control activities increases, the need tostrengthen health systems, and to train and support staff in technical andmanagement expertise, will become more urgent. Targets for coverage set by the World Health Assembly for control of lymphatic¿ODULDVLV VFKLVWRVRPLDVLV VRLOWUDQVPLWWHG KHOPLQWKLDVHV DQG WUDFKRPD ZLOOnot be met, especially in WHO’s African and South-East Asia regions, unlessinterventions with preventive chemotherapy increase. In 2008, only 8% ofpeople with schistosomiasis had access to high-quality medicines. Donations ofSUD]LTXDQWHO IURP WKH SULYDWH VHFWRU DQG IXQGV IRU LWV SURGXFWLRQ DUH LQVXI¿FLHQW WRprovide the quantities of this essential medicine needed to control schistosomiasis.The provision of medicines to treat soil-transmitted helminthiases also must beLQFUHDVHG VLJQL¿FDQWO 3URGXFWLRQ RI PHGLFLQHV XVHG WR WUHDW 17V PXVW EH PDGHmore attractive to companies that manufacture generic pharmaceuticals. A research strategy is required to develop and implement new medicines,notably for leishmaniasis and trypanosomiasis; new methods for vector control;vaccines for dengue; and new diagnostics that will be accessible to all who needthem. The Strategic Technical and Advisory Group for NTDs, at its meeting in Genevain late June 2010, reviewed this report and commended it to the communitydedicated to the global prevention and control of these diseases of poverty. The theme at the global partners’ meeting in Geneva in April 2007 was thata turning point had been reached in the efforts to overcome NTDs. The contentof this report demonstrates that there can be no turning back: the concept of³QHJOHFWHG´ LV FRQ¿QHG WR WKH KLVWRU RI SXEOLF KHDOWK ix
  11. 11. Part 1 1 Neglected tropical diseases: a paradigm shift © Sarah CleavelandI n 2003, the World Health Organization (WHO) initiated a paradigm shift in the control and elimination of a group of neglected tropical diseases (NTDs). The process – led by the former Director-General, the late Dr JW Lee –involved an important strategic change, from a traditional approach centred ondiseases to one responding to the health needs of marginalized communities. The new approach uses integrated interventions based on tools for controllingNTDs. From a public-health perspective, this change translated into the provisionof care and the delivery of treatment to underserved populations. The shiftensures a more efficient use of limited resources and the alleviation of povertyand accompanying illness for millions of people living in rural and urban areas. This emerging vision was sharpened at a meeting held in Berlin, Germany,in December 2003 that convened experts from diverse sectors, including publichealth, economics, human rights, research, nongovernmental organizations(NGOs) and the pharmaceutical industry. The meeting set the scene for WHO totranslate the new approach into a strategic policy and formulate ways of providingpoor populations with an effective and comprehensive solution to some of theirhealth problems. From 2003 to 2007, bold steps were taken to develop a frameworkfor tackling NTDs in a coordinated and integrated way. Details of the frameworkare set out in section 4 of this report and in WHO’s Global plan to combat neglectedtropical diseases 2008–2015. 1
  12. 12. First WHO report on neglected tropical diseases 1.1 Common features of neglected tropical diseases The 17 neglected tropical diseases profiled in this report share several common features, which are summarized in Box 1.4.1. The most profound commonality is their stranglehold on populations whose lives are ravaged by poverty. During the past decade, the international community’s recognition of this unacceptable situation has stimulated the growth of a community of partners committed to resolving this double bind of disease and poverty. Working to overcome the impact of NTDs represents a largely untapped development opportunity to alleviate the poverty of many populations and thereby make a direct impact on the achievement of the Millennium Development Goals (MDGs) as well as fulfilling WHO’s mission: ensuring attainment of the highest standard of health as a fundamental human right of all peoples. 1.2 New strategic approaches Preventive chemotherapy – a strategy first used for delivering anthelminthic medicines by means of a population-based approach – focuses on optimizing the use of single-administration medicines targeted simultaneously at more than one form of helminthiasis. Efforts to tackle helminth infections in a coordinated fashion can be traced back to the 2001 World Health Assembly resolution WHA54.19 on schistosomiasis and soil-transmitted helminth infections, which set common objectives and goals for their prevention and control. Five years later in 2006, this concept was further developed when WHO published a manual on preventive chemotherapy in human helminthiases recommending the integrated implementation of disease interventions against the four main helminth infections (lymphatic filariasis, onchocerciasis, schistosomiasis and soil-transmitted helminthiases) based on the coordinated use of a set of powerful anthelminthic medicines with an impressive safety record. Preventive chemotherapy is now implemented worldwide and is used to treat more than half a billion people every year. The success of preventive chemotherapy is attributable to a number of factors including: the impact of preventive chemotherapy in reducing morbidity and sustaining decreases in transmission; demonstration of the association of helminth infections with poverty and disadvantage, and of the geographical overlap of the four main helminth infections targeted; the added benefit of controlling a number of infections and infestations not specifically targeted by the intervention (such as strongyloidiasis, scabies and lice);2
