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Inservice presentation/Age-related macular degeneration
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  • Using the eye model I made earlier in the semester, I would begin the presentation by asking the audience if they know where the macula is in the eye. I would show them on the eye model how it is a small point on the retina in the very back of the eye.
  • What you are seeing, or not seeing, is what the vision of an individual who has age-related macular degeneration might be like. You’ll notice that you cannot see anything directly in front of you, but you can still see the surrounding area. By moving your fist closer to your eye and than farther away, you can see the range of impact that age-related macular degeneration can have on vision.
  • The macula is on the center of the retina and is made mostly of cones, which are cells that help us see fine detail and colors. The rest of the surrounding area on the retina is made mostly of rods, which are responsible for night vision, peripheral vision and are better at detecting movement than the cones.
  • Drusen may be present on the retina of younger people as well, but these are typically hard drusen, meaning that the deposits have definable edges. As you age, they become known as soft drusen because the edges become less defined.
  • Just the presence of drusen alone on the retina and pigment changes is known as early-stage AMD. The end-stage, or late-stage of the dry form is known as geographic atrophy.
  • The wet form is also known as neovascular age-related macular degeneration.
  • This form is much more severe than dry AMD.
  • Notice how the normal retina appears pink and has no drusen. The picture on the right has soft drusen throughout the retina. At this point, vision would not be affected too much.
  • The picture on the right shows the large mass of drusen known as geographic atrophy. This area would cause a scotoma, or blind spot in the central vision. The picture on the right shows a sub-retinal hemorrhage, which left untreated will cause permanent vision loss. The size, location and number of these hemorrhages varies from person to person.
  • Peripheral vision is not affected because rods are responsible for that area of vision. The macula is responsible for central and color vision.
  • While geographic atrophy is worse than early AMD, if it is not located in the area of finest central vision, some central vision may be retained.
  • Dry AMD may progress over several years, but wet AMD progresses much more quickly, sometimes within several weeks or days. Because of the speed in which neovascularization can occur, patients are encouraged to monitor their vision with an Amsler grid regularly so they can detect any changes in their vision.
  • AMD is a genetic or hereditary disease, but lifestyle may increase or decrease the risk of developing AMD, especially the wet form.
  • You’ll notice that many of the risk factors are associated with cardiovascular disease.
  • Many of these activities are things that depend on having fine central vision or color vision. Any activities that use one or both of these may be affected (sewing, eating off a plate, etc).
  • Even if individuals are genetically predisposed to AMD, they should make lifestyle changes that reduce the amount of risk. They should modify their behavior as much as possible based on the previously mentioned risk factors.
  • The AREDS study did not show that people who did not have AMD or even early AMD benefitted by taking this formulation. Only those in the intermediate or later stages were shown to benefit.
  • This study is currently ongoing, with a scheduled end date of around 2014. Studies have shown that lutein and zeaxanthin have a protective effect on the macula. These pigments are both already present in the macula, and this study is examining whether or not consuming more of them increases their impact.
  • Laser photocoagulation uses a high-intensity laser to destroy leaky blood vessels, but it causes indiscriminate damage to blood vessels in the retina. Photodynamic therapy is more controlled: it uses a medication that is injected intravenously and then activated by an infrared laser that destroys neovascularization. However, both of them can damage healthy blood vessels and some patients develop disciform scars as a result of the treatment. These two treatments are older and not used as commonly as more recently developed treatments.
  • VEGF is the protein responsible for the growth of abnormal blood vessels. These drugs bind to the VEGF protein and inhibit it’s activity. They are shown to be safe and effective in treating AMD. Anti-VEGF treatments are the most recent FDA approved treatments for AMD. However, Avastin is not currently FDA approved for treating AMD but it is approved for treating colon cancer.
  • There have been concerns in the past that cataract surgery increased the risk of AMD, but recent studies are showing that this is not the case.
  • Some individuals with AMD will develop this syndrome – it should be explained so that if hallucinations do occur, the individual realizes that it is due to physical changes, and not psychosis.
  • Individuals at risk for AMD or who have been diagnosed with AMD are encouraged to use an Amsler grid at home on a regular basis. Even with frequent use of an Amsler grid, individuals should continue to see their eye doctor on a regular basis.
  • The Amsler grid may also be black with white lines.
  • An individual might see distortions or blind spots of the Amsler grid, which they are already aware of and have seen their doctor about. However, if they notice any new changes, then they need to contact their doctor as soon as possible, as this could be an indication of the formation of new blood vessels under the retina.
  • These pictures demonstrate what the vision of someone who has AMD might look like. Note that in the picture on the right a central scotoma, or blind spot, exists, and the surrounding area appears wavy and distorted. The remaining area in the peripheral vision also appears blurry as a result of decreased visual acuity.  The size and location of central scotomas will vary from person to person.   
