When gloubular heads bind to actin filaments, which is a wound structure, the heads interact with the actin monomers and the head bends/moves, which causes the actin filaments to bend in, towards the minus end. This shortens the length of the sarcomere
Formation of leading edge, protrusion of lamellipodia and filopodia
(red spots under cell adhere to filaments on the substratume, myosin I)
cytoplasmic streaming from back to front of cell.
Severing at the back of the cell and contraction of actin filaments. (myosin II)
Focal adhesions are dependent on forward movement
They require the actin filament, and its polymerization, the adhesion to myosin I, and it requires the transmembrane proteins, the integrins, that link actin and myosin to the substrate on which the cell is growing.
Wiskott Aldrich Syndrome - autosomal recessive condition seen in males more, associated with mutation in WASP protein, which works with ARP2/3 allows actin nucleation. Immune system abnormalities because the cells can’t migrate. Increased risks of cancer or infection. Red blood cells are low.