Theories of aging, anti aging

Dr Ling Sien Ngan Anti Aging, Aesthetic Medical Practitioner

Theories of Ageing
Edith Cowan University
Faculty of Communications, Health & Science
Post Graduate Study in Andrology & Men’s Health
Ee 5 December 2004

Every single day, as we age , more and more people are dying of cancer, or simply of old age

Are you doing something about it?

Lowel Anti Aging + Aesthetic Clinic , SS2 ,PJ

Mission:
to enhance QoL
through comprehensive & integrated
anti aging & aesthetic healthcare services.

Anti Aging & Aesthetic medical practitioner 1. Anti Aging medicine 2. Men’s health & Andrology 5. Cosmetic surgery 4. Cosmetic Dermatology 3. Holistic complimentary medicine Aesthetic / External Anti aging

1) Anti aging medicine
Balanced diet
Nutritional supplementations + antioxidants
Detoxification  ( chelation, colon hydrotherapy, FIR sauna, ozoniser okamizu
Correct, moderate exercise.
Weight management
Syndrome X + Mx of chronic deg dse -CDD
Osteoporosis
Bio –identical hormones
Occupational health  noise , chemical
Stress Mx: relaxation  meditation , yoga
Chemoprevention & cancer

vs Wellness Industry Sickness Industry Anti Aging Medicine is Even here can still anti age !

Visible Oxidation damage in action
Free radical damage/oxidative stress, same process causing:
-Iron to rust
- Cut apple turning brown
-Underlying initiator of diseases, e.g.:
Pigmentation, wrinkle   repairable by cream CAD Multiple sclerosis Cancer Alzheimer’s dementia Stroke Macular degeneration

Theories of Ageing
Biologic, epidemiologic, + demographic data – an attempt to identify a cause or process;
Ageing: an extremely complex, multifactorial process;
Different theories not mutually exclusive;
Definition of ageing: open to various interpretations.

Summary of Presentation
Life span and Life expectancy.
Definition of Ageing.
What causes ageing?
Clinical approach to ageing.

Theories of Ageing
What causes ageing?

Life Span
Maximum life span is the theoretic species specific, longest duration of life, excluding premature unnatural life.
Jeanne Calment, died July 1997 at age of 122.
Lowland gorilla: 47 yrs Horse: 35 yrs American hookworm: 15 yrs Earthworm: 6 yrs

Life Expectancy
Life expectancy is the average number of additional years expected for a member of a population, regardless of cause of death.

Theories of Ageing
What causes ageing?

What is Ageing?

Ageing vs Senescence
“ Senescence”:
deteriorative processes that constitute natural causes of death.
“ Ageing”:
processes of accruing maturity with the passage of time, including...
George Martin. In: The ageing process, 1984

Ageing vs Senescence
Positive aspects like:
- becoming wiser
- mellow
- evolution of life style
… “ just like wine, improves as it ages but not as it senesces”.

Stages of Lifespan
Prenatal life
Birth
Postnatal life
neonatal
infancy
childhood
early
middle
late
adolescence
adulthood
senescence
Death
fertilisation-10months
birth thru’week 2
3 wks - 1st birthday
2 - 6 yrs
7 - 10 yrs
prepubertal
6 yrs following puberty
20 - 65 yrs
from 65 yrs
Ee

What is Ageing?
A ubiquitous biologic process, characterised by a progressive, inevitable evolution and maturation until death.
Ee Susan A Gaylord, Mark E Williams. In: Geriatrics Review Syllabus, 1990

Theories of Ageing
What causes ageing?
Ee

Ageing Process
primary ageing
secondary ageing
Ee True primary ageing is an ongoing normal process.

Environmental hazards
Ionising radiation?
Pollutants?
Chemicals
Diet?
Ambient temperature?
Diseases?
Ee

Theories of Ageing
“ The scientific study of ageing has been an odd mixture of the accumulation of mountains of dismal evidence that shows that almost anything you can think of goes wrong with age, and proposals of simplistic theories that try to explain ageing in terms of single processes, ranging from defective testicles to shortened telomeres.”
Ee Brian Charlesworth, an evolutionary biologist

Theories of Ageing
Research in ageing:
Traditional gerontologist
Evolutionary biologist
300 over theories till date!
Ee

Theories of Ageing
“ Programmed” theories – the biological clocks.
“ Error” theories – identify environmental insults.
Ee

Theories of Ageing
Evolutionary
Molecular
Cellular
Systemic
Ee Brian T. Weinert and Poala S. Timiras . Theories of Ageing. J Appl Physiol 95: 1706-1716, 2003.