  13. 13. Neglected tropical diseases: a paradigm shift Part 1 flexibility of treatment that allows the expansion of its target to other helminth infections (such as fascioliasis and other foodborne trematode infections). The use of existing mechanisms to deliver anthelminthic medicines providesa platform to target other communicable diseases (such as trachoma) and pavesthe way for expansion of a public-health approach that shares common featureswith immunization. For protozoan and bacterial diseases, such as human African trypanosomiasis(sleeping sickness), leishmaniasis, Chagas disease and Buruli ulcer (Mycobacteriumulcerans infection), the new focus on improved and timely access to specializedcare through improved case detection and decentralized clinical management isintended to prevent mortality, reduce morbidity and interrupt transmission. Tackling these diseases effectively requires specific and profound expertise. Inthe long term, WHO must ensure that sustainable steps are being taken to preventthese diseases and to promote the development of better, safer, more affordableand simpler-to-use diagnostic methods and medicines. Until such methods become available, the focus remains on optimizing the useof existing treatments and expanding their access to a greater number of people,who may immediately benefit from a more coordinated strategic approach,through innovative and intensified case-management. The approach to vector control has also been revisited in light of the new,integrated strategic framework. Vector control now serves as an important cross-cutting activity aimed at enhancing the impact and the performance of bothpreventive chemotherapy and case-management. Integrated vector managementis an effective combination of different interventions and forms part of anintersectoral and interprogrammatic collaboration within the health sector andwith other sectors, including agriculture and the environment. Its aim is toimprove the efficacy, cost-effectiveness, ecological soundness and sustainabilityof disease control implemented against vector-borne NTDs.1.3 Refocusing Following its second meeting in Berlin in 2005, WHO proposed that thevaguely defined term “other communicable diseases” be changed to the moresharply focused “neglected tropical diseases”. This change neatly encapsulatedthe paradigm shift responsible for the new approach to dealing with NTDs. Thechange recognizes that NTD control can be achieved if three requirements aremet: (i) attention and action are given to the needs of populations affected by 3
  14. 14. First WHO report on neglected tropical diseases NTDs rather than to their diseases; (ii) interventions to deliver treatments are integrated with control measures; and (iii) evidence-based advocacy is deployed to generate resources for control from the international community. In April 2007, WHO convened its first meeting of Global Partners on NTDs, which was attended by more than 200 participants, including representatives from WHO’s Member States, United Nations agencies, the World Bank, philanthropic foundations, universities, pharmaceutical companies, international NGOs and other institutions dedicated to contributing their time, efforts and resources to tackling these diseases. 1.4 Lessons learnt The paradigm shift has enabled Member States and partners to find innovative solutions to enable weak health systems to target the people most in need: the poorest sectors of the population with limited or non-existent financial means. Grouping several diseases together under a new conceptual framework presents an opportunity to recalculate the collective burden associated with this set of diverse afflictions as well as their cumulative public-health relevance. The framework has also enabled WHO to raise the profile of NTDs and to mobilize resources for scaling up implementation of activities for their global control and elimination. This report is confined to 17 NTDs, although some comprise separate infections and thus separate diseases: for example, soil-transmitted helminthiases comprise three separate infections and therefore three separate diseases. There are 149 countries and territories where NTDs are endemic, at least 100 of which are endemic for 2 or more diseases, and 30 countries that are endemic for 6 or more. © Sarah Cleaveland4
  15. 15. Neglected tropical diseases: a paradigm shift Part 1Box 1.4.1 Common features of neglected tropical diseases A proxy for poverty and disadvantage Neglected tropical diseases have an enormous impact on individuals, families and communities in developing countries in terms of disease burden, quality of life, loss of productivity and the aggravation of poverty as well as the high cost of long-term care. They constitute a serious obstacle to socioeconomic development and quality of life at all levels. Affect populations with low visibility and little political voice This group of diseases largely affects low-income and politically marginalized people living in rural and urban areas. Such people cannot readily influence administrative and governmental decisions that affect their health, and often seem to have no constituency that speaks on their behalf. Diseases associated with rural poverty may have little impact on decision-makers in capital cities and their expanding populations. Do not travel widely Unlike influenza, HIV/AIDS and malaria and, to a lesser extent, tuberculosis, most NTDs generally do not spread widely, and so present little threat to the inhabitants of high-income countries. Rather, their distribution is restricted by climate and its effect on the distribution of vectors and reservoir hosts; in most cases, there appears to be a low risk of transmission beyond the tropics. Cause stigma and discrimination, especially of girls and women Many NTDs cause disfigurement and disability, leading to stigma and social discrimination. In some cases, their impact disproportionately affects girls and women, whose marriage prospects may diminish or who may be left vulnerable to abuse and abandonment. Some NTDs contribute to adverse pregnancy outcomes. Have an important impact on morbidity and mortality The once-widespread assumptions held by the international community that people at risk of NTDs experience relatively little morbidity, and that these diseases have low rates of mortality, have been comprehensively refuted. A large body of evidence, published in peer-reviewed medical and scientific journals, has demonstrated the nature and extent of the adverse effects of NTDs. Are relatively neglected by research Research is needed to develop new diagnostics and medicines, and to make accessible interventions to prevent, cure and manage the complications of all NTDs. Can be controlled, prevented and possibly eliminated using effective and feasible solutions The five strategic interventions recommended by WHO (preventive chemotherapy; intensified case- management; vector control; the provision of safe water, sanitation and hygiene; and veterinary public health) make feasible control, prevention and even elimination of several NTDs. Costs are relatively low. 5
