Cytosol of an amoeba is a gel, or plasma gel. The gel is converted to plasmasol, so it’s more fluid and the movement is more fluid
If you have a structure like an amoeba, the cytosol is more gel like than water, so plasma gel. For movement, the gel is converted to plasmasol, so it’s more fluid and the movement is more fluid, which tends to create a force or pressure along membrane as force is mediated
Intermediate Filaments – structure and support for cells
No polar sides! So very good at structural support system for cells.
Cytoplasmic filament (slide 3) have concentrated areas in sites called desmosomes, which provide linkage between cells to hold them. Proteins make desmosomes, but the filaments hold the cells together by interacting with desmosomes. They don’t hold directly to cells, but link to one another to hold cells together in a tissue structure.
Can help regulate what goes in and out of nucleus
(Slide 4) 8-12nm. Begins with assembly of alpha helix monomer, made of four alpha helices with 3 regions that separate the monomer itself. 310-318 amino acids, all of which are hydrophilic. At the end, amino and carboxy terminus, hydrophobic, tend to be regions that associate with other types of proteins.
Coiled-coil dimers come together in a staggered position for amino and carboxy terminus do not overlap, and this allows the tetramers to pack together at the heads, through non-covalent bonding. Eight tetramers are brought together and form a rope-like structure.
Epidermalisis – lysing of the epidermis below cymplex
Mutation in keratin – k14 gene – that is responsible for generating two classes of keratin, I and II, when they can’t function they can’t hold selves together, so blistering wounds can be found on the skin.