Immunoglobulin: Isotypes, Allotypes and Idiotypes
Immunoglobulin Isotypes <ul><li>Definition - Antigenic determinants that characterize the classes and subclasses of heavy ...
Human IgM antiserum Reacts with IgM, IgG, IgA, IgD, IgE React with IgG, IgA, IgD and IgE Absorbed antiserum Reacts only wi...
Immunoglobulin Isotypes <ul><li>Occurrence </li></ul><ul><li>Importance </li></ul><ul><ul><li>Ig levels </li></ul></ul><ul...
Immunoglobulin Allotypes <ul><li>Definition - Antigenic determinants specified  </li></ul><ul><li>by allelic forms of the ...
Human Immunoglobulin Allotypes <ul><li>Nomenclature </li></ul><ul><ul><li>G1m(3) </li></ul></ul><ul><ul><li>Km(1) </li></u...
Human Immunoglobulin Allotypes <ul><li>Genetics (alleles) </li></ul><ul><ul><li>Co-dominant </li></ul></ul><ul><ul><li>aut...
<ul><li>Genetics (pseudoalleles) </li></ul><ul><ul><li>Co-dominant </li></ul></ul>Human Immunoglobulin Allotypes G1m(17) G...
Immunoglobulin Allotypes <ul><li>Definition </li></ul><ul><li>Location </li></ul><ul><li>Occurrence </li></ul><ul><li>Impo...
Immunoglobulin Idiotypes <ul><li>Definition - Unique antigenic determinants present on individual antibody molecules or on...
DNP-BSA Strain A Mouse Anti-DNP Ab Purified anti-DNP Ab Strain A Mouse Ab against combining site of anti-DNP Ab ??  Immuno...
Immunoglobulin Idiotypes <ul><li>Definition </li></ul><ul><li>Location </li></ul>IgG1 (kappa) Person 1 anti-B IgG1 (kappa)...
Immunoglobulin Idiotypes <ul><li>Definition </li></ul><ul><li>Location  </li></ul><ul><li>Importance </li></ul><ul><ul><li...
Ag Id anti-Id + - anti-anti-Id + - Regulation by Id/anti-Id
Immunoglobulin Idiotypes <ul><li>Definition </li></ul><ul><li>Location  </li></ul><ul><li>Importance </li></ul><ul><ul><li...
Anti-Idiotype Vaccines Ag Id anti-Id + - Ag Id anti-Id +
Immunoglobulin Idiotypes <ul><li>Definition </li></ul><ul><li>Location  </li></ul><ul><li>Importance </li></ul><ul><ul><li...
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Iso Allo Idio 2001

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Iso Allo Idio 2001

  1. 1. Immunoglobulin: Isotypes, Allotypes and Idiotypes
  2. 2. Immunoglobulin Isotypes <ul><li>Definition - Antigenic determinants that characterize the classes and subclasses of heavy chains and types and subtypes of light chains </li></ul>
  3. 3. Human IgM antiserum Reacts with IgM, IgG, IgA, IgD, IgE React with IgG, IgA, IgD and IgE Absorbed antiserum Reacts only with IgM Recognizes determinants specific for  heavy chains (isotypes) Immunoglobulin Isotypes ?? ?? ??
  4. 4. Immunoglobulin Isotypes <ul><li>Occurrence </li></ul><ul><li>Importance </li></ul><ul><ul><li>Ig levels </li></ul></ul><ul><ul><li>B cell tumors </li></ul></ul><ul><ul><li>Immunodeficiencies </li></ul></ul><ul><li>Definition </li></ul><ul><li>Location </li></ul>IgM (kappa) IgG1 (kappa)
  5. 5. Immunoglobulin Allotypes <ul><li>Definition - Antigenic determinants specified </li></ul><ul><li>by allelic forms of the Ig genes </li></ul><ul><li>Location </li></ul><ul><li>Occurrence </li></ul><ul><li>Source of anti-allotypic Abs </li></ul>IgG1 (kappa) Person 2 IgG1 (kappa) Person 1
  6. 6. Human Immunoglobulin Allotypes <ul><li>Nomenclature </li></ul><ul><ul><li>G1m(3) </li></ul></ul><ul><ul><li>Km(1) </li></ul></ul>
  7. 7. Human Immunoglobulin Allotypes <ul><li>Genetics (alleles) </li></ul><ul><ul><li>Co-dominant </li></ul></ul><ul><ul><li>autosomal genes </li></ul></ul>Km(1)/Km(3) X Km(1)/Km(1) Km(1)/Km(1) and Km(1)/Km(3) <ul><li>Allelic exclusion </li></ul>
  8. 8. <ul><li>Genetics (pseudoalleles) </li></ul><ul><ul><li>Co-dominant </li></ul></ul>Human Immunoglobulin Allotypes G1m(17) G1m(1) 214 355-358
  9. 9. Immunoglobulin Allotypes <ul><li>Definition </li></ul><ul><li>Location </li></ul><ul><li>Occurrence </li></ul><ul><li>Importance </li></ul><ul><ul><li>Monitoring bone marrow grafts </li></ul></ul><ul><ul><li>Forensic medicine </li></ul></ul><ul><ul><li>Paternity testing </li></ul></ul>
  10. 10. Immunoglobulin Idiotypes <ul><li>Definition - Unique antigenic determinants present on individual antibody molecules or on molecules of identical specificity </li></ul>
  11. 11. DNP-BSA Strain A Mouse Anti-DNP Ab Purified anti-DNP Ab Strain A Mouse Ab against combining site of anti-DNP Ab ?? Immunoglobulin Idiotypes Antigenic determinants created by the HVR = Idiotypes
  12. 12. Immunoglobulin Idiotypes <ul><li>Definition </li></ul><ul><li>Location </li></ul>IgG1 (kappa) Person 1 anti-B IgG1 (kappa) Person 1 anti-A
  13. 13. Immunoglobulin Idiotypes <ul><li>Definition </li></ul><ul><li>Location </li></ul><ul><li>Importance </li></ul><ul><ul><li>V region marker </li></ul></ul><ul><ul><li>Regulation of immune responses </li></ul></ul>
  14. 14. Ag Id anti-Id + - anti-anti-Id + - Regulation by Id/anti-Id
  15. 15. Immunoglobulin Idiotypes <ul><li>Definition </li></ul><ul><li>Location </li></ul><ul><li>Importance </li></ul><ul><ul><li>V region marker </li></ul></ul><ul><ul><li>Regulation of immune responses </li></ul></ul><ul><ul><li>Vaccines </li></ul></ul>
  16. 16. Anti-Idiotype Vaccines Ag Id anti-Id + - Ag Id anti-Id +
  17. 17. Immunoglobulin Idiotypes <ul><li>Definition </li></ul><ul><li>Location </li></ul><ul><li>Importance </li></ul><ul><ul><li>V region marker </li></ul></ul><ul><ul><li>Regulation of immune responses </li></ul></ul><ul><ul><li>Vaccines </li></ul></ul><ul><ul><li>Treatment of B cell tumors (T cell) </li></ul></ul>
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