Novel Field-assisted Diagnostic Chip
      (EFADchip) Technology: A New Era in
      the Application of LOAC to Rapid
    ...
Current & Emergent Infectious Diseases

                                        SARS


                     AIV
          ...
The Recurring Global Problem…
Russian Flu 1889
                                                  In the past, trends show
...
“WHO Raises Pandemic Alert Level”


          “THE UN'S WORLD HEALTH ORGANIZATION
         HAS RAISED THE ALERT OVER SWINE...
Hai Kang Life: Fighting the War!
                                                                 Products & Services
Pion...
Mobile Technology for Point-of-Care
Deployment
                                                Hand carried
             ...
Publications on Influenza Diagnostics
 Neutrophils May Be a Vehicle for Viral Replication and Dissemination in Human H5N1...
Hai Kang Life Corporation (HKLife)
 Established in 1999

 Accomplishments
    Published in Nature Biotechnology, Scienc...
HKLife…from pharma to family…


    Screening              Diagnosis              Treatment        Aftercare




         ...
Business Model                          Portfolio of wholly-owned subsidiaries

                                        ...
Hai Kang Life Corporation (HKLife)




   Beijing R&D Center




                                  Hong Kong Laboratory

C...
The HKLife EFADchip Technology

HKLife is providing an easy to use, mobile and
cost-effective diagnostic solution, enablin...
Key Differentiators of EFADchip Technology

Novel technology drives migration of DNA to reactive sites
   • Rapid hybridiz...
The EFADchip System
                                              Focused on POC needs

                                 ...
Bio-Radar
                            • Pre-emptive surveillance
                            • Efficient containment
Infec...
The Journey for EFADchip Technology

Programmable for specific market applications including the
complete spectrum of mole...
The HKLife Mission                        Booth 2249
                                             HK Pavilion



   “To re...
- Thank You -

          Contact Information:

Tel : (852) 2111 2123 Fax: (852) 2111 9762
        Email : achy@haikanglife...
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Bus Forum Preso Bio 2009 Ec6

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  • Transcript of "Bus Forum Preso Bio 2009 Ec6"

