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Probiotics Probiotics Presentation Transcript

  • NaturalDigestive Well-being
  • 2
    Presentation Outline
    Introduction to Digestive Wellness
    Probiotics: What, Where, How ?
    Probiotic health benefits
    Probiotic products
    Delivery of probiotics
  • 3
    Introduction
    • Currently, people is facing an epidemic of digestive illness directly related to the foods they eat and the way they live.
    • One-third to one-half of all population have digestive illness.
  • 4
    Introduction
    • GI system is the primary gateway by which the external environment interacts with the body.
    • It’s allowing or denying entry
  • 5
    Digestive Wellness
    Gershon M. The Second Brain. Harper Collins, 1998.
  • 6
    Digestive Wellness
    Stipanuk MH. Biochemical and Physiological Aspects of Human Nutrition. WB Saunders Co: Philadelphia, 2000.
  • 7
    Digestive Wellness
    Chronic Gut irritability
    i
    Leaky gut
    i
    Food allergies
    i
    Bact. or yeast overgrowth
    i
    Accumulated toxin
  • 8
    The Critical Functions of Normal Flora:
    Metabolic processes:
    Fermentation
    Vitamin synthesis
    Energy production
    Trophic stimulation:
    Epithelial cell differentiation
    Immunomodulation
    Pathogen protection:
    Competing for nutrients, space, adherence
    Producing bacteriocidins
  • 9
    Today’s Knowledge:Human Microbiota is essential for health
  • 10
  • 11
  • 12
    Today’s Diet, Yesterday’s Genes
  • 13
    Today’s Diet, Yesterday’s Genes
    Most common today dietary patterns compares with the characteristics of ancestral diets.
    Alterations in:
    Glycemic load
    Fiber content
    Essential fatty acid composition
    pH balance
    Macronutrient/micronutrient composition
  • 14
    Digestive Well-being
    The alteration in commensal flora present in IBS in both colonic biopsy samples and stool analysis.
    Swidsinski A, Ladhoff A, Parnthaler A, et al. Mucosal flora in inflammatory bowel disease. Gastroenterology. 2002; 122: 44-54.
    Nobaek S, Johansson ML, Molin G, et al. Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. Am J Gastroenterol. 2000; 95: 1231-38.
  • 15
    Digestive Well-being
    Small bowel bacterial overgrowth (SBBO)
    Bacteria from large bowel produce deleterious effects within the small bowel.
    Normally, the gas production will increase when the food has passed into the large bowel, but SBBO has this increase much earlier.
    Dysbiosis has been noted to be present in 78% of IBS who positive with SBBO.
    With antibiotic, 48% improve from IBS. ( Probiotic? )
    Pimentel M, Chow EJ, Lin HC. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastro. 2000; 95: 3503-6.
  • 16
    Digestive Well-being
    Several other chronic diseases have a high degree of overlap with IBS, including fibromyalgia, intestinal cystitis, and chronic fatigue syndrome.
    Aaron LA, Burke MM, Buchwald D. Overlapping conditions among patients with chronic fatigue syndrome, fibromyalgia, and temporomandibular disorder. Arch intern Med. 2000; 160: 221-27.
  • 17
    Digestive Well-being
    Studies in patients with fibromyalgia have shown that 100% and 77% also have SBBO.
    Pimental M, Mayer AG, Park S, et al. Methane production during lactulose breath test is associated with gastrointestianl disease presentation. Dig Dis Sci. 2003; 48:: 86-92.
    Pimental M, Chow EJ, Hallegua D, et al. Small intestinal bacterial overgrowth: A possible association with fibromyalgia. J Musculoskelet Pain. 2001; 9: 107-13.
  • 18
    Presentation Outline
    Introduction to Digestive Wellness
    Probiotics: What, Where, How ?
    Probiotic health benefits
    Probiotic products
    Delivery of probiotics
  • 19
    Definition of Probiotics
  • 20
    Definition of Probiotics
    Derived from the Greek = “for life”
    First used in 1965 to describe a function that is opposite to that of antibiotics.
    Subsequently “a preparation of or a product containing viable, defined microorganism in sufficient numbers, which alter the micro-flora in a compartment of host and by that exert beneficial health effects on the host”
    Schrezenemeir J, deVrese M. Prebiotics, and synbiotics-approaching a definition. Am J Clin Nutr. 2001; 73:: 3615-645.
  • 21
    Probiotics
    Lactobacilli
    Bifidobacteria
    Streptococcus thermophilus
    Enterocoocus faecium
    Yeast : Saccharomyces boulardii
  • 22
    How do probiotics confer health benefits?
  • 23
    Definition
    Prebiotic:
    “a non-digestible food ingredient which beneficially affects the host by selectively stimulating the growth of and/or activating the metabolism of one (or more) health-promoting bacteria in the intestinal tract”
    Combinations of prebiotics and probiotics are “Synbiotics”.
    Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics.J Nutr. 1995; 125:: 1401-12.
  • 24
    What is Probiotic / Prebiotic ?
    BACTERIA
    CULTURE
    FOOD
    Synbiotic:
    A mixture ofprobiotic
    culture and prebiotic
    Prebiotic:
    Non-digestible foodingre-
    dients that are selevtively
    stimulating growth and acti-
    vity of“friendly” bacteria in
    the colon, thus improving
    health of the host
    Probiotic:
    Live microbialfood supple-
    ment that beneficially affects
    the host byimproving its
    intestinal microbial balance
    Live good bacteria
    in diet
    e.g. Lactobacilli
    Bifidobacteria
    Inulin
    Oligofructose
    Galacto-oligofructose
    Stomach
    Small
    Intestine
    Colon
    Stimulation of
    Activeexogenous active endogenous
    bacteria Friendly bacteria
    Excretion
  • 25
    Presentation Outline
    Introduction to Digestive Wellness
    Probiotics: What, Where, How ?
    Probiotic health benefits
    Probiotic products
    Delivery of probiotics
  • 26
    Probiotic research for digestive health
  • 27
    PB
    PB
    PB
    Optimal mucosal barrier function
    Normal functional
    immune system
    Normal intestinal
    motility
    Balanced intestinal
    Flora, optimal host-
    microbe interaction
    Insult
    • Acute pancreatitis
    • Major surgery
    • Trauma
    • Burns
    Disturbance of mucosal barrier function
    Disturbed immune
    system
    Disturbed intestinal
    motility
    Vicious
    circle
    Bacterial
    overgrowth
    Disturbed mucosal barrier function
    increase in bacterial translocation
    Infectious complications