Whole Foods and Nutrition

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Tools for the Practicing Kinesiologist of The Future

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  • There is some really great nutritional advice in here that goes in depth far more than lots of sites or slides out there. I especially enjoyed the Glutathione slides. Most people don’t realize it is now the number one antioxidant now in the world, yet are bodies are constantly deficient of this molecule.

    I found a great resource to help boost your Glutathione level as well as energy, vitamins and minerals from: http://www.wheyproteinpowders.org/
    Keep up the great work!
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  • Fioricet is often prescribed for tension headaches caused by contractions of the muscles in the neck and shoulder area. Buy now from http://www.fioricetsupply.com and make a deal for you.
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Whole Foods and Nutrition

  1. 1. Presented by Glen Gillard DIP N.T. [Gov Accred] C.E.C.H. Ird. M.C.M.A . Whole Foods and Nutrition:  Tools for the Practicing Kinesiologist in the Future ’
  2. 3. Glucosinolates <ul><li>“ The phenomenal active in certain super foods that prevents, treats and can help beat a variety of chronic conditions” </li></ul>
  3. 4. Broccoli: Anticancer King <ul><li>“ The consumption of cruciferous vegetables has been associated with a reduced risk of cancer of the lung, stomach, colon and rectum. The health benefits of cruciferous vegetables such as broccoli, Brussels sprouts, cabbage, and bok choy have been attributed to their high concentration of glucosinolates. The chemoprotective effect of indol-3-carbinol, a constituent of these vegetables, has been shown to have chemopreventive effects.” </li></ul>Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med 2004;50:145-49
  4. 5. Broccoli: Anticancer King <ul><li>“ Isothiocyanates (found in Broccoli) act as anti-carcinogens by inducing Phase II conjugating enzymes, in particular Glutathion S-tranferases.” </li></ul>Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med 2004;50:145-49
  5. 6. Broccoli Sprouts: An Exceptional Source <ul><li>“ Unexpectedly, 3-day-old sprouts of cultivars of certain crucifers including broccoli and cauliflower contain 10-100 times higher levels of glucoraphanin </li></ul><ul><li>(the glucosinolate of </li></ul><ul><li>sulforaphane) than do </li></ul><ul><li> the corresponding mature </li></ul><ul><li>plants.” </li></ul>Jed W. Fahey, Yuesheng Zhang, and Paul Talalay. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. USA Vol. 94, pp. 10367-10372, September 1997
  6. 7. Broccoli Sprouts: An Exceptional Source <ul><li>“ Extracts of 3-day-old broccoli sprouts (containing either glucoraphanin or sulforaphane as the principal enzyme inducer) were highly effective in reducing the incidence, multiplicity, and rate of development of mammary tumors in dimethylbenz( a )anthracene-treated rats.” </li></ul>Jed W. Fahey, Yuesheng Zhang, and Paul Talalay. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. USA Vol. 94, pp. 10367-10372, September 1997
  7. 9. Broccoli Sprouts: An Exceptional Source <ul><li>“ Dramatic quantitative differences between the inducer potencies of young sprouts and mature crucifers grown from the same seed lots are associated with equally striking qualitative and quantitative differences in the glucosinolate profiles of these plants.” </li></ul>Jed W. Fahey, Yuesheng Zhang, and Paul Talalay. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Natl. Acad. Sci. USA Vol. 94, pp. 10367-10372, September 1997
  8. 11. Sulforaphane from Broccoli Causes G2/M Cell Arrest <ul><li>“ Previously, we showed that sulforaphane (SFN), a naturally occurring cancer chemopreventive agent, effectively inhibits proliferation of PC-3 human prostate cancer cells by causing caspase-9 and caspase-8-mediated apoptosis. Here, we demonstrate that SFM treatment causes an irreversible arrest in the G(2)/M phase of the cell cycle.” </li></ul>Singh SV, Herman-Antosiewicz A, Singh AV, Lew KL, Srivastava SK, Kamath R, Brown KD, Zhang L, Baskaran R. Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cyle 25c. J Biol Checm. 2004 Jun11:279(24):25813-22. Epub 2004 April 08
  9. 12. Sulforaphane from Broccoli Causes G1 Cell Arrest <ul><li>“ We demonstrated that sulforaphane arrested cell-cycle progression in G1 phase by a significant down-modulation of cyclin D3. Moreover, sulforaphane induced apoptosis (and also necrosis), mediated by an increase in the expression of p53, whereas it exerted little effect on bcl-2 and bax levels. These finding indicate that sulforaphane can exert protective effects inhibiting leukemic cell growth.” </li></ul>Fimognari C, Nusse M, Berti F, Iori R, Cantelli-Forti G, Hrelia P. Sulforphane modulates cell cycle and apoptosis in transformed and non-transformed human T lymphocytes. Ann N Y Acad Sci. 2003 Dec;1010:393-8
  10. 13. Isothiocyantes from Broccoli Promote Detoxification <ul><li>“ Plants of the family Brassicaceae contain high levels of glucosinolates. The latter compounds are degraded to isothiocyanates, some of which have been shown to be potent inducers of phase II detoxification enzymes in vitro.” </li></ul>Munday R, Munday CM. Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforphane and related compounds. J Agric Food Chem. 2004 Apr 7;52(7);1867-71.
  11. 14. Isothiocyantes from Broccoli Cause Decreased Cancer Growth <ul><li>“ Taken together, our findings suggest that selected ITCs can rapidly initiate growth inhibition of cancer cells by simultaneously modulating multiple cellular targets, and their antiproliferative activity may be largely unaffected by their metabolism and disposition in vivo.” </li></ul>Zhang Y, Tang L, Gonzalez V. Selected isothiocyantes rapidly induce growth inhibition of cancer cells. Mol Cancer Ther. 2003 Oct;2(10):1045-52
  12. 15. Glycomax Lactoferrin <ul><li>“ Glycomax Lactoferrin is a bioactive glycoprotein (containing 689 amino acids) found in the whey protein fraction of bovine milk. Lactoferrin is also found in human colostrum, breast milk, tears, synovial fluid, seminal plasma and saliva. </li></ul><ul><li>It has been suggested that Lactoferrin plays a role in supporting and complementing the human immune system.” </li></ul>Australian Dairy Proteins
  13. 16. Lactoferrin <ul><li>“ Bovine and human lactoferrin was shown to inhibit growth of human cell carcinomas transplanted in mice.” </li></ul>Tsuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore. Cancer prevention by natural compounds. Drug Metab Pharmacokinet. 2004 Aug;19(4):245-63
  14. 17. Mechanisms of Lactoferrin Chemopreventative Effects. (Source as per previous slide) Oncogene  |  Cell Proliferation  Cell Differentiation  Apoptosis Modification Of Phase 1 Enzyme Anti Angiogenesis Anti Hormone Anti Inflammatory Immune Enhancing Anti Oxidant Prevention
  15. 18. Lacto Forte Designed to Activate the System <ul><li>LactoForte is designed to activate the system LactoForte includes ingredients such as LactoFerrin, Broccoli Sprout Powder and Bovine Trachael Cartilage. </li></ul><ul><li>When the job needs a heavy duty functional food, this complete nutritional package of high biological protein, phytochemicals, lignans and naturally occurring glyconutrients , is one of the best fuels to prevent engine failure . </li></ul><ul><li>LactoForte may support the body during periods of convalescence and help reduce the side effects of chemicals. </li></ul>Ingredients: Bovine tracheal cartilage, Fermented rice bran, Broccoli sprout powder, Supergreens, Spirulina powder, beetroot powder, Beta Glucan 1’3/1’6, Maca root powder, Taurine, Lacto-Ferrin, L-Lysine, Alfalfa powder, Calcium ascorbate, Quercitin, Magnesium aspartate, L-Glutamine, Blueberry powder, Hesperidin 98%, Milk Thistle powder, Aloe vera powder, Folic acid powder, C88 activated quartz meal.