  • These pictures show how the effects of AMD may vary from person to person.
  • I would show examples of writing guides (check writing and letter writing) here. Some great resources for ideas on how to adjust are available at the American Foundation for Blindness website; afb.org. Their Senior Site also has a list of local resources and agencies that may be contacted for additional assistance.
  • A low vision specialist can detect where scotomas, or blind spots are located, and then suggest appropriate assistive devices to use, and provide training on how to use them. This specialist would also provide eccentric viewing training. A rehabilitation therapist can teach individuals with AMD independent living skills.
  • Magnifiers help individuals with AMD read more easily, but for those with more severe vision loss, learning eccentric viewing can be beneficial, as the example in this slide shows.
  • I would close by saying that while AMD can greatly reduce central vision, there is a wide variety of aids that can be used and living skills that can be learned to make life much easier. Having AMD does not mean that you can no longer do any of the things you used to do before.

Inservice presentation/Age-related macular degeneration Inservice presentation/Age-related macular degeneration Presentation Transcript

  • Age-Related Macular Degeneration By: Elizabeth Grigg
  • Group activity
    • Look straight ahead
    • Cover one eye with one hand
    • Make a fist with your other hand
    • Put your fist approximately five inches away from your open eye
    • Move your fist closer to your eye and then farther away
  • Age-related macular degeneration
    • Degenerative disease of the macula, which is the area on the retina responsible for fine central vision as well as color vision .
    • The leading cause of blindness in Americans over the age of 65 (Kaufman, 2009)
    • Two different forms: wet exudative and dry non-exudative, but one person can have both (Perski, n.d.)
    • Often abbreviated as AMD or ARMD
  • What happens in the eye?
    • Dry non-exudative form
      • This form is much more common, occurring in approximately 90% of the cases of AMD (Macular, 2009).
      • Characterized by small yellow spots (fatty deposits) under the retina, called drusen (Kaufman, 2009).
    • Dry non-exudative form continued
      • Over time, the fatty deposits multiply and combine, causing cell death. This is known as geographic atrophy and can cause permanent loss of central vision (Kaufman, 2009).
      • Can progress to the wet form of age-related macular degeneration (Kaufman, 2009).
  • What else?
    • Wet exudative form:
      • Rarer, occurring in approximately 10% of the cases of AMD (Macular, 2009).
      • Characterized by the abnormal growth of blood vessels under the retina, which may leak or hemorrhage (Prasad, Schwartz, & Hubschman, 2010).
    • Wet exudative form continued
      • If a sub-retinal hemorrhage occurs and is not treated immediately, a disciform scar will result, which may cause permanent loss of central vision (Prasad, Schwartz, & Hubschman, 2010).
  • What does age-related macular degeneration look like? Healthy, normal retina Early AMD - drusen appearing on retina Macula Optic disc Yellow spots are drusen Images from http://www.agingeye.net/maculardegen/maculardegeninformation.php
  • As the disease progresses… Late or end-stage dry AMD (geographic atrophy) Geographic atrophy (may lead to) Wet or exudative AMD Sub-retinal hemorrhage Images from http://www.agingeye.net/maculardegen/maculardegeninformation.php
  • How do these forms affect vision?
    • For all types of AMD, peripheral vision is rarely affected (Kaufman, 2009).
    • Early AMD
      • Central vision and visual acuity may be unaffected (Yin et al., 2006).
      • Color vision may be decreased (Bremridge, 2008).
      • Vision may appear wavy or blurry (Pelletier, 2009).
      • May have difficulty adapting from indoor lighting to sunlight (Kaufman, 2009).
  • More effects on vision…
    • Late-stage dry AMD (geographic atrophy)
      • Depending on the location and size of the atrophy, central vision will be affected by scotomas , or blind spots (Kaufman, 2009).
      • Reduced visual acuity; may be 20/200 or worse (Perski, n.d.)
      • Reduced color vision and wavy lines.
  • Effects on vision continued…
    • Wet exudative AMD
      • Central vision will appear wavy (Pelletier, 2009).
      • Reduced visual acuity; may be 20/200 or worse (Perski, n.d.)
      • Central vision can be destroyed permanently by hemorrhaging and subsequent disciform scar (Kaufman, 2009).
  • What are the risk factors?
    • Risk factors are both genetic and environmental (Prasad, Schwartz, & Hubschman, 2010)
      • Age and smoking are two of the biggest risk factors (Coleman et al., 2010)
      • Family history (Kaufman, 2009)
      • Female gender (Bremridge, 2008)
      • More common among Caucasians (Perski, n.d.)