  16. 16. Sixty years of growing concern Part 1 2 Sixty years of growing concern © WHO / Christopher BlackS ince its founding in 1948, WHO has led the common endeavour of protecting people from infectious diseases, recognizing that the interests of its Member States are best served if the peoples of other countries are also helped to livein healthy conditions (1). This report is the first of its kind to review WHO’s work to prevent, control,eliminate and eradicate 17 NTDs. Section 5 provides a detailed account of thesediseases. History shows that NTDs have not been overlooked or neglected byWHO (2). The Fifth World Health Assembly, held in Geneva, Switzerland, inMay 1952, addressed the technical assistance needed by countries to deal withtreponematoses, rabies, leprosy, trachoma, hookworm, schistosomiasis and bothforms of filariasis (3). These diseases are included in WHO’s mandate today (4, 5),and it remains committed and available to attend to requests for prevention andcontrol from countries where NTDs are endemic. In some ways, application of the term “neglected” to the communicable diseasesdiscussed in this report may appear inappropriate, since it is clear that WHO hasnever neglected them. Rather, WHO has consistently highlighted the impact thatthese diseases impose on its Member States. The overt consequences of infectionwith the causative agents of NTDs include skin ulcers, blindness, limb deformitiesand chronic pain. Less evident, but no less debilitating, are lesions to internalorgans, anaemia, growth retardation, impairment of cognitive development, 7
  17. 17. First WHO report on neglected tropical diseases exercise intolerance and fatigue, and the impairment of mental functions through neurological sequelae. These conditions blight the social, educational and professional lives of populations affected by NTDS, most of whom are poor people. Left untreated, diseases such as dengue haemorrhagic fever, human African trypanosomiasis, visceral leishmaniasis and rabies are commonly fatal. The heavy burden imposed by NTDs on poor people has been gaining wider recognition and prominence in countries and by institutions with the capacity to release resources for prevention and control. Effective advocacy has successfully exploited the notion of “neglected” and stimulated health policy-makers to work to overcome NTDs in harmony with the ideals and aims of the MDGs. Tools for treatment interventions in communities can now reach the millions in need. Resources are needed to support the research required to develop new medicines and diagnostics, to produce and test tools for interventions, and to facilitate the clinical management of several NTDs. Advocacy to support activities to overcome NTDs must continue if resources for extending sustainable relief are to be forthcoming. A record of the scale of the most encouraging global response has been published in the Report of the global partners’ meeting on neglected tropical diseases (6). In effect, partners at that meeting demonstrated their response to “the Golden Rule”, displayed as a mosaic by the 20th-century American painter and illustrator Norman Rockwell on a wall in the headquarters of the United Nations in New York: “Do unto others as you would have them do unto you”. 2.1 World Health Assembly resolutions Every year, the World Health Assembly – the supreme decision-making body of WHO – evaluates the status of different health problems and decides whether the adoption of a specific resolution will add impetus to the effort designed to bring relief, and so improve the quality of life of populations at risk. The first resolution on what are now termed NTDs was adopted by the Second World Health Assembly in 1949 (Annex 1). 2.2 Landmarks in prevention and control In addition to the work underpinning and justifying the resolutions of the World Health Assembly, a series of initiatives has been proposed to form partnerships, strengthen measures and raise financial and other support to prevent and control NTDs (Table 2.2.1).8
  18. 18. Sixty years of growing concern Part 1Table 2.2.1 Summary of landmarks in overcoming neglected tropical diseases1948 World Health Organization (WHO) begins work WHO establishes Veterinary Public Health Programme1952 UNICEF and WHO launch Global Yaws Programme1960 WHO launches Programme for the Evaluation and Testing of New Insecticides1974 Onchocerciasis Control Programme for West Africa begins1976 Special Programme for Research and Training in Tropical Diseases established1982 The Carter Center is inaugurated and begins work1987 Mectizan® Donation Program created1995 International Commission for the Certification of Dracunculiasis Eradication established African Programme for Onchocerciasis Control set up1997 Programme Against African Trypanosomiasis established WHO-GET 2020 Alliance (Global Elimination of Trachoma by the year 2020) created Pfizer starts donation of azithromycin1998 Prime Minister Hashimoto of Japan presents his parasite-control initiative to the G8 Meeting Global Buruli Ulcer Initiative established Médecins Sans Frontières initiates a fund to fight neglected tropical diseases from the proceeds of its Nobel Peace Prize1999 WHO Study Group on Future Trends in Veterinary Public Health established2000 WHO Global Programme to Eliminate Lymphatic Filariasis launched Bill Melinda Gates Foundation created Pan African Tsetse and Trypanosomiasis Eradication Campaign created2002 WHO publishes Global defence against the infectious disease threat Publication of the first version of the WHO model formulary2003 First issue of WHO’s newsletter Action Against Worms Drugs for Neglected Diseases Initiative established Berlin, Germany, hosts workshop on intensified control of neglected diseases2004 Third global meeting of the Partners for Parasite Control, leading to publication of Deworming for health and development2005 Strategic and technical meeting on