Biochemistry of Cells Copyright Cmassengale
Uses of Organic Molecules Americans consume an average of 140 pounds of sugar per person per year Cellulose, found in plan...
Uses of Organic Molecules A typical cell in your body has about 2 meters of DNA A typical cow produces over 200 pounds of ...
Water About 60-90 percent of an organism is water Water is used in most reactions in the body Water is called the universa...
Water Properties Polarity Cohesiveness Adhesiveness Surface Tension Copyright Cmassengale
Carbon-based Molecules Although a cell is mostly water, the rest of the cell consists mostly of carbon-based molecules Org...
Carbon is a Versatile Atom It has four electrons in an outer shell that holds eight Carbon can share its electrons with ot...
Hydrocarbons The simplest carbon compounds … Contain only carbon  & hydrogen atoms Copyright Cmassengale
Carbon can use its bonds to:: Attach to other carbons Form an endless diversity of carbon skeletons Copyright Cmassengale
Large Hydrocarbons: Are the main molecules in the gasoline we burn in our cars The hydrocarbons of fat molecules provide e...
Shape of Organic Molecules Each type of organic molecule has a unique three-dimensional shape The shape determines its fun...
Functional Groups are: Groups of atoms that give properties to the compounds to which they attach Gained Electrons Lost El...
Common Functional Groups Copyright Cmassengale
Giant Molecules - Polymers Large molecules are called polymers Polymers are built from smaller molecules called monomers B...
Examples of Polymers Proteins Lipids Carbohydrates Nucleic Acids Copyright Cmassengale
Most Macromolecules are Polymers Polymers are made by stringing together many smaller molecules called monomers Nucleic Ac...
Linking Monomers Cells link monomers by a process   called condensation or dehydration synthesis (removing a molecule of w...
Breaking Down Polymers Cells break down macromolecules by a process called hydrolysis (adding a molecule of water) Water a...
Macromolecules in Organisms There are four categories of large molecules in cells: Carbohydrates Lipids Proteins Nucleic A...
Carbohydrates Carbohydrates include: Small sugar molecules in soft drinks Long starch molecules in pasta and potatoes Copy...
Monosaccharides: Called simple sugars Include glucose, fructose, & galactose Have the same chemical, but different structu...
Monosaccharides Glucose is found in sports drinks Fructose is found in fruits Honey contains both glucose & fructose Galac...
Isomers Glucose & fructose are  isomers  because they’re structures are different, but their chemical formulas are the sam...
Rings In aqueous (watery) solutions, monosaccharides form ring structures Copyright Cmassengale
Cellular Fuel Monosaccharides are the main  fuel  that cells use for cellular work ATP Copyright Cmassengale
Disaccharides A disaccharide is a double sugar They’re made by joining two monosaccharides Involves removing a water molec...
Disaccharides <ul><li>Common disaccharides include : </li></ul><ul><li>Sucrose (table sugar ) </li></ul><ul><li>Lactose (M...
Disaccharides Sucrose is composed of glucose + fructose Maltose is composed of 2 glucose molecules Lactose is made of gala...
Polysaccharides Complex carbohydrates Composed of many sugar monomers linked together Polymers of monosaccharide chains Co...
Examples of Polysaccharides Starch Glycogen Cellulose Glucose Monomer Copyright Cmassengale
Starch Starch is an example of a polysaccharide in plants Plant cells store starch for energy Potatoes and grains are majo...
Glycogen Glycogen is an example of a polysaccharide in animals Animals store excess sugar in the form of glycogen Glycogen...
Cellulose Cellulose is the most abundant organic compound on Earth It forms cable-like fibrils in the tough walls that enc...
Cellulose SUGARS Copyright Cmassengale
Dietary Cellulose Most animals cannot derive nutrition from fiber They have bacteria in their digestive tracts that can br...
Sugars in Water Simple sugars and double sugars dissolve readily in water They are hydrophilic, or “water-loving” WATER MO...
Lipids Lipids are hydrophobic –”water fearing” Includes fats, waxes, steroids, & oils Do NOT mix with water FAT MOLECULE C...
Function of Lipids Fats  store energy , help to  insulate the bod y, and  cushion and protect organs  Copyright Cmassengale
Types of Fatty Acids Unsaturated fatty acids  have less than the maximum number of hydrogens bonded to the carbons (a doub...
