Dyslipidemia case study

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Dyslipidemia case study

Dyslipidemia case study

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  • 1. Male patient aged 35 ys C/o of skin lesions over the extensor surface of both elbows and knees
  • 2. Bp 130/80, pulse 80 regular Neck Chest Heart AbdNS
  • 3. Lab Values Total cholesterol 508 mg% Trigliceride 2894 Random Sugar 338 ECG T wave changes in LIII, aVF,V3-V6
  • 4. Ask patient 3 questions Family history DM, Dyslipedimia Early IHD in family Thyroid disease Drug intake Liver,kidney diseases
  • 5. Inferiolateral ischemia
  • 6. Investigations recomended Lipid profile Liver function Renal function Thyroid function Cardiology consultation Why?
  • 7. Causes of secondary hyperlipidemia Cholestatic liver diseases Nephrotic syndrome Chronic renal failure Hypothyroidism Cigarette smoking Obesity Drugs
  • 8. Expected complications IHD, accelerated atherosclerosis Pancreatitis Gall bladder disease Related to medications Complications of Diabetes
  • 9. Lipoprotein
  • 10. Type of lipoproteins
  • 11. Lipoproteins suclasses
  • 12. Dyslipedimia
  • 13. Lipid Fredrekhsen classification
  • 14. Plan of your treatment Diet Diabetes control IHD, accelerated atherosclerosis Hypolipemic medications,Statin,Fibrate,Resin uptake,ezetimibe, nicotinic acid,lipid apheresis others
  • 15. Mechanism of action Statins Are specific competitive inhibitors of microsomal enzyme HMG-CoA reductase, which catalyses the conversion HMG-Co ATo mevalonate, a rate- determining step in cholesterol synthesis
  • 16. Mechanism of action of Fibrates
  • 17. ADR of Statins Statins , Rhabdomyalgia , Rhabdomyolysis Renal impairement Raise transaminases GIT
  • 18. APHERESIS