  16. 19. Alfalfa Sprouts <ul><li>“ Studies in humans, animals and cell culture systems suggest that dietary phytoestrogens play an important role in prevention of menopausal symptoms, osteoporosis, cancer and heart disease. Broadly defined, phytoestrogens include isoflavones, coumestans, and lignans. Alfalfa sprouts, soybeans, clover and oilseeds (such as flaxseed) are the most significant dietary sources of isoflavones, coumestans, and lignans, respectively. A number of these compounds have been identified in fruits, vegetables and whole grains commonly consumed by humans. .” </li></ul>A News Extract from the Annual Review of Nutrition, 17:353-381 1997,DIETARY PHYTOESTROGENS Kurtzer MS, Xu X
  17. 20. Vitamin K: Mechanisms of Action <ul><li>“ The growth inhibitory and cytotoxic effects of vitamin K have been demonstrated both in vivo and in vitro , yet the mechanisms of action remain unclear. A number of mechanisms have been proposed and the dominant model has focused on the oxidative capacity of vitamin K analogues such as menadione.” </li></ul>Lamson DW, Plaza SM. The anticancer effects of Vitamin K. Altern Med Rev. 2003 Aug;8(3):303-18
  18. 21. Vitamin K: Mechanisms of Action <ul><li>“ Supporting this theory is the observation that menadione increased oxidative stress in malignant cells. Oxidative stress was detected by increased DNA strand breaks due to hydroxyl radicals produced by the presence of menadione in the MCF-7 cell culture.” </li></ul>Lamson DW, Plaza SM. The anticancer effects of Vitamin K. Altern Med Rev. 2003 Aug;8(3):303-18
  19. 22. Vitamin K: Mechanisms of Action <ul><li>“ The oxidative stress produced by K3 can begin a cascade of events leading to the characteristic signs of apoptosis, cell shrinkage, DNA fragmentation, and activation of capsase-3.” </li></ul>Lamson DW, Plaza SM. The anticancer effects of Vitamin K. Altern Med Rev. 2003 Aug;8(3):303-18
  20. 23. Vitamin K: Mechanisms of Action – Cell Cycle Arrest <ul><li>“ The ability of vitamin K to induce cell cycle arrest and cell death may also be explained by the inhibition of protein kinases in association with a cyclin-dependent mechanism.” </li></ul>Lamson DW, Plaza SM. The anticancer effects of Vitamin K. Altern Med Rev. 2003 Aug;8(3):303-18
  21. 24. Diindolylmethane (DIM) <ul><li>“ A number of mechanisms exist whereby DIM can diminish the effects of estrogen on tumor growth. First, DIM induces enzymes such as CYP1A1, which converts estrone to 2-hydroxyestrone and ultimately results in metabolites that are antiproliferative and proapoptotic .” </li></ul>Indole-3-carbinol is a negative regulator of estrogen. Auborn KJ, Fan S, Rosen EM, Goodwin L, Chandraskaren A, Williams DE, Chen D, Carter TH J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S
  22. 25. Folate Prevents Colorectal Cancer <ul><li>“ Folic acid deficiency in humans has been linked with megaloblastic anaemia, neural tube defects in the neonate, and heart disease. Folate has also been implicated in the development of cancer, especially cancer of the colorectum. ” </li></ul>Duthie SJ. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull. 1999;55(3):578-92
  23. 26. Folate Prevents Cancer: Mechanisms <ul><li>“ There appear to be two principal mechanisms through which low folate status may increase the risk of malignancy. Folate deficiency, by reducing intracellular S-adenosylmethionine (SAM), can alter cytosine methylation in DNA, leading to inappropriate activation of proto-oncogenes and induction of malignant transformation . ” </li></ul>Duthie SJ. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull. 1999;55(3):578-92
  24. 27. Folate Prevents Cancer: Mechanisms <ul><li>“ Alternatively, folic acid is crucial for normal DNA synthesis and repair. Folate deficiency may cause an imbalance in DNA precursors, uracil misincorporation into DNA, and chromosome breakage. ” </li></ul>Duthie SJ. Folic acid deficiency and cancer: mechanisms of DNA instability. Br Med Bull. 1999;55(3):578-92
  25. 28. Folate Prevents Colorectal Cancer <ul><li>“ Folate is crucial for normal DNA methylation, synthesis and repair, and deficiency of this nutrient is hypothesized to lead to cancer through disruption of these processes. There is some evidence to suggest that relatively high dietary folate intake might be associated with reduced colorectal cancer risk . ” </li></ul>Terry P, Jain M, Miller AB, Howe GR, Rohan TE. Dietary intake of folic acid and colorectal cancer risk in a cohort of women. Int J Cancer. 2002 Feb 20;97(6):864-7.
  26. 29. Folate Prevents Colorectal Cancer <ul><li>“ Overall, our data lends some support to the hypothesis that high folate intake is associated with a reduced risk of colorectal cancer . ” </li></ul>Terry P, Jain M, Miller AB, Howe GR, Rohan TE.Dietary intake of folic acid and colorectal cancer risk in a cohort of women. Int J Cancer. 2002 Feb 20;97(6):864-7.
  27. 30. Regulating Homocysteine <ul><li>“ Having a high homocysteine level means DNA is more vulnerable to damage, and poorly repaired once damaged. At the other end of the scale, a high level of homocysteine has been found to be a very good indicator as to whether cancer therapies are working. The homocysteine levels rise when tumours grow and fall when they shrink. Forms of cancer already linked to homocysteine include breast, colon and leukaemia among others. </li></ul><ul><li>Low homocysteine is likely to reduce your risk of these by a third. Coupled by other diet and supplement changes can cut the risk by more than 50% .” </li></ul>The H Factor (Book), by Patrick Holford and Dr James Braly. ISBN 0749924195
  28. 31. Phytic Acid Prevents Cancer <ul><li>“ Phytic acid (myo-inositol hexaphosphoric acid) is present in plants, particularly in cereals, nuts, oil seed, legumes, pollen, and spores. It has been reported that phytic acid is chemopreventive in rodent colon and mammary carcinogenesis models, in transplanted fibrosarcoma models.” </li></ul>Midorikawa K, Murata M, Oikawa S, Hiraku Y, Kawanishi S. Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention. Biochem Biophys Res Commun. 2001 Nov 2; 288(3):552-7
  29. 32. Phytic Acid Prevents Cancer via its Antioxidant Effects <ul><li>“ This study revealed that phytic acid efficiently inhibited oxidative DNA damage. Phytic acid decreased the formation of 8-oxodG in cultured cells treated with the H2O2-generating system using glucose oxidase.” </li></ul>Midorikawa K, Murata M, Oikawa S, Hiraku Y, Kawanishi S. Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention. Biochem Biophys Res Commun. 2001 Nov 2; 288(3):552-7
  30. 33. Glutathione Prevents Cancer via Numerous effects <ul><li>“ Glutathione is an important intracellular antioxidant and redox potential regulator that plays a vital role in drug detoxification and elimination and in cellular protection from damage by free radicals, peroxides, and toxins.” </li></ul>Hamilton D, Batist G. Glutathione analogues in cancer treatment. Curr Oncol Rep. 2004 Mar;6(2):116-22.
  31. 34. Glutathione Prevents Cancer via Numerous effects <ul><li>“ Molecular alterations reported in many of the components of the glutathione system in various tumours and cancer cell lines can lead to increased survival and enhanced chemotherapy drug resistance. Several glutathione analogues that target this system have been developed and used experimentally and clinically in an attempt to improve cancer chemotherapy.” </li></ul>Hamilton D, Batist G. Glutathione analogues in cancer treatment. Curr Oncol Rep. 2004 Mar;6(2):116-22.