Types of Fatty Acids Single Bonds in Carbon chain Double bond in carbon chain Copyright Cmassengale
Triglyceride Monomer of lipids Composed of Glycerol & 3 fatty acid chains Glycerol forms the “backbone” of the fat Organic...
Triglyceride Glycerol Fatty Acid Chains Copyright Cmassengale
Fats in Organisms Most animal fats have a high proportion of saturated fatty acids & exist as  solids  at room temperature...
Fats in Organisms Most plant oils tend to be low in saturated fatty acids & exist as  liquids  at room temperature (oils )...
Fats Dietary fat consists largely of the molecule triglyceride composed of glycerol and three fatty acid chains Glycerol F...
Lipids & Cell Membranes <ul><li>Cell membranes are made of lipids called  phospholipids </li></ul><ul><li>Phospholipids ha...
Steroids The carbon skeleton of steroids is bent to form 4 fused rings Cholesterol is the “base steroid” from which your b...
Synthetic Anabolic Steroids They are variants of testosterone Some athletes use them to build up their muscles quickly The...
Proteins Proteins are polymers made of monomers called amino acids All proteins are made of 20 different amino acids linke...
Four Types of Proteins Structural Contractile Storage Transport Copyright Cmassengale
20 Amino Acid Monomers Copyright Cmassengale
Structure of Amino Acids Amino acids have a central carbon with 4 things boded to it: Amino group –NH 2 Carboxyl group -CO...
Linking Amino Acids Cells link amino acids together to make proteins The process is called  condensation  or dehydration P...
Proteins as Enzymes Many proteins act as biological catalysts or enzymes Thousands of different enzymes exist in the body ...
Enzymes Their folded conformation creates an area known as the active site.  Enzymes are globular proteins. The nature and...
Enzyme + Substrate = Product Copyright Cmassengale
How the Enzyme Works Enzymes are reusable!!! Active site changes SHAPE Called INDUCED FIT Copyright Cmassengale
Primary Protein Structure The  primary  structure is the specific sequence of amino acids in a protein Called  polypeptide...
Protein Structures Secondary protein structures occur when protein chains  coil or fold When protein chains called polypep...
Protein Structures or CONFORMATIONS Hydrogen bond Pleated sheet Amino acid (a) Primary structure Hydrogen bond Alpha helix...
Denaturating Proteins Changes in temperature & pH can denature (unfold) a protein so it no longer works Cooking denatures ...
Changing Amino Acid Sequence Substitution of one amino acid for another in hemoglobin causes sickle-cell disease (a) Norma...
Other Important Proteins <ul><li>Blood sugar level is controlled by a protein called  insulin </li></ul><ul><li>Insulin ca...
INSULIN Cell membrane with proteins & phospholipids Copyright Cmassengale
Nucleic Acids Store hereditary information Contain information for making all the body’s proteins Two types exist --- DNA ...
Copyright Cmassengale
Nucleic Acids Nitrogenous base (A,G,C, or T) Phosphate group Thymine (T) Sugar (deoxyribose) Phosphate Base Suga r Nucleic...
Nucleotide – Nucleic acid monomer Copyright Cmassengale
Bases Each DNA nucleotide has one of the following bases: Thymine (T) Cytosine (C) Adenine (A) Guanine (G) <ul><ul><li>Ade...
Nucleotide  Monomers Form long chains called DNA Backbone Nucleotide Bases DNA strand Nucleotides are joined by sugars & p...
DNA Two strands of DNA join together to form a double helix Base pair Double helix Copyright Cmassengale
RNA – Ribonucleic Acid Ribose sugar has an extra –OH or hydroxyl group It has the base uracil (U) instead of thymine (T) N...
ATP – Cellular Energy <ul><li>ATP  is used by cells for  energy </li></ul><ul><li>Adenosine triphosphate </li></ul><ul><li...