intensified control of neglected tropical diseases held in Berlin, Germany First International Conference on the Control of Neglected Zoonotic Diseases: a route to poverty alleviation held at WHO headquarters in Geneva, Switzerland WHO Department of Control of Neglected Tropical Diseases established Bangladesh, India and Nepal sign an agreement to eliminate visceral leishmaniasis by 20152006 Collaboration begins between WHO and the Foundation for Innovative New Diagnostics to develop and evaluate new diagnostic tests for human African trypanosomiasis Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions. A manual for health professionals and programme managers published by WHO2007 Global partners’ meeting on neglected tropical diseases held at WHO headquarters in Geneva, Switzerland Joint meeting on Integrated Control of Neglected Zoonotic Diseases in Africa, held in Nairobi, Kenya2008 Launch of the Neglected Tropical Disease Initiative by the Government of the United States Announcement that neglected tropical diseases are to be targeted following a new £50 million commitment from the Department for International Development of the Government of the United Kingdom 9
  19. 19. First WHO report on neglected tropical diseases Most important has been the development by WHO of a framework for action that gives equal attention to neglected communities and their health problems. The communities where NTDs are entrenched have limited financial resources, a shortage of trained health workers and an urgent need for a stronger infrastructure to facilitate the delivery of health services (7). Implementation of this framework still depends heavily on input from countries where NTDs are not endemic. The response has been significant, thanks to bilateral donations, the generosity of the pharmaceutical industry, and the work of NGOs, implementing agencies, universities and philanthropic institutions. There is, however, growing recognition that successful and sustainable control depend on the political commitment and ownership of interventions by governments of countries where the diseases are endemic. In his Annual Report of 1951 (8), Dr Brock Chisholm – the first Director-General of WHO – was aware of this essential aspect of NTD control. He declared, “Too often countries requesting assistance have been the object of well-meaning but disastrous attempts to superimpose on the local culture foreign patterns which, lacking the necessary foundations, are bound to result in friction, misunderstanding and ultimate failure. In health work, as in all other fields of technical assistance, there can be no question of simply transplanting techniques from one place to another”. 2.3 Strategic and Technical Advisory Group for Neglected Tropical Diseases In 2007, WHO established a Strategic and Technical Advisory Group for neglected tropical diseases to support actions taken to overcome these diseases. The group serves as the principal advisory group to WHO and the Director- General on matters relating to the prevention and control of NTDs worldwide. Its main objective is to support the achievement of the goals contained in the Global plan to combat neglected tropical diseases 2008–2015 (5). Members have expertise in the range of NTDs and represent disease-endemic countries, academia, donors and agencies; the group is supported by WHO’s regional staff and secretariat. In response to advice from the Strategic and Technical Advisory Group, and after consultation with the global NTD community, WHO established three working groups, each with a remit to cover key aspects of managing the control of NTDs: Working Group on access to quality-assured, essential medicines for NTD control, concerned with improving implementation, increasing effectiveness, using economies of scale and developing faster self-reliance by health authorities in endemic countries.10
  20. 20. Sixty years of growing concern Part 1Working Group on monitoring and evaluation, concerned with the needsof national programmes, monitoring disease-specific indicators, andmonitoring coverage of interventions and their impact.Working Group on anthelminthic drug efficacy, concerned with thepossible emergence of drug resistance, which could accelerate as access topreventive chemotherapy expands. REFERENCES 1. Brockington F. World health. Harmondsworth, Penguin Books Ltd., 1958. 2. Account of the First World Health Assembly. Chronicle of the World Health Organization, 1948, 177(2):180–182. 3. Account of the Fifth World Health Assembly. Chronicle of the World Health Organization, 1952, 6:161–250. 4. Global defence against the infectious disease threat. Geneva, World Health Organization, 2003 (WHO/CDS/2003.15). 5. Global plan to combat neglected tropical diseases 2008–2015. Geneva, World Health Organization, 2007 (WHO/CDS/NTD/2007.3). 6. Report of the global partners’ meeting on neglected tropical diseases: a turning point. Geneva, World Health Organization, 2007 (WHO/CDS/NTD/2007.4). 7. Intensified control of neglected diseases: report of an international workshop, Berlin, 10–12 December 2003. Geneva, World Health Organization, 2004 (WHO/CDS/CPE/ CEE/2004.45). 8. The work WHO: 1951. Annual report of the Director-General to the World Health Assembly and to the United Nations. Chronicle of the World Health Organization, 1952, © Sarah Cleaveland 6(7-8):170. 11
  21. 21. Human and economic burden Part 1 3 Human and economic burden © UNP ublic-health planners face the problem of setting priorities for attention – a necessary task since competition for the most effective use of resources is inevitable.3.1 Epidemiological burden The concept of DALYs (disability-adjusted life years) was developed to enablethe burden of individual diseases to be assessed quantitatively and comparatively.The number of DALYs assigned to a specific disease at a particular time givesan estimate of the sum of years of potential life lost due to premature mortalityand the years of productive life lost. WHO’s Department of Health Statistics andInformatics has compiled and published estimates of DALYs for 2004 (1). TheDALYs for a selection of NTDs discussed in this report are set out in Table 3.1.1. 13