  32. 35. Beta-1,3-Glucan: Extraordinary Immune Support <ul><li>“ 70% of rats given a lethal dose of radiation were completely protected from radiation effects when given a dose of yeast beta glucan by mouth AFTER the radiation. Dr. Myra Patchen discovered that beta-glucan is also a free radical scavenger. It is able to protect blood macrophages from free radical attack during and after the radiation allowing these cells to continue to carry their important functions in the irradiated body and release factors important to the restoration of normal bone marrow production.” </li></ul>Immudyne, Inc.
  33. 36. Beta-1,3-Glucan: Extraordinary Immune Support <ul><li>“ When beta-1,3-glucan was added to antibiotic regime in animals challenged with different bacterial (Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli and others) and viral (Herpes virus) pathogens, a reduced amount of antibiotics or antivirals was needed to cope with the infection. It also has an antifungal effect, shown in experiments with Candida albicans. Such a broad anti-infective spectrum of beta-1,3-glucan can be explained only by the fact that the immunostimulation produced by this unique material is non-specific.” </li></ul><ul><li>“ Bird ‘Flu and Beta Glucans” article – www.i-c-m.org.uk </li></ul>Immundyne Inc.
  34. 37. Beta-sitosterol: a new natural compound with chemoprotective/chemopreventive effects . <ul><li>“ This review summarizes the biological activities of presented phytosterols (anti-inflammatory, cholesterol-lowering, anti-microbial, anti-bacterial, anti-fungal effects). Our interest has been focussed especially on their anti-tumor and chemopreventive activity. They have been shown experimentally to inhibit colon and breast cancer development. They act at various stages of tumor development, including inhibition of tumorigenesis, inhibition of tumor promotion, and induction of cell differentiation. They effectively inhibit invasion of tumor cells and metastasis.” </li></ul>Neoplasma. 2004;51(6):407-14.Taraxasterol and beta-sitosterol: new naturally compounds with chemoprotective/chemopreventive effects. Ovesna Z, Vachalkova A, Horvathova K
  35. 38. Spirulina: Cancer Benefits? <ul><li>“ Thus, it has been experimentally proven, in vivo and in vitro that it is effective to treat certain allergies, anemia, cancer, hepatotoxicity, viral and cardiovascular diseases, hyperglycemia, hyperlipidemia, immunodeficiency, and inflammatory processes, among others.” </li></ul>Chamorro G, Salazar M, Arujo KG, do Santos CP, Ceballos G, Castillo LF. Update on the pharmacology of Spirulina (Arthospira), an unconventional food. Arch Latinoam Nutr. 2002 Sep;52(3):232-40.
  36. 39. Spirulina: Cancer Benefits? <ul><li>“ Several of these activities are attributed to Spirulina itself or to some of its components including fatty acids omega-3 or omega-6, beta-carotene, alpha-tocopherol, phycocyanin, phenol compounds, and a recently isolated complex Ca-Spirulan (Ca-SP).” </li></ul>Chamorro G, Salazar M, Arujo KG, do Santos CP, Ceballos G, Castillo LF. Update on the pharmacology of Spirulina (Arthospira), an unconventional food. Arch Latinoam Nutr. 2002 Sep;52(3):232-40.
  37. 40. Spirulina: Cancer Benefits? Mechanisms <ul><li>“ In NK cells, both IFN gamma and cytolysis are up-regulated by Spirulina in 50% of subjects, and IL-18 levels critically affect the yield of IFN gamma .” </li></ul>HIrahashi T, Matsumoto M, Hazeki K, Saeki Y, Ui M, Seya T. Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platenis. Int Immunopharmacol. 2002 Mar;2(4):432-34.
  38. 41. A novel glycoprotein obtained from Chlorella vulgaris strain CK22 shows antimetastatic immunopotentiation. <ul><li>“ A glycoprotein extract (CVS), derived from the unicellular green alga Chlorella vulgaris, strain CK22, exhibited a pronounced anti-tumour effect against both spontaneous and experimentally induced metastasis in mice.” </li></ul>Cancer Immunol Immunother. 1998 Feb;45(6):313-20. A novel glycoprotein obtained from Chlorella vulgaris strain CK22 shows antimetastatic immunopotentiation. Tanaka K, Yamada A, Noda K, Hasegawa T, Okuda M, Shoyama Y, Nomoto K.
  39. 42. Angiogenesis and Cartilage <ul><li>“ Initially, cartilage was considered as a possible natural source of antiangiogenic compounds due to its known avascular nature. To date, a number of in vitro and in vivo studies have suggested the existence of antiangiogenic and anti-tumour compounds in bovine and shark cartilage .” </li></ul>Gonzalez RP, Leyva A, Moraes MO. Shark cartilage as source of antiangiogenic compounds: from basic to clinical research. Biol Pharm Bull. 2001 Oct;24(10):1097-101.
  40. 44. Bovine Cartilage Reduces Metastasis <ul><li>“ In this study we report that Metastatin, a cartilage-derived hyaluronan- binding complex consisting of proteolytic fragments of bovine link protein and aggrecan, is able to block the growth and metastasis of tumour cells .” </li></ul>Liu N, Lapcevich RK, Underhill CB, Han Z, Gao F, Swartz G, Plum SM, Zhang L, Green SJ. Metastatin: a hyaluronan-binding complex from cartilage that inhibits tumour growth. Cancer Res. 2001 Feb 1;6(3):1022-8.
  41. 45. Shark Liver Oil and Cancer <ul><li>“ Sharks have been claimed to be resistant to cancer and oil from their livers have been used in Scandinavian folk medicine as an anti-tumour drug. Shark liver oil contains 40% or more of squalene. Fish liver oil is also rich in squalene and polyunsaturated n-3 fatty acids.” </li></ul>Skopinska-Rozewskaa E, Chorostowska-Wynimko J, Krotiewski M, Rogala E, Sommer E, Demkow U, Skurak H. Inhibitory effect of Greenland shark liver oil combined with squalene and arctic birch ashes on angiogenesis and L-1 sarcoma growth in Balb/c mic. Pol J Vet Sci. 2003;6(3 Supp.)54-6.