Summary of Key Concepts Copyright Cmassengale
Nucleic Acids Copyright Cmassengale
Macromolecules Copyright Cmassengale
Macromolecules Copyright Cmassengale
End Copyright Cmassengale
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Biochemistry Of Cellsppt

  1. 1. Biochemistry of Cells Copyright Cmassengale
  2. 2. Uses of Organic Molecules Americans consume an average of 140 pounds of sugar per person per year Cellulose, found in plant cell walls, is the most abundant organic compound on Earth Copyright Cmassengale
  3. 3. Uses of Organic Molecules A typical cell in your body has about 2 meters of DNA A typical cow produces over 200 pounds of methane gas each year Copyright Cmassengale
  4. 4. Water About 60-90 percent of an organism is water Water is used in most reactions in the body Water is called the universal solvent Copyright Cmassengale
  5. 5. Water Properties Polarity Cohesiveness Adhesiveness Surface Tension Copyright Cmassengale
  6. 6. Carbon-based Molecules Although a cell is mostly water, the rest of the cell consists mostly of carbon-based molecules Organic chemistry is the study of carbon compounds Copyright Cmassengale
  7. 7. Carbon is a Versatile Atom It has four electrons in an outer shell that holds eight Carbon can share its electrons with other atoms to form up to four covalent bonds Copyright Cmassengale
  8. 8. Hydrocarbons The simplest carbon compounds … Contain only carbon & hydrogen atoms Copyright Cmassengale
  9. 9. Carbon can use its bonds to:: Attach to other carbons Form an endless diversity of carbon skeletons Copyright Cmassengale
  10. 10. Large Hydrocarbons: Are the main molecules in the gasoline we burn in our cars The hydrocarbons of fat molecules provide energy for our bodies Copyright Cmassengale
  11. 11. Shape of Organic Molecules Each type of organic molecule has a unique three-dimensional shape The shape determines its function in an organism Copyright Cmassengale
  12. 12. Functional Groups are: Groups of atoms that give properties to the compounds to which they attach Gained Electrons Lost Electrons Copyright Cmassengale
  13. 13. Common Functional Groups Copyright Cmassengale
  14. 14. Giant Molecules - Polymers Large molecules are called polymers Polymers are built from smaller molecules called monomers Biologists call them macromolecules Copyright Cmassengale
  15. 15. Examples of Polymers Proteins Lipids Carbohydrates Nucleic Acids Copyright Cmassengale
  16. 16. Most Macromolecules are Polymers Polymers are made by stringing together many smaller molecules called monomers Nucleic Acid Monomer Copyright Cmassengale
  17. 17. Linking Monomers Cells link monomers by a process called condensation or dehydration synthesis (removing a molecule of water) This process joins two sugar monomers to make a double sugar Remove H Remove OH H 2 O Forms Copyright Cmassengale
  18. 18. Breaking Down Polymers Cells break down macromolecules by a process called hydrolysis (adding a molecule of water) Water added to split a double sugar Copyright Cmassengale
  19. 19. Macromolecules in Organisms There are four categories of large molecules in cells: Carbohydrates Lipids Proteins Nucleic Acids Copyright Cmassengale
  20. 20. Carbohydrates Carbohydrates include: Small sugar molecules in soft drinks Long starch molecules in pasta and potatoes Copyright Cmassengale
  21. 21. Monosaccharides: Called simple sugars Include glucose, fructose, & galactose Have the same chemical, but different structural formulas C 6 H 12 O 6 Copyright Cmassengale
  22. 22. Monosaccharides Glucose is found in sports drinks Fructose is found in fruits Honey contains both glucose & fructose Galactose is called “milk sugar” -OSE ending means SUGAR Copyright Cmassengale
  23. 23. Isomers Glucose & fructose are isomers because they’re structures are different, but their chemical formulas are the same Copyright Cmassengale
  24. 24. Rings In aqueous (watery) solutions, monosaccharides form ring structures Copyright Cmassengale
  25. 25. Cellular Fuel Monosaccharides are the main fuel that cells use for cellular work ATP Copyright Cmassengale
  26. 26. Disaccharides A disaccharide is a double sugar They’re made by joining two monosaccharides Involves removing a water molecule (condensation) Bond called a GLYCOSIDIC bond Copyright Cmassengale
  27. 27. Disaccharides <ul><li>Common disaccharides include : </li></ul><ul><li>Sucrose (table sugar ) </li></ul><ul><li>Lactose (Milk Sugar) </li></ul><ul><li>Maltose (Grain sugar ) </li></ul>Copyright Cmassengale
