Psp Richardson

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  • 1. The tau of PSP Neurofibrillary tangles Tufted astrocytes (Oligodendroglial) Coiled bodies
  • 2. Basal ganglia
  • 3. Subthalamic nucleus
  • 4. Globus pallidus
  • 5. Atrophy of superior colliculus
  • 6. Superior colliculus
  • 7. Substantia nigra
  • 8. Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.
  • 9.  
  • 10. Grade 3
  • 11. Grade 3
  • 12. Dentate nucleus: Grumose degeneration
  • 13. PSP-tau scores Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.
  • 14. Distribution of tau pathology in PSP-tau score >7 Pink = Grade 1 Purple = Grade 2 Red = Grade 3 Brown = Grade 4 Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.
  • 15. Mid-Frontal Hippocampus