Drug Development <ul><ul><li>antibiotic resistance </li></ul></ul><ul><ul><li>drug trials </li></ul></ul><ul><ul><li>drugs...
bacterial   resistance <ul><ul><li>bacteria reproduce once every 20 minutes </li></ul></ul><ul><ul><li>mutations in the DN...
4 phases of clinical trials <ul><ul><li>safety and dosage tests </li></ul></ul><ul><ul><li>check drug works in humans </li...
thalidomide <ul><ul><li>given to pregnant women in 1950’s </li></ul></ul><ul><ul><li>for morning sickness </li></ul></ul><...
northwick park hospital <ul><ul><li>medical trials went wrong </li></ul></ul><ul><ul><li>volunteers nearly died </li></ul>...
reasons for taking part in a drug trial money to assist with medical research to help others to recieve drugs that may hel...
drugs from plants <ul><ul><li>aspirin – willow bark </li></ul></ul><ul><ul><li>wormwood - fights malaria </li></ul></ul><u...
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Drug development

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Drug development

  1. 1. Drug Development <ul><ul><li>antibiotic resistance </li></ul></ul><ul><ul><li>drug trials </li></ul></ul><ul><ul><li>drugs from natural substances </li></ul></ul>
  2. 2. bacterial resistance <ul><ul><li>bacteria reproduce once every 20 minutes </li></ul></ul><ul><ul><li>mutations in the DNA happen can happen </li></ul></ul><ul><ul><li>this can enable some bacteria to be resistant to antibiotic drugs </li></ul></ul><ul><ul><li>exposure to antibiotics increases resistance </li></ul></ul><ul><ul><li>MRSA is a bacteria that cannot be killed ( it is a ‘superbug’) </li></ul></ul><ul><ul><li>new drugs always need to be developed </li></ul></ul>
  3. 3. 4 phases of clinical trials <ul><ul><li>safety and dosage tests </li></ul></ul><ul><ul><li>check drug works in humans </li></ul></ul><ul><ul><li>random testing </li></ul></ul><ul><ul><li>public use </li></ul></ul><ul><ul><li>sample size increases at each stage </li></ul></ul>
  4. 4. thalidomide <ul><ul><li>given to pregnant women in 1950’s </li></ul></ul><ul><ul><li>for morning sickness </li></ul></ul><ul><ul><li>babies had birth limb defects </li></ul></ul>
  5. 5. northwick park hospital <ul><ul><li>medical trials went wrong </li></ul></ul><ul><ul><li>volunteers nearly died </li></ul></ul>
  6. 6. reasons for taking part in a drug trial money to assist with medical research to help others to recieve drugs that may help with an otherwise untreatable disease Videoclip on drug trial How is fair testing carried out in the trial? What is a placebo? What is a double blind trial?
  7. 7. drugs from plants <ul><ul><li>aspirin – willow bark </li></ul></ul><ul><ul><li>wormwood - fights malaria </li></ul></ul><ul><ul><li>st johns wort - depression </li></ul></ul>
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