  28. 28. Disaccharides Sucrose is composed of glucose + fructose Maltose is composed of 2 glucose molecules Lactose is made of galactose + glucose GLUCOSE Copyright Cmassengale
  29. 29. Polysaccharides Complex carbohydrates Composed of many sugar monomers linked together Polymers of monosaccharide chains Copyright Cmassengale
  30. 30. Examples of Polysaccharides Starch Glycogen Cellulose Glucose Monomer Copyright Cmassengale
  31. 31. Starch Starch is an example of a polysaccharide in plants Plant cells store starch for energy Potatoes and grains are major sources of starch in the human diet Copyright Cmassengale
  32. 32. Glycogen Glycogen is an example of a polysaccharide in animals Animals store excess sugar in the form of glycogen Glycogen is similar in structure to starch because BOTH are made of glucose monomers Copyright Cmassengale
  33. 33. Cellulose Cellulose is the most abundant organic compound on Earth It forms cable-like fibrils in the tough walls that enclose plants It is a major component of wood It is also known as dietary fiber Copyright Cmassengale
  34. 34. Cellulose SUGARS Copyright Cmassengale
  35. 35. Dietary Cellulose Most animals cannot derive nutrition from fiber They have bacteria in their digestive tracts that can break down cellulose Copyright Cmassengale
  36. 36. Sugars in Water Simple sugars and double sugars dissolve readily in water They are hydrophilic, or “water-loving” WATER MOLECULE SUGAR MOLECULE -OH groups make them water soluble Copyright Cmassengale
  37. 37. Lipids Lipids are hydrophobic –”water fearing” Includes fats, waxes, steroids, & oils Do NOT mix with water FAT MOLECULE Copyright Cmassengale
  38. 38. Function of Lipids Fats store energy , help to insulate the bod y, and cushion and protect organs Copyright Cmassengale
  39. 39. Types of Fatty Acids Unsaturated fatty acids have less than the maximum number of hydrogens bonded to the carbons (a double bond between carbons ) Saturated fatty acids have the maximum number of hydrogens bonded to the carbons (all single bonds between carbons ) Copyright Cmassengale
  40. 40. Types of Fatty Acids Single Bonds in Carbon chain Double bond in carbon chain Copyright Cmassengale
  41. 41. Triglyceride Monomer of lipids Composed of Glycerol & 3 fatty acid chains Glycerol forms the “backbone” of the fat Organic Alcohol (-OL ending) Copyright Cmassengale
  42. 42. Triglyceride Glycerol Fatty Acid Chains Copyright Cmassengale
  43. 43. Fats in Organisms Most animal fats have a high proportion of saturated fatty acids & exist as solids at room temperature (butter, margarine, shortening) Copyright Cmassengale
  44. 44. Fats in Organisms Most plant oils tend to be low in saturated fatty acids & exist as liquids at room temperature (oils ) Copyright Cmassengale
  45. 45. Fats Dietary fat consists largely of the molecule triglyceride composed of glycerol and three fatty acid chains Glycerol Fatty Acid Chain Condensation links the fatty acids to Glycerol Copyright Cmassengale
  46. 46. Lipids & Cell Membranes <ul><li>Cell membranes are made of lipids called phospholipids </li></ul><ul><li>Phospholipids have a head that is polar & attract water (hydrophilic) </li></ul><ul><li>Phospholipids also have 2 tails that are nonpolar and do not attract water (hydrophobic) </li></ul>Copyright Cmassengale
  47. 47. Steroids The carbon skeleton of steroids is bent to form 4 fused rings Cholesterol is the “base steroid” from which your body produces other steroids Estrogen & testosterone are also steroids Cholesterol Testosterone Estrogen Copyright Cmassengale
  48. 48. Synthetic Anabolic Steroids They are variants of testosterone Some athletes use them to build up their muscles quickly They can pose serious health risks Copyright Cmassengale
  49. 49. Proteins Proteins are polymers made of monomers called amino acids All proteins are made of 20 different amino acids linked in different orders Proteins are used to build cells, act as hormones & enzymes, and do much of the work in a cell Copyright Cmassengale
  50. 50. Four Types of Proteins Structural Contractile Storage Transport Copyright Cmassengale
  51. 51. 20 Amino Acid Monomers Copyright Cmassengale
  52. 52. Structure of Amino Acids Amino acids have a central carbon with 4 things boded to it: Amino group –NH 2 Carboxyl group -COOH Hydrogen -H Side group -R Amino group Carboxyl group R group Side groups Leucine -hydrophobic Serine-hydrophillic Copyright Cmassengale