Evolutionary Theories of Ageing
Mutation accumulation
Disposable soma
Antagonistic pleiotropy
Ee

Molecular Theories of Ageing
Gene regulation
Codon restriction
Error catastrophe
Somatic mutation
Dysdifferentiation
Ee

Cellular Theories of Ageing
Cellular senescence – Telomere theory
Free radical
Wear-and-tear
Apoptosis
Ee

System Theories of Ageing
Neuroendocrine
Immunologic
Rate-of-living
Ee

Theories of Ageing
Biological theories
genotropic
environmental
Psycho-social theories:
Disengagement
Exchange
Labelling
Social Stratification
Political economy
Continuity
Ee

Summary of Presentation
What causes ageing?
Ee

Clinical Approach to Ageing Ee True ageing vs disease states Biologic ageing vs chronologic ageing Promoting positive ageing

Positive Ageing: Pre-requisites
Ageing is not denied;
Perceptions and understanding of ageing are not disempowering;
Differences between people are acknowledged.
Ee Mary Davies

Reconceptualisation of Ageing?
Ageing exclusively characterised by declines in function & in health?
Substantial heterogeneity?
Existence of positive trajectories of ageing?
Possible avoidance of age-related diseases and disabilities?
Ee

Mechanisms of successful ageing
Persistence of normal function and plasticity
Compensatory responses to restore function
Interventions to replace deficient function
Changing of health outcome by modifying risk profiles
Prevention of diseases
Strengthening of social interactions and support
Ee Brian T. Weinert and Poala S. Timiras .

Promote Positive Ageing
Acceptance of ageing
empowerment
individuality
physical activity
social contact/friendship
developing coping skills
valuing experience, knowledge etc.
Denial of ageing
disempowerment
being stereotyped
sedentary lifestyle
social withdrawal
psychological stress
overvaluing paid work
Ee Brendan Kennelly Encourage Avoid

Conclusion
Ageing process is multifactorial and complex;
Research is still ongoing to determine the cause(s) or explain the process of ageing;
None is conclusive;
One important goal: how does intervention signals the body to delay ageing?
“ Successful” ageing is possible.
Ee

Reading List
Brian T. Weinert and Poala S. Timiras . Theories of Ageing. J Appl Physiol 95: 1706-1716, 2003.
Ageing: A natural history; 1995, RE Ricklefs, CE Finch (WH Freeman & Co).
Evolutionary biology of aging; 1991, MR Rose (New York: Oxford University Press).
The Aging Process: therapeutic implications; 1984, RN Butler, AG Bearn (Raven Press).
Geriatrics Review Syllabus: A core curriculum;1989, JC Beck (American Geriatrics Society).
Aging as a biological phenomenon: Review in Clinical Gerontology, Vol 1, No. 1, 1991.
Ee

How to choose Miss universe supplements ?
GMP --Supp manufacturing : poorly regulated
--Pharm factory adherence > food factory  pharm grade OTC sure better
Label, full disclosure + address
--Contain actual amount stated

Choose Ms universe supplement
Where products marketed ?
--Only locally in USA , < stringent
--To Canada, Australia, Europe > stringent  send on-site inspection regularly
--3 rd party certification on Quality of manufacturing
QC testing ( dissolvability )
--3/9 prenatal Vit ever dissolved – Uni of marryland

Antioxidant help good cell
Side effect of chemo, radio = oxidative stress to normal cell
Taking ^ dose antioxidant  ^ defense of normal cell while on chemo
 while chemo work at peak, side effect @ minimal---  win-win
Cancer cell receive double whammy
Oxidative stress from antioxidant (now pro-oxidant)
Chemo stress

Vit E Co Q10 B-carotene + vit A Against damage by chemo to lung, liver, kidney, heart, skin Against damage by Adriamycin to heart < side effect of chemo + radio Rx All these antioxidant  protect against damage to DNA of normal cell  From chemo + Radio Rx

INTERNAL BEAUTY CARE

If ageing can be halted... Ee The Lost Horizon Would you choose to be in it?

SEEKING A GOOD LIFE STYLE ?
Physically and emotionally strong
Age gracefully
Feel good factor

Be all that you are Show it off
VIBRANT
RADIANT
VITALITY
Thank you

My contact
E mail; [email_address]
Web; www.aestheticandyou.com
You tube; www.youtube.com/lowelantiaging
Face book; www.facebook.com/drdavidling

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Theories of aging, anti aging

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