4.21.2010

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4.21.2010

  1. 1. 4.21.2010<br /><ul><li>Adhesion
  2. 2. Cadherins
  3. 3. Link through homophylic binding
  4. 4. Desmosomes
  5. 5. Transmembrane proteins link to
  6. 6. Link to cell membrane to one another
  7. 7. Intermediate filaments are ke
  8. 8. keratin filaments
  9. 9. plakoglobin
  10. 10. desmoplakin
  11. 11. Tight Junctions
  12. 12. Not very strong connections, actually wake
  13. 13. Form bead-like pathways at the apical side
  14. 14. Helps seal apical side of cells so molecules can’t diffuse in a random way
  15. 15. Creates intercellular space between cells at apical and basal side
  16. 16. Made of transmembrane proteins
  17. 17. Llow for restricted movement and regulated movement of metabolic moecules
  18. 18. Gap Junctions
  19. 19. Help link cells together
  20. 20. Connexon – refers to
  21. 21. Made up of six gap junction proteins (connexins)
  22. 22. Cancer
  23. 23. Tumor
  24. 24. Unrestricted growth
  25. 25. Dedifferentiation/avoid differentiation
  26. 26. Cancer Cells
  27. 27. Reproduce w/o normal restriction on mitosis - clonal
  28. 28. Can invade/colonize regions outside of source
  29. 29. Neoplastic
  30. 30. Uncontrolled growth of cells
  31. 31. Loss of contact inhibition
  32. 32. Loss of ECM attachment (basal lamina)
  33. 33. Loss of growth factor dependence
  34. 34. Major way of controlling mitosis
  35. 35. Regulator of G1 checkpoint where environment will regulate how often a cell divides
  36. 36. Ras pathway RB
  37. 37. Loss senescence
  38. 38. Have a disorganized cytoskeleton
  39. 39. Benign – neoplastic cells clustered in the source tissue
  40. 40. Can be easily removed
  41. 41. Metastatic Cells
  42. 42. Secondary tumors that are formed by malignant cells
  43. 43. Malignant – used to characterize the cell’s ability to populate a tissue source
  44. 44. Normally, we have a single layer in cells, contact inhibition, will stop dividing when bumped into each other
  45. 45. Cell lines
  46. 46. Immortal cell lines
  47. 47. Human cells usually die
  48. 48. Mice cells, crisis stage, emergence of immortal variant
  49. 49. Tubulin makes microtubules
  50. 50. Why do neoplastic cells develop?
  51. 51. Changes in gene expression and chromosomes number
  52. 52. Aneuploidy
  53. 53. Describes any karyotypes that is different form the normal 2n haploid
  54. 54. Abnormally formed chromosomes
  55. 55. Benzo(a)pyrene

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