  42. 46. Rice Bran <ul><li>“ Rice bran has been shown to bolster the vitality of the internal organs, especially the adrenals, thymus, spleen, and thyroid, which increase in size and exhibit additional anti-stress effects.” </li></ul>HEALING WITH WHOLE FOODS, pp. 12-17 Paul Pitchford, North Atlantic Books
  43. 47. Rice Bran <ul><li>“ Rice bran contains GPx, an enzyme, anti-oxidant, that reduces mucus, boosts respiratory function, and helps detoxify the body.” </li></ul>HEALING WITH WHOLE FOODS, pp. 12-17 Paul Pitchford, North Atlantic Books
  44. 48. Quercetin is Anti-carcinogenic <ul><li>“ Quercetin prevents transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF)-induced human PC-3 prostate cancer cell proliferation .” </li></ul>Huynh H et al. Int J Oncol 2003 Sep;(23):821-9 Huang YT et al. Br J Pharmacol 1999 Nov;128(5):999-1010
  45. 49. Quercetin is Anti-carcinogenic <ul><li>“ Quercetin inhibits the synthesis of heat shock proteins in tumours and blocks the export of lactate from tumours creating a lethal level of intracellular acidity. More effective against hypoxic tumours and in hyperthermia .” </li></ul>Kim JH Cancer Res 1984;44(1):102-6
  46. 50. Lysine <ul><li>“ The use of lysine, an amino acid, in combination with ascorbic vitamin C will lead to a breakthrough in the control of many forms of cancer and other diseases.” </li></ul>Dr Mathias Rath, NY Speech 2002
  47. 51. Lysine <ul><li>“… lysine blocks the enzyme’s ability to digest collagen by binding to it. If there is enough lysine to block enzyme molecules the movement of cells through the tissue can practically stop. I want to emphasize the words “enough lysine”. This is very important, because lysine, like vitamin C, cannot be produced in our body. We can only get it from our diet, therefore, deficiency of lysine is likely. This means that our body’s ability to control collagen digestion can be compromised if intake of lysine is too low.” </li></ul>The &quot;Cancer Research Report&quot; was presented by Dr. Aleksandra Niedzwiecki on Sunday, November 28, 2001 at the Health Symposium in Berlin
  48. 52. Lysine <ul><li>“ This graph shows that in the presence of lysine only 16% of cancer cells can move through collagen. This inhibitory effect is even more pronounced in the presence of additional nutrients such as vitamin C and proline. .” </li></ul>The &quot;Cancer Research Report&quot; was presented by Dr. Aleksandra Niedzwiecki on Sunday, November 28, 2001 at the Health Symposium in Berlin
  49. 53. Taurine <ul><li>“ Previously, we demonstrated in vitro that taurine significantly attenuated rIL-2-induced endothelial cell injury, whereas the tumor cytotoxicity of lymphokine-activated killer (LAK) cells was enhanced, and established that this effect was Ca^sup 2+^ -dependent. This demonstrates the duality of the action of taurine through enhancement of effector cell activity against the tumor target while protecting the endothelium from the deleterious effects associated with rIL-2 immunotherapy.” </li></ul>Host defense--A role for the amino acid taurine? JPEN: Journal of Parenteral and Enteral Nutrition, Jan/Feb 1998 by Stapleton, Philip P, O'Flaherty, Lean, Redmond, H Paul, Bouchier-Hayes, David J
  50. 54. Taurine <ul><li>“ Taurine or betaine pretreatment in lipopolysaccharide-injected rats caused significant decreases in plasma transaminase activities and hepatic malondialdehyde and DC levels, and significant increases in glutathione and alpha-tocopherol (not betaine) levels without changing ascorbic acid levels and SOD and glutathione peroxidase activities in the liver.” Taurine is observed to act as an antioxidant of ONOO- to decrease lipid peroxidation and thus affect liver plasma membrane Na+, K+-ATPase by restoring its activity. </li></ul>Eur J Gastroenterol Hepatol. 2005 Sep;17(9):917-21. The effect of taurine or betaine pretreatment on hepatotoxicity and prooxidant status induced by lipopolysaccharide treatment in the liver of rats. Balkan J, Parldar FH, Dogru-Abbasoglu S, Aykac-Toker G, Uysal M.
  51. 55. Taurine <ul><li>“ Taurine is observed to act as an antioxidant of ONOO- to decrease lipid peroxidation and thus affect liver plasma membrane Na+, K+-ATPase by restoring its activity.” </li></ul>World J Gastroenterol. 2005 Jun 21;11(23):3554-7. Peroxynitrite induced decrease in Na+, K+-ATPase activity is restored by taurine. Kocak-Toker N, Giris M, Tulubas F, Uysal M, Aykac-Toker G.
  52. 56. Herpes <ul><li>“ Among the 10 588 patients hospitalised with herpes zoster whom we identified, 1427 cancers were observed compared with 1239 expected (relative risk=1.2, 95% confidence interval 1.1-1.2). The risk was substantially elevated during the first year of follow-up, mainly for haematological cancer .” </li></ul>The risk and prognosis of cancer after hospitalisation for herpes zoster: a population-based follow-up study. Sorensen HT, Olsen JH, Jepsen P, Johnsen SP, Schonheyder HC, Mellemkjaer Br J Cancer. 2004 Oct 4;91(7):1275-9.
  53. 57. Turmeric <ul><li>“ Turmeric is one of the key ingredients in many curries, giving them colour and flavour. Curcumin derived from Turmeric gives curry its yellow colour and having both strong anti-oxidant and anti-inflammatory properties.” </li></ul>Drug Metab Pharmacokinet. 2004 Aug;19(4):245-63.Cancer prevention by natural compounds. Osuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore MA
  54. 58. Turmeric <ul><li>“ Curcumin inhibited chemically induced skin, forestomach, and colon carcinogenesis in post-initiation stage in animals .” </li></ul>Drug Metab Pharmacokinet. 2004 Aug;19(4):245-63.Cancer prevention by natural compounds. Osuda H, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore MA
  55. 59. Beetroot Prevents Cancer <ul><li>“ An in vivo anti-tumour promoting activity evaluation against the mice skin and lung bioassays also revealed a significant tumour inhibitory effect. The combined findings suggest that beetroot ingestion can be one of the useful means to prevent cancer.” </li></ul>Kapadia GJ, Tokuda H, Konoshima T, Nishino H. Chemoprevention of lung and skin cancer by Beta vulgaris (Beet) root extract. Cancer Lett. 1996 Feb 27;100(1-2):211-4
  56. 60. Vitamin B12 deficiency: a new risk factor for breast cancer? <ul><li>“ B12 status may influence breast carcinogenesis and therefore may be a modifiable risk factor for breast cancer prevention .” </li></ul>Nutr Rev. 1999 Aug;57(8):Vitamin B12 deficiency: a new risk factor for breast cancer? Choi SW
  57. 61. Natural Medicines that Prevent Prostate Cancer <ul><li>“ A large amount of data supports the use of other agents as potential preventatives, including selenium, vitamin E, vitamin D, other 5-alpha-reductase inhibitors, cycloxygenase-2 inhibitors, lycopene, and green tea.” </li></ul>Klein EA, Thompson IM. Update on chemoprevention of prostate cancer. Curr Opin Urol. 2004 May;14(3):143-9
  58. 62. Vitamin C Prevents Gastric Cancers <ul><li>“ Experimental gastric tumors seem to produce more reactive oxygen species than non neoplasic gastric tissue. The reduction of oxidative stress and gastric tumor incidence in rats were induced by the intake of ascorbic acid. Therefore, it may have a role in the prevention of gastric carcinoma . ” </li></ul>Oliveira CP, Kassab P, Lopasso FP, Souza HP, Janiszewski M, Laurindo FR, Iriya K, Laudanna AA. Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress. World J Gastroenterol. 2003 Mar;9(3):446-8.
  59. 63. Vitamin C Prevents Cancer: Mechanisms of Action <ul><li>“ Proposed mechanisms of action for ascorbic acid (ascorbate, vitamin C) in the prevention and treatment of cancer include (1) enhancement of the immune system, (2) stimulation of collagen formation necessary for &quot;walling off&quot; tumors …. ” </li></ul>Head KA. Ascorbic acid in the prevention and treatment of cancer. Altern Med Rev. 1998 Jun;3(3):174-86. Review.
  60. 64. Vitamin C Prevents Cancer: Mechanisms of Action <ul><li>“… (3) inhibition of hyaluronidase which keeps the ground substance around the tumor intact and prevents metastasis, (4) prevention of oncogenic viruses, (5) correction of an ascorbate deficiency often seen in cancer patients, (6) expedition of wound healing after cancer surgery ... ” </li></ul>Head KA. Ascorbic acid in the prevention and treatment of cancer. Altern Med Rev. 1998 Jun;3(3):174-86. Review.
  61. 65. Vitamin C Prevents Cancer: Mechanisms of Action <ul><li>“… (7) enhancement of the effect of certain chemotherapy drugs, (8) reduction of the toxicity of other chemotherapeutic agents such as Adriamycin, (9) prevention of free radical damage, and (10) neutralization of carcinogenic substances. ” </li></ul>Head KA. Ascorbic acid in the prevention and treatment of cancer. Altern Med Rev. 1998 Jun;3(3):174-86. Review.