  22. 22. First WHO report on neglected tropical diseases Table 3.1.1 Estimated number of disability-adjusted life years (DALYs) (in thousands) by cause (neglected tropical disease), and by WHO region (excluding the European Region)a, 2004 WHO region Neglected tropical disease Worldb Eastern South-East Western African Americas Mediterranean Asia Pacific Human African 1 673 1 609 0 62 0 0 trypanosomiasis Chagas disease 430 0 426 0 0 0 Schistosomiasis 1 707 1 502 46 145 0 13 Leishmaniasis 1 974 328 45 281 1 264 51 Lymphatic filariasis 5 941 2 263 10 75 3 525 65 Onchocerciasis 389 375 1 11 0 0 Leprosy 194 25 16 22 118 13 Dengue 670 9 73 28 391 169 Trachoma 1 334 601 15 208 88 419 Ascariasisc 1 851 915 60 162 404 308 Trichuriasisc 1 012 236 73 61 372 269 Hookworm diseasec 1 092 377 20 43 286 364 a Source: The global burden of disease: 2004 update (1). b Because estimates from the European Region were omitted from the table, numbers for the regions may not always add up to the world’s total. c Soil-transmitted helminthiases. There is consensus about the need for DALYs or an objective measure of the burden of disease. However, there is some criticism of the procedures used to make the estimates, and considerable concern about the quality and reliability of the raw data available for generating the estimates. Four reasons may be offered to support this cause for concern. Firstly, for any disease there may be little information on numbers of cases and deaths because surveillance systems and platforms for most NTDs and infections in animal reservoirs are weak or non-existent. Secondly, national and regional estimates for some diseases are often derived from a few studies carried out in high-risk populations. Thirdly, for some conditions, such as schistosomiasis, there is uncertainty about the accuracy of the disability weights that should be attached to small or moderate reductions in physical function, to14
  23. 23. Human and economic burden Part 1pain and to other forms of impairment. Small differences in disability weights,when multiplied by large numbers of affected people, yield highly variableestimates of DALYs lost. Fourthly, the less overt or subtle morbidity of the highlyprevalent NTDs affects the severity of concurrent infection and disease. DALYestimates still have to take account of this complication. Estimates of DALYs for Buruli ulcer, cysticercosis, dracunculiasis,echinococcosis, endemic syphilis, foodborne trematode infections (clonorchiasis,fascioliasis, opisthorchiasis) and rabies are not explicitly stated. However, theycontribute to the burden of disease caused by NTDs, and some have exceedinglyhigh mortality if left undiagnosed and untreated. The 55 000 deaths attributedannually to rabies feature in the DALYs estimated for miscellaneous causes.3.2 Economic burden DWD DERXW WKH HFRQRPLF EXUGHQ RI 17V DUH FRQ¿QHG WR VPDOO VWXGLHV LQlimited geographical areas. More work is needed to quantify the impact ofNTDs on the productivity of women. Where data exist, the economic impact isVLJQL¿FDQW )RU H[DPSOH OPSKDWLF ¿ODULDVLV FDXVHV DOPRVW 86 ELOOLRQ D HDU LQlost productivity (2) and the annual global expenditure for rabies prevention andFRQWURO H[FHHGV 86 ELOOLRQ E :+2¶V FRQVHUYDWLYH DVVHVVPHQW3.2.1 Economic impact 7KHUH LV DQ XQTXDQWL¿DEOH GLPHQVLRQ WR WKH EXUGHQ RI 17V WKDW VDSV WKHunpaid work and productivity of millions of women. In countries where NTDsare endemic, women are the caregivers when children and family members arehealthy and when they are sick; they collect water and fuel, grow vegetables andtend crops, provide meals and maintain the household (3). This vital work isunpaid and would be easier if women were relieved from the burden of NTDs. Inlow-income countries, children are an economic resource, and improving theirhealth will help them better perform their daily tasks. $ TXDQWL¿DEOH GLPHQVLRQ WR WKH EXUGHQ RI GLVHDVH FDXVHG E 17V LV WKH ORVVof productivity and its impact on the productivity of individuals, households,communities and nations. That people with poor health and crippling disabilitiesare less productive than their healthy counterparts cannot be challenged, butFDUHIXOO VWUDWL¿HG DQDOVHV RI WKH UHVXOWV RI ZHOOGHVLJQHG ODUJHVFDOH OLYHVWRFNLQYHVWLJDWLRQV DUH UDUH 8QGHUVWDQGLQJ WKH HIIHFW RI 17V RQ SURGXFWLYLW ZLOOhelp promote prevention and control activities, and assure governments anddonors that resources directed towards these endeavours are a good investment.Information about the impact of several NTDs is shown in Table 3.2.1.1. 15
  24. 24. First WHO report on neglected tropical diseases Table 3.2.1.1 Economic costs of selected neglected tropical diseasesa (data are the latest available) Disease Setting Reported productivity lossb Estimated 752 000 working days/year lost due to premature deaths. US$ 1.2 billion/year in lost productivity in 7 southernmost countries. Chagas disease Latin America Absenteeism of workers affected by Chagas disease in Brazil represented an estimated minimum loss of US$ 5.6 million/year.c The societal monetary cost of Taenia solium cysticercosis was estimated at Eastern Cape US$ 15.27 million (95% CI US$ 51.6–299 million) in India, US$ 28.3 million province (US$ 7.1–42.9 million) in Honduras and US$ 16.6 million (US$ 8.3–22.8 million) Cysticercosis (South Africa), in the Eastern Cape province (South Africa). The total annual costs associated with Honduras, India cysticercosis were estimated at US$ 13 million; the monetary burden per case of human cysticercosis amounted to US$ 252. The average total economic burden was estimated at US$ 29.3 million (US$ 27.5–31.1 million). Dengue fever India Costs in the private health sector were estimated to be almost 4 times that of public sector expenditures. The financial burden of the disease in estimates of purchasing power parity is 4.1 Echinococcosis Global billion international dollars annually, of which 46% is due to human treatment and morbidity and 54% is associated animal-health costs. Annual economic burden of lymphatic filariasis measured in lost productivity reported in 1998 was about US$ 1.7 billion in 2008, taking into account inflation in Lymphatic Various countries that are part of the African Programme for Onchocerciasis Control. filariasis countries ERRs are 25% at the end of the investment period in 2019, and 28% over 30 years. The programme breaks even in the tenth year. Lymphatic