  • More risk factors…
    • Risk factors continued
      • Excessive sunlight exposure (Bremridge, 2008)
      • High blood pressure (Yin et al., 2006)
      • High body mass index (Singh & Tewari, 2009)
      • Diet high in saturated fats (Singh & Tewari, 2009)
      • Diet low in omega-3 fatty acids and fish (Singh & Tewari, 2009)
  • How does AMD affect daily living?
    • Individuals with AMD often have difficulty with any activity that depends on fine central vision or color vision:
      • Driving, especially at night
      • Recognizing faces
      • Reading fine print
      • Sorting clothes
      • Increased difficulty with glare
      • Increased risk of falls
      • (Kaufman, 2009; Bremridge, 2008)
  • What are the treatments or cures?
    • Dry non-exudative AMD
      • No cure available (Singh & Tewari, 2009)
      • Current focus is on prevention through lifestyle changes
        • Smoking cessation (Kaufman, 2009)
        • Diet high in omega-3 fatty acids, fish, and dark green leafy vegetables (Singh & Tewari, 2009)
        • Exercise regularly (Macular, 2009)
        • Wear sunglasses outside (Macular, 2009)
  • Treatments or cures
    • Dry AMD
      • AREDS study – nutritional supplements found to slow progression of AMD
        • vitamin C, 500 mg; vitamin E; 400 IU; beta carotene, 15mg) with or without zinc (80 mg) and copper (2 mg) (Singh & Tewari, 2009)
        • However, beta carotene increased risk of lung cancer in smokers and zinc increased number of urologic problems (Singh & Tewari, 2009; Pelletier, 2009).
    • Dry AMD continued
      • AREDS 2 (follow-up study)
        • Determine if removal of beta-carotene and reduction in zinc is as effective as original formulation (Singh & Tewari, 2009).
        • New formulation includes addition of omega-3 fatty acids, lutein, and zeaxanthin (these are pigments that exist in the macula) (Slotnick, 2010).
  • Treatments or cures
    • Wet exudative AMD
      • Laser photocoagulation
      • Photodynamic therapy
      • Neither of these show significant improvements in vision nor do they prevent reoccurrences (Prasad, Schwartz, & Hubschman, 2010).
    • Wet exudative AMD
      • Intravitreal injections of anti-VEGF drugs (Macugen,Lucentis, and Avastin)
      • Surgery is used to remove sub-retinal hemorrhages (Prasad, Schwartz, & Hubschman, 2010).
  • What about cataracts?
    • Studies have shown that there is no increased risk of advanced age-related macular degeneration after cataract surgery (Hasson, 2009).
  • Charles Bonnet Syndrome
    • Realistic visual hallucinations associated with vision loss (Bremridge, 2008)
    • May be caused by brain attempting to interpret incomplete images (Bremridge, 2008)
  • What research is being done?
    • Preventing AMD
      • Reduce vitamin A in retina in order to slow the deterioration of rods, which is thought to contribute to AMD (Webb & Kubota, 2009).
      • Some studies focusing on the role of mutations in the Complement H factor, which is part of the immune system (Kaufman, 2009).
  • More research
    • Slowing the progression of AMD
      • Implantable device that contains genetically engineered cells that help slow death of cells in retina (Prasad, Schwartz, & Hubschman, 2010).
    • Potential cures in the future
      • Stem cell transplants
      • Gene therapy (Prasad, Schartz, & Hubschman, 2010)
    • This simple tool helps detect changes in vision, such as possible progression from dry to wet AMD (Pelletier, 2009).
    • The Amsler grid is made of evenly spaced horizontal and vertical lines.  A small dot is located in the center of the grid for fixation. 
    Detecting AMD or changes in vision: the Amsler grid
  • The Amsler grid Taken from: http://www.stlukeseye.com/eyeq/amslerprint.html
  • Instructions on using the Amsler grid
    • Use a bright reading light
    • Hold the chart approximately 14-16 inches from your eye
    • Cover one eye
    • Look at center dot
    • Note irregularities (wavy, size, gray, fuzzy)
    • Repeat the test with your other eye
    • Contact an ophthalmologist if you see any irregularities or notice any changes d                                                       
  • How might the Amsler grid look to a person who has AMD? First image from http:// www.nei.nih.gov/photo/keyword.asp?conditions =Age-Related+Macular+Degeneration+%28AMD%29 Second image from http://www.cnib.ca/en/your-eyes/eye-conditions/amd/diagnosing/diagnostic-tests/Default.aspx
  • What might the world look like to someone who has AMD?