  62. 66. Lycopene benefits Reproductive Cancers: Potent Antidoxidant <ul><li>“ Interest has been heightened in lycopene, in particular, as it has a large number of double bonds and thus has been found to be the most potent scavenger of oxygen free radicals of all the carotenoids.” </li></ul>Barber NJ, Barber J. Lycopene and prostate cancer. Prostate Cancer Prostatic Dis. 2002 Mar;5(1):6-12
  63. 67. Lycopene benefits Prostate Cancer: Reducing IGF-1 <ul><li>“ In prostate cancer, in particular, a study has demonstrated inhibition of cell line proliferation in the presence of physiological concentrations of lycopene in combination with alpha-tocopherol. Interestingly, a large study has linked lower levels of IGF-1 (high levels of which are associated with the incidence of prostate cancer) with increased tomato intake in the diet.” </li></ul>Barber NJ, Barber J. Lycopene and prostate cancer. Prostate Cancer Prostatic Dis. 2002 Mar;5(1):6-12
  64. 68. Selenium Reduces Most Cancers <ul><li>“ The complete, 13 years, results of the Nutritional Prevention of Cancer Trial have been analysed, causing some speculation over the robustness of the previously reported findings of reduction of cancer risks by supplements of selenium (Se) to a cohort of older Americans. These analyses confirmed that Se supplementation was associated with marked reductions in risks to total (all-site except skin) carcinomas and to cancers of the prostate and colon-rectum .” </li></ul>Combs GF Jnr. Status of selenium in prostate cancer prevention. Br J Cancer. 2004 Jul 19;91(2):195-9. Review
  65. 69. Molecular chemoprevention by Selenium <ul><li>“ The results …. indicate that selenium, independent of its form and the target organ examined, alters several genes in a manner that can account for cancer prevention. Selenium can up regulate genes related to phase II detoxification enzymes, certain selenium-binding proteins and select apoptotic genes, while down regulating those related to phase I activating enzymes and cell proliferation.” </li></ul>Mutat Res. 2005 Aug 11; Molecular chemoprevention by selenium: A genomic approach. El-Bayoumy K, Sinha R.
  66. 70. Carotenoids Induce Apoptosis <ul><li>“ Apoptosis was induced in human MDR1 transfected mouse lymphoma cells and human breast cancer MDA-MB-231 (HTB-26) cell lines in the presence of lycopene, zeaxanthin and capsanthin.” </li></ul>Molnar J, Gyemant N, Mucsi I, Molnar A, Szabo M, Kortvelyesi T, Varga A, Molnar P, Toth G. Modulation of multidrug resistance and apoptosis of cancer cells by selected carotenoids. In Vivo. 2004 Mar-Apr:18(2):237-44
  67. 71. Garlic Inhibits a Number of Cancers <ul><li>“ Allicin is the major ingredient in crushed garlic and has been shown to inhibit the proliferation of human mammary, endometrial and colon cancer cells.” </li></ul>Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med 2004;50:145-49
  68. 72. Garlic Inhibits a Number of Cancers, in a number of ways <ul><li>“ Garlic components have been found to block covalent binding of carcinogens to DNA, enhance degradation of carcinogens, have antioxidant and free radical scavenging properties and to regulate cell proliferation, apoptosis and immune responses.” </li></ul>Das S. Garlic – A Natural Source of Cancer Preventive Compounds. Asian Pac J Cancer Prev. 2002;3(4):305-11
  69. 73. Garlic Regulates the Cell Cycle and Hormones <ul><li>“ Garlic contains allyl sulphides which in their volatile state contribute to the strong odour. The sulphur compounds inhibit cell proliferation of cancer cells, modulate cell cycle activity and interfere with hormone action in cancer cells.” </li></ul>Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med 2004;50:145-49
  70. 74. Garlic Induces Apoptosis in Cancer Cells <ul><li>“ We found that allicin inhibited the growth of cancer cells of murine and human origin. Allicin induced the formation of apoptotic bodies, nuclear condensation and a typical DNA ladder in cancer cells. Furthermore, activation of caspases-3, -8 and -9 and cleavage of poly (ADP-ribose) polymerase were induced by allicin.” </li></ul>Oommen S, Anto RJ, Srinivas G, Karunagaran D. Allicin (from Garlic) induces caspase-mediated apoptosis in cancer cells. Eur J Pharmacol. 2004 Feb 6;485(1-3):97-103
  71. 75. Flax Seeds Decrease VEGF <ul><li>“ Angiogenesis is important in tumour growth, progression and metastatic dissemination. Vascular endothelial growth factor (VEGF) is one key factor in promotion of breast cancer angiogenesis. VEGFs are bioactive in the extracellular space where they become available to the endothelial cells. Phytoestrogens such as lignans have been shown to alter breast cancer incidence and be cancer-protective in rats.” </li></ul>Dabrosin C, Chen J, Wang L, Thompson LU. Flaxseed inhibits metastasis and decreases extra cellular vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett. 2002 Nov 8;185(1):31-37
  72. 76. Flax Seeds Decrease VEGF <ul><li>“ We show that supplementation of 10% flaxseed, the richest source of mammalian lignans, to nude mice with established human breast tumours reduced tumour growth and metastasis. Moreover, flaxseed decreased extracellular levels of </li></ul><ul><li>VEGF, which may be one </li></ul><ul><li>mechanistic explanation to the decreased tumour growth and metastasis.” </li></ul>Dabrosin C, Chen J, Wang L, Thompson LU. Flaxseed inhibits metastasis and decreases extra cellular vascular endothelial growth factor in human breast cancer xenografts. Cancer Lett. 2002 Nov 8;185(1):31-37
  73. 77. Grape Seeds (GSP) Prevents Prostate Cancer <ul><li>“ These data suggest that inhibition of metastasis-specific MMPs in tumour cells by GSP is associated with the inhibition of activation of MAPK and NF kappa B pathways, and thus provides the molecular basis for the development of GSP as a novel chemopreventive agent for both androgen-sensitive and –insensitive prostate cancer therapies.” </li></ul>Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxurubicin against human breast carcinoma cells. Breast Cancer Res Treat. 2004 May;85(1):1-12
  74. 78. Grape Seeds (GSP) Treats Prostate Cancer <ul><li>“ These findings suggest that GSE possesses in vivo anticancer efficacy against hormone-refactory human PCA, which is associated with its antiproliferative, pro-apoptotic and antiangiogenic activities together with up regulation of IGFBP-3.” </li></ul>Singh RP, Tyagi AK, Dhanalakshmi S, Agarwal R, Agarwal C. Grape seed extract inhibits advanced human prostate tumour growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. Int J Cancer. 2004 Feb 20;108(5):733-40
  75. 79. Grape Seeds (GSE) are Synergistic with Chemotherapy <ul><li>“ Together, these results suggest a strong possibility of synergistic efficacy of GSE and doxorubicin combination for breast cancer treatment, independent of oestrogen receptor status of the cancer cell.” </li></ul>Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R. Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxurubicin against human breast carcinoma cells. Breast Cancer Res Treat. 2004 May;85(1):1-12
  76. 80. Anthocyanins Prevent Cancer via Numerous Effects <ul><li>“ Anthocyanin-rich extracts, potent antioxidants and commercially available food colouring agents, have been reported to inhibit the growth of various cancer cell lines. We investigated the effect of semi-purified anthocyanin-rich extract from fruits of Aronia meloncarpa, on normal colon and colon cancer cell lines.” </li></ul>Malik M, Zhao C, Schoene N, Guisti MM, Moyer MP, Magnuson BA. Anthocyanin-rich extract from Aronia meloncarpa E induces a cell cycle block in colon cancer but not in normal colonic cells. Nutr Cancer. 2003;46(2):186-96.