    1. 1. Novel Field-assisted Diagnostic Chip (EFADchip) Technology: A New Era in the Application of LOAC to Rapid Point-of-Care Diagnosis Albert Cheung Hoi Yu PhD CEO & Chairman Hai Kang Life Corporation Limited, Hong Kong, China Beijing Hai Kang DNA Chips Limited, Beijing, China Vice Director & Professor Neuroscience Research Institute, Peking University, China Professor Infectious Disease Center, Peking University, China May 20th Bio 2009 Business Forum www.HAIKANGLIFE.com 1
    2. 2. Current & Emergent Infectious Diseases SARS AIV HPV HIV Hepatitis Global pandemic Anthrax preparedness requires a comprehensive infectious disease surveillance system 2
    3. 3. The Recurring Global Problem… Russian Flu 1889 In the past, trends show Spanish Flu 1918 that influenza epidemics have reappeared nearly every 30 years. The world is overdue for another Asian Flu 1957 major pandemic. Hai Kang Life is making efficient use of the most advanced nucleic acid-based diagnostic technologies to Hong Kong Flu 1968 help prevent global disasters, ensuring the health and safety of society. Avian Flu 1997+ Swine Flu 2009 3
    4. 4. “WHO Raises Pandemic Alert Level” “THE UN'S WORLD HEALTH ORGANIZATION HAS RAISED THE ALERT OVER SWINE FLU TO LEVEL FIVE - ONE SHORT OF A FULL-BLOWN GLOBAL EPIDEMIC, OR PANDEMIC” A/H1N1 WHO update May 15th 33 countries 6497 confirmed cases 65 deaths BBC News April 30th 2009 4
    5. 5. Hai Kang Life: Fighting the War! Products & Services Pioneering the development of advanced nucleic  Clinical Testing acid-based diagnostic platform technologies  Veterinary Enhanced Real-Time PCR  Food Safety NASBA World’s 1st AIV detection kit (2000) NASBA-EOC SARS kit released in response to Asian epidemic (2003) NASBA-POC LOAC development program (2006) MULTIPLEX NASBA Release of Influenza A/H1N1 detection kit (May 2009) Lab-on-a-Chip Availability of Mobile Field Unit for Point-of-Care deployment (2009) INNOVATION 5
    6. 6. Mobile Technology for Point-of-Care Deployment  Hand carried  Self-contained  User friendly  Heating Block  Centrifuge  UV Lamp  Reagents  Pipettes  NASBA-based detection  Consumables  No fluorescence  Comparable sensitivity to conventional PCR 6
    7. 7. Publications on Influenza Diagnostics  Neutrophils May Be a Vehicle for Viral Replication and Dissemination in Human H5N1 Avian Influenza. CID 47,1375-1378 (2008)  H5N1 Infection of the respiratory tract and beyond: a viral localization study. Lancet 370, 1137-45 (2007)  Detection of animal viruses using using nucleic acid sequence-based amplification (NASBA). Dev Biol (Basel), 126, 7-15 (2006)  NASBA – A new method to detect avian influenza virus. China Biotechnology 25, 91-94 (2005)  Application of avian influenza (AIV) detection kits using nucleic acid sequence-based amplification to detect AIV. J Jpn Soc Poult Dis 41, 151-158 (2005)  The necessity of molecular diagnosis for avian influenza. Nat Biotechnol 22, 267 (2004)  Nucleic acid sequence-based amplification methods to detect avian influenza virus. BBRC 313,336-342 (2004)  Rapid and sensitive detection of avian influenza virus subtype H7 using NASBA. BBRC 300, 507-515 (2003)  Comparison of nucleic acid-based detection of avian influenza H5N1 with virus isolation. BBRC 302, 377-383  A NASBA method to detect high- and low-pathogenicity H5 avian influenza viruses. Avian Dis. 47, 1069-1074 (2003)  Detection of highly pathogenic and low pathogenic avian influenza A subtype H5 (Eurasian lineage) using NASBA. J. Virol. Methods. 103, 213-225 (2002) 7
    8. 8. Hai Kang Life Corporation (HKLife)  Established in 1999  Accomplishments  Published in Nature Biotechnology, Science, NEJM and Lancet  Approved foreign veterinary product manufacturer by Japan Ministry of Agriculture, Fisheries and Forestry (JMAFF)  Government funded Pneumonia Detection System program  Member of China national task forces for pandemic diseases (SARS, AIV…)  Collaborations with international organizations including WHO, FAO, OIE  International recognition for rapid and accurate response to recurring outbreaks of AIV, FMD, SARS… 8
    9. 9. HKLife…from pharma to family… Screening Diagnosis Treatment Aftercare Medication Drug Discovery Working closely with pharmaceutical companies, hospitals, clinics and patients around the world to deliver the highest quality molecular diagnostic products and services… 9
    10. 10. Business Model  Portfolio of wholly-owned subsidiaries  Advanced DNA-based diagnostic tools  ISO accredited testing services  World class team of scientists, engineers and technologists  Utilizing best practices from East and West  Strong academic and institutional links  Scientific Advisory Board comprising renowned scientists  Worldwide patent portfolio: LOAC, Bird Flu, Foot & Mouth, GMO…  Innovative flagship technology to revolutionize POC diagnostics 10
    11. 11. Hai Kang Life Corporation (HKLife) Beijing R&D Center Hong Kong Laboratory Compartmentalized facilities in Beijing Laboratory 11
    12. 12. The HKLife EFADchip Technology HKLife is providing an easy to use, mobile and cost-effective diagnostic solution, enabling rapid throughput Yes / No screening for simple or multiplex analysis of dangerous diseases Electric Field Assisted Diagnostic chip EFADchip 12
    13. 13. Key Differentiators of EFADchip Technology Novel technology drives migration of DNA to reactive sites • Rapid hybridization within minutes • No undesirable electrochemical reactions and instabilities Signal detection system does not require fluorescence • No tagging of samples is necessary • Using colloidal nanogold for detection in harsh environments Simple and reliable platform technology • Scaleable and cost effective with established materials and processes • Modest setup cost and inexpensive re-useable chip cartridge • Designed for widespread adoption at POC 13
    14. 14. The EFADchip System  Focused on POC needs  A matrix of biological reactions on a single chip platform  Selective detection of multiple pathogens from the same sample  Fully automated…hybridization, detection and data analysis  Low cost reactor/detector and reusable chip cartridge  Requires only small volumes of reagents and analytes 14
    15. 15. Bio-Radar • Pre-emptive surveillance • Efficient containment Infectious Diseases • Security & Forensics Food Testing • Detect viral or bacterial infection • Genetically Modified (Hepatitis, HIV, HPV, Organisms Anthrax, Influenza…) EFADchip • Bacterial & viral • Blood Screening contaminations Platform Applications Veterinary Diagnosis Tumor Detection • Foot-and-mouth disease • Screen for tumor • Avian influenza Environmental markers (BRCA1 Monitoring (breast cancer, • Newcastle disease ovarian cancer…) • E. Coli in food and drinking water • Legionella in air conditioning cooling systems 15
    16. 16. The Journey for EFADchip Technology Programmable for specific market applications including the complete spectrum of molecular diagnostics, drug discovery, bio- security and forensics Precursor to a bio-radar surveillance system for early- warning and responsive containment, encompassing all current and emerging pathogens No More Ensuring the Health Indiscriminate Culling! Opens the door to & Safety of Society! Personalized Medicine & Companion Diagnostics 16
    17. 17. The HKLife Mission Booth 2249 HK Pavilion “To revolutionize the practice of clinical diagnostics, providing effective platforms for point-of-care applications focused on personalized medicine and pre-emptive surveillance of emerging pathogens and diseases” Hai Kang Life welcomes you on the journey… 17
    18. 18. - Thank You - Contact Information: Tel : (852) 2111 2123 Fax: (852) 2111 9762 Email : achy@haikanglife.com Website : www.haikanglife.com Serving the World with Biotechnology 18

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