Your SlideShare is downloading. ×
Final Presentation
Upcoming SlideShare
Loading in...5

Thanks for flagging this SlideShare!

Oops! An error has occurred.

Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

Final Presentation


Published on

1 Comment
  • Be the first to like this

No Downloads
Total Views
On Slideshare
From Embeds
Number of Embeds
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

No notes for slide


  • 1. Nutritional Influence on Alzheimer’s Disease Presentation by: Dinesh Kommareddy
  • 2. The Issue
    • Alzheimer’s Disease - a neurodegenerative phenomenon that primarily affects those of age 60 or above.
      • Symptoms:
      • A decrease in cognitive function
      • Impairment of the brain’s ability to efficiently retain memory
      • Mental disorientation
  • 3. The Enemy
    • The primary malefactor associated with the pathology of Alzheimer’s Disease is a plaque called: “Amyloid-Beta” (A β )
    • Composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers
    • Inhibit the brain’s ability to relay information throughout the body
    • Information cannot processed efficiently and ‘new memory’ cannot be easily retained
  • 4. How Amyloid-Beta Works
    • Your Brain is responsible for everything you are able to do including: running, eating, laughing, breathing, sleeping, etc.
    • The nerve cells that make up your brain ( neurons ) relay electrochemical signals to one another
    • Amyloid-Beta blocks these electrochemical interactions
  • 5. How Amyloid-Beta Works (cont.)
    • As a person grows older. Amyloid-beta deposits begin to accumulate on the brain.
    • These plaques occupy the space needed for neurotransmitters to transfer between neurons.
    • Information tends to get lost resulting in decreases of cognitive ability.
  • 6. A Nutritional Perspective
    • Buttered popcorn , curry , and carrots all serve as potential contributors in the cure for Alzheimer’s Disease.
    • Maintaining a diet with proper nutrition, is a principle which is not reinforced with enough scientific evidence to have a persuasive influence in today’s society.
    • By researching the nutritional aspects of Alzheimer’s Disease, I hope to find extra incentive to maintain a healthy diet in order to guide the world into a healthier, more burden-free lifestyle.
  • 7. How does Nutrition affect Alzheimer’s Disease? (Buttered Popcorn)
    • Buttered popcorn is a food item that is rich in saturated fats.
    • A diet primarily composed of saturated fats and little to no carbohydrates (a ketogenic diet ) helps alleviate the effects of Alzheimer’s Disease. [ Journal of Nutrition and Metabolism (October,2005)]
    • From a scientific point of view, the saturated fats decompose portions of the amyloid-beta plaques, clearing up some space for the transmission of information.
  • 8. How does Nutrition affect Alzheimer’s Disease? (Curry)
    • The orange-red color of curry is due to the pigment “ Curcumin” .
    • For centuries, Curcumin has been used in traditional Indian medicine to treat inflammation and help wound healing.
    • Curcumin can prevent the formation of amyloid fibers. [ The Journal of Biological Chemistry (February, 2005) ]
      • Mice that ate a curcumin diet had fewer beta amyloid proteins in their brain than mice fed a normal diet.
  • 9. How does Nutrition affect Alzheimer’s Disease? (Carrots)
    • Carrots, are food items rich in the orange pigment, “beta-carotene”
    • Taking supplements of the antioxidant beta carotene for a prolonged period of time(15+ years) lessens the decline of cognitive ability affiliated with Alzheimer's disease. [ Archives of Internal Medicine (November, 2007)]
    • Beta-carotene is not risk free. In studies regarding smokers, it has been shown that an influx of beta-carotene actually increases the chance of lung cancer. [ Journal of the National Cancer Institute (December, 2004)]
    • Thus, more research is needed in order to provide to the community a safe dosage of beta-carotene that doesn’t give rise to other abnormalities.
  • 10. My Contribution to the cause
    • Much like the previous studies, I hope to find my own nutritional breakthrough.
    • I want to be able to experiment with several types of food and examine it’s influence on an Alzheimer’s patient
    • I intend to not only derive a nutritional benefactor that alleviates Alzheimer’s symptoms, but to also conduct research that provides sufficient evidence to why there are benefits to maintaining a proper nutrition.
  • 11. Thanks for Listening!
    • Any Questions?