  77. 81. Anthocyanins Prevent Cancer via Numerous Effects <ul><li>“ The treated cells showed a blockage at G1/G0 and G2/M phases of the cell cycle. The cell cycle arrest coincided with an increased expression of the p21WAF1 and p27KIP1 genes and decreased expression of cyclin A and B genes. NCM460 normal colon cells demonstrated <10% growth inhibition at the highest concentration of 50 mg/ml extract.” </li></ul>Malik M, Zhao C, Schoene N, Guisti MM, Moyer MP, Magnuson BA. Anthocyanin-rich extract from Aronia meloncarpa E induces a cell cycle block in colon cancer but not in normal colonic cells. Nutr Cancer. 2003;46(2):186-96.
  78. 82. Fish Oils are Anticarcinogenic Agents: Studies <ul><li>“ Recent intervention studies in breast cancer patients indicate that n-3 fatty acids, and docosahexaenoic acid (DHA) in particular, increase the response to chemo-preventive agents. In patients with colorectal cancer, eicosapentaenoic acid (EPA) and DHA decrease cell proliferation, and modulate favourably the balance between colonic cell proliferation and apoptosis.” </li></ul>Simopoulos AP. The traditional diet of Greece and cancer. Eur J Cancer Prev. 2004 Jun;13(3)219-230
  79. 83. Fish Oils are Anticarcinogenic Agents: Mechanisms <ul><li>“ Many mechanisms are involved, including suppression of neoplastic transformation, cell growth inhibition, and enhanced apoptosis and anti-angiogenicity, through the inhibition of eicosanoid production from n-6 fatty acids; and suppression of cyclooxygenase 2 (COX-2), interleukin 1 (IL1) and IL-6 gene expression by n-3 fatty acids.” </li></ul>Simopoulos AP. The traditional diet of Greece and cancer. Eur J Cancer Prev. 2004 Jun;13(3)219-230
  80. 84. Olive Oil Protects Against Cancer <ul><li>“ Cumulative evidence suggests that olive oil may have a role in the prevention of coronary disease and several types of cancer because of its high levels of monounsaturated fatty acids and polyphenolic compounds.” </li></ul>Hu FB. The Mediterranean diet and mortality – olive oil and beyond. N Engl J Med. 2003 Jun 26;348(26):2595-6
  81. 85. Olive Oil and Fish Oil Protects Against Bowel Cancer <ul><li>“ Supplementation with fish oil or olive oil results in an induction of apoptosis and cell differentiation. The latest effect was also induced by oleic and linoleic acid. Fish oil diminishes significantly cell proliferation. Supplementation with fish oil and olive oill results in an early downregulation of COX-2 followed by a decrease in Bcl-2 expression.” </li></ul>Lior X, Pons E, Roca A, Alvarez M, Mane J, Fernandex-Banares F, Gassull MA. The effects of fish oil, olive oil, oleic acid and linoeic acid on colorectal neoplastic processes. Clin Nutr. 2003 Feb; 22(1_:71-9
  82. 86. Olive Oil Protects Against Breast Cancer in Offspring <ul><li>“ These results indicate that perinatal exposure to Olive oil may have a protective effect against future development of mammary cancer in female offspring, whereas high-fat diets fed to pregnant and lactating rats, in particular corn oil, may be deleterious.” </li></ul>Stark AH, Kossoy G, Zusman I, Yarden G, Madar Z. Olive oil consumption during pregnancy and lactation in rats influences mammary cancer development in female offspring. Nutr Cancer. 2003;46(1):59-65
  83. 87. Olive Oil: Bottom Line <ul><li>“ High consumption of extra-virgin olive oils, which are particularly rich in phenolic antioxidants, ie hydroxytyrosol, tyrosol, oleuropein, lignans, as well as squalene and oleic acid, should afford considerable protection against cancer (colon, breast, skin), coronary heart disease and ageing by inhibiting oxidative stress.” </li></ul>Filik L, Ozyilkan O. Olive oil consumption and cancer risk. Eur J Clin Nutr. 2003 Jan;57(1):191
  84. 88. Mediterranean Diets Protect Against Lung Cancer <ul><li>“ After careful control for several smoking variables, we found a protective effect for high consumption of carrots (odds ratio [OR] = 0.67), tomatoes (OR = 0.59), white meat (OR = 0.66), exclusive use of olive oil (OR = 0.67), and regular consumption of sage (OR = 0.43).” </li></ul>Fortes C, Forastiere F, Farchi S, Mallone S, Trequattrinni T, Anatra F, Schmid G, Perucci CA. The protective effect of the Mediterranean diet on lung cancer. Nutr Cancer. 2003;46(1):30-7.
  85. 89. Avocado Contains Persenone A, an Anticancer Component <ul><li>“ This study thus suggests that persenone A is a possible agent to prevent inflammation-associated diseases including cancer .” </li></ul>Kim OK, Murakami A, Takahashi D, Nakamura Y, Torikai K, Kim HW, Ohigashi H. An avocado constituent, persenone A, suppresses expression of inducible forms of nitric oxide synthase and cyclooxygenase in macrophages, and hydrogen peroxide generation in mouse skin. Biosci Biotechnol Biochem. 2000 Nov;64(11):2504-7.
  86. 90. Berries (Anthocyanins) Reduce Cancer Risk <ul><li>“ Principal therapeutic benefits attributable to anthocyanins include antioxidant protection and maintenance of DNA integrity. Anthocyanins also serve as anti-inflammatory and anti-mutagenic agents and provide cardioprotection by maintaining vascular permeability .” </li></ul>Bagchi D, Sen CK, Bagchi M, Atalay M. Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemistry (Mosc). 2004 Jan;69(1):75-80
  87. 91. Berries (Anthocyanins) Reduce Cancer Risk <ul><li>“ Free radicals oxidatively damage lipids and proteins and compromise genomic DNA integrity. They are widely recognized as the root cause of numerous degenerative diseases including cancer. Antioxidants function as inhibitors at both initiation and promotion/propagation/transformation stages of tumor promotion/carcinogenesis, and protect cells against oxidative damage.” </li></ul>Bagchi D, Sen CK, Bagchi M, Atalay. Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemistry (Mosc). 2004 Jan;69(1):75-80
  88. 92. Bagchi D, Sen CK, Bagchi M, Atalay M.Anti-angiogenic, antioxidant, and anti-carcinogenic properties of a novel anthocyanin-rich berry extract formula. Biochemistry (Mosc). 2004 Jan;69(1):75-80 Inhibition of VEGF by Berries
  89. 93. Vitamin E Reduces Cancer Growth and Proliferation <ul><li>“ Human evidence indicates an inverse relationship between vitamin E levels and tumour incidence. Binding proteins for vitamin E exist in plasma as well as in cells and have been identified in tumour cells as well. Tocotrienols have a negative effect on growth and proliferation of some types of human cancer cells.” </li></ul>Drisko JA, Chapman J, Hunter VJ. The use of antioxidant therapies during chemotherapy. Gynecol Oncol. 2003 Mar;88(3):434-9. Review.
  90. 94. Green Tea: Anticancer Drink <ul><li>“ Tea is one of the most popular beverages in the world and the consumption of tea has been associated with a decreased risk of developing cancer of the ovary, oral cavity, colon, stomach, and prostate. This beneficial health effect has been attributed to the catechins in tea: (-)-epicatechin (EC), (-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG).” </li></ul>Heber D. Vegetables, fruits and phytoestrogens in the prevention of diseases. J Postgrad Med. 2004 Apr-Jun;50(2):145-9.
