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Final Presentation
Final Presentation
Final Presentation
Final Presentation
Final Presentation
Final Presentation
Final Presentation
Final Presentation
Final Presentation
Final Presentation
Final Presentation
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Final Presentation

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  1. Nutritional Influence on Alzheimer’s Disease Presentation by: Dinesh Kommareddy
  2. The Issue <ul><li>Alzheimer’s Disease - a neurodegenerative phenomenon that primarily affects those of age 60 or above. </li></ul><ul><ul><li>Symptoms: </li></ul></ul><ul><ul><li>A decrease in cognitive function </li></ul></ul><ul><ul><li>Impairment of the brain’s ability to efficiently retain memory </li></ul></ul><ul><ul><li>Mental disorientation </li></ul></ul>www.cartoonstock.com
  3. The Enemy <ul><li>The primary malefactor associated with the pathology of Alzheimer’s Disease is a plaque called: “Amyloid-Beta” (A β ) </li></ul><ul><li>Composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers </li></ul><ul><li>Inhibit the brain’s ability to relay information throughout the body </li></ul><ul><li>Information cannot processed efficiently and ‘new memory’ cannot be easily retained </li></ul>http://opm.phar.umich.edu/images/proteins/1rw6.gif
  4. How Amyloid-Beta Works <ul><li>Your Brain is responsible for everything you are able to do including: running, eating, laughing, breathing, sleeping, etc. </li></ul><ul><li>The nerve cells that make up your brain ( neurons ) relay electrochemical signals to one another </li></ul><ul><li>Amyloid-Beta blocks these electrochemical interactions </li></ul>http://www.nia.nih.gov/NR/rdonlyres/32A1583F-3009-4292-964D-
  5. How Amyloid-Beta Works (cont.) <ul><li>As a person grows older. Amyloid-beta deposits begin to accumulate on the brain. </li></ul><ul><li>These plaques occupy the space needed for neurotransmitters to transfer between neurons. </li></ul><ul><li>Information tends to get lost resulting in decreases of cognitive ability. </li></ul>
  6. A Nutritional Perspective <ul><li>Buttered popcorn , curry , and carrots all serve as potential contributors in the cure for Alzheimer’s Disease. </li></ul><ul><li>Maintaining a diet with proper nutrition, is a principle which is not reinforced with enough scientific evidence to have a persuasive influence in today’s society. </li></ul><ul><li>By researching the nutritional aspects of Alzheimer’s Disease, I hope to find extra incentive to maintain a healthy diet in order to guide the world into a healthier, more burden-free lifestyle. </li></ul>
  7. How does Nutrition affect Alzheimer’s Disease? (Buttered Popcorn) <ul><li>Buttered popcorn is a food item that is rich in saturated fats. </li></ul><ul><li>A diet primarily composed of saturated fats and little to no carbohydrates (a ketogenic diet ) helps alleviate the effects of Alzheimer’s Disease. [ Journal of Nutrition and Metabolism (October,2005)] </li></ul><ul><li>From a scientific point of view, the saturated fats decompose portions of the amyloid-beta plaques, clearing up some space for the transmission of information. </li></ul>
  8. How does Nutrition affect Alzheimer’s Disease? (Curry) <ul><li>The orange-red color of curry is due to the pigment “ Curcumin” . </li></ul><ul><li>For centuries, Curcumin has been used in traditional Indian medicine to treat inflammation and help wound healing. </li></ul><ul><li>Curcumin can prevent the formation of amyloid fibers. [ The Journal of Biological Chemistry (February, 2005) ] </li></ul><ul><ul><li>Mice that ate a curcumin diet had fewer beta amyloid proteins in their brain than mice fed a normal diet. </li></ul></ul>http://www.canceractive.com/cimg/i140__Curcumin.JPG
  9. How does Nutrition affect Alzheimer’s Disease? (Carrots) <ul><li>Carrots, are food items rich in the orange pigment, “beta-carotene” </li></ul><ul><li>Taking supplements of the antioxidant beta carotene for a prolonged period of time(15+ years) lessens the decline of cognitive ability affiliated with Alzheimer's disease. [ Archives of Internal Medicine (November, 2007)] </li></ul><ul><li>Beta-carotene is not risk free. In studies regarding smokers, it has been shown that an influx of beta-carotene actually increases the chance of lung cancer. [ Journal of the National Cancer Institute (December, 2004)] </li></ul><ul><li>Thus, more research is needed in order to provide to the community a safe dosage of beta-carotene that doesn’t give rise to other abnormalities. </li></ul>
  10. My Contribution to the cause <ul><li>Much like the previous studies, I hope to find my own nutritional breakthrough. </li></ul><ul><li>I want to be able to experiment with several types of food and examine it’s influence on an Alzheimer’s patient </li></ul><ul><li>I intend to not only derive a nutritional benefactor that alleviates Alzheimer’s symptoms, but to also conduct research that provides sufficient evidence to why there are benefits to maintaining a proper nutrition. </li></ul>
  11. Thanks for Listening! <ul><li>Any Questions? </li></ul>

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