The Models of Alzheimer’s Disease (Part I) Speaker : Jimmy Lu Advisor : Hsing Mei Web Computing Laboratory (WECO Lab) Computer Science and Information Engineering Department Fu Jen Catholic University
Three models Network damage model General mechanism that destructs brain network Pattern of lesions in Alzheimer’s disease Accurate definition of the stage in AD Cholinergic hypothesis Parameters which affect the progress of the AD Combine these three to an algorithm.
Reference H. Braak and E. Braak, Pattern of cortical lesions in Alzheimer's disease. In: K. Iqbal, B. Winblad, T. Nishimura, M. Takeda and H. M. Wisniewski, Editors, Alzheimer's Disease: Biology, Diagnosis, and Therapeutics, Wiley, New York (1997), pp. 227–237. H. Braak and E. Braak, Neuropathologicalstageing of Alzheimer-related changes. ActaNeuropathol. 82 (1991), pp. 239–259.