Your SlideShare is downloading. ×
New diabetes drug invokana has major treatment
Upcoming SlideShare
Loading in...5
×

Thanks for flagging this SlideShare!

Oops! An error has occurred.

×
Saving this for later? Get the SlideShare app to save on your phone or tablet. Read anywhere, anytime – even offline.
Text the download link to your phone
Standard text messaging rates apply

New diabetes drug invokana has major treatment

801

Published on

Published in: Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total Views
801
On Slideshare
0
From Embeds
0
Number of Embeds
1
Actions
Shares
0
Downloads
7
Comments
0
Likes
0
Embeds 0
No embeds

Report content
Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
No notes for slide

Transcript

  • 1. New Diabetes Drug Invokana Has MajorTreatment - And Market - PotentialA new treatment option will soon be available to people with type 2 diabetes with the FDA’sapproval on Friday of Invokana, a first-in-class medication to lower blood sugar.Johnson & Johnson’s Invokana (generic name canagliflozin) attacks blood sugar right from theget go, reducing the amount of sugar absorbed from food into the bloodstream. The body thenflushes the excess sugar out in the urine.The medical profession – and analysts – have been paying close attention to Invokana because itlowers blood sugar by a different mechanism than the other diabetes drugs on the market.(Metformin, which I wrote about last week for its anti-cancer and anti-aging benefits, is one ofthe other popular diabetes medications available.)Controlling blood sugar is the key to preventing the many side effects caused by diabetes, suchas vision loss, nerve damage, kidney damage, and increased risk of heart attack and stroke.Johnson & Johnson’s application for Invokana cited nine clinical trials involving more than10,000 patients. The main side effects found were urinary tract infections (UTIs) and yeastinfections caused by large amounts of sugar in the urine. (Women prone to UTIs are familiarwith this problem.) Forbes’ Matthew Herper reports that this problem could limit Invokana’ssales, according to some analysts’ predictions. People taking Invokana were also found to havethe potential to become dizzy or faint when standing up suddenly, giving the drug the potential tocause falls, which can be particularly dangerous to the elderly.Invokana’s action takes place in the kidneys – it blocks an enzyme, sodium-glucose co-transporter 2, from putting sugar removed by the kidneys back in the bloodstream. Thereforesome members of the FDA’s advisory panel expressed concern that Invokana should not betaken by people with moderate to severe kidney disease.Invokana was found in trials to raise cholesterol, both LDL or bad cholesterol and HDL, or“good” cholesterol. An elevated risk of stroke and heart attack was found in the first 30 daysafter starting the medication, but after 30 days Invokana reduced these risks.Some diabetes drugs, in particular the former “blockbuster” Avandia, have run into troublebecause of increased heart attack risk. Avandia is now restricted to patients who’ve tried andfailed to respond to other medications, and is banned in Europe. The FDA required Johnson &Johnson to conduct five additional long-term studies of Invokana’s effects on cardiac health,liver problems, cancer, and pancreatic disease.Any diabetes drug that works well – and has limited side effects – has major market potentialsimply because there are so many people with diabetes.

×