filariasis causes almost US$ 1.3 billion/year in lost productivity. Soil-transmitted On the basis of the estimated rate of return to education in Kenya, deworming is likely to increase the net present value of wages by more than US$ 40 per treated helminthiases Kenya person. Benefit-to-cost ratio = 100. Deworming may increase adult income by 40%. After a series of computations, of which the disability rate was regarded as the Schistosomiasis Philippines most important, a total of 45.4 days off-work lost per infected person/year was obtained. Various The economic cost of trachoma in terms of lost productivity is estimated at Trachoma countries US$ 2.9 billion annually. CI = confidence interval; ERR = economic rate of return. a Source: Reproduced with permission from Conteh L et al. (4). b All costs and losses are inflated from their original year of calculation and converted to their 2008 US$ equivalent with a constant dollar rate. c The base year of costs is not given, so costs remain in original form. The published sources from which these tables are based should be consulted for details of the costs involved.16
  25. 25. Human and economic burden Part 13.2.2 Costs of interventions Assessing the burden of NTDs in terms of DALYs is a powerful approachthat can be used to evaluate the gains made, and the costs of interventions fortheir prevention and control. Put simply, how many DALYs can be averted byinvesting fully in a programme to control NTDs (including the costs of planning,administration, staffing, training, community relations, logistics, medicines,procurement and reporting)? For example, the cost of treating a patient withlymphatic filariasis using ivermectin and albendazole (donated by Merck Co.,Inc., and GlaxoSmithKline) ranges from US$ 0.05 to US$ 0.10 per person treated,while the cost of the DALYs averted is reckoned to be US$ 5.90. Results of thissort are encouraging for NTD control provided that the full costs of interventionhave been identified. An economic analysis of deworming campaigns among school-aged childrenconducted in seven countries (Cambodia, Egypt, Ghana, the Lao People’sDemocratic Republic, Myanmar, the United Republic of Tanzania and Viet Nam)calculated a cost of US$ 0.07 per each round of drug distribution (or US$ 70 000to cover 1 million school-aged children), with minimal variation among countries(5). This calculation includes the costs of training, health education, procurementand distribution of medicines, media campaigns, monitoring and supervision. Economic evaluations of the Onchocerciasis Control Programme in west Africashow a net present value (equivalent discounted benefits minus discounted costs)of US$ 919 million for the programme over 39 years, using a conservative 10%rate to discount future health and productivity gains. The net present value for theAfrican Programme for Onchocerciasis Control is calculated at US$ 121 millionover 21 years, also using a 10% discount rate. However, the economic successof ivermectin distribution is sensitive to the fact that the drug itself has beendonated. The market value of donations made by Merck Co. Inc., to the AfricanProgramme for Onchocerciasis Control for just 1 year considerably outweighsthe benefits calculated for both the Onchocerciasis Control Programme andthe African Programme for Onchocerciasis Control over the duration of theseprojects. Table 3.2.2.1 VXPPDUL]HV WKH ¿QGLQJV RI DQ DWWHPSW WR FDOFXODWH WKH $/Vaverted for several NTDs in relation to the costs of their treatment and control.The published sources from which this table is based should be consulted for © Sarah Cleavelanddetails of the costs involved. 17
  26. 26. First WHO report on neglected tropical diseases Table 3.2.2.1 Cost-effectiveness of controlling neglected tropical diseasesa Cost per DALY Disease Intervention averted (US$) Chagas disease Vector control 317 In implementation units (districts) where prevalence is greater than 1%, annual mass drug administration to treat the entire at-risk population for 5–7 years: ivermectin and albendazole in Africa, and diethylcarbamazine and albendazole in 5–10 onchocerciasis-free countries: Lymphatic filariasis x to interrupt transmission and achieve elimination of the public-health problem 35 x to initiate morbidity control, surgery and lymphoedema management 1–4 To provide salt fortified with diethylcarbamazine (China) 59–370 Vector control Mass school-based treatment with praziquantel and albendazole combined with 10–23 Schistosomiasis schistosomiasis treatment Mass school-based treatment with praziquantel alone 410–844 Trachoma control based on SAFE strategy (Surgery, Antibiotic treatment, Face Trachoma 5–100 washing and Environmental control) Onchocerciasis Community-directed treatment programmes with ivermectin 9 Soil-transmitted helminthiases (hookworm, Mass school-based treatment with albendazole or mebendazole 2–11 roundworm, and whipworm) Case-detection and treatment with multidrug therapy using donated drugs 46 Leprosy Prevention of disability 1–122 Case-management 716–1757 Dengue fever control Environmental control more than 2440 Leishmaniasis Case detection and treatment; vector control. 11–22 Case-finding and treatment: Human African Less than 12 trypanosomiasis Less than 24 a Source: Reproduced with permission from Conteh L et al. (4).18
  27. 27. Human and economic burden Part 1REFERENCES 1. The global burden of disease: 2004 update. Geneva, World Health Organization, 2008. 2. Ramaiah KD et al. The economic burden of lymphatic filariasis in India. Parasitology Today, 2000, 16:151-253. 3. Momson JH, Kinnard V, eds. Different places, different voices. London, Routledge, 1993. 4. Conteh L, Engels T, Molyneux D. Socioeconomic aspects of neglected tropical diseases. Lancet, 2010, 375:239–247. 5. Montresor A et al. Estimation of the cost of large-scale school deworming programmes with benzimidazoles. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2010, 104:129–132. 19
