ANATOMY AND PHYSIOLOGY OF NEUROMUSCULAR JUNCTION PRESENTOR : Dr Goutham MODERATOR : Dr Vijesh
 
NEUROMUSCULAR JUNCTION <ul><li>Synapse b/w motor nerve and muscle </li></ul><ul><li>Each motor neuron runs from ventral ho...
MUSCLE END <ul><li>Corrugated with invaginations to form primary and secondary cleft along muscle </li></ul><ul><li>Should...
PERIJUNCTIONAL ZONE  <ul><li>Area beyond the junctional area </li></ul><ul><li>Critical to NMJ transmission  </li></ul><ul...
 
<ul><li>Vesicles containing transmitters are seen clustering alongside the nerve terminal – ACTIVE ZONES / RELEASE SITE </...
FORMATION OF ACETYLCHOLINE <ul><li>How ?  </li></ul><ul><li>Axoplasm </li></ul><ul><li>CHOLINE  +  ACETYL CoA </li></ul><u...
TRANSMISSION <ul><li>MEPP  : produced by quanta/packages </li></ul><ul><li>At rest potential difference is -90 mV </li></u...
CALCIUM CHANNELS -TYPES <ul><li>P type  L type </li></ul><ul><li>1.voltage dependant  non dependant </li></ul><ul><li>2.no...
SYNAPTIC VESICLE
SYNAPTIC VESICLE <ul><li>VESICLE PROTIENS </li></ul><ul><li>Synaptophysin  </li></ul><ul><li>Synaptotagmin </li></ul><ul><...
EXOCYTOSIS
REMOVAL OF Ach
RECEPTORS <ul><li>Ach RECEPTOR </li></ul><ul><li>Post junctional,junctional and extra junctional </li></ul><ul><li>Pre jun...
CONTD….. <ul><li>Has 5 subunits. </li></ul><ul><li>Alpha(2),beta,delta,epsilon. </li></ul><ul><li>Both alpha units occupie...
MECHANISM OF ION FLOW <ul><li>Receptor undergo conformational change </li></ul><ul><li>Opens channel </li></ul><ul><li>All...
 
MUSCLE CONTRACTION <ul><li>Myofibrils consists of sacromeres. </li></ul><ul><li>Each sacromere –actin and myosin. </li></u...
EXTRA JUNCTIONAL RECPTORS <ul><li>Denervation of the muscle. </li></ul><ul><li>Seen in  </li></ul><ul><li>Fetus </li></ul>...
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Anatomy and physiology of neuromuscular junction

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Anatomy and physiology of neuromuscular junction

  1. 1. ANATOMY AND PHYSIOLOGY OF NEUROMUSCULAR JUNCTION PRESENTOR : Dr Goutham MODERATOR : Dr Vijesh
  2. 3. NEUROMUSCULAR JUNCTION <ul><li>Synapse b/w motor nerve and muscle </li></ul><ul><li>Each motor neuron runs from ventral horn of spinal cord </li></ul><ul><li>Gap b/w nerve and muscle is the synaptic cleft which is 20 nm wide </li></ul>
  3. 4. MUSCLE END <ul><li>Corrugated with invaginations to form primary and secondary cleft along muscle </li></ul><ul><li>Shoulders contain Ach receptors which are densely packed </li></ul>
  4. 5. PERIJUNCTIONAL ZONE <ul><li>Area beyond the junctional area </li></ul><ul><li>Critical to NMJ transmission </li></ul><ul><li>Has high density of sodium channels </li></ul><ul><li>Responds to depolarisation produced by Ach receptors and initiates contraction </li></ul>
  5. 7. <ul><li>Vesicles containing transmitters are seen clustering alongside the nerve terminal – ACTIVE ZONES / RELEASE SITE </li></ul><ul><li>Voltage gated calcium channels present in b/w vesicles through which calcium enters and cause release of transmitter </li></ul>
  6. 8. FORMATION OF ACETYLCHOLINE <ul><li>How ? </li></ul><ul><li>Axoplasm </li></ul><ul><li>CHOLINE + ACETYL CoA </li></ul><ul><li>( CAT ) </li></ul><ul><li>ECF mitochondria </li></ul><ul><li>diet </li></ul><ul><li>hydrolyzed acetylcholine </li></ul><ul><li>liver </li></ul>
  7. 9. TRANSMISSION <ul><li>MEPP : produced by quanta/packages </li></ul><ul><li>At rest potential difference is -90 mV </li></ul><ul><li>During AP > Na + influx >depolarization > opens Ca channels > release of Ach from vesicles </li></ul>
  8. 10. CALCIUM CHANNELS -TYPES <ul><li>P type L type </li></ul><ul><li>1.voltage dependant non dependant </li></ul><ul><li>2.not affected by Ca channel blockers affected </li></ul><ul><li>3.release of transmitter </li></ul>
  9. 11. SYNAPTIC VESICLE
  10. 12. SYNAPTIC VESICLE <ul><li>VESICLE PROTIENS </li></ul><ul><li>Synaptophysin </li></ul><ul><li>Synaptotagmin </li></ul><ul><li>Synaptobrevin </li></ul><ul><li>CLINICAL ASPECT : </li></ul><ul><li>Botulinum toxin/tetanus toxin </li></ul>
  11. 13. EXOCYTOSIS
  12. 14. REMOVAL OF Ach
  13. 15. RECEPTORS <ul><li>Ach RECEPTOR </li></ul><ul><li>Post junctional,junctional and extra junctional </li></ul><ul><li>Pre junctional . </li></ul>
  14. 16. CONTD….. <ul><li>Has 5 subunits. </li></ul><ul><li>Alpha(2),beta,delta,epsilon. </li></ul><ul><li>Both alpha units occupied by agonist. </li></ul>
  15. 17. MECHANISM OF ION FLOW <ul><li>Receptor undergo conformational change </li></ul><ul><li>Opens channel </li></ul><ul><li>Allows cation movement </li></ul><ul><li>AP created </li></ul>
  16. 19. MUSCLE CONTRACTION <ul><li>Myofibrils consists of sacromeres. </li></ul><ul><li>Each sacromere –actin and myosin. </li></ul><ul><li>Tropomyosin and troponin attached to actin </li></ul><ul><li>AP transverse tubules,sarcoplasmic reticulum releases ca++. </li></ul>
  17. 20. EXTRA JUNCTIONAL RECPTORS <ul><li>Denervation of the muscle. </li></ul><ul><li>Seen in </li></ul><ul><li>Fetus </li></ul><ul><li>Pts with stroke </li></ul><ul><li>Spinal cord injuries </li></ul><ul><li>Burns </li></ul><ul><li>bedridden </li></ul>
  18. 21. THANK YOU
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