Neoplastic cells that divide in an unrestricted way but remain in source tissue
Don’t have to mecome malignant necessarily, form metasteses (1/1000 cells that has become neoplastic can become metastatic
Can form a tumor, often clonal – arising from a SINGLE cell, which most cancers are often from
If undergone a mutation, benign cells can loose dependence on attachment to one another as well as to the basal lamina and actively secrete proteases that chew away basal lamina and connective tissue/proteoglycans in connective tissue to move into blood stream and through it.
Have the ability to migrate to a secondary source
Can form metastastes/metastasize in secondary site
Cells attach to endothelium and secrete proteases that allow them to move into tissues of secondary source – extravazation, the same sort of mechanisms that immune cells use to move to another point from the capillaries