  28. 28. Ways forward Part 1 4 Ways forward © WHO /Harold Ruiz4.1 Approaches to overcoming neglected tropical diseases WHO recommends five strategies for the prevention and control of NTDs: (i)preventive chemotherapy; (ii) intensified case-management; (iii) vector control;(iv) provision of safe water, sanitation and hygiene; and (v) veterinary publichealth. Working to overcome individual NTDs or a group of these diseases shouldrely on a combination of the five strategic approaches. For example, in order tocontrol the morbidity caused by lymphatic filariasis, individuals will benefitfrom preventive chemotherapy; individuals with hydrocoele will require case-management. Bringing the vectors of Wuchereria and Brugia under control willrequire appropriate management of water resources. The SAFE strategy (Surgery,Antibiotic treatment, Facial cleanliness and Environmental improvement) used 21
  29. 29. First WHO report on neglected tropical diseases to control trachoma combines the large-scale distribution of medicines with individual case-management and environmental improvement. Surgery for trichiasis prevents progression to blindness. Azithromycin or tetracycline eye ointment offered to populations at risk cures the infection and reduces person- to-person transmission. WHO fosters technical expertise in each strategy. Sustaining the health benefits will require integration and implementation of the strategies within the national health programmes of countries where NTDs are endemic. This vision is encapsulated in most if not all of the resolutions of the World Health Assembly pertaining to NTDs (Annex 1) irrespective of specific, measurable public-health targets. 4.1.1 Preventive chemotherapy Developed by WHO to control morbidity in populations at risk of infection or illness, preventive chemotherapy depends on the large-scale distribution of high-quality, safety-tested medicines. Preventive chemotherapy is the main intervention for controlling lymphatic filariasis, onchocerciasis, schistosomiasis and soil-transmitted helminthiases. This intervention contributes to the control of trachoma and, depending on the choice of medicine, relieves strongyloidiasis, scabies and lice. The application of preventive chemotherapy as a public-health measure to control helminthiasis depends on the mass distribution of seven broad- spectrum anthelminthic medicines: albendazole, diethylcarbamazine, ivermectin, levamisole, mebendazole, praziquantel and pyrantel (Table 4.1.1.1). WHO recommends these medicines be used not only because of their ease of administration and efficacy but also because of their excellent safety profiles and minimal side-effects (1). The safety record of these medicines when used for preventive chemotherapy is such that individual diagnosis is not justified in areas of high endemicity. These medicines are administered as a single, oral dose, either as a single-dose tablet (e.g. albendazole 500 mg or mebendazole 400 mg) or as a dose calculated according to weight or height (dose poles are used to calculate doses for ivermectin and praziquantel). As a result, non-medically trained people, including schoolteachers and community volunteers, can be recruited to deliver these medicines to many people who are beyond the reach of the peripheral health-care system (2). The frequency of administration ranges from once to twice yearly, according to the prevailing epidemiology of the targeted infections. Preventive chemotherapy using azithromycin to control morbidity in trachoma forms an effective component of the SAFE strategy. Guidance on the optimum use of preventive chemotherapy under a range of conditions is explained in WHO’s manual on preventive chemotherapy in human helminthiasis (3).22
  30. 30. Ways forward Part 1Table 4.1.1.1 WHO-recommended anthelminthic medicines for use in preventive chemotherapya,b,c Diethyl- Disease Albendazole Mebendazole Ivermectin Praziquantel Levamisoled Pyranteld carbamazine Target diseases for which a well- Ascariasis √ √ – (√) – √ √ defined strategy is available Hookworm √ √ – – – √ √ Lymphatic √ – √ √ – – – filariasis Onchocerciasis – – – √ – – – Schistosomiasis – √ – – Trichuriasis √ √ – (√) – (√)e (√)e Clonorchiasis – – – – √ – – Target diseases for which a strategy is being developed Opisthorchiasis – – – – √ – – Paragonimiasis – – – – √ – – Strongyloidiasis √ (√) – √ – – √ Taeniasis – – – – up to 10 mg/ – – kg Cutaneous larva migrants √ (√) – (√) – (√) (√) (zoonotic ancylostomiasis) Ectoparasitic Additional benefits infections – – – √ – – – (scabies and lice) Enterobiasis √ √ – (√) – (√) √ Intestinal – – – – √ – – trematodiases Visceral larva migrants – – √ (√) – – – (toxocariasis)a Source: adapted from Preventive chemotherapy in human helminthiasis (3).b Prescribing information and contraindications are given in the WHO model formulary 2004.c In this table, √ indicates medicines recommended by WHO for treatment of the relevant disease, and (√) indicates medicines that are not recommended for treatment but that have a (suboptimal) effect against the disease.d At present, levamisole and pyrantel do not have a prominent role in preventive chemotherapy as described in this manual. However, they remain useful drugs for treating soil-transmitted helminthiases, and since – unlike albendazole and mebendazole – they do not belong to the benzimidazole group, they are expected to contribute to the management of drug-resistant soil-transmitted helminthiases should that problem emerge.e Levamisole and pyrantel have only a limited effect on trichuriasis but, when used in combination with oxantel, pyrantel has an efficacy against trichuriasis comparable to that observed with mebendazole. 23
