Geoffrey H. Siwo, Victoria Lam, Ian Sander & Fit2Cure Players
Fit2Cure Team
Human + Computer Intelligence Democratizing Me...
ARE WE HEALTHIER THAN 100 YEARS AGO?
100 YEARS, 100% INCREASE IN HUMAN LIFESPAN
MORE CHILDREN LIVE BEYOND 5TH BIRTHDAY
BUT DESPITE THE PROGRESS …
CURRENT MEDICINE CAN’T COPE UP
• > 10,000 diseases
• Same disease in a different patient is not exactly the same
• 95% of ...
LEARNING FROM THE PAST TO MAKE A BETTER
FUTURE
OUR PROGRESS IS DUE TO COLLECTIVE &
CUMULATIVE INTELLIGENCE
BRAIN SIZE = INTELLIGENCE
BRAIN SIZE HAS STAGNATED IN >30,000 YEARS
A BABY AT BIRTH TODAY IS NO MORE INTELLIGENT
THAN HIS/ HER ANCESTOR 100 YEARS AGO
IMAGINE IF PRACTICALLY ANYONE COULD ACTIVELY
ENGAGE IN DRUG DISCOVERY
..YES IT’S POSSIBLE
2003: Undergraduate in Africa doing computational modeling of HIV on a pay-to-go computer
… IN AFRICA
2003 to 2005: organi...
…IN USA
• 15 year old Jack Andraka develops pancreatic cancer test: 100 times more
sensitive and 28 times cheaper
IT’S GOING TO HAPPEN EVERYWHERE AS 3
BILLION MORE PEOPLE JOIN THE INTERNET
ITS GOING TO GET EVEN BETTER!
LET’S BUILD TOOLS TO SCALE DISCOVERY TO A
MILLION PEOPLE
GalaxyZoo (2007): User base 250,000+
Significant contribution due to program: 1.25
million galaxies classified CAPTCHAS : ...
FIT2CURE
PLAY, LEARN AND DISCOVER
FILE NDA: FDA
approval (2-3yrs)
Identify disease
Isolate protein involved in disease (2-5yrs)
Find a drug effective agains...
Fit2CureTM
GAME INTERFACE
Fit2CureTM
Competition! +
Social Impact
Compete with friends!
In the future:
For our top scoring players, we
will be donat...
EMERGENT PATTERNS IN PLAY TRACE
• Expectation-maximization
(EM) based mining of
player data
-user interface design
- novel...
Time(Mins)
HIV-1 Protease
PLAYERS CAN DO REAL SCIENCE!
DESIGN YOUR MEDICINE IN FUTURE
Connecting Fit2Cure to Your
Genetics: Fit2CureMyDisease
• Fit2Cure links personal genome data from the company 23andMe
• F...
ACKNOWLEDGEMENTS
University of Notre Dame
• Dean Gregory Crawford
• Prof. Richard Taylor
Funding
College of Science Innova...
Fit2Cure: The Future of Health in the Palm of your Hands.
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Fit2Cure: The Future of Health in the Palm of your Hands .

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Talk at DePaul University, School of Computing and Digital Media, Chicago, IL

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  • Play, learn and discover!
  • >10,000 diseases, less than 5% have cures, complex genetics of humans (each of us is difererent), drugs don’t work in all people, we have been designing drugs for the average person, no one is average!!
  • My journey: Solving a scientific problem without a lab- HIV drug resistance (incidentally presented this in Chcago). Forming a Bioinformatics group where we self trained. Give example of Jack Andraka. What if we make it so easy for millions of people? Computing technologies are exponentially growing for more than 100 years. A hope that one day kids in school, even in Africa, will be part of a major discovery for their own disease
  • Fit2Cure: The Future of Health in the Palm of your Hands .

