The Management of Obesity Celso M. Fidel MD,FPSGS,FPCS Diplomate Philippine Board of Surgery
Introduction   <ul><li>Obesity  is a very serious health problem.  </li></ul><ul><li>The advent of modern  bariatric surge...
Assessing Severity   <ul><li>The  body mass index  (BMI) is  dividing the weight in kilograms by the height in meters squa...
Assessing Severity   <ul><li>The  body mass index  has proven to be a clinically relevant measure of obesity that can be l...
Assessing Severity   <ul><li>Abdominal obesity  is more predictive of the presence of metabolic risk factors (e.g., insuli...
Assessing Severity   <ul><li>Waist circumference is more closely correlated with visceral obesity  . Population survey dat...
Assessing Severity <ul><li>Other risk factors include :  </li></ul><ul><li>1. Elevated fasting triglycerides (>150 mg/dL) ...
Assessing Severity <ul><li>The National Heart, Lung and Blood Institute guidelines  </li></ul><ul><li>Define patients with...
Assessing Severity <ul><li>Medical obesity  is further subclassified into three categories: </li></ul><ul><li>Class 1 obes...
Assessing Severity <ul><li>In 1991, the National Institutes of Health defined  morbidly obese  individuals generally excee...
Assessing Severity <ul><li>In 1991, the National Institutes of Health defined  . </li></ul><ul><li>Superobesity  is a term...
Assessing Severity <ul><li>The relationship between body mass and Weight Classification: </li></ul><ul><li>BMI  < 18.5----...
Etiology   <ul><li>Storage of consumed energy as triglycerides within adipose tissue is a normal physiological process. It...
Etiology   <ul><li>The changes that have been witnessed over the past decades most likely have occurred as  energy expendi...
Etiology   <ul><li>The  properties  of the major macronutrients consumed by humans have substantially different core prope...
Nutritional and Metabolic Properties of the Common Macronutrients Properties Fat Protein Carbohydrate Alcohol Kcal/g 9 4 4...
Etiology   <ul><li>As the table illustrates </li></ul><ul><li>1. Fat has a very high energy density and  </li></ul><ul><li...
Nutritional and Metabolic Properties of the Common Macronutrients Properties Fat Protein Carbohydrate Alcohol Kcal/g 9 4 4...
Etiology   <ul><li>For these reasons, the importance of fat intake as a determinant of weight gain should be apparent—espe...
Etiology   <ul><li>Major determinants of energy expenditure are </li></ul><ul><li>The resting metabolic rate  (which is th...
Etiology   <ul><li>Behavioral factors that may vary genetically </li></ul><ul><li>1.The  preference for fat  in the diet <...
Etiology   <ul><li>Various metabolites, besides fatty acids or triglycerides, that are released by adipose tissue during s...
Etiolog y   <ul><li>Nutrient ingestion into the stomach or proximal intestine elicits hormonal signals that release  neuro...
Etiology   <ul><li>Leptin  is a good example  of the fundamental principles of neurohormonal signaling between the periphe...
Etiology   <ul><li>Leptin’s effects on food intake are governed by its effects on receptors within the arcuate nucleus of ...
Etiology   <ul><li>Humans born with homozygous loss of function mutations of the leptin gene (and who, therefore cannot pr...
Etiology   <ul><li>The Prader-Willi syndrome is a well-recognized disorder characterized </li></ul><ul><li>by childhood-on...
Etiology   <ul><li>The Prader-Willi syndrome  .  </li></ul><ul><li>They often include alterations in the  leptin-hypothala...
Etiology   <ul><li>Ghrelin  discovered in 1999, is a growth hormone secretagogue that is synthesized predominantly by the ...
Etiology   <ul><li>Obesity is associated with decreased circulating ghrelin levels. After gastric bypass surgery, ghrelin ...
  Medical problems associated with Obesity   <ul><li>Gastroesophageal reflux </li></ul><ul><li>2. Coronary artery disease ...
  Medical problems  associated with Obesity   <ul><li>Cancer of the: </li></ul><ul><li>1. Esophagus </li></ul><ul><li>2. S...
  Medical problems associated with Obesity   <ul><li>Cancer: </li></ul><ul><li>9. Gallbladder </li></ul><ul><li>10. Colon ...
Medical problems associated with  Obesity   <ul><li>Morbidity from obesity is increased in the presence of: </li></ul><ul>...
Medical problems associated with Obesity   <ul><li>Morbidity from obesity is increased in the presence of : </li></ul><ul>...
Medical problems associated with Obesity  <ul><li>Cardiovascular risks associated w/ significant obesity.   </li></ul><ul>...
Medical management of Obesity   <ul><li>Medications are classified into:  </li></ul><ul><li>1. Those that  decrease food i...
Medical management of Obesity   <ul><li>Appetite suppressants are believed to work by  increasing the availability of neur...
Medical management of Obesity   <ul><li>Sibutramine  works by inhibiting the uptake of these neurotransmitters. This drug ...
Medical management of Obesity   <ul><li>Orlistat  reduces nutrient absorption  by binding to gastrointestinal lipase and p...
Medical management of Obesity   <ul><li>The currently accepted approach is to combine  caloric restriction  with  exercise...
Guidelines  Treatment of Overweight and Obese Patients BMI/m Kg/m2  Health Risk Risk with comorbidities Treatment <25 Mini...
Surgical management of obesity <ul><li>Bariatric surgery should be offered </li></ul><ul><li>To appropriate patients with ...
Surgical management of obesity <ul><li>Candidates  for surgical therapy must be willing and able to comply with: </li></ul...
Surgical management of obesity <ul><li>Patients  who should  not undergo bariatric surgery </li></ul><ul><li>1. Ongoing dr...
Surgical management of obesity <ul><li>Surgical treatment is the only way to obtain consistent, durable weight loss for mo...
Surgical management of obesity <ul><li>Surgical treatment is indicated for patients with: </li></ul><ul><li>1. BMIs of 40 ...
Surgical management of obesity <ul><li>In all instances, the best care for morbidly obese patients provides unfettered acc...
Criteria for Surgical Treatment of Obesity <ul><li>BMI >40 or BMI between 35 and 40 in  </li></ul><ul><li>individuals with...
Criteria for Surgical Treatment of Obesity <ul><li>Not yet uniformly recommenced for children or adolescents (less than 18...
Preoperative Preparation <ul><li>Nutritional evaluation and education are critically important components of preoperative ...
Preoperative Preparation <ul><li>Psychiatric evaluation helps to prepare patients for operation and their postoperative re...
Preoperative Preparation <ul><li>1. All patients should have an electrocardiogram  </li></ul><ul><li>performed preoperativ...
Preoperative Preparation <ul><li>4. Patients who are diagnosed with significant sleep apnea require treatment with continu...
Preoperative Preparation <ul><li>5.  Obesity hypoventilation syndrome  may also be present in many obese patients. The syn...
Preoperative Preparation <ul><li>6. Patients with sleep apnea, the obesity hypoventilation syndrome, or any other signific...
Preoperative Preparation <ul><li>7. Finally, many patients with severe gastroesophageal reflux, dysphagia, nausea, vomitin...
Preoperative Preparation <ul><li>8. Preoperative laboratory evaluation typically include </li></ul><ul><li>a. Hemoglobin <...
Preoperative Preparation <ul><li>8. Preoperative laboratory evaluation typically include </li></ul><ul><li>g. Blood glucos...
Preoperative Preparation <ul><li>9. Obesity likely increases the risk of  </li></ul><ul><li>postoperative wound infections...
Historical Perspective and Overview <ul><li>A useful paradigm is to categorize bariatric procedures as:  </li></ul><ul><li...
Historical Perspective and Overview <ul><li>The rationale for the surgical treatment of obesity has been based on three fu...
Major Types of Bariatric Surgical Procedures <ul><li>1. Malabsorptive </li></ul><ul><li>    </li></ul><ul><li>2. Restricti...