  91. 95. Green Tea Inhibits Cancer Growth <ul><li>“ In recent years, epigallocatechin-3-gallate (EGCG), the major polyphenolic constituent present in green tea, has shown remarkable effects in inhibiting cancer cell growth both in cell </li></ul><ul><li>culture system and in in vivo </li></ul><ul><li>tumour models .” </li></ul>Gupta S, Hussain T, Mukhtar H. Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells. Arch Biochem Biophys. 2003 Feb 1;410(1):177-85.
  92. 96. Green Tea Upregulates p21, an anti cancer gene <ul><li>“ Earlier studies in our laboratory have shown that treatment of androgen-sensitive and androgen-insensitive human prostrate carcinoma cells with EGCG resulted in G0/G1 phase cell cycle arrest and apoptosis, irrespective of the p53 status of these cells. This effect was mediated by upregulation in the protein expression of WAF1/P21 .” </li></ul>Gupta S, Hussain T, Mukhtar H. Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells. Arch Biochem Biophys. 2003 Feb 1;410(1):177-85.
  93. 97. Green Tea Normalises the Cyclins that Drive Cancer Cells <ul><li>“ In the present study, we demonstrate that EGCG, via modulation in the cki-cyclin-cdk machinery, results in a G1 phase arrest of the cell cycle followed by apoptosis of human prostate carcinoma cells .” </li></ul>Gupta S, Hussain T, Mukhtar H. Molecular pathway for (-)-epigallocatechin-3-gallate-induced cell cycle arrest and apoptosis of human prostate carcinoma cells. Arch Biochem Biophys. 2003 Feb 1;410(1):177-85.
  94. 98. Fulvic Acid <ul><li>“ Patients with cancer causing tumors of the esophagus had 100% success rate in preventing tumor progression into the cancerous state when treated for two years with a humic extract solution.” </li></ul>Yuan, Shenyuan; Fulvic Acid, 4 1988; in Application of Fulvic acid and its derivatives in the fields of agriculture and medicine; First Edition: June 1993
  95. 99. Fulvic Acid <ul><li>“ Outpatient medical hospital studies on thyroid tumors, some cancerous, showed that injections with a special humic extract was 90% successful in stopping tumor growth and diminishing size of tumors, with 80% of patients having complete cures.” </li></ul><ul><li>For more information on Fulvic Acid please visit www.info-archive.com </li></ul>He, Shenyi, et al; Humic acid in Jiangxi Province, 1 (1982)
  96. 101. Buffered Vitamin C Flush <ul><li>Involves the consumption of very high doses of buffered Vitamin C for a 1-2 day period to magnify detoxification and strengthen the Immune system. </li></ul><ul><li>The Vitamin C must contain a good percentage of bioflavonoids and must be buffered with a spectrum of buffering minerals. </li></ul><ul><li>Instructions: </li></ul><ul><li>Add 1tsp (2000mgs) of Vitamin C to a glass of water and repeat every 1/2 hr until diarrhea results. </li></ul><ul><li>Subtract 1 tsp from total of tsps needed to produce diarrhea and add this amount to a drink every 4 hrs for 1-2 days. </li></ul><ul><li>Decrease dosage if stool becomes watery. </li></ul>Nutri-Tech Solutions Pty Ltd “Nutrition Matters” 2005, Qld, Australia.
  97. 102. BioActiv Buffered Vitamin C with Hesperidin and Minerals <ul><li>The World's most popular nutrient! Vitamin C is even better in this formula! </li></ul><ul><li>Hesperidin is derived from the pith of unripened lemons. </li></ul><ul><li>Try this great tasting, economical, refreshing, revitalising, immune boosting formula. </li></ul><ul><li>BioActiv Buffered Vitamin C Powder is the best tasting product in its class. </li></ul><ul><li>This formula has less overall sugars than its main rival, fits into the budget price bracket, has extra minerals to add further value and health benefits and is a practitioner exclusive product that is useful for the whole family. </li></ul>Ingredients: Each 2 gram contains: Ascorbic Acid 800mg, Calcium Ascorbate 200mg, Hesperidin 190mg, Calcium Phosphate 100mg, Magnesium Phosphate 190mg, Zinc Sulphate Monohydrate 2.9mg and balanced exipients: Fructose, Glucose, Silica, Steviosides, with a tangy natural lemon flavour.
  98. 103. BioActiv Super B Liquid <ul><li>Vital Links for optimal cellular energy.  </li></ul><ul><li>Developed to assist rapid absorption. </li></ul><ul><li>First high potency B complex liquid, high in </li></ul><ul><li>additional co factors (choline & inositol).  </li></ul><ul><li>FREE from sorbitol, yeast and artificial colours.  </li></ul><ul><li>Pure B Vitamins in a purified water solution.. Each 5ml dose contains: Thiamine HCl (B1) 30mg, Riboflavine (B2) 5mg, Nicotinamide (B3), 50mg, Dexpanthenol (provitamin B5) 50mg, Pyridoxine HCl (B6), 30mg, Folic Acid 215mcg, Cyancobalamin (B12) 215mcg, Biotin 30mcg, Inositol 125mcg, Choline Bitartrate 250mg . The Practitioner may supervise the patient towards a higher dose when energy is needed in the treatemnt of chronic conditions. Serving Suggestion:  Take 5ml 2 times daily with meals (10ml/day = 50 days) or as prescribed. </li></ul>
  99. 104. Ingredients: Whey powder (from Milk), whey protein concentrate (from Milk), dextrose (from tapioca), inulin, mineral salts (calcium carbonate), natural vanilla, emulsifier (tartaric acid), minerals (magnesium oxide, zinc sulphate, ferrous gluconate, potassium iodide), stabliser ( potassium phosphate), vegetable gums (xanthan gum, guar gum), antioxidant (a-tocepherol), vitamins (C,E, niacin, riboflavin, B6 thiamine, A, folate, D, B12). NU-WHEY Nu-Whey is a super nutritious low allergy whey powder. It is the first whey milk substitute to be free of casein, gluten, corn, soy and wheat. Mixes in an instant. 100 grams make a litre of the delicious milk alternative that when mixed will keep in the fridge for 4-5 days. Suitable for children, adults and great for sportspeople. Highly suited to those with difficulties with certain food absorption, allergies and who are convalescing . Please do not confuse with regular whey powder, this magnificent product is very different in nutrition, taste and is reasonably instantly mixed. Use as a substitute in all recipes that call for cows milk. We tested the several brands of whey milk drinks on the market and found they all contained casein. One major brand did not have this disclosed in their ingredients list. This is not the ethical “whey” to go. Nu-Whey helps release energy slowly to help vitality and sustain appetite. Whey proteins are easy to digest into branch chain amino acids which aid muscle repair and growth. Nu-Whey is a probiotic to assist the good bacteria (from fermented foods in the diet) to flourish and maintain gastro-intestinal hygiene. DOES MILK MAKE YOUR PATIENTS SICK?
  100. 105. Gluten intolerance <ul><li>A major cause of gastrointestinal inflammation and may be a precursor to inflammation in the large bowel, including polyps . </li></ul>BrighterLife products are free of many allergy triggering ingredients. We have chosen easy to digest flours, i.e. Rice Flour, Potato Starch and Tapioca Starch. A small amount of raw sugar is used in some of our products to improve palatability. This raw sugar can be sifted out if required. We use a unique whey formula which has pre-digested qualities. All maltodextrins and dextrose are sourced from Tapioca. This product has also been endorsed by the Australian Coeliac Society as Gluten Free.
