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Cell Cycle Control Mechanisms
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Cell Cycle Control Mechanisms

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  • 1. Cell Cycle Controls
    Biology 3 Kawashima
    Philippine Science High School
    SY 2009-2010
  • 2. Key Terms and Concepts
    Checkpoints
    Cyclins
    Cyclin-dependent kinases
  • 3.
  • 4. G1 Checkpoint
    Also known as “Restriction Point” in mammalian cells
    Cells that go through G1 usually complete the cell cycle
    Cells that do not receive the go-signal exit the cell cycle
    Quiescent non-dividing stage called G0 phase
  • 5. G1 checkpoint
    Continue with G1 and proceed to S
    Exit cycle; switch to nondividing state
  • 6. G2 Checkpoint
    MPF or maturation promoting factor drives the cell past the G2 checkpoint
    MPF is a protein complex composed of cyclins and cyclin-dependent kinases (Cdk)
    Accumulated cyclin in G2 associate with cyclin-dependent kinases
  • 7.
  • 8.
  • 9. M Phase Checkpoint
    Ensures that chromosomes are properly attached to mitotic spindle (composed of microtubules)
    Anaphase promoting complex (APC) is inactive until kinetochores have interacted with microtubules
    Activation of APC indirectly triggers breakdown of cyclins
  • 10.
  • 11. External Signals Affect Regulation