Major Types of Bariatric Surgical Procedures <ul><li>3. Mostly restrictive </li></ul><ul><li>4. Mostly malabsorptive </li>...
.  Major Types of Bariatric Surgical Procedures <ul><li>1. Malabsorptive </li></ul><ul><li>   Jejunoileal and jejunocolic ...
.  Major Types of Bariatric Surgical Procedures <ul><li>3. Mostly restrictive </li></ul><ul><li>(1)   Short-limb (50–100 c...
Vertical Banded gastroplasty   <ul><li>The VBG is purely restrictive in nature, limiting the amount of solid food that can...
Vertical Banded gastroplasty   <ul><li>Techniques  Used in  VBC </li></ul><ul><li>1. Mason first described the vertical ba...
Vertical Banded gastroplasty   <ul><li>Techniques  Used in  VBC </li></ul><ul><li>5. 27F thoracostomy tube is passed from ...
Vertical Banded gastroplasty   <ul><li>Techniques  Used in  VBC </li></ul><ul><li>8. A 2.5-cm window is created through th...
Vertical Banded gastroplasty   <ul><li>Techniques  Used in  VBC </li></ul><ul><li>10.  Pouch volume is measured by instill...
Vertical Banded gastroplasty   <ul><li>Techniques  Used in  VBC </li></ul><ul><li>The laparoscopic technique  follows the ...
Vertical Banded gastroplasty   <ul><li>Techniques  Used in  VBC </li></ul><ul><li>The laparoscopic technique  follows the ...
Vertical Banded gastroplasty   <ul><li>Techniques  Used in  VBC </li></ul><ul><li>The laparoscopic technique  follows the ...
Vertical Banded gastroplasty
 
Efficacy of VBG <ul><li>VBC achieve acceptable weight loss results </li></ul><ul><li>Series of 305 patients followed for 2...
Efficacy of VBG <ul><li>Complications </li></ul><ul><li>Over all morbidity rate of VBG- under 10% </li></ul><ul><li>mortal...
Efficacy of VBG <ul><li>Complications </li></ul><ul><li>Late Complications </li></ul><ul><li>1. Stoma stenosis </li></ul><...
Efficacy of VBG <ul><li>Advantages </li></ul><ul><li>1. Significant improvement in comorbidities like  </li></ul><ul><li>d...
Efficacy of VBG <ul><li>Disadvantages </li></ul><ul><li>Long term weight loss is less successful when: </li></ul><ul><li>1...
Laparoscopic Gastric banding <ul><li>Mechanism of Action </li></ul><ul><li>Use of Silicone band </li></ul><ul><li>Restrict...
Adjustable gastric band
Efficacy of lGb <ul><li>Mean Excess weight loss in 1 and 2  years  55 to 56% </li></ul>
Laparoscopic Gastric banding <ul><li>Complications </li></ul><ul><li>Intraoperative Complications </li></ul><ul><li>1. Spl...
Laparoscopic Gastric banding <ul><li>Complications </li></ul><ul><li>Early postoperative Complications </li></ul><ul><li>1...
Laparoscopic Gastric banding <ul><li>Complications </li></ul><ul><li>Late Complications </li></ul><ul><li>1. Slippage of B...
Laparoscopic Gastric banding <ul><li>Advantages </li></ul><ul><li>1. Simple procedure and less operative time </li></ul><u...
Laparoscopic Gastric banding <ul><li>Disadvantages </li></ul><ul><li>Potential for site complicaton  </li></ul><ul><li>Nee...
 
Open roux en y gastric bypass <ul><li>Mechanism of action </li></ul><ul><li>Both a gastric restrictive </li></ul><ul><li>a...
Roux en y gastric bypass
Open roux en y gastric bypass <ul><li>1. Weight  loss  from gastric bypass is superior  </li></ul><ul><li>than purely rest...
Open roux en y gastric bypass <ul><li>Early Complications </li></ul><ul><li>1.  ANASTOMOTIC LEAK with  </li></ul><ul><li>p...
Open roux en y gastric bypass <ul><li>late Complications </li></ul><ul><li>1. Stomach stenosis  15% </li></ul><ul><li>2. M...
Open roux en y gastric bypass <ul><li>late Complications </li></ul><ul><li>7. Metabolic Complications </li></ul><ul><li>a....
Open roux en y gastric bypass <ul><li>Advantages </li></ul><ul><li>1. RYGB is more effective than vertical bonded </li></u...
Open roux en y gastric bypass <ul><li>disAdvantages </li></ul><ul><li>1. Dumping syndrome in a lot of patients  </li></ul>...
Open roux en y gastric bypass <ul><li>disAdvantages </li></ul><ul><li>c. Vasomotor symptoms like palpitation,  </li></ul><...
 
Laparoscopic roux en y gastric bypass <ul><li>Mechanism of action </li></ul><ul><li>1. Both gastric restrictive & mildly m...
Laparoscopic roux en y gastric bypass <ul><li>Efficacy </li></ul><ul><li>1. After 24 months follow up mean excess </li></u...
Laparoscopic roux en y gastric bypass <ul><li>complications </li></ul><ul><li>1. Pulmonary embolism 0- 1.5% </li></ul><ul>...
Laparoscopic roux en y gastric bypass <ul><li>advantages </li></ul><ul><li>1. Better cosmesis </li></ul><ul><li>2. Less po...
 
Laparoscopic roux en y gastric bypass <ul><li>disadvantages </li></ul><ul><li>1. Technically challenging, advance laparosc...
biliopancreatic diversion with duodenal switch
Bilio pancreatic procedures <ul><li>Mechanism of Action </li></ul><ul><li>1. The BPD is a procedure developed by Nicola  <...
Bilio pancreatic procedures <ul><li>Indications </li></ul><ul><li>1.This procedure is primarily indicated for the  </li></...
Bilio pancreatic procedures <ul><li>contraindications </li></ul><ul><li>1. Patients with anemia, hypocalcemia and </li></u...
Bilio pancreatic procedures <ul><li>Efficacy </li></ul><ul><li>1. Excellent and durable result </li></ul><ul><li>2. Mean e...
Bilio pancreatic procedures <ul><li>Technique </li></ul><ul><li>1. A subtotal gastrectomy is performed, leaving a  </li></...
Bilio pancreatic procedures <ul><li>Technique </li></ul><ul><li>3.The distal 250 cm of small intestine is anastomosed to t...
Bilio pancreatic procedures <ul><li>Technique </li></ul><ul><li>A modification of this technique with a duodenal switch in...
Bilio pancreatic procedures <ul><li>Technique </li></ul><ul><li>laparoscopic approach </li></ul><ul><li>1. Six to eight la...
Bilio pancreatic procedures <ul><li>Technique </li></ul><ul><li>3.  This allows for a lower marginal ulcer rate (0 to 1%),...
Bilio pancreatic procedures <ul><li>complications  </li></ul><ul><li>1.  Anemia  30% </li></ul><ul><li>2.  Protein Calorie...
Bilio pancreatic procedures <ul><li>complications  </li></ul><ul><li>9.  Prolongation of prothrombin time </li></ul><ul><l...
Bilio pancreatic procedures <ul><li>Late complications  </li></ul><ul><li>1. Intestinal Obstruction-  0.2% </li></ul><ul><...
Bilio pancreatic procedures <ul><li>Advantages </li></ul><ul><li>Even if patients consume a great quantity of food, the ma...
Bilio pancreatic procedures <ul><li>Advantages </li></ul><ul><li>The  laparoscopic BPD  with duodenal switch is an effecti...
Bilio pancreatic procedures <ul><li>Advantages </li></ul><ul><li>Offers better wt. loss than restrictive procedures becaus...
Bilio pancreatic procedures <ul><li>DisAdvantages </li></ul><ul><li>1.The BPD is technically a more complex procedure than...
Bilio pancreatic procedures <ul><li>DisAdvantages </li></ul><ul><li>2. Severe vitamin deficiencies may occur, leading to o...
