Directionality of               higher-order auditory pathways                                          Determining causal...
Overview          •   Theoretical background               •   Study time course          •   Task paradigm               ...
Pathway                     functions                                              pSTG                                   ...
Age influence                              Perani et al., PNAS 2011Dominic Portain, Imaging Meeting 13.08.2012   Max Planck...
rior, middle, and inferior temporal gyrus, respectively; Pr:us; F2: middle frontal gyrus; PrF3op: precentral gyrus/F3op: s...
Task  •     Picture-Selection task  •     216 trials (Pilot, 18min)        304 trials (MEG, 25min)  •     Tutorial: random...
DWI                                                Procedure                                              Localizing indiv...
Time course                                   Goals                   Pilot (behavioral)               Task is quickly sol...
MEG     Acquisition                                                                             1000 Hz resolution        ...
Special thanks:                        •   Alfred Anwander                        •   Michael Skeide                      ...
Upcoming SlideShare
Loading in …5
×

Study proposal: Dohorap

677 views
598 views

Published on

Published in: Health & Medicine, Technology
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
677
On SlideShare
0
From Embeds
0
Number of Embeds
3
Actions
Shares
0
Downloads
0
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide
  • Hi,\nDominic Portain, Burkhard Maess (MEG group)\nplanning to do MEG study\nDirectionality of auditory pathways\ncausality in signals from higher-order syntax\n
  • Anatomical and functional background\nHow I arrived at my particular task paradigm\nWhat I’m going to do with the MEG data\nWhen exactly I need the scanner\nwhat exactly I’m going to measure\nand I’ll be open for discussion afterwards\n
  • According to Friederici, 2011\nlanguage processing: two major pathways\nventral path: simple syntax and semantics\nAlready \ndorsal: phonemics and complex syntax\narea of interest: dorsal path II, connecting pSTG and BA44\n
  • We also know, slow development of D2:\nnot fully analyzed yet\nno trace in newborns, fully developed in adults\nslow growth, round about between 7 and 15 years\n-> interesting to study children at the age of 10\npossibility to compare with adults\n
  • We need:\n- a task suitable for children and adults\n- something that requires the dorsal pathway II\n- decision: subject-object paradigm\n“Where is the monkey, that is pulled by the tiger?”\n- Cooke, Stromswold, and inhouse: Michael Skeide\n- chosen because of fMRI activation\n
  • In the following, I give you a clear example how this paradigm works in our experiment:\n- dual picture\n- spoken sentence: “Where is the \n- response left/right\n- about 5 seconds per trial\n- tutorial for initial learning\n- feedback: correct response, accuracy, speed\n- pilot study: possibility for cheating by case selection\n- did not have to listen until the end of the sentence to fulfill the task\n- cheating-proof sentence\n
  • MEG data is localized by using a FEM head model\nsource space data \n
  • Pilot study is run right now\nplan to test during autumn vacation\n
  • \n
  • \n
  • Study proposal: Dohorap

    1. 1. Directionality of higher-order auditory pathways Determining causality in source space: a FEM-aided MEG study Dominic Portain Burkhard Maess A.D. Friederici Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, GermanyDominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences
    2. 2. Overview • Theoretical background • Study time course • Task paradigm • Acquisition • Data analysis • DiscussionDominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences
    3. 3. Pathway functions pSTG Friederici, 2011Dominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences
    4. 4. Age influence Perani et al., PNAS 2011Dominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences
    5. 5. rior, middle, and inferior temporal gyrus, respectively; Pr:us; F2: middle frontal gyrus; PrF3op: precentral gyrus/F3op: superior temporal sulcus; AG: angular gyrus; Fusa: anteriors; a, p, l, m, d, v: anterior, posterior, lateral, middle, dorsal,ctively. Paradigm yrus and the frontal operculum in the frontal lobe. ion – action cycle that is supported by these fronto-eas connected through the arcuate fasciculus fibers tom) permits the implementation of a motor-sound-er than pure-sound-based, phoneme representation • d Poeppel, 2004). “Subject-object” paradigm In such a model, articulatory the primary and common ist deron which both (“Wo objects Affe, den der Tiger zieht?”)duction and speech perception develop and act, in • fMRI evidence: Cooke 2002, Stromswoldwith Liberman’s motor theory of speech (Liberman , 2000). 1996 Vigneau 2006, NeuroImage •al working-memory loop Activation in pSTG/STS duringSentence (and text) clusters. Top: sagittal projection map of the 161 Fig. 4. syntactic comprehension activation peaks derived from studies on sentence (green) and syntactic • Contrast in BA44 the he issues investigated by neuroimaging concerns the between phonological and semantic processing inbetween subject/object-first conditions (light green) processing; clusters are segregated by the algorithm for spatial classification and their standard error on the y and z axes (yellow). Note that in the frontal lobe the peaks issued from studies investigating syntaxobe. As a matter of fact, lesion studies have not clearlyether the analysis of language sounds and the processing are located more dorsally. In the temporal lobe, the spatial distribution of meaning are segregated or not in the left F3. Recent sentence and syntax peak is not different. Bottom: four of the sentence Dominic Portain, Imaging Meeting 13.08.2012 clusters are in closeMax Planck Institutesemantic ones, and clusters involved relationship with for Human Cognitive and Brain Sciencesns on this topic have produced contradictory results. In
    6. 6. Task • Picture-Selection task • 216 trials (Pilot, 18min) 304 trials (MEG, 25min) • Tutorial: random trials “Wo ist der Hase, den der Vogel schiebt?” until 90% correct “Wo ist der Hase, der den Vogel schiebt?” • •Feedback: Correct response immediate: “Wo ist das Tier, das der Vogel schiebt?” • delayed: Accuracy, Speed “Wo ist das Tier, das den Vogel schiebt?”Dominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences
    7. 7. DWI Procedure Localizing individual dorsal path II image T1 + T2 Segmentation Head FEM source Source image model localization space MRT restricting to BA44 and pSTG MEG Electrode- space localized causality research signals signals analysis answerDominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences
    8. 8. Time course Goals Pilot (behavioral) Task is quickly solvable now 20 children, aged 10 Prevention of mental shortcuts Hypotheses Oct Main (MEG) Information flow along D2 2012 30 children, aged 10 Early top-down modulation early Control (MEG) Dependency on development of D2 2013 30 adultsDominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences
    9. 9. MEG Acquisition 1000 Hz resolution 330 Hz bandwidth horizontal acquisition T1_mpr_sag_ADNI_12ch T2_spc_sag_P2_iso DWI_standard_12ch 12-channel head coil 12-channel head coil 12-channel head coil Flip angle: 9° Flip angle: 120° Flip angle: 90° Repetition time: 2300ms Repetition time: 3200ms Repetition time: 12.9s Echo time: 2.96ms Echo time: 402ms Echo time: 100ms Inversion time: 900ms Matrix: 256x258 Matrix: 128x128 Matrix: 256x240 FOV: 250x250x176 mm FOV: 220x220x151mm FOV: 256x240x176 mm Resolution: 0.5x0.5x1mm Resolution: 1.7x1.7x1.7mm Resolution: 1x1x1mm ~7min ~9.5min ~19min = 36min x 30 subjectsDominic Portain, Imaging Meeting 13.08.2012 Max Planck Institute for Human Cognitive and Brain Sciences
    10. 10. Special thanks: • Alfred Anwander • Michael Skeide • Christine Schipke • Maria Felber • Jens Brauer • Katja Kirsche • Yvonne WolffXXX Max Planck Institute for Human Cognitive and Brain Sciences

    ×