The Site Network Solution

Corporate Snapshot Founded in 1999 Headquarters located in Raleigh, NC Privately owned Initial business silo; Software solutions for physician practices Primary business silo; CT Select Site Network, launched in 2006 Metrics - 75 Employees - 339 US Investigators - 60 Netherlands Investigators

Founded in 1999

Headquarters located in Raleigh, NC

Privately owned

Initial business silo; Software solutions for physician practices

Primary business silo; CT Select Site Network, launched in 2006

Metrics - 75 Employees

- 339 US Investigators

- 60 Netherlands Investigators

CORPORATE STRUCTURE: Pete Bechtel, CEO – 25 years experience Gray Kirby, PharmD, VP Clinical Research – 25 years experience Marty Frazier, Director of Business Development – 30 years experience Richard Sanderson, Director of Clinical Services – 25 years experience Experienced, Full-Time Clinical Research Coordinators and Managers Dedicated Data Integration Team

CORPORATE STRUCTURE:

Pete Bechtel, CEO – 25 years experience

Gray Kirby, PharmD, VP Clinical Research – 25 years experience

Marty Frazier, Director of Business Development – 30 years experience

Richard Sanderson, Director of Clinical Services – 25 years experience

Experienced, Full-Time Clinical Research Coordinators and Managers

Dedicated Data Integration Team

Common Site Challenges: Selecting Qualified Sites Identifying Appropriate Patients Slow or Non-enrolling Sites Patient Retention Meeting Enrollment Timelines

Common Site Challenges:

Selecting Qualified Sites

Identifying Appropriate Patients

Slow or Non-enrolling Sites

Patient Retention

Meeting Enrollment Timelines

CT Select Solutions: Qualified sites with Pre-Selected Patients Rapid Start-Up (within 30 Days) Immediate Enrollment Achieving your enrollment timeline Controlling your trial budget

CT Select Solutions:

Qualified sites with Pre-Selected Patients

Rapid Start-Up (within 30 Days)

Immediate Enrollment

Achieving your enrollment timeline

Controlling your trial budget

Qualified Sites with Pre-Selected Patients: Clinical Data Repository (CDR) *HIPAA Compliant Electronic Medical Records Practice Management System Lab Data Medication Data Personal Health Information Pre-selection based on protocol criteria Primary indication (ICD-9, CPT code) Age, Gender, Special Populations Medication criteria Lab criteria

Qualified Sites with Pre-Selected Patients:

Clinical Data Repository (CDR) *HIPAA Compliant

Electronic Medical Records

Practice Management System

Lab Data

Medication Data

Personal Health Information

Pre-selection based on protocol criteria

Primary indication (ICD-9, CPT code)

Age, Gender, Special Populations

Medication criteria

Lab criteria

CDR Process Flow EMR PMS Lab Medications SmartForms Query Protocol Specific Patient Criteria eCast CDR CT Select Investigator Identified

EMR

PMS

Lab

Medications

SmartForms

Rapid Start-up: Site Identification Utilizing our proprietary CDR to identify qualified sites with pre-selected patients Centralized Process – all sites use: Central IRBs Reg Doc Collection Contracting & Budgeting

Rapid Start-up:

Site Identification

Utilizing our proprietary CDR to identify qualified sites with pre-selected patients

Centralized Process – all sites use:

Central IRBs

Reg Doc Collection

Contracting & Budgeting

Controlling your Trial Budget Central budgeting for CT Select sites All costs are included in the site budget Enrollment without costly Recruitment Programs Most trials can enroll from PIs existing patients Pre-Identified patients from the CDR Predictable enrollment eliminates budget overruns

Controlling your Trial Budget

Central budgeting for CT Select sites

All costs are included in the site budget

Enrollment without costly Recruitment Programs

Most trials can enroll from PIs existing patients

Pre-Identified patients from the CDR

Predictable enrollment eliminates budget overruns

Community-based Therapeutic Coverage: Internal Medicine Family Practice Pediatrics OB/GYN Cardiology Endocrinology Geriatrics Neurology Urology Allergy/Immunology Otolaryngology Ophthalmology Dermatology Emergency Medicine Long Term Care

CT select ™ Network Locations Current: Miami, Ft. Lauderdale, FL Atlanta, Athens, GA Charleston, SC Fayetteville, Raleigh, Wilmington, NC Baltimore, Laurel, MD Philadelphia, PA Northern, NJ Whiteplains, Brooklyn, NY St. Louis, MO Charleston, WV Netherlands

Current: Miami, Ft. Lauderdale, FL

Atlanta, Athens, GA

Charleston, SC

Fayetteville, Raleigh, Wilmington, NC

Baltimore, Laurel, MD

Philadelphia, PA

Northern, NJ

Whiteplains, Brooklyn, NY

St. Louis, MO

Charleston, WV

Netherlands

CT select ™ Network Locations Future: Chicago, IL Cleveland, OH Houston, Dallas, TX Phoenix, AZ Los Angeles, San Francisco, CA Seattle, WA France Germany Belgium UK Asia

Future: Chicago, IL

Cleveland, OH

Houston, Dallas, TX

Phoenix, AZ

Los Angeles, San Francisco, CA

Seattle, WA

France

Germany

Belgium

UK

Asia

Utilizing the CT Select ™ Network Patient criteria determined by the protocol Query the CDR to pre-identify sites & patients within the CT Select Network Review the protocol with the investigator for interest Present sites to the sponsor for evaluation Approved sites utilize the CT Select infrastructure: Central IRBs & Reg Doc Collection Budget & Contract Negotiation eCast Regional CRC Network Rapid initiation of sites (4 weeks or less) Patient enrollment begins…

Patient criteria determined by the protocol

Query the CDR to pre-identify sites & patients within the CT Select Network

Review the protocol with the investigator for interest

Present sites to the sponsor for evaluation

Approved sites utilize the CT Select infrastructure:

Central IRBs & Reg Doc Collection

Budget & Contract Negotiation

eCast Regional CRC Network

Rapid initiation of sites (4 weeks or less)

Patient enrollment begins…

CT Select ™ Commitment Community-Based Investigators with CRCs Multiple Therapeutic Specialties US & EU Sites 1,500,000 Unique Patient Records Rapid Start-up Reduce or Eliminate Patient Recruitment Programs and Associated Budgets

Community-Based Investigators with CRCs

Multiple Therapeutic Specialties

US & EU Sites

1,500,000 Unique Patient Records

Rapid Start-up

Reduce or Eliminate Patient Recruitment Programs and Associated Budgets

Questions & Next Steps Contact: Laura Bridgman, MPH [email_address] 910.599.1474