Bilio pancreatic procedures <ul><li>DisAdvantages </li></ul><ul><li>. Replacement of fat-soluble vitamins is needed for pa...
Bilio pancreatic procedures <ul><li>DisAdvantages </li></ul><ul><li>The laparoscopic BPD is a technically demanding, lengt...
Bilio pancreatic procedures <ul><li>DisAdvantages </li></ul><ul><li>5. Protein malnutrition with:  </li></ul><ul><li>a. An...
Bilio pancreatic procedures <ul><li>Treatment  requires </li></ul><ul><li>1.  Prolonged hyperalimentation  </li></ul><ul><...
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The Management Of Obesity

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  • The Management Of Obesity

    1. 1. The Management of Obesity Celso M. Fidel MD,FPSGS,FPCS Diplomate Philippine Board of Surgery
    2. 2. Introduction <ul><li>Obesity is a very serious health problem. </li></ul><ul><li>The advent of modern bariatric surgery is increasingly recognized as an important therapeutic option for many patients with clinically significant obesity. </li></ul>
    3. 3. Assessing Severity <ul><li>The body mass index (BMI) is dividing the weight in kilograms by the height in meters squared </li></ul><ul><li>In adults, a normal body mass index measures between 18.5 and 24.9. </li></ul><ul><li>The BMI is closely, but not necessarily precisely, related to body fat content. </li></ul>
    4. 4. Assessing Severity <ul><li>The body mass index has proven to be a clinically relevant measure of obesity that can be linked to health outcomes. </li></ul><ul><li>The BMI associated with the lowest risk of death is within the normal range for most men and lies within the normal to overweight range for most women . </li></ul>
    5. 5. Assessing Severity <ul><li>Abdominal obesity is more predictive of the presence of metabolic risk factors (e.g., insulin resistance) than is an elevated BMI alone. </li></ul><ul><li>Waist circumference and the waist:hip ratio , used in conjunction with the BMI, may more accurately identify patients with central adiposity who are at risk for significant medical comorbidities, including cardiovascular disease. </li></ul>
    6. 6. Assessing Severity <ul><li>Waist circumference is more closely correlated with visceral obesity . Population survey data indicate that a waist circumference exceeding 98 cm in men and 87 cm in women can help identify patients who have an increased risk for cardiovascular disease </li></ul>
    7. 7. Assessing Severity <ul><li>Other risk factors include : </li></ul><ul><li>1. Elevated fasting triglycerides (>150 mg/dL) </li></ul><ul><li>2. Elevated high-density lipoprotein cholesterol </li></ul><ul><li>3. Hypertension (blood pressure >130/85 mm Hg) </li></ul><ul><li>4. Hyperglycemia (fasting plasma glucose levels >110 mg/dL) </li></ul><ul><li>The presence of any three of these risk factors identifies patients who have the metabolic syndrome </li></ul>
    8. 8. Assessing Severity <ul><li>The National Heart, Lung and Blood Institute guidelines </li></ul><ul><li>Define patients with body mass indices between 25 and 29.9 kg/m 2 body surface area as overweight </li></ul><ul><li>Those with BMIs exceeding 30 kg/m 2 are classified as obese </li></ul>
    9. 9. Assessing Severity <ul><li>Medical obesity is further subclassified into three categories: </li></ul><ul><li>Class 1 obesity for patients with body mass indices between 30 and 34.9 kg/m 2 </li></ul><ul><li>Class 2 obesity for BMIs between 35 and 39.9 </li></ul><ul><li>Class 3 obesity for patients with BMIs that exceed 40 kg/m 2 </li></ul>
    10. 10. Assessing Severity <ul><li>In 1991, the National Institutes of Health defined morbidly obese individuals generally exceed ideal body weight by 100 lb or more or are 100% over ideal body weight , patients as those with BMIs of 35 kg/m 2 or greater who had significant obesity-related conditions, or those with BMIs 40 kg/m 2 or greater in the absence of medical comorbidities. </li></ul>
    11. 11. Assessing Severity <ul><li>In 1991, the National Institutes of Health defined . </li></ul><ul><li>Superobesity is a term that is occasionally used to identify patients who have a body weight exceeding ideal body weight by 225% or more, BMIs equal to 50 kg/m 2 or greater. The National Institutes of Health definitions are similar to those of the World Health Organization. </li></ul>
    12. 12. Assessing Severity <ul><li>The relationship between body mass and Weight Classification: </li></ul><ul><li>BMI < 18.5-------------- Underweight </li></ul><ul><li>BMI 18.5-24.9-------- Normal </li></ul><ul><li>BMI 25---29.9--------- Overweight </li></ul><ul><li>BMI 30---34.9--------- Obesity class 1 </li></ul><ul><li>BMI 35---39.9--------- Obesity class 2 </li></ul><ul><li>BMI > 40------------------ Obesity class 3 </li></ul>
    13. 13. Etiology <ul><li>Storage of consumed energy as triglycerides within adipose tissue is a normal physiological process. It is appropriate to suppose that such a storage process would provide a survival advantage to the host during times of starvation or increased energy demands because the consumption of adipose tissue via hydrolysis releases fatty acids that can be used as an energy source by many tissues. </li></ul>
    14. 14. Etiology <ul><li>The changes that have been witnessed over the past decades most likely have occurred as energy expenditure has declined due to less physical activity, while food intake has remained the same or increased. </li></ul><ul><li>Energy balance is regulated by the balance between food intake and energy expenditure. </li></ul>
    15. 15. Etiology <ul><li>The properties of the major macronutrients consumed by humans have substantially different core properties that predict their effect on energy intake in most instances </li></ul><ul><li>Macronutrient's thermic effect , otherwise known as nutrient-induced thermogenesis , is the energy cost to the body of absorbing, processing, and storing an orally ingested food. </li></ul>
    16. 16. Nutritional and Metabolic Properties of the Common Macronutrients Properties Fat Protein Carbohydrate Alcohol Kcal/g 9 4 4 7 Energy density High Low Low Hjgh Nutrient-induced thermogenesis (percent of energy content) 2-3% 25-30 % 6-8% 15-20% Storage capacity High None Low None Autoregulation Poor Good Good Poor Ability to suppress hunger Low High High May stimulate hunger
    17. 17. Etiology <ul><li>As the table illustrates </li></ul><ul><li>1. Fat has a very high energy density and </li></ul><ul><li>storage capacity </li></ul><ul><li>2. It is subject to less autoregulation </li></ul><ul><li>3. It suppresses appetite somewhat less than </li></ul><ul><li>other macronutrients in general </li></ul><ul><li>4. It requires the least amount of energy for it to </li></ul><ul><li>be metabolized. </li></ul>
    18. 18. Nutritional and Metabolic Properties of the Common Macronutrients Properties Fat Protein Carbohydrate Alcohol Kcal/g 9 4 4 7 Energy density High Low Low Hjgh Nutrient-induced thermogenesis (percent of energy content) 2-3% 25-30 % 6-8% 15-20% Storage capacity High None Low None Autoregulation Poor Good Good Poor Ability to suppress hunger Low High High May stimulate hunger
    19. 19. Etiology <ul><li>For these reasons, the importance of fat intake as a determinant of weight gain should be apparent—especially as compared with protein or carbohydrate. </li></ul>