  53. 53. Linking Amino Acids Cells link amino acids together to make proteins The process is called condensation or dehydration Peptide bonds form to hold the amino acids together Carboxyl Amino Side Group Dehydration Synthesis Peptide Bond Copyright Cmassengale
  54. 54. Proteins as Enzymes Many proteins act as biological catalysts or enzymes Thousands of different enzymes exist in the body Enzymes control the rate of chemical reactions by weakening bonds, thus lowering the amount of activation energy needed for the reaction Copyright Cmassengale
  55. 55. Enzymes Their folded conformation creates an area known as the active site. Enzymes are globular proteins. The nature and arrangement of amino acids in the active site make it specific for only one type of substrate. Copyright Cmassengale
  56. 56. Enzyme + Substrate = Product Copyright Cmassengale
  57. 57. How the Enzyme Works Enzymes are reusable!!! Active site changes SHAPE Called INDUCED FIT Copyright Cmassengale
  58. 58. Primary Protein Structure The primary structure is the specific sequence of amino acids in a protein Called polypeptide Amino Acid Copyright Cmassengale
  59. 59. Protein Structures Secondary protein structures occur when protein chains coil or fold When protein chains called polypeptides join together, the tertiary structure forms because R groups interact with each other In the watery environment of a cell, proteins become globular in their quaternary structure Copyright Cmassengale
  60. 60. Protein Structures or CONFORMATIONS Hydrogen bond Pleated sheet Amino acid (a) Primary structure Hydrogen bond Alpha helix (b) Secondary structure Polypeptide (single subunit) (c) Tertiary structure (d) Quaternary structure Copyright Cmassengale
  61. 61. Denaturating Proteins Changes in temperature & pH can denature (unfold) a protein so it no longer works Cooking denatures protein in eggs Milk protein separates into curds & whey when it denatures Copyright Cmassengale
  62. 62. Changing Amino Acid Sequence Substitution of one amino acid for another in hemoglobin causes sickle-cell disease (a) Normal red blood cell Normal hemoglobin 1 2 3 4 5 6 7. . . 146 (b) Sickled red blood cell Sickle-cell hemoglobin 2 3 1 4 5 6 7. . . 146 Copyright Cmassengale
  63. 63. Other Important Proteins <ul><li>Blood sugar level is controlled by a protein called insulin </li></ul><ul><li>Insulin causes the liver to uptake and store excess sugar as Glycogen </li></ul><ul><li>The cell membrane also contains proteins </li></ul><ul><li>Receptor proteins help cells recognize other cells </li></ul>Copyright Cmassengale
  64. 64. INSULIN Cell membrane with proteins & phospholipids Copyright Cmassengale
  65. 65. Nucleic Acids Store hereditary information Contain information for making all the body’s proteins Two types exist --- DNA & RNA Copyright Cmassengale
  66. 66. Copyright Cmassengale
  67. 67. Nucleic Acids Nitrogenous base (A,G,C, or T) Phosphate group Thymine (T) Sugar (deoxyribose) Phosphate Base Suga r Nucleic acids are polymers of nucleotides Nucleotide Copyright Cmassengale
  68. 68. Nucleotide – Nucleic acid monomer Copyright Cmassengale
  69. 69. Bases Each DNA nucleotide has one of the following bases: Thymine (T) Cytosine (C) Adenine (A) Guanine (G) <ul><ul><li>Adenine (A) </li></ul></ul><ul><ul><li>Guanine (G) </li></ul></ul><ul><ul><li>Thymine (T) </li></ul></ul><ul><ul><li>Cytosine (C) </li></ul></ul>Copyright Cmassengale
  70. 70. Nucleotide Monomers Form long chains called DNA Backbone Nucleotide Bases DNA strand Nucleotides are joined by sugars & phosphates on the side Copyright Cmassengale
  71. 71. DNA Two strands of DNA join together to form a double helix Base pair Double helix Copyright Cmassengale
  72. 72. RNA – Ribonucleic Acid Ribose sugar has an extra –OH or hydroxyl group It has the base uracil (U) instead of thymine (T) Nitrogenous base (A,G,C, or U) Sugar (ribose) Phosphate group Uracil Copyright Cmassengale
  73. 73. ATP – Cellular Energy <ul><li>ATP is used by cells for energy </li></ul><ul><li>Adenosine triphosphate </li></ul><ul><li>Made of a nucleotide with 3 phosphate groups </li></ul>Copyright Cmassengale
  74. 74. Summary of Key Concepts Copyright Cmassengale
  75. 75. Nucleic Acids Copyright Cmassengale
  76. 76. Macromolecules Copyright Cmassengale
  77. 77. Macromolecules Copyright Cmassengale
  78. 78. End Copyright Cmassengale
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