A new pathogenic e coli francisco muñoz maestre

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  • 1. Francisco Muñoz Maestre A NEW PATHOGENIC E COLI
  • 2. Index  Introduction  Pathogenics E. coli  New pathogenic E. coli  Case study  Symptoms and cures  Bibliography
  • 3. INTRODUCTION  What is E. coli ? E. coli is a bacteria, inhabitant of our gastrointestinal tract and one of bacterial species most frequently isolated in cultures.  When is E. coli a pathogenic bacteria? When they acquire certain genetic material.
  • 4. PATHOGENICS E. COLI 1  There are a lot of types but I’m going to explain most important types:  ENTEROTOXIGENIC ESCHERICHIA COLI (ETEC) watery diarrhea in young humans and other mammals  ENTEROPATHOGENIC ESCHERICHIA COLI (EPEC)most commonly among children less than six months of age in developing countries
  • 5. PATHOGENICS E. COLI 2  ENTEROHEMORRHAGIC ESCHERICHIA COLI (EHEC)capable of producing Shiga toxin  ENTEROINVASIVE ESCHERICHIA COLI (EIEC)closely related to Shigella and causes disease that is similar to shigellosis  ENTEROAGGREGATIVE ESCHERICHIA COLI (EAEC) acute diarrheal illness among many different subpopulations in both developing and industrialized regions
  • 6. NEW PATHOGENIC E COLI O104:H4  First isolates date back to 2001, described like HUSEC41  It turned up again in 2006, in a woman who contracted HUS in Korea.  The current is a recombinant of two pathogenic E. coli types, enterohaemolytic E. coli (EHEC) and enteroaggregative E. coli (EAEC)  E. coli O104:H4 also contains an array of antibiotic resistance genes conferring resistance to a lot of antibiotic like ampicillin, amoxicillin, streptomycin, …
  • 7. NEW PATHOGENIC CASE  Between 2 May and 14 June 2011, 3,332 cases (818 cases of HUS) from 13 European Union Member States, and 36 patients died.  95% from Germany and they came from northern Germany  Some 100 patients need an organ transplant or will require dialysis.  The source was vegetable sprouts from an organic farm in Lower Saxony in northern Germany.
  • 8.  There are two symptoms that are special in this E. coli: bloody diarrhea and Hemolytic-uremic syndrome (HUS, the major systemic complication of EHEC infection)  There are a lot of experiments but there aren’t any cure now for that.
  • 9. BIBLIOGRAPHY • http://www.sciencedirect.com/science/article/pii/S14733099 11701657 • http://www.i-sis.org.uk/ E_coli_O104_H4_Newly_Emergent_Pathogen.php • http://www.uptodate.com/contents/pathogenic-escherichia- coli • http://www.uptodate.com/contents/clinical-manifestations- diagnosis-and-treatment-of-enterohemorrhagic-escherichia- coli-ehec?source=see_link