    20. 20. Etiology <ul><li>Major determinants of energy expenditure are </li></ul><ul><li>The resting metabolic rate (which is the amount of energy needed to maintain the body's core functions at rest) </li></ul><ul><li>The energy required to process the food consumed (which is the nutrient-induced thermogenesis described above </li></ul><ul><li>The energy consumed by physical activity. </li></ul><ul><li>. </li></ul>
    21. 21. Etiology <ul><li>Behavioral factors that may vary genetically </li></ul><ul><li>1.The preference for fat in the diet </li></ul><ul><li>2. Metabolic adaptations to food restriction </li></ul><ul><li>3. Tolerance for physical activity </li></ul><ul><li>4. The frequenc y of meals. </li></ul>
    22. 22. Etiology <ul><li>Various metabolites, besides fatty acids or triglycerides, that are released by adipose tissue during starvation include various </li></ul><ul><li>Cytokines and prostaglandins that may help regulate energy balance </li></ul><ul><li>Resistin and Fibronectin that may influence carbohydrate metabolism </li></ul>
    23. 23. Etiolog y <ul><li>Nutrient ingestion into the stomach or proximal intestine elicits hormonal signals that release neuropeptides , which in turn alter body metabolism </li></ul><ul><li>Pleptin, ghrelin , which is normally associated with appetite stimulation (i.e., is orexigenic) </li></ul><ul><li>Insulin and cholecystokinin are normally anorexic </li></ul>
    24. 24. Etiology <ul><li>Leptin is a good example of the fundamental principles of neurohormonal signaling between the periphery and the central nervous system </li></ul><ul><li>Leptin is a cytokinelike polypeptide hormone that is known to influence long-term changes in satiety. It is produced predominantly by adipose tissue and its circulating levels are proportional to the amount of fat stored as adipose tissue. </li></ul>
    25. 25. Etiology <ul><li>Leptin’s effects on food intake are governed by its effects on receptors within the arcuate nucleus of the hypothalamus. There it induces the production of -melanocyte stimulating hormone MSH) from propiomelanocortin </li></ul><ul><li>MSH binds with melanocortin 4 receptors within hypothalamic nuclei and inhibits food intake </li></ul><ul><li>Leptin also decreases the production of appetite-inducing neuropeptides such as neuropeptide Y </li></ul>
    26. 26. Etiology <ul><li>Humans born with homozygous loss of function mutations of the leptin gene (and who, therefore cannot produce leptin) eventually develop morbid obesity. </li></ul><ul><li>These unfortunate individuals continuously seek food and eat much more than normal Other phenotypical manifestations includes </li></ul><ul><li>1. Adrenal insufficiency </li></ul><ul><li>2. Changes in hair color </li></ul><ul><li>3. Impaired fertility are common </li></ul>
    27. 27. Etiology <ul><li>The Prader-Willi syndrome is a well-recognized disorder characterized </li></ul><ul><li>by childhood-onset upper body obesity </li></ul><ul><li>short stature </li></ul><ul><li>mental retardation </li></ul><ul><li>hypogonadism. </li></ul>
    28. 28. Etiology <ul><li>The Prader-Willi syndrome . </li></ul><ul><li>They often include alterations in the leptin-hypothalamic feedback loop of important signal precursors such as: </li></ul><ul><li>1. Propiomelanocortin </li></ul><ul><li>2. Leptin gene </li></ul><ul><li>3. Leptin receptor </li></ul><ul><li>4. Melanocortin 4 receptor mutations </li></ul>
    29. 29. Etiology <ul><li>Ghrelin discovered in 1999, is a growth hormone secretagogue that is synthesized predominantly by the stomach. </li></ul><ul><li>Its levels rise just before meals and with short-term food restriction, or prolonged starvation in general and may be an important orexigenic (i.e., appetite-stimulating) signal. </li></ul><ul><li>Ghrelin levels normally fall rapidly after meals. Like leptin, ghrelin metabolism may be dysregulated in obese subjects. </li></ul>
    30. 30. Etiology <ul><li>Obesity is associated with decreased circulating ghrelin levels. After gastric bypass surgery, ghrelin levels fall but do not increase as expected before meals </li></ul><ul><li>Low levels of ghrelin and its metabolic dysregulation may be at least partially responsible for the sustained weight loss after surgical procedures that resect and/or bypass a significant portion of the stomach. </li></ul>
    31. 31. Medical problems associated with Obesity <ul><li>Gastroesophageal reflux </li></ul><ul><li>2. Coronary artery disease </li></ul><ul><li>3. Cerebrovascular accident </li></ul><ul><li>4. Congestive heart failure </li></ul><ul><li>5. Hypertension </li></ul><ul><li>6. Dyslipidemia </li></ul><ul><li>7. Cholelithiasis and gallbladder disease </li></ul><ul><li>8. Osteoarthritis and degenerative joint disease </li></ul><ul><li>9. Slap apnea </li></ul>
    32. 32. Medical problems associated with Obesity <ul><li>Cancer of the: </li></ul><ul><li>1. Esophagus </li></ul><ul><li>2. Stomach </li></ul><ul><li>3. Liver </li></ul><ul><li>4. Pancreas </li></ul><ul><li>5. Kidney </li></ul><ul><li>6. Prostate </li></ul><ul><li>7. Ovaries </li></ul><ul><li>8. Uterus </li></ul>
    33. 33. Medical problems associated with Obesity <ul><li>Cancer: </li></ul><ul><li>9. Gallbladder </li></ul><ul><li>10. Colon </li></ul><ul><li>Non Hodgkin’s lymphoma </li></ul><ul><li>Multiple myeloma </li></ul><ul><li>Menstrual Abnormalities </li></ul><ul><li>Impaired fertility and increased risk of adverse outcome after pregnancy </li></ul><ul><li>Stress inccontinence </li></ul>
    34. 34. Medical problems associated with Obesity <ul><li>Morbidity from obesity is increased in the presence of: </li></ul><ul><li>1. Preexisting coronary artery or peripheral artery disease </li></ul><ul><li>2.Type II diabetes </li></ul><ul><li>3. Hypertension </li></ul><ul><li>4. Smoking </li></ul>
    35. 35. Medical problems associated with Obesity <ul><li>Morbidity from obesity is increased in the presence of : </li></ul><ul><li>5. Elevated low-density or decreased high-density lipoprotein levels </li></ul><ul><li>6. Increased fasting blood sugar concentrations </li></ul><ul><li>7. Patients with a family history of early-onset heart disease </li></ul>
    36. 36. Medical problems associated with Obesity <ul><li>Cardiovascular risks associated w/ significant obesity. </li></ul><ul><li>1. Overweight women have 50% > risk of heart failure compared to women with normal BMIs. </li></ul><ul><li>2.The risk is twofold higher in obese females. </li></ul><ul><li>3. Obese men have a 90% greater risk of heart failure. </li></ul><ul><li>4. Overall, approximately 11% of all heart failure cases in men and 14% in women can be attributed to obesity alone. </li></ul>
    37. 37. Medical management of Obesity <ul><li>Medications are classified into: </li></ul><ul><li>1. Those that decrease food intake by suppressing appetite or increasing satiety </li></ul><ul><li>2. Those that decrease nutrient absorption . </li></ul>
    38. 38. Medical management of Obesity <ul><li>Appetite suppressants are believed to work by increasing the availability of neurotransmitters which suppress appetite such as: </li></ul><ul><li>1. norepinephrine </li></ul><ul><li>2. serotonin </li></ul><ul><li>3 . dopamine </li></ul>
