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Psp Richardson
 

Psp Richardson

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for Neuro CPC 091808

for Neuro CPC 091808

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    Psp Richardson Psp Richardson Presentation Transcript

    • The tau of PSP Neurofibrillary tangles Tufted astrocytes (Oligodendroglial) Coiled bodies
    • Basal ganglia
    • Subthalamic nucleus
    • Globus pallidus
    • Atrophy of superior colliculus
    • Superior colliculus
    • Substantia nigra
    • Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.
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    • Grade 3
    • Grade 3
    • Dentate nucleus: Grumose degeneration
    • PSP-tau scores Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.
    • Distribution of tau pathology in PSP-tau score >7 Pink = Grade 1 Purple = Grade 2 Red = Grade 3 Brown = Grade 4 Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.
    • Mid-Frontal Hippocampus