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4.21.2010

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Transcript

  • 1. 4.21.2010<br />
    • Adhesion
    • 2. Cadherins
    • 3. Link through homophylic binding
    • 4. Desmosomes
    • 5. Transmembrane proteins link to
    • 6. Link to cell membrane to one another
    • 7. Intermediate filaments are ke
    • 8. keratin filaments
    • 9. plakoglobin
    • 10. desmoplakin
    • 11. Tight Junctions
    • 12. Not very strong connections, actually wake
    • 13. Form bead-like pathways at the apical side
    • 14. Helps seal apical side of cells so molecules can’t diffuse in a random way
    • 15. Creates intercellular space between cells at apical and basal side
    • 16. Made of transmembrane proteins
    • 17. Llow for restricted movement and regulated movement of metabolic moecules
    • 18. Gap Junctions
    • 19. Help link cells together
    • 20. Connexon – refers to
    • 21. Made up of six gap junction proteins (connexins)
    • 22. Cancer
    • 23. Tumor
    • 24. Unrestricted growth
    • 25. Dedifferentiation/avoid differentiation
    • 26. Cancer Cells
    • 27. Reproduce w/o normal restriction on mitosis - clonal
    • 28. Can invade/colonize regions outside of source
    • 29. Neoplastic
    • 30. Uncontrolled growth of cells
    • 31. Loss of contact inhibition
    • 32. Loss of ECM attachment (basal lamina)
    • 33. Loss of growth factor dependence
    • 34. Major way of controlling mitosis
    • 35. Regulator of G1 checkpoint where environment will regulate how often a cell divides
    • 36. Ras pathway RB
    • 37. Loss senescence
    • 38. Have a disorganized cytoskeleton
    • 39. Benign – neoplastic cells clustered in the source tissue
    • 40. Can be easily removed
    • 41. Metastatic Cells
    • 42. Secondary tumors that are formed by malignant cells
    • 43. Malignant – used to characterize the cell’s ability to populate a tissue source
    • 44. Normally, we have a single layer in cells, contact inhibition, will stop dividing when bumped into each other
    • 45. Cell lines
    • 46. Immortal cell lines
    • 47. Human cells usually die
    • 48. Mice cells, crisis stage, emergence of immortal variant
    • 49. Tubulin makes microtubules
    • 50. Why do neoplastic cells develop?
    • 51. Changes in gene expression and chromosomes number
    • 52. Aneuploidy
    • 53. Describes any karyotypes that is different form the normal 2n haploid
    • 54. Abnormally formed chromosomes
    • 55. Benzo(a)pyrene

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