  31. 31. First WHO report on neglected tropical diseases Progress towards including preventive chemotherapy in control programmes has been made in some endemic countries, but a considerable scale up will be needed if targets set in resolutions of the World Health Assembly are to be met (Annex 1). Global coverage of preventive chemotherapy for the specific forms of helminthiasis is shown in Figure 4.1.1.1. The coverage rates are based on information that is available from WHO’s preventive chemotherapy and transmission control databank (4). A clear difference is noticeable between the rates of coverage for onchocerciasis, lymphatic filariasis, schistosomiasis and soil- transmitted helminthiases. The quality and completeness of data are better for onchocerciasis and lymphatic filariasis, probably because the medicines used to treat these diseases are available in sufficient quantities as part of donations made by the private sector. For reporting purposes, countries are required to submit detailed progress reports before the next year’s supply of donated drugs can be granted. For soil-transmitted helminthiases and schistosomiasis, the situation is different. Even though a large proportion of the population affected by soil- transmitted helminthiases receives albendazole through the Global Programme to Eliminate Lymphatic Filariasis, there is a need to purchase large quantities of generic medicines for reaching persons affected by this disease in areas where lymphatic filariasis is not endemic. Given the large quantities of medicine needed to achieve the required coverage for schistosomiasis and soil-transmitted helminthiases, and the strict timing required for the medicines to be available at the country level, some form of centralized drug supply mechanism should be established, as it is for vaccines supplied for routine immunization. In fact, preventive chemotherapy for schistosomiasis and soil-transmitted helminthiases may have higher coverage than that shown in Table 4.1.1.2. The reported low coverage may be explained by difficulties encountered in collecting and managing data. Since many community-based treatments for schistosomiasis and soil-transmitted helminthiases are delivered by a diverse range of organizations and nongovernmental development organizations, there is a need for greater coordination in reporting. Coverage data are not systematically reported to national authorities by all implementing agencies and are not routinely sent on to the regional and global level of WHO, leading to an underestimation of the numerator. The denominator in calculating coverage may not always be reliable for soil-transmitted helminthiases and particularly for schistosomiasis, which is a highly focal disease.24
  32. 32. Ways forward Part 1 Fig. 4.1.1.1 Global coverage (%)a of preventive chemotherapy for schistosomiasis, soil-transmitted helminthiases, lymphatic filariasis and onchocerciasisb 70 60 50 Coverage (%) 40 30 20 10 0 2006 2007 2008 2006 2007 2008 2006 2007 2008 2006 2007 2008 2005 2005 2005 2005 Schistosomiasis Soil-transmitted Lymphatic Onchocerciasis helminthiases filariasis Yeara Coverage shown is the proportion of the global population requiring preventive chemotherapy with the appropriate package of medicine for each helminthic infection that has been treated annually between 2005 and 2008. For soil- transmitted helminthiases, the target population is children aged 1–15 years.b Source: WHO preventive chemotherapy and transmission control databank (available at: http://www.who.int/ neglected_diseases/preventive_chemotherapy/databank/en/).Table 4.1.1.2 Number of people reached by preventive chemotherapy for at least one neglected tropical disease, 2008 Number of countries Number of people reached by preventive WHO region reporting to WHO chemotherapy for at least one disease African 34 167 575 966 Americas 16 10 987 288 Eastern Mediterranean 7 14 986 795 European 1 37 319 South-East Asia 9 437 651 823 Western Pacific 8 36 831 068 Global 75 668 070 2594.1.2 Intensified case-management Intensified case-management involves caring for infected individuals andthose at risk of infection. The key processes are (i) making the diagnosis as earlyas possible, (ii) providing treatment to reduce infection and morbidity, and (iii)managing complications. This intervention is justified as a principal strategy forcontrolling and preventing those NTDs for which there are © Sarah Cleaveland available no medicines 25
  33. 33. First WHO report on neglected tropical diseases for preventive chemotherapy. Infection may be asymptomatic for long periods and require confirmation of diagnosis because of the toxicity of medicines. WHO focuses on the prevention and control of Buruli ulcer, Chagas disease, human African trypanosomiasis, leishmaniasis (in its cutaneous, mucocutaneous and visceral forms), leprosy and yaws. For Chagas disease, human African trypanosomiasis and visceral leishmaniasis, diagnosis needs to be simplified and made less invasive without losing sensitivity. For these six and other NTDs, there is an urgent need to shorten the length of time that occurs between suspecting infection and making the diagnosis so that treatment can begin without delay. Innovative work is required to improve diagnostic methods and provide safer medicines for administration under shorter treatment regimens. The medicines for treatment of the six target diseases include nifurtimox and benznidazole for Chagas disease; pentamidine, suramin, melarsoprol, eflornithine and nifurtimox for human African trypanosomiasis; pentavalent antimonials (sodium stibogluconate and meglumine antimoniate), amphotericin B, paromomycin and miltefosine for visceral leishmaniasis; multidrug therapy for leprosy using a combination of rifampicin, clofazimine and dapsone for multibacillary leprosy, and rifampicin and dapsone for paucibacillary leprosy; a combination of rifampicin and streptomycin or amikacin for Buruli ulcer; and benzathine penicillin for yaws. Most of these medicines are donated to WHO, facilitating the delivery of high-quality treatment free of charge to targeted populations in endemic areas. 4.1.3 Vector control Vector-borne diseases account for about 17% of the estimated global burden of communicable diseases (5). Most NTDs involve vector transmission: insects transmit the infectious agents of dengue and other virus-induced diseases, Chagas disease, human African trypanosomiasis, leishmaniasis, lymphatic filariasis and onchocerciasis; snails are essential in transmitting the agents of foodborne trematodiasis and schistosomiasis; crustaceans are essential for transmission of the agents of dracunculiasis and foodborne paragonimiasis. Understanding vector biology is an essential component for explaining and predicting the epidemiology of vector-borne disease. The promotion of integrated vector management is a component of the Global plan to combat neglected tropical diseases 2008–2015 (6). This approach to vector control requires a rational decision-making process to optimize the use of resources. Effective integrated vector management will be strengthened through26

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