    39. 39. Medical management of Obesity <ul><li>Sibutramine works by inhibiting the uptake of these neurotransmitters. This drug may also stimulate thermogenesis , although this effect is modest and constitutes only 3–5% of the average person's resting metabolic rate. </li></ul><ul><li>Randomized controlled trials indicate that the average patient will lose approximately 3–4 kg over 8–52 weeks of treatment. </li></ul>
    40. 40. Medical management of Obesity <ul><li>Orlistat reduces nutrient absorption by binding to gastrointestinal lipase and prevents the hydrolysis of dietary fat into absorbable free fatty acids and monoacylglycerols. </li></ul><ul><li>Patients who are treated with orlistat excrete about a third of the dietary fat that they consume in their stools and can be expected to lose about 9% of their baseline weight on average. </li></ul>
    41. 41. Medical management of Obesity <ul><li>The currently accepted approach is to combine caloric restriction with exercise and behavioral modification as the initial treatment recommendation for most overweight or obese patients. </li></ul><ul><li>Diet modification , exercise , and behavioral modifications should be the cornerstones of every treatment plan. </li></ul>
    42. 42. Guidelines Treatment of Overweight and Obese Patients BMI/m Kg/m2 Health Risk Risk with comorbidities Treatment <25 Minimal Low Healthy eating,exercise & lifestyle changes 25-26.9 Low Moderate 27-29.9 Moderate High All of the above plus low caloric diet 30-34.9 High Very High All of the above plus pharmacotherapy or very low 35-39.9 Very High Extremely High Caloric diet >40 Extremely High Extremely High All of the above plus Bariatric Surgery
    43. 43. Surgical management of obesity <ul><li>Bariatric surgery should be offered </li></ul><ul><li>To appropriate patients with BMIs of 40 kg/m 2 or greater (or between 35 and 40 kg/m 2 if any of the previously described significant medical comorbidities are present) </li></ul><ul><li>Who have failed medical treatment, nutritional treatment, lifestyle changes, behavioral modification, or other conservative therapies. </li></ul>
    44. 44. Surgical management of obesity <ul><li>Candidates for surgical therapy must be willing and able to comply with: </li></ul><ul><li>Postoperative dietary recommendations </li></ul><ul><li>Exercise </li></ul><ul><li>Follow-up requirements </li></ul>
    45. 45. Surgical management of obesity <ul><li>Patients who should not undergo bariatric surgery </li></ul><ul><li>1. Ongoing drug or alcohol dependency </li></ul><ul><li>2. Who are unstable or otherwise unfit </li></ul><ul><li>psychiatrically </li></ul><ul><li>3. Who are unable to undergo general </li></ul><ul><li>anesthesia </li></ul>
    46. 46. Surgical management of obesity <ul><li>Surgical treatment is the only way to obtain consistent, durable weight loss for most morbidly obese patients </li></ul>
    47. 47. Surgical management of obesity <ul><li>Surgical treatment is indicated for patients with: </li></ul><ul><li>1. BMIs of 40 kg/m 2 or greater </li></ul><ul><li>  </li></ul><ul><li>2. BMIs of 35–40 kg/m 2 with obesity-related comorbidities    </li></ul><ul><li>3. When medical, nutritional, and behavioral therapies are ineffective </li></ul>
    48. 48. Surgical management of obesity <ul><li>In all instances, the best care for morbidly obese patients provides unfettered access to, and evaluation by, a multidisciplinary team comprised of : </li></ul><ul><li>1. Nutritionists </li></ul><ul><li>2. Physical or exercise therapists </li></ul><ul><li>3. Surgeons </li></ul><ul><li>4. Medical specialists </li></ul><ul><li>5. Psychiatrists. </li></ul>
    49. 49. Criteria for Surgical Treatment of Obesity <ul><li>BMI >40 or BMI between 35 and 40 in </li></ul><ul><li>individuals with high-risk comorbid or </li></ul><ul><li>severe lifestyle limitations for greater </li></ul><ul><li>than 5 years </li></ul><ul><li>2. Absence of secondary cause of morbid </li></ul><ul><li>obesity </li></ul><ul><li>3. Ability and willingness to cooperate with </li></ul><ul><li>long-term follow-up </li></ul><ul><li>4. Acceptable operative risk </li></ul>
    50. 50. Criteria for Surgical Treatment of Obesity <ul><li>Not yet uniformly recommenced for children or adolescents (less than 18 years of age), or patients over the age of 60 </li></ul>
    51. 51. Preoperative Preparation <ul><li>Nutritional evaluation and education are critically important components of preoperative preparation. </li></ul><ul><li>Psychiatric evaluation helps some patients cope more effectively with various stressors that may surface in their interpersonal relationships after surgery. </li></ul>
    52. 52. Preoperative Preparation <ul><li>Psychiatric evaluation helps to prepare patients for operation and their postoperative recuperation, and also helps to identify patients with eating disorders , severe depression , psychosis , or other mood disturbances that could adversely affect outcome. </li></ul>
    53. 53. Preoperative Preparation <ul><li>1. All patients should have an electrocardiogram </li></ul><ul><li>performed preoperatively. </li></ul><ul><li>2. Stress testing & even cardiac catheterization </li></ul><ul><li>may be indicated for intermediate- or high- </li></ul><ul><li>risk patients. </li></ul><ul><li>3. Polysomnographic evaluation at a sleep </li></ul><ul><li>center for all morbidly obese patients who </li></ul><ul><li>are being evaluated for surgical treatment. </li></ul>
    54. 54. Preoperative Preparation <ul><li>4. Patients who are diagnosed with significant sleep apnea require treatment with continuous positive airway pressure and are at risk for acute upper airway obstruction and significant cardiac arrhythmias postoperatively. </li></ul>
    55. 55. Preoperative Preparation <ul><li>5. Obesity hypoventilation syndrome may also be present in many obese patients. The syndrome is defined by the presence of significant hypoxemia with arterial partial pressure of oxygen less than 55 mm Hg , and hypercarbia with a partial pressure of carbon dioxide greater than 47 mm Hg. </li></ul>
    56. 56. Preoperative Preparation <ul><li>6. Patients with sleep apnea, the obesity hypoventilation syndrome, or any other significant airway or parenchymal lung disease should be evaluated by a pulmonologist preoperatively </li></ul>
    57. 57. Preoperative Preparation <ul><li>7. Finally, many patients with severe gastroesophageal reflux, dysphagia, nausea, vomiting, abdominal pain, or a prior history of gastric or intestinal surgery may require formal evaluation of the gastrointestinal tract including barium swallow, upper G I series, esophagogastroduodenoscopy, esophageal manometry, and pH testing and computed tomography of the abdomen with and without contrast. </li></ul>
    58. 58. Preoperative Preparation <ul><li>8. Preoperative laboratory evaluation typically include </li></ul><ul><li>a. Hemoglobin </li></ul><ul><li>b. Hematocrit </li></ul><ul><li>c.Platelet count measurements </li></ul><ul><li>d. Assessment of electrolyte levels </li></ul><ul><li>e. BUN </li></ul><ul><li>f. Creatine . </li></ul>
    59. 59. Preoperative Preparation <ul><li>8. Preoperative laboratory evaluation typically include </li></ul><ul><li>g. Blood glucose </li></ul><ul><li>h. Liver function </li></ul><ul><li>i. Pap smears </li></ul><ul><li>j. Pregnancy testing performed routinely. </li></ul><ul><li>K. Hemoglobin A 1c </li></ul><ul><li>l. Posteroanterior and lateral radiographs of the chest evaluated routinely. </li></ul>
