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Pharm Distribution Narrated
 

Pharm Distribution Narrated

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    Pharm Distribution Narrated Pharm Distribution Narrated Presentation Transcript

    • Distribution Team Haberman Greg Dane Amanda Haberman Whitney Joseph/Woods Lauren Hinchey
    • Distribution  Today we are only focusing on distribution of drugs and why a nurse should know this  The analogy of highways will be used to help explain difficult ideas Site of Action
    • Distribution  Distribution is the movement of drugs throughout the human body  The way drugs travel is through the blood of the vascular system
    • The Vascular System
    • Blood Flow to Tissues VS.
    • Exiting the Vascular System  Once drugs have left the vascular system, they must pass between capillary cells
    • Site of Action  Some drugs must enter the cell to reach the site of action  Other drugs interact with receptors on the outside of the cell
    • Stop and Think!  Understanding distribution is an important factor to nursing, you must be able to determine if a drug can reach it’s target  What about the young, elderly and pregnant?
    • Blood-Brain Barrier  A blood-brain barrier (BBB) refers to the structure of capillaries in the central nervous system  The BBB is a major site of blood to central nervous system exchange  Tight junctions, between cells that make up the walls of most capillaries, keep drugs from passing through  Drugs must be lipid-soluble or have a transporter to cross the BBB  Some drugs dissolve directly into the membrane
    • Some drugs are not able to enter through the blood-brain barrier!
    • Placental Drug Transfer  Membranes of the placenta keep circulation of mother and fetus separate, however it is not an absolute barrier  Drugs that pass the placenta can cause significant birth defects
    • Protein Binding  Drugs most often form reversible bonds with proteins in the body  Protein Albumin is the most common, it makes up 50- 75% of blood proteins  Because Albumin cannot leave the bloodstream, it restricts bound drugs from reaching their sites of
    • Patient Safety
    • Sources Abbot, N. J. (2009). Structure and Function of the Blood-Brain Barrier. Medline. <http://ncbi.nlm.nih.gov/pubmed/19664713. ESRD Network of New England. <networkofnewengland.org/albfac.pdf. Lehne, R. A. (2013). Pharmacology for Nursing Care 8th ed. St. Louis, MO: Elsevier Inc. Pharmacokinetics: Distribution. <http://psych. fullerton.edu/mwhite/475pdf475 Pharmacokinetics-Distribution.pdf.