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Final Presentation

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  • 1. Nutritional Influence on Alzheimer’s Disease Presentation by: Dinesh Kommareddy
  • 2. The Issue
    • Alzheimer’s Disease - a neurodegenerative phenomenon that primarily affects those of age 60 or above.
      • Symptoms:
      • A decrease in cognitive function
      • Impairment of the brain’s ability to efficiently retain memory
      • Mental disorientation
    www.cartoonstock.com
  • 3. The Enemy
    • The primary malefactor associated with the pathology of Alzheimer’s Disease is a plaque called: “Amyloid-Beta” (A β )
    • Composed of a tangle of regularly ordered fibrillar aggregates called amyloid fibers
    • Inhibit the brain’s ability to relay information throughout the body
    • Information cannot processed efficiently and ‘new memory’ cannot be easily retained
    http://opm.phar.umich.edu/images/proteins/1rw6.gif
  • 4. How Amyloid-Beta Works
    • Your Brain is responsible for everything you are able to do including: running, eating, laughing, breathing, sleeping, etc.
    • The nerve cells that make up your brain ( neurons ) relay electrochemical signals to one another
    • Amyloid-Beta blocks these electrochemical interactions
    http://www.nia.nih.gov/NR/rdonlyres/32A1583F-3009-4292-964D-
  • 5. How Amyloid-Beta Works (cont.)
    • As a person grows older. Amyloid-beta deposits begin to accumulate on the brain.
    • These plaques occupy the space needed for neurotransmitters to transfer between neurons.
    • Information tends to get lost resulting in decreases of cognitive ability.
  • 6. A Nutritional Perspective
    • Buttered popcorn , curry , and carrots all serve as potential contributors in the cure for Alzheimer’s Disease.
    • Maintaining a diet with proper nutrition, is a principle which is not reinforced with enough scientific evidence to have a persuasive influence in today’s society.
    • By researching the nutritional aspects of Alzheimer’s Disease, I hope to find extra incentive to maintain a healthy diet in order to guide the world into a healthier, more burden-free lifestyle.
  • 7. How does Nutrition affect Alzheimer’s Disease? (Buttered Popcorn)
    • Buttered popcorn is a food item that is rich in saturated fats.
    • A diet primarily composed of saturated fats and little to no carbohydrates (a ketogenic diet ) helps alleviate the effects of Alzheimer’s Disease. [ Journal of Nutrition and Metabolism (October,2005)]
    • From a scientific point of view, the saturated fats decompose portions of the amyloid-beta plaques, clearing up some space for the transmission of information.
  • 8. How does Nutrition affect Alzheimer’s Disease? (Curry)
    • The orange-red color of curry is due to the pigment “ Curcumin” .
    • For centuries, Curcumin has been used in traditional Indian medicine to treat inflammation and help wound healing.
    • Curcumin can prevent the formation of amyloid fibers. [ The Journal of Biological Chemistry (February, 2005) ]
      • Mice that ate a curcumin diet had fewer beta amyloid proteins in their brain than mice fed a normal diet.
    http://www.canceractive.com/cimg/i140__Curcumin.JPG
  • 9. How does Nutrition affect Alzheimer’s Disease? (Carrots)
    • Carrots, are food items rich in the orange pigment, “beta-carotene”
    • Taking supplements of the antioxidant beta carotene for a prolonged period of time(15+ years) lessens the decline of cognitive ability affiliated with Alzheimer's disease. [ Archives of Internal Medicine (November, 2007)]
    • Beta-carotene is not risk free. In studies regarding smokers, it has been shown that an influx of beta-carotene actually increases the chance of lung cancer. [ Journal of the National Cancer Institute (December, 2004)]
    • Thus, more research is needed in order to provide to the community a safe dosage of beta-carotene that doesn’t give rise to other abnormalities.
  • 10. My Contribution to the cause
    • Much like the previous studies, I hope to find my own nutritional breakthrough.
    • I want to be able to experiment with several types of food and examine it’s influence on an Alzheimer’s patient
    • I intend to not only derive a nutritional benefactor that alleviates Alzheimer’s symptoms, but to also conduct research that provides sufficient evidence to why there are benefits to maintaining a proper nutrition.
  • 11. Thanks for Listening!
    • Any Questions?

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