    60. 60. Preoperative Preparation <ul><li>9. Obesity likely increases the risk of </li></ul><ul><li>postoperative wound infections. Antibiotic </li></ul><ul><li>prophylaxis is indicated according to the: </li></ul><ul><li>a. Likelihood of wound contamination </li></ul><ul><li>b. The type of procedure planned. </li></ul><ul><li>Rate of wound infection after laparoscopic </li></ul><ul><li>gastric bypass appears reduced by 75% </li></ul><ul><li>compared with open gastric bypass surgery. </li></ul>
    61. 61. Historical Perspective and Overview <ul><li>A useful paradigm is to categorize bariatric procedures as: </li></ul><ul><li>1. Restrictive </li></ul><ul><li>2. Malabsorptive </li></ul><ul><li>3. Combination of both </li></ul>
    62. 62. Historical Perspective and Overview <ul><li>The rationale for the surgical treatment of obesity has been based on three fundamental goals: </li></ul><ul><li>1. Reducing caloric absorption by bypassing </li></ul><ul><li>portions of the stomach and small bowel </li></ul><ul><li>2. Reducing gastric capacity via banding, </li></ul><ul><li>stapling, or transection </li></ul><ul><li>3. Performing operations that induce </li></ul><ul><li>malabsorption and restrict food intake . </li></ul>
    63. 63. Major Types of Bariatric Surgical Procedures <ul><li>1. Malabsorptive </li></ul><ul><li>   </li></ul><ul><li>2. Restrictive </li></ul>
    64. 64. Major Types of Bariatric Surgical Procedures <ul><li>3. Mostly restrictive </li></ul><ul><li>4. Mostly malabsorptive </li></ul><ul><li>  </li></ul>
    65. 65. . Major Types of Bariatric Surgical Procedures <ul><li>1. Malabsorptive </li></ul><ul><li>   Jejunoileal and jejunocolic bypasses (no longer recommended </li></ul><ul><li>2. Restrictive </li></ul><ul><li>(1) Vertical banded gastroplasty </li></ul><ul><li>(2) Adjustable silicone gastric banding </li></ul>
    66. 66. . Major Types of Bariatric Surgical Procedures <ul><li>3. Mostly restrictive </li></ul><ul><li>(1)   Short-limb (50–100 cm) Roux-en-Y </li></ul><ul><li>gastric bypass </li></ul><ul><li>(2) Long-limb (150 cm) Roux-en-Y gastric </li></ul><ul><li>bypass </li></ul><ul><li>4. Mostly malabsorptive </li></ul><ul><li>  Biliopancreatic diversion with or without </li></ul><ul><li>duodenal switch </li></ul>
    67. 67. Vertical Banded gastroplasty <ul><li>The VBG is purely restrictive in nature, limiting the amount of solid food that can be consumed at one time, which leads to a calorie deficit. Of note, liquid intake is not limited by this procedure, and as such can be utilized to overcome the intended effect of the operation. A proximal gastric pouch empties through a calibrated stoma, which is reinforced by a strip of mesh or a Silastic ring. </li></ul>
    68. 68. Vertical Banded gastroplasty <ul><li>Techniques Used in VBC </li></ul><ul><li>1. Mason first described the vertical banded </li></ul><ul><li>Gastroplasty in 1982 </li></ul><ul><li>2. Ewald tube is passed through the mouth and into the stomach to facilitate isolation of the esophagus, and later facilitates pouch volume measurement and calibration of the stoma. </li></ul><ul><li>3.The esophagus is encircled w/ a Penrose drain. </li></ul><ul><li>4. The lesser omentum is opened </li></ul>
    69. 69. Vertical Banded gastroplasty <ul><li>Techniques Used in VBC </li></ul><ul><li>5. 27F thoracostomy tube is passed from this opening behind the stomach and up to the angle of His through the gastrophrenic ligament </li></ul><ul><li>6. An anvil for a circular stapler is held in the lesser sac against the posterior stomach wall. </li></ul><ul><li>7. A trocar is pushed through both walls of the stomach at a point about 8 to 9 cm below the angle of His and into the anvil </li></ul>
    70. 70. Vertical Banded gastroplasty <ul><li>Techniques Used in VBC </li></ul><ul><li>8. A 2.5-cm window is created through the </li></ul><ul><li>proximal stomach, firing a circular stapler w/ </li></ul><ul><li>Ewald tube pressed against lesser curvature. </li></ul><ul><li>9. A line of four rows of 90-mm staples leads from the circular opening to the angle of His to create a pouch 50 mL in size or smaller. </li></ul>
    71. 71. Vertical Banded gastroplasty <ul><li>Techniques Used in VBC </li></ul><ul><li>10. Pouch volume is measured by instilling </li></ul><ul><li>saline into Ewald tube. Some surgeons use </li></ul><ul><li>a linear cutting stapler to create the pouch. </li></ul><ul><li>11. A strip of polypropylene mesh measuring 7 </li></ul><ul><li>by 1.5 cm is placed around the lesser </li></ul><ul><li>curvature channel and is sewn to itself to </li></ul><ul><li>create a 5.0 to 5.5 cm collar circumference. </li></ul>
    72. 72. Vertical Banded gastroplasty <ul><li>Techniques Used in VBC </li></ul><ul><li>The laparoscopic technique follows the same principles. </li></ul><ul><li>Using a five-trocar technique, the abdomen is </li></ul><ul><li>entered and the left hepatic lobe is retracted </li></ul><ul><li>anteriorly. </li></ul><ul><li>2. The peritoneal reflection lateral to the angle of His is incised. </li></ul><ul><li>3. The gastrohepatic omentum is incised and the lesser sac is entered. </li></ul>
    73. 73. Vertical Banded gastroplasty <ul><li>Techniques Used in VBC </li></ul><ul><li>The laparoscopic technique follows the same principles. </li></ul><ul><li>4. A 25-mm circular stapler is used to create a window through the stomach, 4 cm below the angle of His, near the lesser curvature of the stomach. </li></ul><ul><li>5. A 60-mm linear stapler is inserted into this opening and is fired along a 9-mm esophageal bougie to create a divided staple line leading to the angle of His. </li></ul>
    74. 74. Vertical Banded gastroplasty <ul><li>Techniques Used in VBC </li></ul><ul><li>The laparoscopic technique follows the same principles. </li></ul><ul><li>6. A 5-cm band of polypropylene mesh is sutured around the gastric pouch. </li></ul><ul><li>Another technique involves linear cutting stapler to excise a wedge of fundus, creating a 20-mL pouch w/o use of circular stapler . A polypropylene mesh or polytetrafluoroethylene band is sutured around distal end of gastroplasty </li></ul>
    75. 75. Vertical Banded gastroplasty
    76. 77. Efficacy of VBG <ul><li>VBC achieve acceptable weight loss results </li></ul><ul><li>Series of 305 patients followed for 2 years- mean excess loss of 61% </li></ul><ul><li>Series of 250 patients followed for 5 years- Mean excess wt. loss 60% for Morbidly obese </li></ul><ul><li>Mean excess wt. loss 52% for super obese </li></ul><ul><li>A significant number of patients have required a reoperation following VBG </li></ul>
    77. 78. Efficacy of VBG <ul><li>Complications </li></ul><ul><li>Over all morbidity rate of VBG- under 10% </li></ul><ul><li>mortality rate of 0- 38% </li></ul><ul><li>Early Complications </li></ul><ul><li>Splenectomy 3% </li></ul><ul><li>Peritonitis from leak 6% </li></ul>
    78. 79. Efficacy of VBG <ul><li>Complications </li></ul><ul><li>Late Complications </li></ul><ul><li>1. Stoma stenosis </li></ul><ul><li>2. Staple line dehiscence 48% </li></ul><ul><li>3. Reflux Esophagitis </li></ul><ul><li>4. Intractable vomiting 30-50% </li></ul>
