Pharm Distribution Narrated

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Pharm Distribution Narrated

  1. 1. Distribution Team Haberman Greg Dane Amanda Haberman Whitney Joseph/Woods Lauren Hinchey
  2. 2. Distribution  Today we are only focusing on distribution of drugs and why a nurse should know this  The analogy of highways will be used to help explain difficult ideas Site of Action
  3. 3. Distribution  Distribution is the movement of drugs throughout the human body  The way drugs travel is through the blood of the vascular system
  4. 4. The Vascular System
  5. 5. Blood Flow to Tissues VS.
  6. 6. Exiting the Vascular System  Once drugs have left the vascular system, they must pass between capillary cells
  7. 7. Site of Action  Some drugs must enter the cell to reach the site of action  Other drugs interact with receptors on the outside of the cell
  8. 8. Stop and Think!  Understanding distribution is an important factor to nursing, you must be able to determine if a drug can reach it’s target  What about the young, elderly and pregnant?
  9. 9. Blood-Brain Barrier  A blood-brain barrier (BBB) refers to the structure of capillaries in the central nervous system  The BBB is a major site of blood to central nervous system exchange  Tight junctions, between cells that make up the walls of most capillaries, keep drugs from passing through  Drugs must be lipid-soluble or have a transporter to cross the BBB  Some drugs dissolve directly into the membrane
  10. 10. Some drugs are not able to enter through the blood-brain barrier!
  11. 11. Placental Drug Transfer  Membranes of the placenta keep circulation of mother and fetus separate, however it is not an absolute barrier  Drugs that pass the placenta can cause significant birth defects
  12. 12. Protein Binding  Drugs most often form reversible bonds with proteins in the body  Protein Albumin is the most common, it makes up 50- 75% of blood proteins  Because Albumin cannot leave the bloodstream, it restricts bound drugs from reaching their sites of
  13. 13. Patient Safety
  14. 14. Sources Abbot, N. J. (2009). Structure and Function of the Blood-Brain Barrier. Medline. <http://ncbi.nlm.nih.gov/pubmed/19664713. ESRD Network of New England. <networkofnewengland.org/albfac.pdf. Lehne, R. A. (2013). Pharmacology for Nursing Care 8th ed. St. Louis, MO: Elsevier Inc. Pharmacokinetics: Distribution. <http://psych. fullerton.edu/mwhite/475pdf475 Pharmacokinetics-Distribution.pdf.

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