Search strategy

Dean Giustini, UBC health librarian & instructor | dean.giustini@ubc.ca | LIBR2195 Week 11 July 2011 Search Assignment #1 – Example of an A+ = 95%Here is an example of an answer that I thought was complete and tried to go as far withthis question as I hope you all can do in my summer 2011 class. If you do two questionsin this kind of detail, you can rest assured you will get 10/10. Please don’t cut and pasteyour search for me; I’d prefer you tell me about it than try to decipher a screenshot.Let me know if you need my help. ~DeanReference question:1. A physician wants to find clinical trials written from 2003-2006 that demonstratepaxil’s efficacy for post-partum depression (PPD). Problem is the physician need articlesthat discuss the risks in prescribing paxil for breast-feeding women.2. What is the clinical question?“In patients taking paxil for post-partum depression, are there clinical trials from 2003 to2006 that cover what risk the mother’s breast milk poses to the baby?”3. Important keywords for this search? Paxil is trade name; (paroxetine); SSRI is class;post-partum depression (PPD) see also: ante-natal and post-natal depression; adverseeffects; risks; risk assessment; risk factors; clinical trials; infant; mother.4. Research paxil and post-partum depression. • See concepts and words in a dictionary to understand basics • See print and e-CPS; MeSH database, MedlinePlus (Drugs): Dorland’s Dictionary entry; Wikipedia has entry on Paxil and Merck; • see eMedicine. Paxil is a brand name of GlaxoSmithLine. Paroxetine hydrochloride [drug name]. Drug class: selective serotonin reuptake inhibitor (SSRIs) treats depression and anxiety disorders. Admin’d orally.5. Index terms: MeSH & keywords: • Various combinations of “Paroxetine”[MeSH] AND “Depression, Postpartum” [MeSH] AND “risk assessment” [MeSH] “breast feeding”[MeSH] OR “milk, human”[MeSH] OR “lactation”[MeSH].

Dean Giustini, UBC health librarian & instructor | dean.giustini@ubc.ca | LIBR2195 Week 11 July 2011 • Keywords can be used to increase retrieval if results look unhelpful or irrelevant. Limits: 2003-2006, Humans, English, Clinical Trial. Clinical queries.6. Databases consulted to start: • PubMed.gov • Google Scholar • Scirus. I like Scirus as a free alternative to EMBASE – see the range of resultsDocumented search:PUBMED SEARCHThis search requires a thorough review of research in PubMed. In order, I mapped theterms from above:1. paxil maps to Paroxetine[MeSH] 2377 results vs. 1325 results as [MAJR]2. post-partum depression maps to Depression, Postpartum[MeSH]3. AND’ing the MeSH sets = 10 results, added to clipboard4. Given the few results, I did a keyword search for “postpartum” AND “depression” and(“Paxil” OR “paroxetine”) = 21 references5. When I OR’d the 10 results and the 21 results = 21 references, same citations6. When limited to “ENGLISH”, I got 19. And LIMIT to clinical trial:J Clin Psychiatry. 2004 Sep;65(9):1236-41. The use of paroxetine and cognitive-behavioral therapy in postpartum depression and anxiety: a randomized controlledtrial.Misri S, Reebye P, Corral M, Milis L.7.These references may be useful, but I still wanted to pursue other articles becausethese dealt with PPD and paxil, and not risks to the baby when mother is breastfeeding.Therefore, I used keyword variations to get these articles:a) Berle JO, Steen VM, Aamo TO, Breilid H, Zahlsen K, Spigset O. Breastfeeding duringmaternal antidepressant treatment with serotonin reuptake inhibitors: infant exposure,

Dean Giustini, UBC health librarian & instructor | dean.giustini@ubc.ca | LIBR2195 Week 11 July 2011clinical symptoms, and cytochrome p450 genotypes.J Clin Psychiatry. 2004Sep;65(9):1228-34. PMID: 15367050 [PubMed - indexed for MEDLINE]b) Merlob P, Stahl B, Sulkes J. Paroxetine during breast-feeding: infant weight gain andmaternal adherence to counsel.Eur J Pediatr. 2004 Mar;163(3):135-9. Epub 2004 Jan 24.PMID: 14745552 [PubMed - indexed for MEDLINE]c) Hendrick V, Fukuchi A, Altshuler L, Widawski M, Wertheimer A, Brunhuber MV. Use ofsertraline, paroxetine and fluvoxamine by nursing women. Br J Psychiatry. 2001Aug;179:163-6. PMID: 11483479 [PubMed - indexed for MEDLINE] GOOGLE SCHOLARUsing terms from above, I searched:http://scholar.google.com/scholar?q=postpartum+depression+++paxil+OR+paroxetine+%22breast+feeding%22&;hl=en&lr=&c2coff=1&as_subj=med&scoring=r&as_ylo=2001CINAHL is not as useful as Google scholar here as its focus is nursing whereas GS crawlspeer-reviewed medical research, websites and open access journals. I should checkPsycINFO and LactMed, time permitting.

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Search strategy

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