    •                                           
    Normal vision The same scene as viewed by a person with age-related macular degeneration Images from: http://www.nei.nih.gov/health/maculardegen/armd_facts.asp#1a
  • More examples… Clockwise from top: First image from http://www.dukehealth.org/eye_center/specialties/macular_degeneration/care_guides/macular _degeneration_frequently_asked_questions Second image from http://www.stlukeseye.com/conditions/MacularDegeneration.html Third image from http://www.nei.nih.gov/photo/sims/images/ESD11.jpg
  • What are some things individuals can use to adapt to their vision loss?
    • magnifiers
    • appropriate lighting to reduce glare
    • reading materials with larger fonts
    • writing guides
    • talking devices (clock, scale, computer software, etc.)
    • contrast throughout the home to keep objects visible
    • tactile objects or add raised bumps
    • sighted guide
      • (Redesigning, n.d.)
  • More suggestions
    • Individuals with AMD should schedule a visit with a low vision specialist and a rehabilitation therapist to learn about which devices to use and how to use them (Kaufman, 2009).
    • Eccentric viewing (the use of peripheral vision to read) can make reading easier for those with severe central vision loss (Symptoms, 2004).
  • How eccentric viewing can help Advanced vision Magnifier alone Eccentric viewing defect + magnifier Images from http://www.agingeye.net/maculardegen/maculardegensymptoms.php
  • Local resources
    • Here! Lighthouse of Pinellas offers variety of services
    • Florida Division of Blind Services: http://www.myflorida.com/dbs/
    • Pinellas Talking Book Library: http://www.pplc.us/tbl/
    • WUSF Radio Reading Service: http://www.wusf.usf.edu/radio/radio_ reading_service_on_wusf
  • References
    • Brembridge, T. (2008). Caring for people with age-related macular degeneration. Nursing & Residential Care , 10 (9), 443. Retrieved from CINAHL database.
    • Coleman, A. L., Seitzman, R. L., Cummings, S. R., Yu, F., Cauley, J. A., Ensrud, K. E.,…Mangione, C.M. (2010). The association of smoking and alcohol use with age-related macular degeneration in the oldest old: The study of osteoporotic fractures. American Journal of Ophthalmology, 149 (1), 160-169. doi: 10.1016/j.ajo.2009.07.025
    • Hasson, M. (2009, October). Increased risk of advanced AMD after cataract surgery unfounded. Ocular Surgery News Europe , p. 6. Retrieved from Academic Search Complete database.
    • Jeganathan, V., & Verma, N. (2009). Safety and efficacy of intravitreal anti-VEGF injections for age-related macular degeneration. Current Opinion in Ophthalmology , 20 (3), 223-225. Retrieved from CINAHL with Full Text database.
  • References continued…
    • Kaufman, S. (2009). Developments in age-related macular degeneration: diagnosis and treatment. Geriatrics , 64 (3), 16-19. Retrieved from CINAHL database.
    • Macular degeneration info. (2009, May 19). University of Illinois Eye & Ear Institute. Retrieved from The Eye Digest website: http://www.agingeye.net/maculardegen /maculardegeninformation.php
    • Pelletier, A.L. (2009). Vision loss in older persons. American Family Physician , 79(11), 963-70. MEDLINE® is the source for the citation and abstract of this record.
    • Perski, T. B. (n.d.). Age-related understanding macular degeneration. Retrieved from Macular Degeneration International website: http://www.maculardegeneration .org/agedex.html
  • Continued…
    • Prasad, P.S., Schwartz, S.D., Hubschman, J.P. (2010). Age-related macular degeneration: Current and novel therapies. Maturitas . doi: 10.1016/j.maturitas.2010.02.006.
    • Redesigning your home. (n.d.). American Foundation for the Blind. Retrieved from the AFB Senior Site website: http://www.afb.org/seniorsite.asp ?SectionID=65&TopicID=299.
    • Singh, C., & Tewari, A. (2009). Supplements, lifestyle and AMD: What we know today. Review of Ophthalmology , 16 (10), 55-58. Retrieved from Academic Search Complete database.
    • Slotnick, S. (2010). Portable and at-home tech for AMD. Review of Optometry , 147 (2), 45-49. Retrieved from Academic Search Complete database.
  • Continued…
    • Symptoms of macular degeneration. (2004). University of Illinois Eye & Ear Institute. Retrieved from The Eye Digest website: http://www.agingeye.net/maculardegen /maculardegensymptoms.php
    • Webb, J., & Kubota, R. (2009). Potential dry AMD treatment slows visual cycle to prolong eye health. Optometry Times , 1 (9), 20-22. Retrieved from Academic Search Complete database.
    • Yin, W., Klein, R., Cong, S., Mitchell, P., Couper, D., Hong, L., et al. (2006). Age-related macular degeneration and risk for stroke. Annals of Internal Medicine , 145 (2), 98-W22. Retrieved from Academic Search Complete database.