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Linfomi

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  • 1. WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues (2009)
  • 2.
    • Precursor Lymphoid Neoplasms
    • Mature B -Cell Neoplasms
    • Mature T -Cell & NK -Cell Neoplasms
    • Hodgkin lymphoma
    • Post-Transplant Lymphoproliferative Disorders (PTLD)
    CLASSIFICAZIONE DELLE NEOPLASIE LINFOPROLIFERATIVE ---------------------------------------------------------------------------------------- NHL HL
  • 3.  
  • 4.  
  • 5. Figure 14-4 Origin of lymphoid neoplasms. Stages of B- and T-cell differentiation from which specific lymphoid tumors emerge are shown. Key: CLP, common lymphoid precursor; BLB, pre-B lymphoblast; NBC, naive B cell; MC, mantle B cell; GC, germinal center B cell; MZ, marginal zone B cell; DN, CD4/CD8 double negative pre-T cell; DP, CD4/CD8 double positive pre-T cell; PTC, peripheral T cell. Downloaded from: Robbins & Cotran Pathologic Basis of Disease (on 14 July 2009 05:32 PM) © 2007 Elsevier
  • 6.
    • Precursor Lymphoid Neoplasms
    • B lymphoblastic leukemia / lymphoma NOS
    • B lymphoblastic leukemia / lymphoma with recurrent genetic abnormalities
    • B lymphoblastic leukemia / lymphoma with t(9;22); bcr-abl1
    • B lymphoblastic leukemia / lymphoma with t(v;11q23); MLL rearranged
    • B lymphoblastic leukemia / lymphoma with t(12:21); TEL-AML1 & ETV6-RUNX1
    • B lymphoblastic leukemia / lymphoma with hyperploidy
    • B lymphoblastic leukemia / lymphoma with hypodiploidy
    • B lymphoblastic leukemia / lymphoma with t(5;14); IL3-IGH
    • B lymphoblastic leukemia / lymphoma with t(1;19); E2A-PBX1 & TCF3-PBX1
    • T lymphoblastic leukemia / lymphoma
  • 7. Mature B-Cell Neoplasms
    • Chronic lymphocytic leukemia / small lymphocytic lymphoma
    • B-cell prolymphocytic leukemia
    • Splenic marginal zone lymphoma
    • Hairy cell leukemia
    • Lymphoplasmacytic lymphoma / Waldenstrom macroglobulinemia
    • Heavy chain disease
    • Plasma cell myeloma
    • Solitary plasmacytoma of bone
    • Extraosseous plasmacytoma
    • Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type
    • Nodal marginal zone lymphoma
    • Follicular lymphoma
    • Primary cutaneous follicular lymphoma
    • Mantle cell lymphoma
    • Diffuse large B-cell lymphoma, NOS
    • (T-cell / histiocyte-rich type; primary CNS type ; primary leg skin type & EBV+ elderly type)
    • Diffuse large B-cell lymphoma with chronic inflammation
    • Lymphomatoid granulomatosis
    • Primary mediastinal large B-cell lymphoma
    • Intravascular large B-cell lymphoma
    • ALK+ large B-cell lymphoma
    • Plasmablastic lymphoma
    • Large B-cell lymphoma associated with HHV8+ Castleman disease
    • Primary effusion lymphoma
    • Burkitt lymphoma
    • B cell lymphoma, unclassifiable, Burkitt-like
    • B cell lymphoma, unclassifiable, Hodgkin lymphoma-like
  • 8. Mature T-Cell & NK-Cell Neoplasms
    • T-cell prolymphocytic leukemia
    • T-cell large granular lymphocytic leukemia
    • Chronic lymphoproliferative disorder of NK-cells.
    • Aggressive NK-cell leukemia
    • Systemic EBV+ T-cell lymphoproliferative disorder of childhood
    • Hydroa vacciniforme-like lymphoma
    • Adult T-cell lymphoma/leukemia
    • Extranodal T-cell/NK-cell lymphoma, nasal type
    • Enteropathy-associated T-cell lymphoma
    • Hepato-splenic T-cell lymphoma
    • Subcutaneous panniculitis-like T-cell lymphoma
    • Mycosis fungoides
    • S eza ry syndrome
    • Primary cutaneous CD30+ T-cell lymphoproliferative disorder
    • Primary cutaneous gamma-delta T-cell lymphoma
    • Peripheral T-cell lymphoma, NOS
    • Angioimmunoblastic T-cell lymphoma
    • Anaplastic large cell lymphoma, ALK+ type
    • Anaplastic large cell lymphoma, ALK- type
  • 9. Hodgkin lymphoma
    • Nodular lymphocyte-predominant Hodgkin lymphomas
    • Classic Hodgkin lymphomas
    • Nodular sclerosis Hodgkin lymphoma
    • Lymphocyte-rich classic Hodgkin lymphoma
    • Mixed cellularity Hodgkin lymphoma
    • Lymphocyte depletion Hodgkin lymphoma
  • 10. Post-Transplant Lymphoproliferative Disorders (PTLD)
    • Plasmacytic hyperplasia
    • Infectious mononucleosis like PTLD
    • Polymorphic PTLD
    • Monomorphic PTLD (B & T/NK cell types)
    • Classic HD type PTLD