    1. 1. Geoffrey H. Siwo, Victoria Lam, Ian Sander & Fit2Cure Players Fit2Cure Team Human + Computer Intelligence Democratizing Medical Discovery DePaul School of Computing and Digital Media, Chicago, IL FIT2CURE: THE FUTURE OF HEALTH IN THE PALM OF YOUR HANDS
    2. 2. ARE WE HEALTHIER THAN 100 YEARS AGO?
    3. 3. 100 YEARS, 100% INCREASE IN HUMAN LIFESPAN
    4. 4. MORE CHILDREN LIVE BEYOND 5TH BIRTHDAY
    5. 5. BUT DESPITE THE PROGRESS …
    6. 6. CURRENT MEDICINE CAN’T COPE UP • > 10,000 diseases • Same disease in a different patient is not exactly the same • 95% of diseases have no cure • >50% of diseases are rare (affects <1 in 1500 people) • Rising cost of healthcare, shortage of doctors
    7. 7. LEARNING FROM THE PAST TO MAKE A BETTER FUTURE
    8. 8. OUR PROGRESS IS DUE TO COLLECTIVE & CUMULATIVE INTELLIGENCE
    9. 9. BRAIN SIZE = INTELLIGENCE
    10. 10. BRAIN SIZE HAS STAGNATED IN >30,000 YEARS
    11. 11. A BABY AT BIRTH TODAY IS NO MORE INTELLIGENT THAN HIS/ HER ANCESTOR 100 YEARS AGO
    12. 12. IMAGINE IF PRACTICALLY ANYONE COULD ACTIVELY ENGAGE IN DRUG DISCOVERY
    13. 13. ..YES IT’S POSSIBLE
    14. 14. 2003: Undergraduate in Africa doing computational modeling of HIV on a pay-to-go computer … IN AFRICA 2003 to 2005: organized Bioinformatics training for fellow students 2010: Students in 2003 group organize First Virtual Bioinformatics Conference in Africa
    15. 15. …IN USA • 15 year old Jack Andraka develops pancreatic cancer test: 100 times more sensitive and 28 times cheaper
    16. 16. IT’S GOING TO HAPPEN EVERYWHERE AS 3 BILLION MORE PEOPLE JOIN THE INTERNET
    17. 17. ITS GOING TO GET EVEN BETTER!
    18. 18. LET’S BUILD TOOLS TO SCALE DISCOVERY TO A MILLION PEOPLE
    19. 19. GalaxyZoo (2007): User base 250,000+ Significant contribution due to program: 1.25 million galaxies classified CAPTCHAS : Number of people using CAPTCHAs in a day: 100 million, Number of words deciphered by humans using CAPTCHAs in a year: 440 million Foldit (2008): User base 250,000+ people, best players are non- scientists, shown that people can fold proteins better than the best computer algorithms; able to find structure of M-PMV (HIV retroviral protease) in 3 weeks—which eluded scientist for over a decade Recently, research groups have been asking interested non- scientists to help with large scale scientific problems Usually takes the form of a game or computer program where citizens are asked to perform tasks better suited to humans than computer CITIZEN SCIENCE
    20. 20. FIT2CURE PLAY, LEARN AND DISCOVER
    21. 21. FILE NDA: FDA approval (2-3yrs) Identify disease Isolate protein involved in disease (2-5yrs) Find a drug effective against disease protein (2-5yrs) Preclinical Testing (1-3yrs) Formulation & Scale-up FILE IND: Human clinical trials (2-10yrs) Fit2Cure DRUG DISCOVERY AND DEVELOPMENT
    22. 22. Fit2CureTM GAME INTERFACE
    23. 23. Fit2CureTM Competition! + Social Impact Compete with friends! In the future: For our top scoring players, we will be donating (real) money to an approved research center or rare & neglected disease institute of your choosing, and in your name.
    24. 24. EMERGENT PATTERNS IN PLAY TRACE • Expectation-maximization (EM) based mining of player data -user interface design - novel scientific insights
    25. 25. Time(Mins) HIV-1 Protease PLAYERS CAN DO REAL SCIENCE!
    26. 26. DESIGN YOUR MEDICINE IN FUTURE
    27. 27. Connecting Fit2Cure to Your Genetics: Fit2CureMyDisease • Fit2Cure links personal genome data from the company 23andMe • Fit2Cure can alert you when you are playing with a protein in which you have mutations or allergic drug reactions Fit2CureTM
    28. 28. ACKNOWLEDGEMENTS University of Notre Dame • Dean Gregory Crawford • Prof. Richard Taylor Funding College of Science Innovation Entrepreneurship Fund (supported by Charles Edison Fund) Dynamoid Apps • Blair Lyons • Laura Gonzalez

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