Pemetrexed dr. varun


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Pemetrexed dr. varun

  2. 2. • Pemetrexed disodium heptahydrate – C20H19N5Na2O6•7H2O • L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo- 1Hpyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt, heptahydrate
  3. 3. • ALIMTA – – white to either light yellow or green-yellow lyophilized solid – intravenous infusion – single-dose vials – 100-mg or 500-mg vial – contains pemetrexed disodium equivalent to 100 mg pemetrexed and 106 mg mannitol or 500 mg pemetrexed and 500 mg mannitol, respectively.
  4. 4. INDICATIONS• Nonsquamous Non-Small Cell Lung Cancer - Combination with Cisplatin – initial treatment of locally advanced or metastatic• Nonsquamous Non-Small Cell Lung Cancer – Maintenance • whose disease has not progressed after four cycles of platinum-based first-line chemotherapy.• Nonsquamous Non-Small Cell Lung Cancer – After Prior Chemotherapy – as a single-agent for locally advanced or metastatic• Mesothelioma – in combination with cisplatin for malignant pleural mesothelioma whose disease is unresectable
  5. 5. DOSAGE AND ADMINISTRATION• recommended dose of ALIMTA is 500 mg/m² administered as an intravenous infusion over 10 minutes on Day 1 of each 21-day cycle.
  6. 6. Premedication Regimen• Vitamin Supplementation – low-dose oral folic acid preparation daily. – At least 5 daily doses of folic acid must be taken during the 7- day period preceding the first dose of ALIMTA – should continue during the full course of therapy and for 21 days after the last dose – intramuscular injection of vitamin B12 – week preceding the first dose of ALIMTA and every 3 cycles thereafter. – In clinical trials, the dose of folic acid studied ranged from 350 to 1000 mcg, and the dose of vitamin B12 was 1000 mcg
  7. 7. • Pretreatment with dexamethasone (or equivalent) reduces the incidence and severity of cutaneous reaction.• In clinical trials, dexamethasone 4 mg was given by mouth twice daily the day before, the day of, and the day after ALIMTA administration
  8. 8. Monitoring• CBC – in the clinical study before each dose and on days 8 and 15 of each cycle
  9. 9. Dose Reduction for ALIMTA (single-agent or in combination) and Cisplatin - Hematologic ToxicitiesNadir ANC <500/mm³ and nadir 75% of previous dose platelets >50,000/mm³. (pemetrexed and cisplatin).Nadir platelets <50,000/mm³ 75% of previous dosewithout bleeding regardless of (pemetrexed and cisplatin). nadir ANC. Nadir platelets <50,000/mm³ 50% of previous dose with bleedinga, regardless of (pemetrexed and cisplatin). nadir ANC.
  10. 10. Dose Reduction for ALIMTA (single-agent or in combination) and Cisplatin - Nonhematologic Toxicities DOSE OF DOSE OF ALIMTA CISPLATIN (MG/M²) (MG/M²)Any Grade 3 or 4 toxicities except 75% of previous 75% of previous mucositis dose dose Any diarrhea requiring 75% of previous 75% of previoushospitalization (irrespective of dose doseGrade) or Grade 3 or 4 diarrhea 50% of previous 100% of Grade 3 or 4 mucositis dose previous dose
  11. 11. Dose Reduction for ALIMTA (single-agent or in combination) and Cisplatin – Neurotoxicity DOSE OF ALIMTA DOSE OF CISPLATINCTC GRADE (MG/M²) (MG/M²) 0-1 100% of previous dose 100% of previous dose 2 100% of previous dose 50% of previous dose
  12. 12. Discontinuation Recommendation• should be discontinued if a patient experiences any hematologic or nonhematologic Grade 3 or 4 toxicity – after 2 dose reductions or – immediately if Grade 3 or 4 neurotoxicity is observed
  13. 13. Renally Impaired Patients• In clinical studies, patients with creatinine clearance ≥45 mL/min required no dose adjustments• should not be administered to patients whose creatinine clearance is <45 mL/min
  14. 14. • Caution should be exercised when administering ALIMTA concurrently with NSAIDs to patients whose creatinine clearance is <80 mL/min
  15. 15. Preparation and Administration Precautions• use of gloves is recommended. – If a solution of ALIMTA contacts the skin, wash the skin immediately and thoroughly with soap and water – not a vesicant. There is no specific antidote for extravasation of ALIMTA. To date, there have been few reported cases of ALIMTA extravasation.• Reconstitute each 100-mg vial with 4.2 ml and each 500-mg vial with 20 mL of 0.9% Sodium Chloride Injection 25 mg/mL• ALIMTA is physically incompatible with diluents containing calcium, including Lactated Ringers Injection
  16. 16. • Coadministration of ALIMTA with other drugs and diluents has not been studied, and therefore is not recommended• ALIMTA is compatible with standard polyvinyl chloride (PVC) administration sets and intravenous solution bags.
  17. 17. • further diluted into a solution of 0.9% Sodium Chloride Injection (preservative free), so that the total volume of solution is 100 ml. ALIMTA is administered as an intravenous infusion over 10 minutes.• Chemical and physical stability of reconstituted and infusion solutions of ALIMTA were demonstrated for up to 24 hours following initial reconstitution, when stored at refrigerated or ambient room temperature
  18. 18. SIDE EFFECTS
  19. 19. DRUG INTERACTIONS• ALIMTA is primarily eliminated unchanged by renal excretion• Non-Steroidal Anti-Inflammatory Drugs – can decrease the clearance of pemetrexed • Caution should be used when administering NSAIDs concurrently with ALIMTA to patients with mild to moderate renal insufficiency (creatinine clearance from 45 to 79 mL/min) – NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of 2 days before, the day of, and 2 days following administration of ALIMTA.
  20. 20. • Nephrotoxic Drugs – Concomitant administration of nephrotoxic drugs could result in delayed clearance of ALIMTA
  21. 21. • There was no effect of elevated AST, ALT, or total bilirubin on the pharmacokinetics of pemetrexed
  22. 22. Pregnancy Category D• Pemetrexed administered intraperitoneally to mice during organogenesis was embryotoxic, fetotoxic and teratogenic in mice• Women of childbearing potential should be advised to avoid becoming pregnant. Women should be advised to use effective contraceptive measures to prevent pregnancy during treatment with ALIMTA
  23. 23. • It is not known whether ALIMTA or its metabolites are excreted in human milk.• Efficacy of ALIMTA in pediatric patients has not been demonstrated. – pediatric patients with recurrent solid tumors in a Phase 1 study(32 patients) and a Phase 2 study (72 patients) – No responses were observed in this Phase 2 trial.• No dose reductions other than those recommended for all patients are necessary for patients 65 years of age or older
  24. 24. • No carcinogenicity studies have been conducted with pemetrexed.• Pemetrexed was clastogenic in the in vivo micronucleus assay in mouse bone marrow but was not mutagenic in multiple in vitro tests
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