  101. 106. BioActiv G.N.B (GLYCO NUTRITIONAL BLEND) <ul><li>G.N.B. has a pleasant taste that most people enjoy in water, fruit or vegetable juice. The ingredients are an excellent synergy and may assist with absorption and utilisation of other natural remedies. </li></ul><ul><li>G.N.B. was designed as a highly concentrated food to give the body nutritional support to assist the self-healing processes. </li></ul><ul><li>G.N.B. was the first super green product in Australia to incorporate the methylating benefits of MSM and Dimethyl-Glycine. </li></ul><ul><li>It is best used as an adjunct to diet, herbal and homeopathic remedies. Packed with highly Nutritious Food Factors & Concentrates known for fortifying body systems. </li></ul><ul><li>May assist a variety of burned out syndromes that predispose one to a loss of energy and poor intestinal motility. </li></ul><ul><li>  </li></ul><ul><li>Ingredients: Green Barley, Whey Protein Concentrate (WPC80), Whey Protein Isolate (WPI90), Lecithin, Rice Bran, Bee Pollen, Beetroot, DMG (Di Methyl Glycine), Licorice Root, Psyllium Husk, Slippery Elm, Hesperidin, L-Glutamine, Yucca Powder, MSM (Methyl Sulphonyl Methane), Carob Powder, Guar Gum, Organic Lactic Ferments (Hawaiian Spirulina, Dunaliella Salina, Chlorella, Barley Grass, Wheat Grass, Alfalfa Grass, Oat Grass, Kelp, New Guinea Yam), Natural Vanilla, Chrysanthemum Powder, BioActivated Silica Dioxide. </li></ul>
  102. 107. Bio-Activ Beta.Pro 300b Ingredients: Green Barley Pwdr, Rice Bran, Whey Protein Conc. Bee Pollen, Lecithin, Beta-Sitosterol, Soy Protein Isolate, Oligofructose, Siberian Ginseng, Glucosamine, Inositiol Hexaphosphate, DMG, MSM, Tumeric, Horsetail, Tienchi Ginseng, Liquorice Root, Bovine Tracheal Cartilage, L-Taurine, Calcium Carbonate, Sarsaparilla, L-Glutamine, Magnesium Citrate, Quercetin, Vegetable Derived Multistrain Lactobacilli, Natural Lemon Flavour, Cinnamon, Chrysanthemum Leaf Pwdr. Zinc Oxide, Selenium Yeast, Potassium Iodide Natural Power Foods plus Plant Sterol Concentrates that are natural sources of Anti0xidants and energy Metabolites. These factors help regulate biochemical pathways. Assist with gut hygiene and mucosa support Excellent support for liver function, bile production and detoxification.
  103. 108. OXYGEN
  104. 109. <ul><li>Vital for Life </li></ul><ul><li>Biocatalyst </li></ul><ul><li>Oxygen Starvation caused by:- </li></ul><ul><ul><ul><ul><li>Toxic Stress </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Emotional Stress </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Physical trauma and infections </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Reduction in available atmospheric oxygen </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Increase in Carbon Monoxide </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Improper Food </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Lack of Exercise </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Smoking </li></ul></ul></ul></ul><ul><ul><ul><ul><li>High intake of alcohol </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Pollution </li></ul></ul></ul></ul>Oxygen
  105. 110. Why Di-Oxymed? <ul><li>Di-Oxymed is manufactured using non-chemical formulation with no mixing of potentially toxic chemicals. </li></ul><ul><li>One of the highest concentrations of </li></ul><ul><li>bioavailable stabilized oxygen available today. </li></ul><ul><li>Colourless, non-toxic, hypoallergenic and completely safe to use with no known toxicity for man of animals. </li></ul><ul><li>Low salt – less than 20ppm </li></ul><ul><li>Balanced to the pH of the bloodstream, </li></ul>
  106. 111. Diatomic Oxygen <ul><li>Oxygen is the most vital element to the human body. 90% of our body's life energy is created by oxygen. Insufficient oxygen means insufficient biological resources which can result in ailments ranging from mild fatigue to life threatening diseases. Di-Oxymed, provides a highly effective solution to one of our most perplexing problems: How to feed our bodies more oxygen thus allowing our bodies to more effectively oxidize and metabolize life and health giving nutrients . </li></ul>Practitioner Only
  107. 112. BioResearch Homoeopathic Complexes
  108. 113. <ul><li>Why BioResearch? </li></ul>
  109. 114. The Formulae <ul><li>Low Ethanol </li></ul><ul><li>Sublingual </li></ul><ul><li>Ingredients act synergistically together </li></ul><ul><li>Multiple potencies </li></ul><ul><li>Provings unlikely </li></ul><ul><li>Safe for Pregnancy </li></ul><ul><li>Safe for Infants </li></ul><ul><li>Safe for the Elderly </li></ul><ul><li>Ease of Compliance </li></ul><ul><li>Pleasant Taste </li></ul><ul><li>Children Easy to Dose </li></ul><ul><li>The Formulae can be used as Part of a Treatment Regime </li></ul><ul><li>Inexpensive Start-up Costs </li></ul><ul><li>Up to 5 year use by date </li></ul>
  110. 115. The Protocols <ul><li>BioResearch Protocols - the best combinations of BioResearch Formulae for temporary relief of symptoms for specific disorders </li></ul><ul><li>Treatment protocols are simple with great results </li></ul><ul><li>  </li></ul>
  111. 116. BioResearch Protocol No 1 – Parasitic Infection [May assist with the temporary relief of symptoms of] <ul><li>Adult </li></ul><ul><li>Formula WRM , 10 drops 3 times daily ½ hour before meals </li></ul><ul><li>Formula VSL , 3-6 drops 3 times daily ½ hour after meals </li></ul><ul><li>30 day programme </li></ul>
  112. 117. BioResearch Protocol No 2 – Parasitic Infection with constipation [May assist with the temporary relief of symptoms of] <ul><li>Adult Dose </li></ul><ul><li>Formula WRM , 10 drops 3 times daily ½ hour before meals </li></ul><ul><li>Formula GT , 3-6 drops 3 times daily ½ hour after meals </li></ul><ul><li>Prescribe until the constipation is relieved then transfer to Protocol No 1 for the remainder of the 30 day programme </li></ul>
  113. 118. <ul><li>Some clients may require more than a 30 day programme of BioResearch Protocol No 1 or Protocol No 2. Depending on the presenting symptoms you may need to repeat for another 30 day programme. </li></ul>
  114. 119. Formula 12 <ul><li>INGREDIENTS: (Potency 6C, 12C, 15C) </li></ul><ul><li>Calc. fluor. Tissue Strengthener CANCER </li></ul><ul><li>Calc. phos. Cell Builder CAPRICORN </li></ul><ul><li>Calc. sulf. Suppuration Remover SCORPIO </li></ul><ul><li>Ferrum phos. Inflammation Remover PISCES </li></ul><ul><li>Kali. mur. Congestion Remover GEMINI </li></ul><ul><li>Kali. phos. Nerve Power Activate ARIES </li></ul><ul><li>Kali. sulf. Cell Oxygenator VIRGO </li></ul><ul><li>Mag. phos. Neuromuscular Co-Ordinator LEO </li></ul><ul><li>Nat. mur. Fluid Balancer AQUARIUS </li></ul><ul><li>Nat. phos. Metabolic Acid Remover LIBRA </li></ul><ul><li>Nat. sulf. Problem Fluid Remover TAURUS </li></ul><ul><li>Silicea Calcium Organizer SAGITTURUS </li></ul>
  115. 120. BioResearch Protocol 61 – General Tonic <ul><li>Formula 12 , 10 drops, once daily on rising </li></ul><ul><li>Formula GT , 3-6 drops , 4 times daily ½ hour after meals and at bedtime </li></ul><ul><li>or in 600ml of water with 5 ml of </li></ul><ul><li>BioActiv Di-Oxymed </li></ul>
  116. 121. <ul><li>The End </li></ul><ul><li>Presented by Glen Gillard </li></ul><ul><li>DIP N.T (GOV ACCRED) C.E.C.H Ird. M.C.M.A </li></ul>

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