    79. 80. Efficacy of VBG <ul><li>Advantages </li></ul><ul><li>1. Significant improvement in comorbidities like </li></ul><ul><li>dyspnea, hypertension, diabetes mellitus, </li></ul><ul><li>quality of life </li></ul><ul><li>2. Minimal long term metabolic or nutritional </li></ul><ul><li>deficiency </li></ul><ul><li>3. Less operating time </li></ul><ul><li>4. No anastomosis required </li></ul>
    80. 81. Efficacy of VBG <ul><li>Disadvantages </li></ul><ul><li>Long term weight loss is less successful when: </li></ul><ul><li>1. Patient eat sweet food </li></ul><ul><li>2. In high liquid caloric intake </li></ul><ul><li>3. Less effective in terms of weight loss as </li></ul><ul><li>compared to gastric bypass </li></ul>
    81. 82. Laparoscopic Gastric banding <ul><li>Mechanism of Action </li></ul><ul><li>Use of Silicone band </li></ul><ul><li>Restricts amount of ingested solid food </li></ul><ul><li>Adjustable nature of the band </li></ul>
    82. 83. Adjustable gastric band
    83. 84. Efficacy of lGb <ul><li>Mean Excess weight loss in 1 and 2 years 55 to 56% </li></ul>
    84. 85. Laparoscopic Gastric banding <ul><li>Complications </li></ul><ul><li>Intraoperative Complications </li></ul><ul><li>1. Splenic injury 0 to 1 % </li></ul><ul><li>2. Esophageal injury 0 to 1% </li></ul><ul><li>3. Gastric injury 0 to 1% </li></ul><ul><li>4. Conversion to open procedure 1 to 2 % </li></ul><ul><li>5. Bleeding 0 to 1% </li></ul>
    85. 86. Laparoscopic Gastric banding <ul><li>Complications </li></ul><ul><li>Early postoperative Complications </li></ul><ul><li>1. Bleeding 0.5 % </li></ul><ul><li>2. Wound infection 0 to 1% </li></ul><ul><li>3. Food intolerance 0 to 11% </li></ul>
    86. 87. Laparoscopic Gastric banding <ul><li>Complications </li></ul><ul><li>Late Complications </li></ul><ul><li>1. Slippage of Band 7- 21% </li></ul><ul><li>2. Band Erosion 2 to 7.5% </li></ul><ul><li>3. Leakage of reservoir </li></ul><ul><li>4. Persistent vomiting </li></ul>
    87. 88. Laparoscopic Gastric banding <ul><li>Advantages </li></ul><ul><li>1. Simple procedure and less operative time </li></ul><ul><li>2. Mortality is low 0.06% </li></ul><ul><li>3. No staple liner or anastomosis </li></ul><ul><li>4. Recovery is rapid and hospital stay is short </li></ul>
    88. 89. Laparoscopic Gastric banding <ul><li>Disadvantages </li></ul><ul><li>Potential for site complicaton </li></ul><ul><li>Need for frequent </li></ul><ul><li>postoperative visit for </li></ul><ul><li>gastric band adjustment </li></ul>
    89. 91. Open roux en y gastric bypass <ul><li>Mechanism of action </li></ul><ul><li>Both a gastric restrictive </li></ul><ul><li>and </li></ul><ul><li>Mildly malabsorptive procedure </li></ul>
    90. 92. Roux en y gastric bypass
    91. 93. Open roux en y gastric bypass <ul><li>1. Weight loss from gastric bypass is superior </li></ul><ul><li>than purely restrictive procedures . </li></ul><ul><li>2 . Five year weight loss was 48 -74 % loss of </li></ul><ul><li>excess weight. </li></ul><ul><li>3. RYGB- to prevent the progression of non </li></ul><ul><li>insulin dependent Diabetes Mellitus, reduce </li></ul><ul><li>the mortality from Diabetes Mellitus and </li></ul><ul><li>Cardiovascular disease. </li></ul>
    92. 94. Open roux en y gastric bypass <ul><li>Early Complications </li></ul><ul><li>1. ANASTOMOTIC LEAK with </li></ul><ul><li>peritonitis - 1.2% </li></ul><ul><li>2. Acute distal gastric dilatation </li></ul><ul><li>3. Severe wound infection </li></ul>
    93. 95. Open roux en y gastric bypass <ul><li>late Complications </li></ul><ul><li>1. Stomach stenosis 15% </li></ul><ul><li>2. Marginal Ulcer 13% </li></ul><ul><li>3. Intestinal Obstruction </li></ul><ul><li>4. Internal Hernia </li></ul><ul><li>5. Staple line destruction </li></ul><ul><li>6. Incisional Hernia </li></ul>
    94. 96. Open roux en y gastric bypass <ul><li>late Complications </li></ul><ul><li>7. Metabolic Complications </li></ul><ul><li>a. Deficiencies of: </li></ul><ul><li>Calcium, thiamine, Vit B12 30-70% </li></ul><ul><li>Folate 9- 18% </li></ul><ul><li>Iron 20-49% </li></ul><ul><li>b. Anemia 18-35% </li></ul>
    95. 97. Open roux en y gastric bypass <ul><li>Advantages </li></ul><ul><li>1. RYGB is more effective than vertical bonded </li></ul><ul><li>gastroplasty </li></ul><ul><li>2. Presence of dumping syndrome encourages </li></ul><ul><li>patient to avoid sweet food </li></ul>
    96. 98. Open roux en y gastric bypass <ul><li>disAdvantages </li></ul><ul><li>1. Dumping syndrome in a lot of patients </li></ul><ul><li>a. Due to rapid emptying hyperosmolar boluses </li></ul><ul><li>in small intestines </li></ul><ul><li>b. Bloating, nausea, vomiting, diarrhea and </li></ul><ul><li>abdominal pain after intake of milk and </li></ul><ul><li>sweet products </li></ul>
    97. 99. Open roux en y gastric bypass <ul><li>disAdvantages </li></ul><ul><li>c. Vasomotor symptoms like palpitation, </li></ul><ul><li>diaphoresis and lightheadedness </li></ul><ul><li>2. Distal gastric distention – hiccups and left </li></ul><ul><li>shoulder pain </li></ul><ul><li>3. Internal hernia </li></ul>
    98. 101. Laparoscopic roux en y gastric bypass <ul><li>Mechanism of action </li></ul><ul><li>1. Both gastric restrictive & mildly malabsortive </li></ul><ul><li>procedure </li></ul><ul><li>2. Small gastric pouch restricts gastric intake </li></ul><ul><li>while the Roux Y configuration provides </li></ul><ul><li>malabsorpton of calories and nutrients </li></ul>
    99. 102. Laparoscopic roux en y gastric bypass <ul><li>Efficacy </li></ul><ul><li>1. After 24 months follow up mean excess </li></ul><ul><li>weight loss ranges from 69- 82% </li></ul><ul><li>2. Most comorbidities were improved and </li></ul><ul><li>eradicated </li></ul>
    100. 103. Laparoscopic roux en y gastric bypass <ul><li>complications </li></ul><ul><li>1. Pulmonary embolism 0- 1.5% </li></ul><ul><li>2. Anastomotic leak 1.5- 5.8% </li></ul><ul><li>3. Bleeding 0- 3.3% </li></ul><ul><li>4. Stenosis of gastroepinoctomy 1.6- 6.3% </li></ul><ul><li>5. Internal Hernia 2.5% </li></ul><ul><li>6. Marginal Ulcer 1.4% </li></ul><ul><li>7. Gallstone 1.4% </li></ul>
    101. 104. Laparoscopic roux en y gastric bypass <ul><li>advantages </li></ul><ul><li>1. Better cosmesis </li></ul><ul><li>2. Less postoperative pain </li></ul><ul><li>3. Attenuation of postoperative stress response </li></ul><ul><li>4. Reduce wound infection, dehiscence </li></ul><ul><li>5. Incisional Hernia </li></ul><ul><li>6. Improvement of postoperative pulmonary </li></ul><ul><li>function </li></ul>
    102. 106. Laparoscopic roux en y gastric bypass <ul><li>disadvantages </li></ul><ul><li>1. Technically challenging, advance laparoscopy </li></ul><ul><li>of steep learning curve </li></ul><ul><li>2. Approach may be difficult in super obese </li></ul><ul><li>patients </li></ul>
    103. 107. biliopancreatic diversion with duodenal switch
    104. 108. Bilio pancreatic procedures <ul><li>Mechanism of Action </li></ul><ul><li>1. The BPD is a procedure developed by Nicola </li></ul><ul><li>Scopinaro of Italy. </li></ul><ul><li>2. The procedure combines gastric restriction </li></ul><ul><li>with an intestinal malabsorptive procedure. </li></ul><ul><li>3. A 50- to 100-cm common absorptive </li></ul><ul><li>alimentary channel is created proximal to the </li></ul><ul><li>ileocecal valve; digestion and absorption are </li></ul><ul><li>limited to this segment of bowel </li></ul>
    105. 109. Bilio pancreatic procedures <ul><li>Indications </li></ul><ul><li>1.This procedure is primarily indicated for the </li></ul><ul><li>superobese </li></ul><ul><li>2.Those who have failed restrictive bariatric </li></ul><ul><li>procedures. </li></ul><ul><li>3. Less commonly, some surgeons perform BPD </li></ul><ul><li>as primary operation in the non-superobese. </li></ul>
    106. 110. Bilio pancreatic procedures <ul><li>contraindications </li></ul><ul><li>1. Patients with anemia, hypocalcemia and </li></ul><ul><li>osteoporosis </li></ul><ul><li>2. Those who cannot comply with the strigent </li></ul><ul><li>supplementation regimen </li></ul>
    107. 111. Bilio pancreatic procedures <ul><li>Efficacy </li></ul><ul><li>1. Excellent and durable result </li></ul><ul><li>2. Mean excess weight loss in 8 years 72-78% </li></ul>
    108. 112. Bilio pancreatic procedures <ul><li>Technique </li></ul><ul><li>1. A subtotal gastrectomy is performed, leaving a </li></ul><ul><li>proximal 200-mL gastric pouch for patient who </li></ul><ul><li>are superobese, or 400-mL pouch for others. </li></ul><ul><li>2.A Roux-en-Y anastomosis is created 50 to 100 </li></ul><ul><li>cm proximal to the ileocecal valve </li></ul><ul><li>degree of malabsorption </li></ul>
    109. 113. Bilio pancreatic procedures <ul><li>Technique </li></ul><ul><li>3.The distal 250 cm of small intestine is anastomosed to the gastric pouch with a 2- to 3-cm stoma. </li></ul><ul><li>4. A concomitant cholecystectomy is performed because of the high incidence of postoperative cholelithiasis with this degree of malabsorption </li></ul>
    110. 114. Bilio pancreatic procedures <ul><li>Technique </li></ul><ul><li>A modification of this technique with a duodenal switch involves </li></ul><ul><li>1. A greater curvature sleeve gastrectomy </li></ul><ul><li>2. With maintenance of the continuity of the antrum, pylorus, and first portion of the duodenum. This allows for a lower marginal ulcer rate (0 to 1%) and a lower incidence of dumping syndrome </li></ul>
    111. 115. Bilio pancreatic procedures <ul><li>Technique </li></ul><ul><li>laparoscopic approach </li></ul><ul><li>1. Six to eight laparoscopic ports are inserted. A sleeve gastrectomy is performed to create a gastric reservoir of 150 to 200 mL. </li></ul><ul><li>2.To perform the biliopancreatic diversion with a duodenal switch, the continuity of the antrum, pylorus, and first portion of the duodenum is maintained. </li></ul>
    112. 116. Bilio pancreatic procedures <ul><li>Technique </li></ul><ul><li>3. This allows for a lower marginal ulcer rate (0 to 1%), and a lower incidence of dumping syndrome because the pylorus is preserved </li></ul><ul><li>4.The ileum is divided 250 cm proximal to the ileocecal valve and is anastomosed to the stomach. </li></ul><ul><li>5. A Roux-en-Y anastomosis is created, leaving a common channel 100 cm long </li></ul>
    113. 117. Bilio pancreatic procedures <ul><li>complications </li></ul><ul><li>1. Anemia 30% </li></ul><ul><li>2. Protein Calorie Malnutrition 30% </li></ul><ul><li>3. Dumping syndrome </li></ul><ul><li>4. Marginal Ulcer </li></ul><ul><li>5. Vit B 12 deficiency </li></ul><ul><li>6. Hypocalcemia </li></ul><ul><li>7. Osteoporosis </li></ul><ul><li>8. Night blindness </li></ul>
    114. 118. Bilio pancreatic procedures <ul><li>complications </li></ul><ul><li>9. Prolongation of prothrombin time </li></ul><ul><li>10. Early Surgical Complication </li></ul><ul><li>Wound infection </li></ul><ul><li>Wound dehiscence 1.2 % </li></ul>
    115. 119. Bilio pancreatic procedures <ul><li>Late complications </li></ul><ul><li>1. Intestinal Obstruction- 0.2% </li></ul><ul><li>2. Protein Malnutrition- 7% </li></ul><ul><li>3. Iron deficiency anemia- 1.2% </li></ul><ul><li>4. Stomas Ulcer- 2.8% </li></ul><ul><li>5. Mortality- 2.5% </li></ul><ul><li>6. Morbidity-15% </li></ul>
    116. 120. Bilio pancreatic procedures <ul><li>Advantages </li></ul><ul><li>Even if patients consume a great quantity of food, the malabsorptive component of the BPD allows excellent results in terms of weight loss. </li></ul><ul><li>This operation may be more effective than gastric bypass or restrictive surgery in patients with severe morbid obesity (e.g., BMI greater than 70 kg/m 2 ), or in those who have failed to maintain weight loss following gastric bypass or restrictive bariatric surgery. </li></ul>
    117. 121. Bilio pancreatic procedures <ul><li>Advantages </li></ul><ul><li>The laparoscopic BPD with duodenal switch is an effective minimally invasive procedure for weight loss. </li></ul>
    118. 122. Bilio pancreatic procedures <ul><li>Advantages </li></ul><ul><li>Offers better wt. loss than restrictive procedures because of the malabsorptive component of the operation. The operation may be valuable in patients w/ severe morbid obesity or in those who have failed to maintain weight loss following gastric bypass surgery or restrictive procedures </li></ul>
    119. 123. Bilio pancreatic procedures <ul><li>DisAdvantages </li></ul><ul><li>1.The BPD is technically a more complex procedure than the restrictive procedures. Protein malnutrition with </li></ul><ul><li>a. anemia </li></ul><ul><li>b. hypoalbuminemia </li></ul><ul><li>c. edema </li></ul><ul><li>d. alopecia </li></ul><ul><li>are among the serious adverse sequelae </li></ul>
    120. 124. Bilio pancreatic procedures <ul><li>DisAdvantages </li></ul><ul><li>2. Severe vitamin deficiencies may occur, leading to osteoporosis and night-blindness. </li></ul><ul><li>3. Treatment requires prolonged hyperalimentation and supplementation. </li></ul><ul><li>4.Patients have four to six foul-smelling stools per day, reflecting the fat malabsorption from this procedure. </li></ul><ul><li>5. Patients may also experience bloating and heartburn following this procedure. </li></ul>
    121. 125. Bilio pancreatic procedures <ul><li>DisAdvantages </li></ul><ul><li>. Replacement of fat-soluble vitamins is needed for patients following BPD or BPD-DS. </li></ul><ul><li>The laparoscopic approach may be especially challenging in patients: </li></ul><ul><li>With multiple previous abdominal surgeries </li></ul><ul><li>Previous weight loss surgery </li></ul><ul><li>With an enlarged fatty liver </li></ul><ul><li>With a large amount of intra-abdominal fat. </li></ul>
    122. 126. Bilio pancreatic procedures <ul><li>DisAdvantages </li></ul><ul><li>The laparoscopic BPD is a technically demanding, lengthy laparoscopic procedure, with potential for nutritional sequelae similar to open BPD. Patients may experience </li></ul><ul><li>1. Abdominal bloating </li></ul><ul><li>2. Malodorous stools </li></ul><ul><li>3. Heartburn </li></ul><ul><li>4. Abdominal pain. . </li></ul>
    123. 127. Bilio pancreatic procedures <ul><li>DisAdvantages </li></ul><ul><li>5. Protein malnutrition with: </li></ul><ul><li>a. Anemia </li></ul><ul><li>b. Hypoalbuminemia </li></ul><ul><li>c. Edema </li></ul><ul><li>d. Alopecia </li></ul><ul><li>are potential postoperative sequelae. Severe vitamin deficiencies may be observed. </li></ul>
    124. 128. Bilio pancreatic procedures <ul><li>Treatment requires </li></ul><ul><li>1. Prolonged hyperalimentation </li></ul><ul><li>2. Possibly reoperation to lengthen the common channel. </li></ul>
    125. 129. Thank You

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